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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | multiple interactions | EXP | | 6480464 | bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]; more ... | CTD | PMID:20821261 | (+)-pilocarpine | decreases expression | EXP | | 6480464 | Pilocarpine results in decreased expression of GABRD mRNA | CTD | PMID:20821261 | (+)-pilocarpine | decreases expression | ISO | RGD:62194 | 6480464 | Pilocarpine results in decreased expression of GABRD protein | CTD | PMID:15456836 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:733681 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GABRD mRNA | CTD | PMID:21296121 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62194 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GABRD mRNA | CTD | PMID:21570461 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:62194 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GABRD mRNA | CTD | PMID:20188158 | 3alpha-hydroxy-5beta-pregnan-20-one | decreases expression | EXP | | 6480464 | Pregnanolone results in decreased expression of GABRD protein | CTD | PMID:16914187 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GABRD mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of GABRD mRNA | CTD | PMID:21839799 | carbamazepine | multiple interactions | EXP | | 6480464 | Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA] | CTD | PMID:20821261 | diazepam | increases expression | EXP | | 6480464 | Diazepam results in increased expression of GABRD mRNA | CTD | PMID:15802192 | dichlorvos | decreases expression | EXP | | 6480464 | Dichlorvos results in decreased expression of GABRD mRNA | CTD | PMID:19146868 | ethanol | decreases expression | EXP | | 6480464 | Ethanol deficiency results in decreased expression of GABRD mRNA | CTD | PMID:17403139 | finasteride | multiple interactions | EXP | | 6480464 | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD mRNA]; more ... | CTD | PMID:16879715 PMID:16914187 | finasteride | multiple interactions | EXP | | 6480464 | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD protein]; more ... | CTD | PMID:16914187 PMID:16879715 | fluoxetine | decreases expression | EXP | | 6480464 | Fluoxetine results in decreased expression of GABRD mRNA | CTD | PMID:17033635 | gamma-aminobutyric acid | multiple interactions | ISO | RGD:733681 | 6480464 | benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]] | CTD | PMID:18762200 | gamma-aminobutyric acid | multiple interactions | ISO | RGD:62194 | 6480464 | gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]; more ... | CTD | PMID:18762200 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of GABRD mRNA | CTD | PMID:20080153 | methylmercury chloride | decreases expression | EXP | | 6480464 | methylmercuric chloride results in decreased expression of GABRD mRNA | CTD | PMID:19651682 | morphine | increases expression | EXP | | 6480464 | Morphine results in increased expression of GABRD mRNA | CTD | PMID:15183518 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of GABRD mRNA | CTD | PMID:19146868 | parathion | decreases expression | EXP | | 6480464 | Parathion results in decreased expression of GABRD mRNA | CTD | PMID:19146868 | pentobarbital | affects response to substance | ISO | RGD:62194 | 6480464 | GABRD protein affects the susceptibility to Pentobarbital | CTD | PMID:15201633 | pentobarbital | increases expression | ISO | RGD:62194 | 6480464 | Pentobarbital results in increased expression of GABRD mRNA | CTD | PMID:8848253 | perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of GABRD mRNA | CTD | PMID:20136073 | pirinixic acid | increases expression | ISO | RGD:62194 | 6480464 | pirinixic acid results in increased expression of GABRD mRNA | CTD | PMID:20813756 | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of GABRD protein | CTD | PMID:16879715 PMID:15834956 | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of GABRD protein | CTD | PMID:15834956 PMID:16879715 | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of GABRD mRNA | CTD | PMID:16914187 PMID:16879715 | progesterone | decreases expression | EXP | | 6480464 | Progesterone results in decreased expression of GABRD protein | CTD | PMID:16914187 | progesterone | affects expression | EXP | | 6480464 | Progesterone metabolite affects the expression of GABRD mRNA | CTD | PMID:16879715 | progesterone | multiple interactions | EXP | | 6480464 | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD protein]; more ... | CTD | PMID:16879715 PMID:16914187 | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of GABRD mRNA | CTD | PMID:16879715 PMID:16914187 | progesterone | multiple interactions | EXP | | 6480464 | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD mRNA]; more ... | CTD | PMID:16914187 PMID:16879715 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of GABRD mRNA | CTD | PMID:17108153 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of GABRD mRNA | CTD | PMID:19651682 | zinc atom | affects expression | EXP | | 6480464 | Zinc affects the expression of GABRD mRNA | CTD | PMID:16413754 | zinc(0) | affects expression | EXP | | 6480464 | Zinc affects the expression of GABRD mRNA | CTD | PMID:16413754 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | GABAergic synapse |
| Morphine addiction | |
| Neuroactive ligand-receptor interaction | |
| Nicotine addiction | |
| Retrograde endocannabinoid signaling | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | GABAergic synapse |
| Morphine addiction | |
| Neuroactive ligand-receptor interaction | |
| Nicotine addiction | |
| Retrograde endocannabinoid signaling | |
References - curated
References - uncurated| PubMed | 12477932 |
| 1312131 | |
| 1312132 | |
| 1379501 | |
| 15152020 | |
| 15489334 | |
| 15708482 | |
| 15834956 | |
| 16879715 | |
| 17056007 | |
| 17395622 | |
| 17854781 | |
| 18079275 | |
| 18406065 | |
| 19665523 | |
| 21298071 | |
| 21368141 | |
| 21395866 | |
| 21439793 | |
| 22213233 | |
| 2561970 | |
| 8195163 |
RGD Disease Portals| Gabrd has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gabrd (Rattus norvegicus) |
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| GABRD (Homo sapiens) |
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| Gabrd (Mus musculus) |
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Position Markers| RH143455 |
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| RH139554 |
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| BF390464 |
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| PMC23157P1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_017289 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058985 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058985 | (Get FASTA) |
| GenBank Protein | AAA41182 | (Get FASTA) |
| AAC42035 | (Get FASTA) | |
| AAH87714 | (Get FASTA) | |
| CAA49603 | (Get FASTA) | |
| EDL81296 | (Get FASTA) | |
| P18506 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000016385 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000022246 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000022246 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 29689 | ENTREZGENE |
| Gene3D-CATH | Neur_chan_lig_bd | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000016385 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55489 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7317154 | IMAGE-MGC_LOAD |
| InterPro | GABAA_rcpt | UniProtKB/Swiss-Prot |
| GABAAd_rcpt | UniProtKB/Swiss-Prot | |
| Neur_chan_lig_bd | UniProtKB/Swiss-Prot | |
| Neur_channel | UniProtKB/Swiss-Prot | |
| Neurotrans-gated_channel_TM | UniProtKB/Swiss-Prot | |
| Neurotransmitter_ion_chnl_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00192644 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:29689 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105467 | IMAGE-MGC_LOAD |
| PANTHER | Neur_channel | UniProtKB/Swiss-Prot |
| Pfam | Neur_chan_LBD | UniProtKB/Swiss-Prot |
| Neur_chan_memb | UniProtKB/Swiss-Prot | |
| PRINTS | GABAARDELTA | UniProtKB/Swiss-Prot |
| GABAARECEPTR | UniProtKB/Swiss-Prot | |
| NRIONCHANNEL | UniProtKB/Swiss-Prot | |
| PROSITE | NEUROTR_ION_CHANNEL | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Neu_channel_TM | UniProtKB/Swiss-Prot |
| Neur_chan_LBD | UniProtKB/Swiss-Prot | |
| TIGR | TC220573 | |
| TIGRFAMs | LIC | UniProtKB/Swiss-Prot |
| UniGene | Rn.10927 | ENTREZGENE |
| UniProt | GBRD_RAT | UniProtKB/Swiss-Prot |
| Q6LBJ4_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-11-04 | Gabrd | gamma-aminobutyric acid (GABA) A receptor, delta | Gabrd | gamma-aminobutyric acid (GABA-A) receptor, subunit delta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-03-11 | Gabrd | gamma-aminobutyric acid (GABA-A) receptor, subunit delta | Gabrd | gamma-aminobutyric acid (GABA) A receptor, delta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-18 | Gabrd | gamma-aminobutyric acid (GABA) A receptor, delta | Gabrd | gamma-aminobutyric acid A receptor, delta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Gabrd | gamma-aminobutyric acid A receptor, delta | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
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| More on Gabrd | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61901 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




