GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | App | decreases response to substance | EXP | | 6480464 | CTD | resveratrol results in decreased susceptibility to APP protein | PMID:15134381 | App | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Ascorbic Acid]; resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols]; resveratrol inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; resveratrol inhibits the reaction [APP protein modified form results in decreased activity of GSR protein]; resveratrol inhibits the reaction [APP protein modified form results in decreased expression of ARC protein]; resveratrol inhibits the reaction [APP protein modified form results in decreased expression of DLG4 protein]; resveratrol inhibits the reaction [APP protein modified form results in decreased expression of GSK3B protein modified form]; resveratrol inhibits the reaction [APP protein modified form results in decreased expression of IDE protein]; resveratrol inhibits the reaction [APP protein modified form results in increased abundance of Lipid Peroxides]; resveratrol inhibits the reaction [APP protein modified form results in increased expression of MAPT protein modified form]; resveratrol inhibits the reaction [APP protein modified form results in increased expression of MAPT protein]; resveratrol inhibits the reaction [APP protein results in increased acetylation of RELA protein]; resveratrol inhibits the reaction [APP protein results in increased expression of and results in increased activity of NOS2 protein]; resveratrol inhibits the reaction [APP protein results in increased expression of PTGS2 protein]; resveratrol inhibits the reaction [APP protein results in increased secretion of Dinoprostone]; resveratrol promotes the reaction [Catechin results in decreased susceptibility to APP protein] | PMID:15134381 PMID:16183991 PMID:16685418 PMID:25654502 | App | affects binding | ISO | APP (Homo sapiens) | 6480464 | CTD | resveratrol binds to [APP protein binds to APP protein] | PMID:17597573 | App | affects folding | ISO | APP (Homo sapiens) | 6480464 | CTD | resveratrol affects the folding of APP protein modified form | PMID:23386614 | App | decreases expression | ISO | APP (Homo sapiens) | 6480464 | CTD | resveratrol results in decreased expression of APP protein modified form | PMID:20080969 | App | decreases expression | ISO | App (Mus musculus) | 6480464 | CTD | resveratrol results in decreased expression of APP protein; resveratrol results in decreased expression of APP protein modified form | PMID:20080969 PMID:22118570 PMID:23129026 | App | decreases secretion | ISO | App (Mus musculus) | 6480464 | CTD | resveratrol results in decreased secretion of APP protein mutant form | PMID:16162502 | App | increases degradation | ISO | APP (Homo sapiens) | 6480464 | CTD | resveratrol results in increased degradation of APP protein modified form | PMID:20080969 | App | multiple interactions | ISO | APP (Homo sapiens) | 6480464 | CTD | [Plant Extracts co-treated with Resveratrol] results in increased expression of APP mRNA; [Resveratrol results in increased phosphorylation of PRKAA1 protein] which results in decreased expression of APP protein modified form; dorsomorphin inhibits the reaction [Resveratrol results in decreased expression of APP protein modified form]; lactacystin inhibits the reaction [Resveratrol results in decreased secretion of APP protein]; PSMB5 protein affects the reaction [Resveratrol results in decreased secretion of APP protein]; Resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides]; Resveratrol results in decreased secretion of and results in increased degradation of APP protein; YU101 inhibits the reaction [Resveratrol results in decreased secretion of APP protein] | PMID:16162502 PMID:16212921 PMID:20080969 PMID:23557933 | App | multiple interactions | ISO | App (Mus musculus) | 6480464 | CTD | resveratrol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]; resveratrol inhibits the reaction [APP protein results in increased phosphorylation of NFKBIA protein]; resveratrol inhibits the reaction [APP protein results in increased phosphorylation of STAT1 protein]; resveratrol inhibits the reaction [APP protein results in increased phosphorylation of STAT3 protein]; resveratrol inhibits the reaction [APP protein results in increased secretion of IL6 protein]; resveratrol inhibits the reaction [APP protein results in increased secretion of TNF protein] | PMID:22118570 PMID:24254769 | | ||||||||||||||||||||||
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