GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | App | affects expression | EXP | | 6480464 | CTD | lead acetate affects the expression of APP protein | PMID:36539177 | App | decreases methylation | EXP | | 6480464 | CTD | lead acetate results in decreased methylation of APP promoter | PMID:21117136 PMID:22764079 | App | increases expression | EXP | | 6480464 | CTD | lead acetate results in increased expression of APP mRNA; lead acetate results in increased expression of APP protein; lead acetate results in increased expression of APP protein alternative form; lead acetate results in increased expression of APP protein modified form | PMID:21117136 PMID:22764079 PMID:24806610 PMID:25088297 PMID:29908845 | App | multiple interactions | EXP | | 6480464 | CTD | Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] | PMID:25088297 | App | increases expression | ISO | APP (Homo sapiens) | 6480464 | CTD | lead acetate results in increased expression of APP protein modified form | PMID:24462621 | App | increases expression | ISO | App (Mus musculus) | 6480464 | CTD | lead acetate results in increased expression of APP mRNA; lead acetate results in increased expression of APP protein; lead acetate results in increased expression of APP protein modified form | PMID:22279679 PMID:23867794 | App | multiple interactions | ISO | APP (Homo sapiens) | 6480464 | CTD | [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein; [lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in increased expression of BACE1 protein]; tolfenamic acid inhibits the reaction [lead acetate results in increased expression of APP protein modified form] | PMID:24462621 PMID:31843630 | App | multiple interactions | ISO | App (Mus musculus) | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in increased expression of APP mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of APP protein | PMID:31730887 PMID:32058320 | | ||||||||||||||||||||||
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