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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:16680
Term: S-adenosyl-L-homocysteine
Definition: An organic sulfide that is the S-adenosyl derivative of L-homocysteine.
Chemical ID: MESH:D012435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appdecreases methylationISOApp (Mus musculus)6480464CTDS-Adenosylhomocysteine results in decreased methylation of APP promoterPMID:19635394
Appincreases expressionISOApp (Mus musculus)6480464CTDS-Adenosylhomocysteine results in increased expression of APP proteinPMID:22064374
Appmultiple interactionsISOApp (Mus musculus)6480464CTDBetaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP proteinPMID:19635394
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