Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of WNK1 mRNA | CTD | PMID:17557909 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1616541 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of WNK1 mRNA | CTD | PMID:21354282 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1616541 | 6480464 | Tetrachlorodibenzodioxin affects the expression of WNK1 mRNA | CTD | PMID:21570461 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of WNK1 mRNA | CTD | PMID:21346803 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of WNK1 mRNA | CTD | PMID:22504374 | acetazolamide | increases expression | ISO | RGD:1616541 | 6480464 | Acetazolamide results in increased expression of WNK1 mRNA | CTD | PMID:19274763 | all-trans-retinoic acid | decreases expression | ISO | RGD:1343905 | 6480464 | Tretinoin results in decreased expression of WNK1 mRNA | CTD | PMID:15498508 | amiodarone | increases expression | ISO | RGD:1343905 | 6480464 | Amiodarone results in increased expression of WNK1 mRNA | CTD | PMID:19774075 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of WNK1 mRNA | CTD | PMID:16483693 | arsenic atom | decreases expression | ISO | RGD:1616541 | 6480464 | Arsenic results in decreased expression of WNK1 mRNA | CTD | PMID:19654921 | benzo[a]pyrene | increases expression | ISO | RGD:1616541 | 6480464 | Benzo(a)pyrene results in increased expression of WNK1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:1616541 | 6480464 | Benzo(a)pyrene results in decreased expression of WNK1 mRNA | CTD | PMID:22228805 | choline | multiple interactions | ISO | RGD:1616541 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of WNK1 gene | CTD | PMID:20938992 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of WNK1 mRNA alternative form | CTD | PMID:21865292 | folic acid | multiple interactions | ISO | RGD:1616541 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of WNK1 gene | CTD | PMID:20938992 | L-methionine | multiple interactions | ISO | RGD:1616541 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of WNK1 gene | CTD | PMID:20938992 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of WNK1 mRNA | CTD | PMID:22504374 | paraquat | increases expression | ISO | RGD:1616541 | 6480464 | Paraquat results in increased expression of WNK1 mRNA | CTD | PMID:21371552 | phenobarbital | decreases expression | ISO | RGD:1616541 | 6480464 | Phenobarbital results in decreased expression of WNK1 mRNA | CTD | PMID:23091169 | tamibarotene | decreases expression | ISO | RGD:1343905 | 6480464 | Am 80 results in decreased expression of WNK1 mRNA; more ... | CTD | PMID:15498508 | testosterone enanthate | affects expression | ISO | RGD:1343905 | 6480464 | testosterone enanthate affects the expression of WNK1 mRNA | CTD | PMID:17440010 | vancomycin | increases expression | ISO | RGD:1616541 | 6480464 | Vancomycin results in increased expression of WNK1 mRNA | CTD | PMID:18930951 | zoledronic acid | decreases expression | ISO | RGD:1343905 | 6480464 | zoledronic acid results in decreased expression of WNK1 mRNA | CTD | PMID:20977926 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
Molecular Pathway Annotations
References - curated| 1. |
Cope G, etal., J Am Soc Nephrol. 2006 Jul;17(7):1867-74. Epub 2006 Jun 14. |
| 2. |
MGD data from the GO Consortium |
| 3. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 4. |
RGD automated data pipeline |
| 5. |
RGD automated import pipeline for gene-chemical interactions |
| 6. |
RGD Automated Pipelines |
| 7. |
San-Cristobal P, etal., Am J Nephrol. 2008 Jun 12;28(5):860-870. |
| 8. |
Tobin MD, etal., Circulation. 2005 Nov 29;112(22):3423-9. Epub 2005 Nov 21. |
| 9. |
Vitari AC, etal., Biochem J. 2005 Oct 1;391(Pt 1):17-24. |
| 10. |
Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6. |
| 11. |
Wang Z, etal., Biochem Biophys Res Commun. 2004 May 7;317(3):939-44. |
| 12. |
Wilson FH, etal., Science. 2001 Aug 10;293(5532):1107-12. |
| 13. |
Xu B, etal., J Biol Chem 2000 Jun 2;275(22):16795-801. |
| 14. |
Yang CL, etal., J Clin Invest 2003 Apr;111(7):1039-45. |
References - uncurated| PubMed | 12374799 |
| 15057822 | |
| 15060842 | |
| 15242606 | |
| 15350218 | |
| 15583131 | |
| 16204408 | |
| 16428287 | |
| 17194447 | |
| 18521183 | |
| 19644017 | |
| 20525693 |
RGD Disease Portals| Wnk1 has been annotated in the following RGD Disease Portals. |
|||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
Candidate Gene Status
Comparative Map Data| Wnk1 (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| WNK1 (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Wnk1 (Mus musculus) |
|
Position Markers| D4Rat64 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RH143180 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AU047215 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RH135198 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RH140646 |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||
| D8S281 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001002823 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001199095 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_053794 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06033310 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06033311 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06033312 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06033313 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01032621 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01032622 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01032623 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01032624 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01032625 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF227741 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BK004106 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473964 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ177457 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053794 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_446246 | ||||||||||||||||||||
| Peptide Label: | isoform 3 | ||||||||||||||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001002823 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001002823 | ||||||||||||||||||||
| Peptide Label: | isoform 1 | ||||||||||||||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001199095 | |||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | NP_001186024 | |||||||||||||||
| Peptide Label: | isoform 2 | |||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_001002823 | (Get FASTA) |
| NP_001186024 | (Get FASTA) | |
| NP_446246 | (Get FASTA) | |
| GenBank Protein | AAF74258 | (Get FASTA) |
| ABA02202 | (Get FASTA) | |
| DAA04492 | (Get FASTA) | |
| EDM02045 | (Get FASTA) | |
| EDM02046 | (Get FASTA) | |
| Q9JIH7 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009956 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000013355 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000013622 | ENTREZGENE | |
| Ensembl Transcript | ENSRNOT00000013355 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000013621 | ENTREZGENE | |
| Entrez Gene | 116477 | ENTREZGENE |
| Germonline | ENSRNOG00000009956 | UniProtKB/Swiss-Prot |
| InterPro | Kinase-like_dom | UniProtKB/Swiss-Prot |
| Kinase_OSR1/WNK_CCT | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| IPI | IPI00200557 | UniProtKB/Swiss-Prot |
| IPI00205581 | UniProtKB/TrEMBL | |
| IPI00563247 | UniProtKB/TrEMBL | |
| IPI00972852 | UniProtKB/Swiss-Prot | |
| IPI00972854 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:116477 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | OSR1_C | UniProtKB/Swiss-Prot |
| Pkinase | UniProtKB/Swiss-Prot | |
| PROSITE | PROTEIN_KINASE_ATP; FALSE_NEG | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.27409 | ENTREZGENE |
| UniProt | D3ZX61_RAT | UniProtKB/TrEMBL |
| Q3S2I2_RAT | UniProtKB/TrEMBL | |
| WNK1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-05-13 | Wnk1 | WNK lysine deficient protein kinase 1 | Hsn2 | hereditary sensory neuropathy, type II | Data Merged | 9333 | APPROVED |
| 2008-02-19 | Wnk1 | WNK lysine deficient protein kinase 1 | Prkwnk1 | protein kinase, lysine deficient 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-02-14 | Hsn2 | hereditary sensory neuropathy, type II | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2004-02-26 | Prkwnk1 | protein kinase, lysine deficient 1 | Symbol and Name status set to approved | 2225 | APPROVED | ||
| 2002-08-07 | Prkwnk1 | protein kinase, lysine deficient 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | mutation of the human homolog is a cause of pseudohypoaldosteronism type II (PHAII) | 1299306 |
| gene_domains | contains a small N-terminal domain followed by the kinase domain and a long C-terminal tail | 633747 |
| gene_protein | 2126 amino acids and 230 kDa | 633747 |
| More on Wnk1 | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621141 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




