GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | App | decreases expression | ISO | APP (Homo sapiens) | 6480464 | CTD | pioglitazone results in decreased expression of APP protein mutant form | PMID:15817521 | App | decreases expression | ISO | App (Mus musculus) | 6480464 | CTD | pioglitazone results in decreased expression of APP protein | PMID:16407166 | App | multiple interactions | ISO | APP (Homo sapiens) | 6480464 | CTD | pioglitazone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; pioglitazone inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form] | PMID:14586007 | |
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