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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appaffects expressionISOApp (Mus musculus)6480464CTDDDT affects the expression of APP mRNAPMID:35946953
Appincreases expressionISOAPP (Homo sapiens)6480464CTDDDT results in increased expression of APP mRNA; DDT results in increased expression of APP proteinPMID:24473795 PMID:25720399 PMID:35946953
Appincreases expressionISOApp (Mus musculus)6480464CTDDDT results in increased expression of APP mRNA; DDT results in increased expression of APP proteinPMID:35946953
Appmultiple interactionsISOAPP (Homo sapiens)6480464CTDDDT results in increased expression of and results in increased cleavage of APP protein mutant form; DDT results in increased expression of and results in increased secretion of and results in decreased degradation of APP protein modified form; Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]PMID:25720399 PMID:35946953
Appmultiple interactionsISOApp (Mus musculus)6480464CTDTetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]; Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP protein]PMID:35946953
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