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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139 Species: Rattus norvegicus RGD Object: Gene Symbol: App Name: amyloid beta (A4) precursor protein

Acc ID: CHEBI:17500 Term: 7alpha-hydroxycholesterol Definition: The 7alpha-hydroxy derivative of cholesterol. CasRN: 566-26-7 Chemical ID: MESH:C011724

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases chemical synthesis	EXP		6480464	CTD	APP protein results in increased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol	PMID:15591071
decreases secretion	EXP		6480464	CTD	cholest-5-en-3 beta,7 alpha-diol results in decreased secretion of APP protein	PMID:15591071