| 621108 | Erg | ETS transcription factor ERG | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II ( ortholog); ASSOCIATED WITH pulmonary venoocclusive disease; acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil | 11 | 48148149 | 48370472 | Rat | 136 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 621414 | Kcnh2 | potassium voltage-gated channel subfamily H member 2 | ENCODES a protein that exhibits inward rectifier potassium channel activity; monoatomic ion channel activity; potassium channel activity; INVOLVED IN potassium ion transport; regulation of membrane potential; spinal cord development; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenerg yle='font-weight:700;'>ergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alstrom syndrome (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); inward rectifier potassium channel complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 4 | 11719357 | 11751424 | Rat | 855 | description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620304 | Kcnh6 | potassium voltage-gated channel subfamily H member 6 | ENCODES a protein that exhibits inward rectifier potassium channel activity; protein-containing complex binding; voltage-gated potassium channel activity; INVOLVED IN potassium ion transport; ASSOCIATED WITH glucose metabolism disease (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride | 10 | 91449025 | 91471012 | Rat | 73 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 621112 | Kcnh7 | potassium voltage-gated channel subfamily H member 7 | ENCODES a protein that exhibits inward rectifier potassium channel activity; potassium channel activity; protein-containing complex binding; INVOLVED IN circadian rhythm; potassium ion transport; FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred); INT ERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 3 | 67737900 | 68230950 | Rat | 81 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1308370 | Setdb1 | SET domain bifurcated histone lysine methyltransferase 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); histone H3K14ac reader activity (ortholog); INVOLVED IN response to ethanol; response to vitamin; bone development (ortholog); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionin e cycle/metabolic pathway; ASSOCIATED WITH autistic disorder (ortholog); high grade glioma (ortholog); Huntington's disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 2 | 185587722 | 185619084 | Rat | 138 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2322827 | Setdb1-ps1 | SET domain bifurcated histone lysine methyltransferase 1, pseudogene 1 | | 2 | 185678670 | 185683802 | Rat | | old_gene_name | gene, pseudo, VALIDATED [RefSeq] |
| 1310769 | Erg28 | ergosterol biosynthesis 28 homolog | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN lipid metabolic process (inferred); steroid biosynthetic process (inferred); steroid metabolic process (inferred); FOUND IN transport vesicle (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3, 7,8-tetrachlorodibenzodioxine | 6 | 111205102 | 111214068 | Rat | 88 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1585015 | Ergic1 | endoplasmic reticulum-golgi intermediate compartment 1 | INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); ASSOCIATED WITH arthrogryposis multiplex congenita (ortholog); Contracture (ortholog); neurogenic-type arthrogryposis multiplex congenita-2 (ortholog); FOUND IN endoplasmic reticulum-Golgi intermediate compartment (ort holog); nucleoplasm (ortholog); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; bisphenol A | 10 | 17035615 | 17131411 | Rat | 107 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1310606 | Ergic2 | ERGIC and golgi 2 | INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum-Golgi intermediate compartment (ortholog); Golgi apparatus (ortholog); INTERACTS WI TH acetamide; bisphenol A; C60 fullerene | 4 | 182822225 | 182858392 | Rat | 86 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1308144 | Ergic3 | ERGIC and golgi 3 | INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); positive regulation of intracellular protein transport (ortholog); ASSOCIATED WITH Developmental Disease (ortholog); Experimental Neoplasms (ortholog); lung adenocarcinoma (ortholog); FOUND IN endoplasmic reticulum (in ferred); endoplasmic reticulum membrane (inferred); endoplasmic reticulum-Golgi intermediate compartment membrane (inferred); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 3 | 164985108 | 164994897 | Rat | 93 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 41020943 | Ergic2-ps1 | ERGIC and golgi 2, pseudogene 1 | | X | 72361733 | 72363858 | Rat | | symbol , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 2320313 | Ergic2-ps2 | ERGIC and golgi 2, pseudogene 2 | | 5 | 8260548 | 8261652 | Rat | | symbol , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 619771 | Cuzd1 | CUB and zona pellucida-like domains 1 | INVOLVED IN hormone-mediated signaling pathway; trypsinogen activation (ortholog); FOUND IN membrane (ortholog); zymogen granule (ortholog); zymogen granule membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; ammonium chloride | 1 | 195519609 | 195532733 | Rat | 70 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2056 | Adra2a | adrenoceptor alpha 2A | ENCODES a protein that exhibits alpha2-adrenergic receptor activity; adrenergic receptor activity (ortholog); alpha-1B adrenergic receptor binding (ortholog); INVOLVED IN DNA replication ; female pregnancy; G protein-coupled receptor signaling pathway; ASSOCIATED WITH Acute Lung Injury; alcohol dependence; anxiety disorder; FOUND IN axon terminus; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 2,3,4,7,8-Pentachlorodibenzofuran | 1 | 263066780 | 263069580 | Rat | 332 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1359518 | Cln8 | CLN8, transmembrane ER and ERGIC protein | ENCODES a protein that exhibits ceramide binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); adult walking behavior (ortholog); associative learning (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); congenital myopathy 1A (ortholog); epilepsy (ortholog); FOUND IN endopl asmic reticulum (ortholog); endoplasmic reticulum-Golgi intermediate compartment (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 16 | 81451941 | 81462046 | Rat | 183 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 71020 | Lman1 | lectin, mannose-binding, 1 | ENCODES a protein that exhibits identical protein binding; metal ion binding (ortholog); INVOLVED IN early endosome to Golgi transport (ortholog); endoplasmic reticulum organization (ortholog); gene expression (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; protein secretory pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); factor V deficiency (ortholog); factor XIII deficiency (ortholog); FOUND IN endoplasmic reticulum-Golgi intermediate compartment; glutamatergic synapse; postsynaptic Golgi apparatus; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-methoxyethanol | 18 | 61778971 | 61800960 | Rat | 172 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310538 | Lman1l | lectin, mannose-binding, 1 like | ENCODES a protein that exhibits carbohydrate binding (inferred); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH prostate cancer (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum-Golgi intermediate compartment (inferred); endoplasmic ret iculum-Golgi intermediate compartment membrane (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 8 | 66906684 | 66925512 | Rat | 43 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2055 | Adra1a | adrenoceptor alpha 1A | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN negative regulation of Rho protein signal transduction; phospholipase C-activating adrenerg ic receptor signaling pathway; positive regulation of action potential; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH bladder neck obstruction; Brain Injuries; Experimental Diabetes Mellitus; FOUND IN dopaminergic synapse; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (R)-adrenaline; (R)-noradrenaline | 15 | 45005648 | 45111416 | Rat | 325 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 621608 | Egr2 | early growth response 2 | ENCODES a protein that exhibits HMG box domain binding; chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN learning or memory; regulation of neuronal synaptic plasticity; response to insulin; PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH middle cerebral artery infar ction; Tendon Injuries; autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 17beta-estradiol | 20 | 21050149 | 21055201 | Rat | 393 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1359323 | Abhd6 | abhydrolase domain containing 6, acylglycerol lipase | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); monoacylglycerol lipase activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); long-term synaptic depression (ortholog); lysobisphosphatidic acid metabolic process (ortholog); FOUND IN AMPA glutamate recep tor complex (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate | 15 | 19289967 | 19337500 | Rat | 153 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 70969 | Ap3m2 | adaptor related protein complex 3 subunit mu 2 | INVOLVED IN anterograde axonal transport (ortholog); anterograde synaptic vesicle transport (ortholog); synaptic vesicle endocytosis (ortholog); FOUND IN synaptic vesicle; GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 16 | 75908459 | 75937915 | Rat | 101 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1304795 | Apbb1ip | amyloid beta precursor protein binding family B member 1 interacting protein | INVOLVED IN positive regulation of cell adhesion (ortholog); T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN GABA-ergic synapse; presynapse; cytosol (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 17 | 89849474 | 89941099 | Rat | 112 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620624 | Arhgef7 | Rho guanine nucleotide exchange factor 7 | ENCODES a protein that exhibits ATP-dependent protein binding; protein kinase binding; small GTPase binding; INVOLVED IN astrocyte cell migration; postsynaptic actin cytoskeleton organization; presynaptic actin cytoskeleton organization; PARTICIPATES IN adenosine signaling pathway; FOUND IN focal ad hesion; GABA-ergic synapse; growth cone; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 16 | 84373123 | 84484759 | Rat | 196 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620719 | Arhgef9 | Cdc42 guanine nucleotide exchange factor 9 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN receptor clustering; regulation of postsynaptic specialization assembly (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic enceph alopathy 1 (ortholog); FOUND IN cell cortex; GABA-ergic synapse; glycinergic synapse; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil | X | 63929168 | 64087267 | Rat | 118 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2230 | C1qbp | complement C1q binding protein | ENCODES a protein that exhibits adrenergic receptor binding; complement component C1q complex binding; protein kinase C binding; INVOLVED IN cytosolic ribosome assembly (ortholog); mitochondrial RNA catabolic process (ortholog); negative regulation of defense re sponse to virus (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); combined oxidative phosphorylation deficiency 33 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm; extracellular space; GABA-ergic synapse; INTERACTS WITH (R)-adrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 56198534 | 56203185 | Rat | 284 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2246 | Cacna1e | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; voltage-gated monoatomic cation channel activity (ortholog); INVOLVED IN calcium ion import; regulation of synaptic vesicle e xocytosis; behavioral fear response (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH increased kindling response; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse; perikaryon; voltage-gated calcium channel complex; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid | 13 | 69125048 | 69613795 | Rat | 175 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 631360 | Cacna2d2 | calcium voltage-gated channel auxiliary subunit alpha2delta 2 | ENCODES a protein that exhibits voltage-gated calcium channel activity; INVOLVED IN calcium ion transport; muscle cell development (ortholog); neuromuscular junction development (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta rec eptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Cardiac Arrhythmias; Myocardial Ischemia; Ataxia (ortholog); FOUND IN GABA-ergic synapse (ortholog); presynaptic active zone membrane (ortholog); voltage-gated calcium channel complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; androgen antagonist | 8 | 116950860 | 117082159 | Rat | 212 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 631361 | Cacna2d3 | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | ENCODES a protein that exhibits voltage-gated calcium channel activity; INVOLVED IN calcium ion transport; cellular response to insulin-like growth factor stimulus; regulation of presynapse organization (ortholog); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated card iomyopathy pathway; hypertrophic cardiomyopathy pathway; ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN GABA-ergic synapse (ortholog); presynaptic active zone membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 16 | 4105048 | 4919037 | Rat | 109 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305678 | Cadm2 | cell adhesion molecule 2 | INVOLVED IN synaptic membrane adhesion; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); malignant astrocytoma (ortholog); FOUND IN axon; GABA-ergic synapse; glutamatergic synapse; IN TERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 11 | 17994856 | 18971895 | Rat | 91 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307035 | Cadm3 | cell adhesion molecule 3 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN synaptic membrane adhesion; heterophilic cell-cell adhesion (ortholog); homophilic cell-cell adhesion (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth Disease Axonal Type 2FF (ortholog); genetic disease (ortholo g); prostate cancer (ortholog); FOUND IN GABA-ergic synapse; glutamatergic synapse; cell-cell junction (ortholog); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 13 | 88317124 | 88349718 | Rat | 99 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1589642 | Cbln4 | cerebellin 4 precursor | INVOLVED IN inhibitory synapse assembly (ortholog); protein secretion (ortholog); trans-synaptic signaling, modulating synaptic transmission (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); GABA-ergic synapse (ortholog); INTE RACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amitrole; bis(2-ethylhexyl) phthalate | 3 | 181218046 | 181225600 | Rat | 60 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 619741 | Cdh10 | cadherin 10 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN synaptic membrane adhesion (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN GABA-ergic synapse; glutamaterg 0;'>ergic synapse; postsynaptic specialization membrane; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 2 | 70355521 | 70577880 | Rat | 104 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 619745 | Cdh13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (ortholog); cadherin binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to toxic substance; cellular response to xenobiotic stimulus; calcium-dependent cell-cell adhesion (ortholog); ASSOCIATED WITH abnormal cue -induced reinstatement of an extinguished operant behavior for a cocaine reinforcer; saccharin preference; ASSOCIATED WITH coronary restenosis; Lung Neoplasms; substance-related disorder; FOUND IN GABA-ergic synapse; perinuclear region of cytoplasm; synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-acetamidofluorene | 19 | 63258251 | 64296122 | Rat | 281 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 70878 | Cit | citron rho-interacting serine/threonine kinase | ENCODES a protein that exhibits scaffold protein binding; PDZ domain binding (ortholog); protein kinase binding (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle; gamma-aminobutyric acid signaling pathway; Golgi organization; ASSOCIATED WITH binucleate; decreased forebrain size; flat hea d; ASSOCIATED WITH epilepsy; microcephaly; traumatic brain injury; FOUND IN cleavage furrow; GABA-ergic synapse; glutamatergic postsynaptic density; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride | 12 | 46263881 | 46425642 | Rat | 209 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310959 | Clptm1 | CLPTM1 regulator of GABA type A receptor forward trafficking | ENCODES a protein that exhibits GABA receptor binding (ortholog); INVOLVED IN regulation of postsynaptic membrane neurotransmitter receptor levels; inhibitory chemical synaptic transmission (ortholog); memory (ortholog); ASSOCIATED WITH pancreatic cancer (ortholog); FOUND IN GABA-erg eight:700;'>ergic synapse; external side of plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol | 1 | 88417447 | 88449047 | Rat | 94 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306458 | Clstn1 | calsyntenin 1 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); kinesin binding (ortholog); X11-like protein binding (ortholog); INVOLVED IN neurotransmitter receptor transport to postsynaptic membrane (ortholog); positive regulation of synapse assembly (ortholog); positive regulation of synaptic t ransmission (ortholog); FOUND IN GABA-ergic synapse; glutamatergic synapse; postsynaptic density membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; amitrole | 5 | 165314128 | 165377627 | Rat | 146 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1308373 | Cnrip1 | cannabinoid receptor interacting protein 1 | ENCODES a protein that exhibits type 1 cannabinoid receptor binding; INVOLVED IN negative regulation of signaling receptor activity (ortholog); regulation of signaling receptor activity (ortholog); regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (ortholog) ; FOUND IN cytoplasm (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH all-trans-retinoic acid; bisphenol A; gentamycin | 14 | 95664435 | 95707062 | Rat | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621302 | Cntn5 | contactin 5 | INVOLVED IN presynapse assembly (ortholog); sensory perception of sound (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN GABA-ergic synapse (ortholog); presynaptic membrane (ortholog); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7, 8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 8 | 15017424 | 16249418 | Rat | 57 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307076 | Cntnap2 | contactin associated protein 2 | ENCODES a protein that exhibits protease binding; transmembrane transporter binding; enzyme binding (ortholog); INVOLVED IN prepulse inhibition; startle response; action potential initiation (ortholog); ASSOCIATED WITH abnormal auditory brainstem response; abnormal habituation; abnormal prepulse inh ibition; ASSOCIATED WITH autism spectrum disorder; epilepsy; articulation disorder (ortholog); FOUND IN axolemma; dendrite; GABA-ergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A | 4 | 75109358 | 77366258 | Rat | 301 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306459 | Cntnap4 | contactin associated protein family member 4 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN modulation of chemical synaptic transmission (ortholog); neural precursor cell proliferation (ortholog); neuron differentiation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN dendrite (ortholog); GA BA-ergic synapse (ortholog); plasma membrane (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; atrazine; bisphenol A | 19 | 57477447 | 57765173 | Rat | 54 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2431 | Cspg5 | chondroitin sulfate proteoglycan 5 | INVOLVED IN axon regeneration; cytoskeleton organization; glial cell projection elongation; FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 17alpha-ethynyl estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 8 | 119098932 | 119113191 | Rat | 101 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68372 | Ctbp2 | C-terminal binding protein 2 | ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); nuclear retinoic acid receptor binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); negative regulation of DNA-templated transcription (ortholog); positive regul ation of retinoic acid receptor signaling pathway (ortholog); PARTICIPATES IN chronic myeloid leukemia pathway; Notch signaling pathway; Wnt signaling pathway; ASSOCIATED WITH Neoplasm Invasiveness (ortholog); Neoplastic Cell Transformation (ortholog); Prostatic Neoplasms (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine | 1 | 197208536 | 197348802 | Rat | 205 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621511 | Ctsd | cathepsin D | ENCODES a protein that exhibits endopeptidase activity; peptide binding; aspartic-type endopeptidase activity (ortholog); INVOLVED IN protein catabolic process; response to nutrient levels; synaptic vesicle endosomal processing; PARTICIPATES IN ceramide signaling pathway; chaperone mediated autophag y pathway; tuberculosis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); atherosclerosis (ortholog); FOUND IN GABA-ergic synapse; presynaptic endosome; cytosol (ortholog); INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (R)-lipoic acid | 1 | 206956945 | 206968821 | Rat | 507 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620670 | Dcx | doublecortin | ENCODES a protein that exhibits microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN neuron migration; positive regulation of collateral sprouting; positive regulation of endocytosis; ASSOCIATED WITH abnormal brain development; ASSOCIATED WITH alcohol use disorder; brain in farction; Cerebral Hemorrhage; FOUND IN axon; dendrite; GABA-ergic synapse; INTERACTS WITH 2,6-di-tert-butyl-4-methylphenol; 5-fluorouracil; 6-propyl-2-thiouracil | X | 112227455 | 112370291 | Rat | 206 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1309579 | Dtnb | dystrobrevin, beta | ENCODES a protein that exhibits phosphatase binding; DNA binding (ortholog); INVOLVED IN neuron differentiation (ortholog); FOUND IN postsynaptic density; cytoplasm (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodi benzodioxine; 2,4-dinitrotoluene | 6 | 32286022 | 32483007 | Rat | 128 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1596811 | Dynap | dynactin associated protein | INVOLVED IN activation of protein kinase B activity (ortholog); cellular response to ergosterol (ortholog); positive regulation of cell population proliferation (ortholog); FOUND IN Golgi apparatus (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-t etrachlorodibenzodioxine (ortholog); benzo[a]pyrene (ortholog); bisphenol A (ortholog) | 18 | 66160548 | 66227999 | Rat | 22 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 67387 | Eef1a1 | eukaryotic translation elongation factor 1 alpha 1 | ENCODES a protein that exhibits heterocyclic compound binding; identical protein binding; mRNA binding; INVOLVED IN cellular response to nerve growth factor stimulus; cellular response to xenobiotic stimulus; negative regulation of reactive oxygen species biosynthetic process; PARTICIPATES IN chaper one mediated autophagy pathway; translation elongation pathway; RNA transport pathway; ASSOCIATED WITH Burns; Knee Osteoarthritis; Animal Mammary Neoplasms (ortholog); FOUND IN GABA-ergic synapse; postsynapse; cortical actin cytoskeleton (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 88221839 | 88225688 | Rat | 294 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3781 | Eef1a2 | eukaryotic translation elongation factor 1 alpha 2 | ENCODES a protein that exhibits GTPase activity (ortholog); protein kinase binding (ortholog); translation elongation factor activity (ortholog); INVOLVED IN regulation of postsynaptic specialization assembly; response to electrical stimulus; positive regulation of apoptotic process (ortholog); PART ICIPATES IN RNA transport pathway; ASSOCIATED WITH Nerve Degeneration; Alzheimer's disease (ortholog); autistic disorder (ortholog); FOUND IN GABA-ergic synapse; neuronal cell body; cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 3 | 188643455 | 188652633 | Rat | 224 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307666 | Enah | ENAH, actin regulator | ENCODES a protein that exhibits profilin binding (ortholog); SH3 domain binding (ortholog); WW domain binding (ortholog); INVOLVED IN postsynaptic cytoskeleton organization; actin cytoskeleton organization (ortholog); actin filament organization (ortholog); PARTICIPATES IN E-cadherin signaling pathw ay; ASSOCIATED WITH acute myeloid leukemia (ortholog); hepatocellular carcinoma (ortholog); stomach cancer (ortholog); FOUND IN GABA-ergic synapse; postsynapse; cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl; cadmium dichloride | 13 | 96149437 | 96269841 | Rat | 152 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68389 | Epha3 | Eph receptor A3 | ENCODES a protein that exhibits ephrin receptor activity (ortholog); GPI-linked ephrin receptor activity (ortholog); growth factor binding (ortholog); INVOLVED IN cellular response to interleukin-1; fever generation; response to lipopolysaccharide; PARTICIPATES IN altered ephrin - ephrin receptor bi directional signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Fever; Spinal Cord Injuries; atrial fibrillation (ortholog); FOUND IN early endosome (ortholog); GABA-ergic synapse (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide | 11 | 14585041 | 14920721 | Rat | 175 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620177 | Fgf22 | fibroblast growth factor 22 | ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN regulation of synapse maturation (ortholog); trans-synaptic signaling (ortholog); PARTICIPATES IN melanoma pathway; mitogen activated protein kinase signaling pathway; FOUND IN cell surface (ortholog); extrinsic component of postsynaptic density membrane (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride | 7 | 10598254 | 10600945 | Rat | 46 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 61805 | Fgf7 | fibroblast growth factor 7 | ENCODES a protein that exhibits growth factor activity; heparin binding; type 2 fibroblast growth factor receptor binding; INVOLVED IN lung development; ovarian follicle development; phosphatidylcholine biosynthetic process; PARTICIPATES IN glypican signaling pathway; melanoma pathway; mitogen activ ated protein kinase signaling pathway; ASSOCIATED WITH cervical squamous cell carcinoma (ortholog); cleft lip (ortholog); cleft palate (ortholog); FOUND IN extracellular space; extracellular region (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2-amino-2-deoxy-D-glucopyranose; 5-fluorouracil | 3 | 133734557 | 133786678 | Rat | 244 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 70991 | Flot1 | flotillin 1 | ENCODES a protein that exhibits ionotropic glutamate receptor binding; protease binding; INVOLVED IN adherens junction organization (ortholog); axonogenesis (ortholog); caveola assembly (ortholog); PARTICIPATES IN insulin signaling pathway; ASSOCIATED WITH Q fever (ortholog); FOUND IN caveola; floti llin complex; GABA-ergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 20 | 2922662 | 2932906 | Rat | 244 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 61911 | Gabarap | GABA type A receptor-associated protein | ENCODES a protein that exhibits GABA receptor binding; beta-tubulin binding (ortholog); microtubule binding (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway via death domain receptors (ortholog); microtubule cytoskeleton organization (ortholog); positive regulation of proteasomal ubiqui tin-dependent protein catabolic process (ortholog); PARTICIPATES IN autophagy pathway; FOUND IN cell body; GABA-ergic synapse; perinuclear region of cytoplasm; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; ammonium chloride | 10 | 55213465 | 55216787 | Rat | 133 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619864 | Gabbr2 | gamma-aminobutyric acid type B receptor subunit 2 | ENCODES a protein that exhibits G protein-coupled GABA receptor activity; protein heterodimerization activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; neuron-glial cell signaling; ASSOCIATED WITH nic otine dependence; alcohol use disorder (ortholog); autism spectrum disorder (ortholog); FOUND IN GABA-ergic synapse; glutamatergic synapse; postsynaptic membrane; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 5 | 65743073 | 66083695 | Rat | 208 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 61855 | Gabra1 | gamma-aminobutyric acid type A receptor subunit alpha 1 | ENCODES a protein that exhibits diazepam binding; GABA receptor activity; GABA-A receptor activity; INVOLVED IN cellular response to histamine; response to auditory stimulus; response to methamphetamine hydrochloride; ASSOCIATED WITH Binge Drinking; Hearing Loss, Noise-Induced; hepatic encephalopath y; FOUND IN GABA receptor complex; GABA-ergic synapse; postsynaptic specialization membrane; INTERACTS WITH (+)-pilocarpine; 1-bromopropane; 17beta-estradiol | 10 | 27096731 | 27152563 | Rat | 326 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 61856 | Gabra2 | gamma-aminobutyric acid type A receptor subunit alpha 2 | ENCODES a protein that exhibits benzodiazepine receptor activity (ortholog); GABA-gated chloride ion channel activity (ortholog); ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN chloride transmembrane transport (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); inhibitory synapse assembly (ortholog); ASSOCIATED WITH Binge Drinking; cocaine dependence; alcohol dependence (ortholog); FOUND IN dendrite membrane; GABA-ergic synapse; postsynaptic specialization membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alcohol; Alphaxolone | 14 | 37451218 | 37587458 | Rat | 187 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2648 | Gabra3 | gamma-aminobutyric acid type A receptor subunit alpha 3 | ENCODES a protein that exhibits GABA-A receptor activity; GABA-gated chloride ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN auditory behavior; chemical synaptic transmission; response to lead ion; ASSOCIATED W ITH Binge Drinking; autistic disorder (ortholog); bipolar disorder (ortholog); FOUND IN GABA-ergic synapse; postsynaptic specialization membrane; presynaptic active zone membrane; INTERACTS WITH (S)-nicotine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | X | 155301979 | 155543870 | Rat | 129 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621670 | Gabra4 | gamma-aminobutyric acid type A receptor subunit alpha 4 | ENCODES a protein that exhibits transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; INVOLVED IN central nervous system development (ortholog); chloride transmembrane transport (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); A SSOCIATED WITH Ataxia (ortholog); autistic disorder (ortholog); FOUND IN GABA-ergic synapse; postsynaptic specialization membrane; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 17beta-estradiol 3-benzoate | 14 | 36944747 | 37021652 | Rat | 139 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 61859 | Gabra5 | gamma-aminobutyric acid type A receptor subunit alpha 5 | ENCODES a protein that exhibits GABA receptor binding; GABA-A receptor activity; GABA-gated chloride ion channel activity; INVOLVED IN chemical synaptic transmission; associative learning (ortholog); behavioral fear response (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic d isorder (ortholog); bipolar disorder (ortholog); FOUND IN dendrite; GABA-ergic synapse; neuronal cell body membrane; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 117404446 | 117517424 | Rat | 173 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 61861 | Gabra6 | gamma-aminobutyric acid type A receptor subunit alpha6 | ENCODES a protein that exhibits benzodiazepine receptor activity; diazepam binding; GABA-A receptor activity; INVOLVED IN response to ethanol; synaptic transmission, GABAergic; ASSOCIATED WITH alcohol preference; ASSOCIATED WITH Binge Drinking; Cushing Syndrome; obesity; FOUND IN cerebellar Golgi cell to granule cell synapse; dendrite; GABA-ergic synapse; INTERACTS WITH (S)-nicotine; ammonium chloride; Ampullosporin | 10 | 27311965 | 27327337 | Rat | 121 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2649 | Gabrb1 | gamma-aminobutyric acid type A receptor subunit beta1 | ENCODES a protein that exhibits GABA receptor binding; GABA-A receptor activity; ligand-gated monoatomic ion channel activity; INVOLVED IN cellular response to histamine; central nervous system neuron development; monoatomic ion transport; ASSOCIATED WITH hepatic encephalopathy; adult respiratory di stress syndrome (ortholog); autistic disorder (ortholog); FOUND IN dendrite; GABA-A receptor complex; GABA-ergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 14 | 36434339 | 36917920 | Rat | 207 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2650 | Gabrb2 | gamma-aminobutyric acid type A receptor subunit beta 2 | ENCODES a protein that exhibits chloride channel activity; GABA receptor activity; GABA-A receptor activity; INVOLVED IN cellular response to histamine; chloride transmembrane transport; synaptic transmission, GABAergic; ASSOCIATED WITH autistic disorder (orthol og); Cerebral Visual Impairment and Intellectual Disability (ortholog); developmental and epileptic encephalopathy 92 (ortholog); FOUND IN GABA receptor complex; GABA-A receptor complex; GABA-ergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-Dimethylphenol; 6-propyl-2-thiouracil | 10 | 27438127 | 27657680 | Rat | 270 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2651 | Gabrb3 | gamma-aminobutyric acid type A receptor subunit beta 3 | ENCODES a protein that exhibits AP-2 adaptor complex binding; chloride channel activity; GABA-A receptor activity; INVOLVED IN response to auditory stimulus; response to ethanol; synaptic transmission, GABAergic; ASSOCIATED WITH fetal alcohol spectrum disorder; status epilepticus; alcohol dependence (ortholog); FOUND IN cytoplasm; GABA-ergic synapse; inhibitory synapse; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 1 | 117602772 | 117838230 | Rat | 309 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 61901 | Gabrd | gamma-aminobutyric acid type A receptor subunit delta | ENCODES a protein that exhibits GABA-A receptor activity; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN chemical synaptic transmission; chloride transmembrane transport (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); ASSOCIATED WITH alcohol dependence; cocaine dependence; autism spectrum disorder (ortholog); FOUND IN GABA-ergic synapse; glutamatergic synapse; plasma membrane; INTERACTS WITH (+)-pilocarpine; 1,3,5-trinitro-1,3,5-triazinane; 3alpha-hydroxy-5beta-pregnan-20-one | 5 | 171240813 | 171252709 | Rat | 147 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 68320 | Gabre | gamma-aminobutyric acid type A receptor subunit epsilon | ENCODES a protein that exhibits GABA-A receptor activity; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; GABA-gated chloride ion channel activity (ortholog); INVOLVED IN gamma-aminobutyric acid signaling pathway; response to xenobiotic st imulus; negative regulation of chloride transport (ortholog); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN GABA-ergic synapse; postsynaptic membrane; GABA-A receptor complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine | X | 155102078 | 155120821 | Rat | 121 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621735 | Gabrg3 | gamma-aminobutyric acid type A receptor subunit gamma 3 | ENCODES a protein that exhibits chloride channel activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; INVOLVED IN response to xenobiotic stimulus; ASSOCIATED WITH Angelman syndrome (ortholog); autistic disorder (ortholog); Brain Injuries (ortholog); FOUND IN GABA-erg ='font-weight:700;'>ergic synapse (ortholog); plasma membrane (ortholog); synaptic membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A | 1 | 116763332 | 117386770 | Rat | 101 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 61900 | Gabrr1 | gamma-aminobutyric acid type A receptor subunit rho 1 | ENCODES a protein that exhibits GABA receptor activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; INVOLVED IN modulation of chemical synaptic transmission (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamaterg ght:700;'>ergic synapse (ortholog); intracellular vesicle (ortholog); INTERACTS WITH ammonium chloride; bisphenol A; bleomycin A2 | 5 | 52320475 | 52357549 | Rat | 99 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 61902 | Gabrr2 | gamma-aminobutyric acid type A receptor subunit rho 2 | ENCODES a protein that exhibits GABA-A receptor activity; GABA-gated chloride ion channel activity; protein domain specific binding; INVOLVED IN gamma-aminobutyric acid signaling pathway (ortholog); visual perception (ortholog); ASSOCIATED WITH autistic disorder (ortholog); liver disease (ortholog); sensorineural hearing loss (ortholog); FOUND IN GABA-ergic synapse; intracellular vesicle (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride | 5 | 52242564 | 52286255 | Rat | 87 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621564 | Gabrr3 | gamma-aminobutyric acid type A receptor subunit rho3 | ENCODES a protein that exhibits GABA-A receptor activity; GABA-gated chloride ion channel activity; protein domain specific binding; INVOLVED IN chloride transport (inferred); monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); ASSOCIATED WITH restless legs syndro me (ortholog); FOUND IN GABA-ergic synapse (ortholog); postsynaptic membrane (ortholog); INTERACTS WITH ammonium chloride; bisphenol A; capsaicin | 11 | 54372017 | 54424466 | Rat | 48 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2653 | Gad2 | glutamate decarboxylase 2 | ENCODES a protein that exhibits glutamate binding; glutamate decarboxylase activity; protein-containing complex binding; INVOLVED IN cellular response to brain-derived neurotrophic factor stimulus; cellular response to hypoxia; gamma-aminobutyrate shunt; PARTICIPATES IN alanine, aspartate and glutam ate metabolic pathway; beta-alanine metabolic pathway; butanoate metabolic pathway; ASSOCIATED WITH autism spectrum disorder; bipolar disorder; epilepsy; FOUND IN GABA-ergic synapse; inhibitory synapse; neuronal cell body; INTERACTS WITH (+)-pilocarpine; (aminooxy)acetic acid; (S)-nicotine | 17 | 89671718 | 89734246 | Rat | 210 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62071 | Gap43 | growth associated protein 43 | ENCODES a protein that exhibits lysophosphatidic acid binding; phosphatidylinositol phosphate binding; phosphatidylserine binding; INVOLVED IN nervous system development; regulation of postsynaptic specialization assembly; response to auditory stimulus; PARTICIPATES IN N-cadherin signaling pathway; ASSOCIATED WITH Experimental Seizures; Hearing Loss, Noise-Induced; middle cerebral artery infarction; FOUND IN GABA-ergic synapse; presynapse; axon (ortholog); INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 17alpha-ethynylestradiol | 11 | 71882131 | 71975799 | Rat | 273 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2705 | Glra2 | glycine receptor, alpha 2 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); glycine binding (ortholog); glycine-gated chloride ion channel activity (ortholog); INVOLVED IN spinal cord development; synapse assembly; cellular response to amino acid stimulus (ortholog); ASSOCIAT ED WITH genetic disease (ortholog); syndromic X-linked intellectual disability Pilorge type (ortholog); FOUND IN GABA-ergic synapse (ortholog); glycinergic synapse (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | X | 32651931 | 32873277 | Rat | 97 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 69194 | Gphn | gephyrin | ENCODES a protein that exhibits identical protein binding; molecular adaptor activity; molybdopterin adenylyltransferase activity; INVOLVED IN establishment of protein localization; Mo-molybdopterin cofactor biosynthetic process; neurotransmitter receptor localization to postsynaptic specialization membrane; PARTICIPATES IN molybdenum cofactor biosynthetic pathway; Inhibitory synaptic transmission pathway; ASSOCIATED WITH alcohol dependence; acute promyelocytic leukemia (ortholog); alcohol use disorder (ortholog); FOUND IN cytoplasm; cytoplasmic side of plasma membrane; GABA-ergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide | 6 | 102687405 | 103216679 | Rat | 290 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68366 | Grid1 | glutamate ionotropic receptor delta type subunit 1 | ENCODES a protein that exhibits identical protein binding; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential (ortholog); GABA receptor activity (ortholog); INVOLVED IN negative regulation of synaptic plasticity (ortholog); phospholipase C-activating G prot ein-coupled receptor signaling pathway (ortholog); regulation of postsynapse organization (ortholog); ASSOCIATED WITH Colorectal Neoplasms (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN postsynaptic membrane; GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 16 | 10145018 | 10894184 | Rat | 145 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619858 | Grm8 | glutamate metabotropic receptor 8 | ENCODES a protein that exhibits group III metabotropic glutamate receptor activity; G protein-coupled receptor activity (ortholog); glutamate receptor activity (ortholog); INVOLVED IN chemical synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; presynaptic modulation of chemical synaptic transmission; PARTICIPATES IN glutamate signaling pathway; ASSOCIATED WITH epilepsy; Experimental Seizures; Parkinsonism; FOUND IN GABA-ergic synapse; glutamatergic synapse; neuronal cell body; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 56771247 | 57696951 | Rat | 131 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 68436 | Gucy1a1 | guanylate cyclase 1 soluble subunit alpha 1 | ENCODES a protein that exhibits adenylate cyclase activity; cytidylate cyclase activity; nitric oxide binding; INVOLVED IN response to herbicide; cGMP biosynthetic process (ortholog); nitric oxide-cGMP-mediated signaling (ortholog); PARTICIPATES IN long term depression; purine metabolic pathway; ASS OCIATED WITH withdrawal disorder; adenoid cystic carcinoma (ortholog); Colonic Neoplasms (ortholog); FOUND IN guanylate cyclase complex, soluble; protein-containing complex; GABA-ergic synapse (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | 2 | 169716684 | 169780360 | Rat | 217 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2845 | Htr1a | 5-hydroxytryptamine receptor 1A | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding; serotonin binding; INVOLVED IN adenylate cyclase-inhibiting serotonin receptor signaling pathway; behavioral response to nicotine; negative regulation of gamma-aminobutyric acid secretion; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder; anxiety disorder; Catalepsy; FOUND IN axon hillock; GABA-ergic synapse; neuronal cell body; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1-(3-chlorophenyl)piperazine | 2 | 38427169 | 38431733 | Rat | 331 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564717 | Igsf9b | immunoglobulin superfamily, member 9B | ENCODES a protein that exhibits kinase binding (ortholog); INVOLVED IN homophilic cell-cell adhesion (ortholog); positive regulation of inhibitory postsynaptic potential (ortholog); synaptic membrane adhesion (ortholog); FOUND IN GABA-ergic synapse; postsynaptic specialization of symmetric synapse; dendrite (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 8 | 33971779 | 34027390 | Rat | 77 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562618 | Insyn1 | inhibitory synaptic factor 1 | INVOLVED IN chemical synaptic transmission, postsynaptic (ortholog); inhibitory postsynaptic potential (ortholog); postsynaptic specialization organization (ortholog); FOUND IN GABA-ergic synapse (ortholog); postsynaptic density (ortholog); postsynaptic speciali zation (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | 8 | 67799989 | 67810685 | Rat | 50 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2302685 | Insyn2a | inhibitory synaptic factor 2A | INVOLVED IN chemical synaptic transmission, postsynaptic (ortholog); inhibitory postsynaptic potential (ortholog); FOUND IN GABA-ergic synapse (ortholog); postsynaptic density (ortholog); postsynaptic specialization (ortholog); INTERACTS WITH 1-naphthyl isothioc yanate; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 1 | 199127735 | 199183077 | Rat | 50 | description | gene, protein-coding, INFERRED [RefSeq] |
| 1593191 | Iqsec3 | IQ motif and Sec7 domain ArfGEF 3 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN activation of GTPase activity; postsynapse organization; regulation of small GTPase mediated signal transduction; PARTICIPATES IN endocytosis pathway; FOUND IN GABA-erg span>ic synapse; cytosol (ortholog); glycinergic synapse (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; allethrin | 4 | 156283040 | 156379396 | Rat | 95 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2933 | Itpr1 | inositol 1,4,5-trisphosphate receptor, type 1 | ENCODES a protein that exhibits ATP binding; identical protein binding; inositol 1,4,5 trisphosphate binding; INVOLVED IN calcium import into the mitochondrion; cellular response to cAMP; cellular response to hypoxia; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenerg :700;'>ergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH asthma; cardiac arrest; Huntington's disease; FOUND IN dendrite; endoplasmic reticulum membrane; GABA-ergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 142743401 | 143066505 | Rat | 574 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1309421 | Kctd12 | potassium channel tetramerization domain containing 12 | ENCODES a protein that exhibits G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (ortholog); G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential (ortholog); identical protein bindi ng (ortholog); INVOLVED IN regulation of G protein-coupled receptor signaling pathway (ortholog); FOUND IN postsynaptic membrane; presynaptic membrane; GABA-ergic synapse (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; Cuprizon | 15 | 86214786 | 86220725 | Rat | 163 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1596735 | Kctd12b | potassium channel tetramerization domain containing 12b | ENCODES a protein that exhibits G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN regulation of G protein-coupled receptor signaling pathway (ortholog); FOUND IN GABA-ergic synap se (ortholog); presynaptic active zone membrane (ortholog); presynaptic membrane (ortholog); INTERACTS WITH diethylstilbestrol; ketoconazole; 1,2-dichloroethane (ortholog) | X | 20989053 | 21000208 | Rat | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 1308539 | Kif5c | kinesin family member 5C | ENCODES a protein that exhibits apolipoprotein receptor binding; ATP hydrolysis activity; microtubule binding; INVOLVED IN anterograde axonal protein transport; intracellular mRNA localization; anterograde dendritic transport of messenger ribonucleoprotein complex (ortholog); PARTICIPATES IN mitocho ndria transport pathway; ASSOCIATED WITH Alzheimer's disease 3 (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); complex cortical dysplasia with other brain malformations (ortholog); FOUND IN dendrite; GABA-ergic synapse; postsynaptic cytosol; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bis(2-ethylhexyl) phthalate | 3 | 54441266 | 54591630 | Rat | 180 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 727967 | Lhfpl4 | LHFPL tetraspan subfamily member 4 | ENCODES a protein that exhibits GABA receptor binding; INVOLVED IN gamma-aminobutyric acid receptor clustering (ortholog); neurotransmitter receptor localization to postsynaptic specialization membrane (ortholog); regulation of inhibitory synapse assembly (ortholog); FOUND IN inhibitory synapse; GAB A-ergic synapse (ortholog); postsynaptic membrane (ortholog); INTERACTS WITH bisphenol A; C60 fullerene; copper atom | 4 | 147872877 | 147895770 | Rat | 78 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620563 | Lpar1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding; phospholipid binding; lysophosphatidic acid binding (ortholog); INVOLVED IN cellular response to 1-oleoyl-sn-glycerol 3-phosphate; cellular response to oxygen levels; cerebellum development; PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH abnormal craniofacial development; decreased body size; ASSOCIATED WITH hepatocellular carcinoma; Retina Reperfusion Injury; transient cerebral ischemia; FOUND IN dendritic shaft; dendritic spine; GABA-ergic synapse; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 78024139 | 78147071 | Rat | 272 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1585286 | Lrfn4 | leucine rich repeat and fibronectin type III domain containing 4 | INVOLVED IN regulation of postsynaptic density assembly (ortholog); regulation of presynapse assembly (ortholog); synaptic membrane adhesion (ortholog); FOUND IN postsynaptic density membrane; cell surface (ortholog); GABA-ergic synapse (ortholog); INTERACTS WIT H 17beta-estradiol; 4,4'-sulfonyldiphenol; bisphenol A | 1 | 211317980 | 211321272 | Rat | 64 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309357 | Lrfn5 | leucine rich repeat and fibronectin type III domain containing 5 | INVOLVED IN synaptic membrane adhesion; negative regulation of inflammatory response (ortholog); negative regulation of macrophage activation (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN postsynaptic density membrane; cell surface (ortholog); GABA-erg rgic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 6 | 85201465 | 85557872 | Rat | 73 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307031 | Mdga1 | MAM domain containing glycosylphosphatidylinositol anchor 1 | INVOLVED IN brain development; negative regulation of synapse assembly; regulation of synapse maturation; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); FOUND IN GABA-ergic synapse; glutamatergic synapse; plasma m embrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 20 | 7901856 | 7965834 | Rat | 121 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735131 | Mdga2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | INVOLVED IN regulation of synapse maturation; spinal cord motor neuron differentiation; gene expression (ortholog); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN glutamatergic synapse; postsynaptic density membrane; GABA-erg 00;'>ergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; allethrin | 6 | 90482687 | 91346784 | Rat | 79 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562629 | Nbea | neurobeachin | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN hematopoietic stem cell homeostasis (ortholog); intracellular protein localization (ortholog); regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ortholog); ASSOCIATED WITH autis m spectrum disorder (ortholog); autistic disorder (ortholog); Developmental Disease (ortholog); FOUND IN cerebellar Golgi cell to granule cell synapse; extrinsic component of postsynaptic membrane; GABA-ergic synapse; INTERACTS WITH bisphenol A; methoxychlor; PCB138 | 2 | 141930147 | 142489172 | Rat | 107 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619941 | Ncan | neurocan | ENCODES a protein that exhibits calcium ion binding (inferred); carbohydrate binding (inferred); hyaluronic acid binding (inferred); INVOLVED IN modulation of chemical synaptic transmission (ortholog); regulation of postsynapse organization (ortholog); regulation of synapse structural plasticity (or tholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH bipolar disorder (ortholog); dyslexia (ortholog); urinary bladder cancer (ortholog); FOUND IN perineuronal net; synapse; GABA-ergic synapse (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 16 | 19335907 | 19362371 | Rat | 94 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620296 | Nptn | neuroplastin | ENCODES a protein that exhibits cell adhesion molecule binding; transmembrane transporter binding; type 1 fibroblast growth factor receptor binding; INVOLVED IN homophilic cell-cell adhesion; long-term synaptic potentiation; positive regulation of cytosolic calcium ion concentration; ASSOCIATED WITH Developmental Disease (ortholog); hypertension (ortholog); Myocardial Ischemia (ortholog); FOUND IN cell surface; dendrite; GABA-ergic synapse; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 67892678 | 67959231 | Rat | 168 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3199 | Npy5r | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; peptide YY receptor activity; INVOLVED IN eating behavior; generation of ovulation cycle rhythm; negative regulation of acute inflammatory response to antigenic stimulus; ASSOCIATED WITH absen ce epilepsy; alcohol use disorder; coronary restenosis; FOUND IN 9+0 non-motile cilium (ortholog); GABA-ergic synapse (ortholog); membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitriptyline | 16 | 27822055 | 27830012 | Rat | 113 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1303302 | Nrg2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity; epidermal growth factor receptor binding; ErbB-3 class receptor binding; INVOLVED IN epidermal growth factor receptor signaling pathway; ERBB4 signaling pathway; regulation of synapse assembly; PARTICIPATES IN epidermal growt h factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrotoluene | 18 | 27890578 | 28072538 | Rat | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620212 | Nrxn3 | neurexin 3 | ENCODES a protein that exhibits calcium channel regulator activity (ortholog); signaling receptor regulator activity (ortholog); INVOLVED IN adult behavior (ortholog); chemical synaptic transmission (ortholog); learning (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); autism spectrum disor der (ortholog); autistic disorder (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); presynaptic active zone membrane (ortholog); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 6 | 113372667 | 115004073 | Rat | 189 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3218 | Nxph1 | neurexophilin 1 | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN modulation of chemical synaptic transmission (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); synaptic c left (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol | 4 | 37964325 | 38277364 | Rat | 48 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 628723 | Nxph4 | neurexophilin 4 | INVOLVED IN modulation of chemical synaptic transmission (ortholog); FOUND IN GABA-ergic synapse (ortholog); synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl | 7 | 65253043 | 65261864 | Rat | 71 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62060 | Ogt | O-linked N-acetylglucosamine (GlcNAc) transferase | ENCODES a protein that exhibits identical protein binding; peptide binding; protein domain specific binding; INVOLVED IN cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to lipopolysaccharide; PARTICIPATES IN DNA modification pathway; hexosamine biosynt hetic pathway; O-linked glycan biosynthetic pathway; ASSOCIATED WITH Cardiomegaly; congestive heart failure; Experimental Diabetes Mellitus; FOUND IN cerebellar granule cell to Purkinje cell synapse; euchromatin; GABA-ergic synapse; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | X | 70811317 | 70856123 | Rat | 348 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1304753 | Pcdh17 | protocadherin 17 | ENCODES a protein that exhibits calcium ion binding (inferred); INVOLVED IN adult behavior (ortholog); negative regulation of synaptic transmission (ortholog); presynaptic active zone assembly (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamaterg le='font-weight:700;'>ergic synapse (ortholog); postsynaptic membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 15 | 66631549 | 66725007 | Rat | 141 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3322 | Phb1 | prohibitin 1 | ENCODES a protein that exhibits complement component C3a binding (ortholog); complement component C3b binding (ortholog); enzyme binding (ortholog); INVOLVED IN animal organ regeneration; negative regulation of apoptotic process; negative regulation of cell population proliferation; ASSOCIATED WITH Brain Injuries; Experimental Mammary Neoplasms; urinary bladder cancer; FOUND IN extrinsic component of presynaptic active zone membrane; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one | 10 | 81102043 | 81114815 | Rat | 333 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620203 | Phb2 | prohibitin 2 | ENCODES a protein that exhibits amide binding (ortholog); identical protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cellular response to hypoxia; cellular response to retinoic acid; negative regulation of apoptotic process; PARTICIPATES IN estrogen signaling p athway; mitochondria fusion pathway; tamoxifen pharmacodynamics pathway; ASSOCIATED WITH Brain Injuries; FOUND IN axon; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 159203948 | 159208561 | Rat | 255 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620899 | Pik3c3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN autophagosome assembly; endosome organization; phosphatidylinositol 3-kinase/protein kinase B signal transduction; PARTICIPATES I N phosphatidylinositol 3-kinase signaling pathway; autophagy pathway; inositol metabolic pathway; FOUND IN autolysosome (ortholog); axoneme (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH (R)-noradrenaline; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine | 18 | 22119677 | 22203546 | Rat | 251 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3344 | Plcb1 | phospholipase C beta 1 | ENCODES a protein that exhibits calcium ion binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate phospholipase C activity; INVOLVED IN cellular response to fluoride; cellular response to glyceraldehyde; cellular response to ionomycin; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH abnormal depression-related behavior; ASSOCIATED WITH myocardial infarction; acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-(3-chlorophenyl)piperazine | 3 | 142512765 | 143224042 | Rat | 475 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1566287 | Praf2 | PRA1 domain family, member 2 | ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); postsynapse (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; alpha-Zearalanol | X | 17445313 | 17447950 | Rat | 69 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62068 | Ptpro | protein tyrosine phosphatase, receptor type, O | ENCODES a protein that exhibits protein tyrosine phosphatase activity; cadherin binding (ortholog); identical protein binding (ortholog); INVOLVED IN axon guidance (ortholog); cell morphogenesis (ortholog); glomerulus development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Experimental Liver Ci rrhosis (ortholog); focal segmental glomerulosclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); dendritic spine (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 4 | 171895104 | 172105911 | Rat | 198 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619755 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding; GTP binding; GTPase activity; INVOLVED IN actin cytoskeleton organization; actin filament organization; bone resorption; PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathway; azathioprine pharmacodynamics path way; ASSOCIATED WITH congestive heart failure; Left Ventricular Hypertrophy; autosomal dominant intellectual developmental disorder 48 (ortholog); FOUND IN cytosol; GABA-ergic synapse; Golgi membrane; INTERACTS WITH 11-deoxycorticosterone; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 16150411 | 16170864 | Rat | 639 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 628636 | Rnf34 | ring finger protein 34 | ENCODES a protein that exhibits ubiquitin protein ligase activity; ubiquitin-protein transferase activity; p53 binding (ortholog); INVOLVED IN regulation of postsynaptic neurotransmitter receptor internalization; cellular response to cold (ortholog); negative regulation of extrinsic apoptotic signal ing pathway via death domain receptors (ortholog); ASSOCIATED WITH Colonic Neoplasms (ortholog); FOUND IN GABA-ergic synapse; postsynaptic specialization; presynapse; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A | 12 | 39364461 | 39385391 | Rat | 141 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621045 | Rps27 | ribosomal protein S27 | ENCODES a protein that exhibits structural constituent of ribosome (ortholog); INVOLVED IN ribosomal small subunit biogenesis (ortholog); rRNA processing (ortholog); translation at postsynapse (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Diamond-Black fan anemia 17 (ortholog); FOUND IN cytosolic small ribosomal subunit; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 2 | 177963499 | 177964708 | Rat | 166 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3602 | Rps6 | ribosomal protein S6 | ENCODES a protein that exhibits mRNA binding; structural constituent of ribosome; protein kinase binding (ortholog); INVOLVED IN cellular response to ethanol; negative regulation of bicellular tight junction assembly; response to insulin; PARTICIPATES IN ribosome biogenesis pathway; translation path way; insulin signaling pathway; ASSOCIATED WITH Experimental Autoimmune Myocarditis; Liver Failure; Temporomandibular Joint Osteoarthritis; FOUND IN cytosolic small ribosomal subunit; GABA-ergic synapse; presynapse; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol | 5 | 106417680 | 106420540 | Rat | 445 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1310554 | Sema4d | semaphorin 4D | ENCODES a protein that exhibits identical protein binding (ortholog); receptor ligand activity (ortholog); semaphorin receptor binding (ortholog); INVOLVED IN bone trabecula morphogenesis (ortholog); leukocyte aggregation (ortholog); negative regulation of cell adhesion (ortholog); FOUND IN postsyna ptic membrane; extracellular space (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 17 | 13582085 | 13688889 | Rat | 195 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305192 | Sema7a | semaphorin 7A (John Milton Hagen blood group) | ENCODES a protein that exhibits integrin binding (ortholog); INVOLVED IN axon extension (ortholog); integrin-mediated signaling pathway (ortholog); neuron projection development (ortholog); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 11 (ortholog); FOUND IN external side of plasma membrane (ortholog); GABA-ergic synapse (ortholog); presynapse (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 8 | 67244318 | 67267060 | Rat | 172 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307405 | Septin11 | septin 11 | ENCODES a protein that exhibits GTP binding (inferred); nucleotide binding (inferred); INVOLVED IN regulation of synapse organization; ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); methylmalonic acidemia (ortholog); FOUND IN GABA-ergic synaps e; glutamatergic synapse; postsynapse; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether | 14 | 15119760 | 15275222 | Rat | 138 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620904 | Sh3kbp1 | SH3 domain-containing kinase-binding protein 1 | ENCODES a protein that exhibits ubiquitin protein ligase binding; INVOLVED IN positive regulation of B cell activation (ortholog); PARTICIPATES IN endocytosis pathway; ASSOCIATED WITH autistic disorder (ortholog); Colonic Neoplasms (ortholog); immunodeficiency 61 (ortholog); FOUND IN GABA-erg e='font-weight:700;'>ergic synapse; glutamatergic synapse; postsynaptic density; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | X | 38686530 | 39031658 | Rat | 194 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1563434 | Shroom4 | shroom family member 4 | ENCODES a protein that exhibits actin filament binding (ortholog); myosin II binding (ortholog); INVOLVED IN regulation of postsynaptic membrane neurotransmitter receptor levels; actin filament organization (ortholog); brain development (ortholog); ASSOCIATED WITH intellectual disability (ortholog); Stocco Dos Santos type X-linked intellectual disability (ortholog); FOUND IN GABA-ergic synapse; glutamatergic synapse; postsynapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl | X | 18537371 | 18748665 | Rat | 93 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621402 | Slc32a1 | solute carrier family 32 member 1 | ENCODES a protein that exhibits gamma-aminobutyric acid transmembrane transporter activity; gamma-aminobutyric acid:proton antiporter activity; glycine transmembrane transporter activity; INVOLVED IN beta-alanine transport; gamma-aminobutyric acid import; gamma-aminobutyric acid transport; ASSOCIATE D WITH developmental and epileptic encephalopathy (ortholog); Developmental and Epileptic Encephalopathy 114 (ortholog); epilepsy (ortholog); FOUND IN GABA-ergic synapse; inhibitory synapse; presynapse; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol | 3 | 167687245 | 167691714 | Rat | 164 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620533 | Slc6a1 | solute carrier family 6 member 1 | ENCODES a protein that exhibits gamma-aminobutyric acid:sodium:chloride symporter activity; identical protein binding; amino acid:sodium symporter activity (ortholog); INVOLVED IN gamma-aminobutyric acid import; learning; negative regulation of synaptic transmission, GABAerg ;'>ergic; ASSOCIATED WITH brain ischemia; cerebral infarction; epilepsy; FOUND IN cell surface; GABA-ergic synapse; postsynaptic membrane; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate | 4 | 149004447 | 149037840 | Rat | 187 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628737 | Slc6a11 | solute carrier family 6 member 11 | ENCODES a protein that exhibits amino acid binding; gamma-aminobutyric acid:sodium:chloride symporter activity; amino acid:sodium symporter activity (ortholog); INVOLVED IN neurotransmitter transport; response to xenobiotic stimulus; monocarboxylic acid transport (ortholog); ASSOCIATED WITH Experime ntal Seizures; Reperfusion Injury; melanoma (ortholog); FOUND IN cell projection; GABA-ergic synapse; plasma membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 4 | 148853557 | 148968895 | Rat | 122 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1587185 | Slc6a17 | solute carrier family 6 member 17 | ENCODES a protein that exhibits symporter activity (inferred); INVOLVED IN alanine transport; glycine transport; L-leucine transport; ASSOCIATED WITH autosomal recessive intellectual developmental disorder 48 (ortholog); long QT syndrome (ortholog); FOUND IN GABA-erg span>ic synapse; glutamatergic synapse; synapse; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A | 2 | 197795622 | 197843883 | Rat | 94 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1308858 | Slitrk1 | SLIT and NTRK-like family, member 1 | INVOLVED IN regulation of synapse organization; adult behavior (ortholog); axonogenesis (ortholog); ASSOCIATED WITH Gilles de la Tourette syndrome (ortholog); trichotillomania (ortholog); FOUND IN GABA-ergic synapse; glutamaterg pan>ic synapse; postsynaptic density membrane; INTERACTS WITH 17alpha-ethynylestradiol; alpha-Zearalanol; bisphenol A | 15 | 92137703 | 92141741 | Rat | 104 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1561361 | Slitrk2 | SLIT and NTRK-like family, member 2 | INVOLVED IN axonogenesis (ortholog); positive regulation of synapse assembly (ortholog); regulation of presynapse assembly (ortholog); ASSOCIATED WITH intellectual disability (ortholog); non-syndromic X-linked intellectual developmental disorder 111 (ortholog); FOUND IN postsynaptic membrane; dendri te (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | X | 150287418 | 150299832 | Rat | 70 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310506 | Slitrk3 | SLIT and NTRK-like family, member 3 | INVOLVED IN axonogenesis (ortholog); gephyrin clustering involved in postsynaptic density assembly (ortholog); neurotransmitter-gated ion channel clustering (ortholog); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN postsynaptic density membrane; cell surface (ortholog); GABA-erg le='font-weight:700;'>ergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine | 2 | 159983650 | 159996194 | Rat | 81 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620221 | Snap23 | synaptosome associated protein 23 | ENCODES a protein that exhibits SNAP receptor activity; syntaxin binding; INVOLVED IN exocytic insertion of neurotransmitter receptor to postsynaptic membrane; membrane fusion; protein-containing complex assembly; PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose tra nsport pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Myocardial Ischemia (ortholog); FOUND IN GABA-ergic synapse; glutamatergic synapse; postsynapse; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 3 | 127966184 | 127999929 | Rat | 162 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307030 | Strn4 | striatin 4 | ENCODES a protein that exhibits protein domain specific binding; protein-containing complex binding; armadillo repeat domain binding (ortholog); INVOLVED IN regulation of modification of postsynaptic structure; negative regulation of hippo signaling (ortholog); FOUND IN dendritic spine; GABA-erg tyle='font-weight:700;'>ergic synapse; glutamatergic synapse; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 1 | 86614193 | 86639959 | Rat | 82 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621761 | Sumo2 | small ubiquitin-like modifier 2 | ENCODES a protein that exhibits nuclear retinoid X receptor binding; SUMO transferase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular protein localization; negative regulation of DNA-templated transcription; positive regulation of protein sumoylation; PART ICIPATES IN RNA transport pathway; FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol | 10 | 101270899 | 101283458 | Rat | 133 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621141 | Wnk1 | WNK lysine deficient protein kinase 1 | ENCODES a protein that exhibits ATP binding; magnesium ion binding; molecular condensate scaffold activity; INVOLVED IN cell volume homeostasis; cellular hyperosmotic response; cellular response to calcium ion; PARTICIPATES IN Erk5 MAPK signaling pathway; ASSOCIATED WITH transient cerebral ischemia; Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 4 (ortholog); FOUND IN cytoplasm; cytosol; GABA-ergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 4 | 154800590 | 154926147 | Rat | 338 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1589737 | Zdhhc5 | zDHHC palmitoyltransferase 5 | ENCODES a protein that exhibits palmitoyltransferase activity (ortholog); protein-cysteine S-palmitoyltransferase activity (ortholog); INVOLVED IN regulation of postsynaptic membrane neurotransmitter receptor levels; positive regulation of NLRP3 inflammasome complex assembly (ortholog); positive reg ulation of pattern recognition receptor signaling pathway (ortholog); FOUND IN dendrite; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 3 | 90178734 | 90206889 | Rat | 130 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620775 | Sc5d | sterol-C5-desaturase | ENCODES a protein that exhibits C-5 sterol desaturase activity; delta7-sterol 5(6)-desaturase activity; sterol desaturase activity (ortholog); INVOLVED IN cholesterol biosynthetic process via lathosterol; cholesterol biosynthetic process (ortholog); cholesterol biosynthetic process via desmosterol ( ortholog); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Lathosterolosis (ortholog); FOUND IN endoplasmic reticulum membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 8 | 51526669 | 51538277 | Rat | 255 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |