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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of LPAR1 mRNA | CTD | PMID:12075121 PMID:15901920 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of LPAR1 mRNA | CTD | PMID:15901920 PMID:12075121 | 17beta-estradiol | affects expression | ISO | RGD:731581 | 6480464 | Estradiol affects the expression of LPAR1 mRNA | CTD | PMID:14699072 | 17beta-estradiol | multiple interactions | ISO | RGD:731581 | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of LPAR1 mRNA | CTD | PMID:20404318 | 17beta-estradiol | affects expression | ISO | RGD:731582 | 6480464 | Estradiol affects the expression of LPAR1 mRNA | CTD | PMID:15598610 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731581 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LPAR1 mRNA | CTD | PMID:19684285 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731582 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LPAR1 mRNA | CTD | PMID:18691609 | 2-methylcholine | affects expression | ISO | RGD:731581 | 6480464 | beta-methylcholine affects the expression of LPAR1 mRNA | CTD | PMID:21179406 | 4-hydroxynon-2-enal | increases expression | ISO | RGD:731582 | 6480464 | 4-hydroxy-2-nonenal results in increased expression of LPAR1 mRNA | CTD | PMID:19191707 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:731581 | 6480464 | [decitabine co-treated with vorinostat] affects the expression of LPAR1 mRNA | CTD | PMID:17330099 | acrolein | decreases expression | ISO | RGD:731582 | 6480464 | Acrolein results in decreased expression of LPAR1 mRNA | CTD | PMID:18515264 | all-trans-retinoic acid | decreases expression | ISO | RGD:731581 | 6480464 | Tretinoin results in decreased expression of LPAR1 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of LPAR1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:731582 | 6480464 | Benzo(a)pyrene results in increased expression of LPAR1 mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LPAR1 mRNA | CTD | PMID:15901920 PMID:12075121 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LPAR1 mRNA | CTD | PMID:12075121 PMID:15901920 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of LPAR1 mRNA | CTD | PMID:19167457 | chloroprene | increases expression | ISO | RGD:731582 | 6480464 | Chloroprene results in increased expression of LPAR1 mRNA | CTD | PMID:23125180 | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of LPAR1 mRNA | CTD | PMID:23125180 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of LPAR1 mRNA | CTD | PMID:18668222 | choline | multiple interactions | ISO | RGD:731582 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA; more ... | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | RGD:731582 | 6480464 | Cisplatin results in decreased expression of LPAR1 mRNA | CTD | PMID:21151649 | cocaine | decreases expression | ISO | RGD:731581 | 6480464 | Cocaine results in decreased expression of LPAR1 mRNA | CTD | PMID:15009677 | corticosterone | increases expression | EXP | | 6480464 | Corticosterone results in increased expression of LPAR1 mRNA | CTD | PMID:15755911 | curcumin | decreases expression | ISO | RGD:731581 | 6480464 | Curcumin results in decreased expression of LPAR1 mRNA | CTD | PMID:17999991 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of LPAR1 mRNA | CTD | PMID:21266533 | doxorubicin | affects response to substance | ISO | RGD:731581 | 6480464 | LPAR1 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | elemental selenium | increases expression | ISO | RGD:731581 | 6480464 | Selenium results in increased expression of LPAR1 mRNA | CTD | PMID:19244175 | folic acid | multiple interactions | ISO | RGD:731582 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LPAR1 gene; more ... | CTD | PMID:20938992 | fonofos | increases methylation | ISO | RGD:731581 | 6480464 | Fonofos results in increased methylation of LPAR1 promoter | CTD | PMID:22847954 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of LPAR1 mRNA | CTD | PMID:12075121 | hydrazine | decreases expression | ISO | RGD:731582 | 6480464 | hydrazine results in decreased expression of LPAR1 mRNA | CTD | PMID:15282401 | iron atom | decreases expression | EXP | | 6480464 | Iron deficiency results in decreased expression of LPAR1 mRNA | CTD | PMID:19821111 | L-methionine | multiple interactions | ISO | RGD:731582 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA; more ... | CTD | PMID:20938992 | lead(0) | decreases expression | ISO | RGD:731581 | 6480464 | Lead results in decreased expression of LPAR1 mRNA | CTD | PMID:19921347 | lysophosphatidic acid | increases response to substance | ISO | RGD:731581 | 6480464 | LPAR1 protein results in increased susceptibility to lysophosphatidic acid | CTD | PMID:16809448 | lysophosphatidic acid | multiple interactions | ISO | RGD:731581 | 6480464 | lysophosphatidic acid inhibits the reaction [CXCR1 protein binds to LPAR1 protein]; more ... | CTD | PMID:16224106 | methotrexate | affects response to substance | ISO | RGD:731581 | 6480464 | LPAR1 protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPAR1 mRNA | CTD | PMID:18164116 | parathion | increases methylation | ISO | RGD:731581 | 6480464 | Parathion results in increased methylation of LPAR1 promoter | CTD | PMID:22847954 | perfluorooctane-1-sulfonic acid | affects expression | EXP | | 6480464 | perfluorooctane sulfonic acid affects the expression of LPAR1 mRNA | CTD | PMID:20136073 | selenium atom | increases expression | ISO | RGD:731581 | 6480464 | Selenium results in increased expression of LPAR1 mRNA | CTD | PMID:19244175 | succimer | multiple interactions | ISO | RGD:731582 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of LPAR1 mRNA | CTD | PMID:21641980 | terbufos | increases methylation | ISO | RGD:731581 | 6480464 | terbufos results in increased methylation of LPAR1 promoter | CTD | PMID:22847954 | tetrachloromethane | affects expression | ISO | RGD:731582 | 6480464 | Carbon Tetrachloride affects the expression of LPAR1 mRNA | CTD | PMID:17484886 | undecane | increases expression | EXP | | 6480464 | undecane results in increased expression of LPAR1 protein | CTD | PMID:17337753 | valproic acid | increases expression | ISO | RGD:731581 | 6480464 | Valproic Acid results in increased expression of LPAR1 mRNA | CTD | PMID:19101580 | valproic acid | increases expression | ISO | RGD:731582 | 6480464 | Valproic Acid results in increased expression of LPAR1 mRNA | CTD | PMID:19136453 | vincaleukoblastine | affects response to substance | ISO | RGD:731581 | 6480464 | LPAR1 protein affects the susceptibility to Vinblastine | CTD | PMID:16217747 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Gap junction |
| Neuroactive ligand-receptor interaction | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | LPA receptor mediated events (PID:200013) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Gap junction |
| Neuroactive ligand-receptor interaction | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | LPA receptor mediated events (PID:200013) |
References - curated| 1. |
Allard J, etal., Eur J Neurosci. 1998 Mar;10(3):1045-53. |
| 2. |
Allard J, etal., Glia. 1999 Apr;26(2):176-85. |
| 3. |
Chen J, etal., FEBS Lett. 2006 Aug 21;580(19):4737-45. Epub 2006 Jul 31. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Hama K, etal., FEBS Lett 2002 Jul 17;523(1-3):187-92. |
| 6. |
Kim J, etal., Cell Signal. 2006 Oct;18(10):1695-701. Epub 2006 Feb 28. |
| 7. |
Kim MK, etal., Biochem Pharmacol. 2005 Dec 5;70(12):1764-71. Epub 2005 Oct 20. |
| 8. |
MGD data from the GO Consortium |
| 9. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. |
Obo Y, etal., Mutat Res. 2009 Jan 15;660(1-2):47-50. Epub 2008 Oct 21. |
| 11. |
Pilpel Y and Segal M, J Neurochem. 2006 Jun;97(5):1379-92. Epub 2006 Apr 21. |
| 12. |
RGD automated data pipeline |
| 13. |
RGD automated import pipeline for gene-chemical interactions |
| 14. |
Savitz SI, etal., Brain Res. 2006 Nov 6;1118(1):168-75. Epub 2006 Oct 5. |
| 15. |
Stankoff B, etal., Mol Cell Neurosci 2002 Jul;20(3):415-28. |
| 16. |
Yang C, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1290-8. Epub 2008 Oct 31. |
| 17. |
Zhou ZB, etal., Int J Mol Sci. 2009 Jul 13;10(7):3194-208. |
References - uncurated| PubMed | 12477932 |
| 12847111 | |
| 15489334 | |
| 16970915 | |
| 19026987 | |
| 19757175 | |
| 20553953 | |
| 21244430 | |
| 22021336 | |
| 22197817 | |
| 22580000 |
RGD Disease Portals| Lpar1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Lpar1 (Rattus norvegicus) |
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| LPAR1 (Homo sapiens) |
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| Lpar1 (Mus musculus) |
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Position Markers| UniSTS:143241 |
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| RH131839 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053936 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06037348 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06037349 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06037350 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06037351 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06037352 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01037047 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01037048 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01037049 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01037050 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01037051 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF014418 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF090347 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC089227 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474039 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230395 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053936 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_446388 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_446388 | (Get FASTA) |
| GenBank Protein | AAB86381 | (Get FASTA) |
| AAG24469 | (Get FASTA) | |
| AAH89227 | (Get FASTA) | |
| EDL91653 | (Get FASTA) | |
| EDL91654 | (Get FASTA) | |
| EDL91655 | (Get FASTA) | |
| P61794 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013656 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000043652 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000044348 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 116744 | ENTREZGENE |
| Germonline | ENSRNOG00000013656 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 1072 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7320884 | IMAGE-MGC_LOAD |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| LPA_rcpt | UniProtKB/Swiss-Prot | |
| LPA_rcpt_EDG2 | UniProtKB/Swiss-Prot | |
| IPI | IPI00231300 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:116744 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105279 | IMAGE-MGC_LOAD |
| PANTHER | LPA_rcpt | UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | EDG2RECEPTOR | UniProtKB/Swiss-Prot |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| LPARECEPTOR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.11200 | ENTREZGENE |
| UniProt | LPAR1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-04-25 | Lpar1 | lysophosphatidic acid receptor 1 | Edg2 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Edg2 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Edg2 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Lpar1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620563 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




