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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appincreases abundanceEXP 6480464CTDAPP protein modified form results in increased abundance of DinoprostonePMID:20171164
Appincreases expressionEXP 6480464CTDDinoprostone results in increased expression of APP protein modified formPMID:20171164
Appmultiple interactionsEXP 6480464CTDPTGES2 promotes the reaction [APP protein modified form results in increased abundance of Dinoprostone]; resveratrol inhibits the reaction [APP protein results in increased secretion of Dinoprostone]PMID:16685418 PMID:20171164
Appincreases secretionISOAPP (Homo sapiens)6480464CTDAPP protein modified form results in increased secretion of DinoprostonePMID:28721267
Appmultiple interactionsISOAPP (Homo sapiens)6480464CTDCNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]; Dronabinol inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]; L 685458 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]PMID:28721267
Appmultiple interactionsISOApp (Mus musculus)6480464CTD[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone]PMID:23261590
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