Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2139
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	App
Name:	amyloid beta precursor protein

Acc ID:	CHEBI:9288
Term:	streptozocin
Definition:	An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID:	MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
App	increases expression	EXP		6480464	CTD	Streptozocin results in increased expression of APP protein modified form	PMID:21290839
App	multiple interactions	EXP		6480464	CTD	Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]	PMID:21290839
App	increases expression	ISO	App (Mus musculus)	6480464	CTD	Streptozocin results in increased expression of APP mRNA; Streptozocin results in increased expression of APP protein; Streptozocin results in increased expression of APP protein modified form	PMID:21069392 PMID:30481507 PMID:34428446
App	multiple interactions	ISO	App (Mus musculus)	6480464	CTD	5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]; Alendronate inhibits the reaction [Streptozocin results in increased expression of APP protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of APP protein]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]	PMID:30481507 PMID:34428446

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