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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | autophagic vacuole assembly | | IMP | | 2303129 | | RGD | | cytokinesis | | ISO | RGD:732994 | 1624291 | PMID:20208530 | RGD | PMID:20208530 | cytokinesis | | ISS | UniProtKB:Q8NEB9 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | early endosome to late endosome transport | | ISO | RGD:732994 | 1624291 | PMID:14617358 | RGD | PMID:14617358 | early endosome to late endosome transport | | ISS | UniProtKB:Q8NEB9 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | endosome organization | | IMP | | 2303129 | | RGD | | phosphatidylinositol-3-phosphate biosynthetic process | | ISO | RGD:732994 | 1624291 | PMID:20208530 | RGD | PMID:20208530 | phosphatidylinositol-mediated signaling | | IDA | | 633560 | | RGD | | protein phosphorylation | | ISO | RGD:732995 | 1624291 | MGI:MGI:3510060|PMID:15010863 | RGD | MGI:MGI:3510060 PMID:15010863 | protein processing | | IMP | | 628447 | | RGD | | regulation of protein secretion | | IMP | | 628447 | | RGD | | response to leucine | | IEP | | 2303128 | | RGD | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Inositol phosphate metabolism |
| Metabolic pathways | |
| Phagosome | |
| Phosphatidylinositol signaling system | |
| Regulation of autophagy | |
| Tuberculosis | |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Inositol phosphate metabolism |
| Metabolic pathways | |
| Phagosome | |
| Phosphatidylinositol signaling system | |
| Regulation of autophagy | |
| Tuberculosis | |
References - curated| 1. |
Campos-Toimil M, etal., Curr Biol 2002 Feb 5;12(3):211-5. |
| 2. |
Carbott DE, etal., Apoptosis 2002 Feb;7(1):69-76. |
| 3. |
Eskelinen EL, etal., Traffic. 2002 Dec;3(12):878-93. |
| 4. |
Haller D, etal., J Biol Chem 2002 Oct 11;277(41):38168-78. |
| 5. |
Hunyady L, etal., J Cell Biol 2002 Jun 24;157(7):1211-22. |
| 6. |
Irani C, etal., Am J Physiol Lung Cell Mol Physiol 2002 Apr;282(4):L854-62. |
| 7. |
Ito N, etal., J Biol Chem 2002 Nov 22;277(47):44898-904. |
| 8. |
Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81. |
| 9. |
KEGG |
| 10. |
MacKenzie MG, etal., J Physiol. 2009 Jan 15;587(Pt 1):253-60. Epub 2008 Nov 17. |
| 11. |
MGD data from the GO Consortium |
| 12. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 13. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 14. |
RGD automated data pipeline |
| 15. |
RGD automated import pipeline for gene-chemical interactions |
| 16. |
RGD comprehensive gene curation |
| 17. |
Row PE, etal., Biochem J 2001 Feb 1;353(Pt 3):655-61. |
| 18. |
Silfani TN and Freeman EJ, Arch Biochem Biophys 2002 Jun 1;402(1):84-93. |
| 19. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 20. |
Sun GW, etal., Endocrinology 2003 Mar;144(3):793-801. |
| 21. |
Tu VC, etal., J Pharmacol Exp Ther 2002 Mar;300(3):1101-10. |
| 22. |
Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23. |
| 23. |
Yu C, etal., J Biol Chem 2002 Dec 27;277(52):50230-6. |
References - uncurated| PubMed | 12198247 |
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| 17393104 | |
| 17437535 | |
| 18040895 | |
| 18716370 | |
| 18777595 | |
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RGD Disease Portals| Pik3c3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pik3c3 (Rattus norvegicus) |
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| PIK3C3 (Homo sapiens) |
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| Pik3c3 (Mus musculus) |
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Position Markers| RH140704 |
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| BF388154 |
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| AU048898 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022958 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06094438 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01094304 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01094305 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ006710 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC061981 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473974 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022958 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_075247 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_075247 | (Get FASTA) |
| GenBank Protein | AAH61981 | (Get FASTA) |
| CAA07199 | (Get FASTA) | |
| EDL76162 | (Get FASTA) | |
| O88763 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000017840 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000060791 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000066816 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 65052 | ENTREZGENE |
| Gene3D-CATH | PI3/4_kinase_cat | UniProtKB/Swiss-Prot |
| PI3Ka | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000017840 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 1986 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:5597998 | IMAGE-MGC_LOAD |
| InterPro | ARM-type_fold | UniProtKB/Swiss-Prot |
| C2_Ca-dep | UniProtKB/Swiss-Prot | |
| C2_Ca/lipid-bd_dom_CaLB | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| PI3/4_kinase_cat | UniProtKB/Swiss-Prot | |
| PI3/4_kinase_CS | UniProtKB/Swiss-Prot | |
| PI3K_C2 | UniProtKB/Swiss-Prot | |
| PI3K_Vps34 | UniProtKB/Swiss-Prot | |
| PI_Kinase | UniProtKB/Swiss-Prot | |
| PInositide-3_kin_accessory_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00212514 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:65052 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72433 | IMAGE-MGC_LOAD |
| PANTHER | PI_Kinase | UniProtKB/Swiss-Prot |
| Pfam | PI3_PI4_kinase | UniProtKB/Swiss-Prot |
| PI3K_C2 | UniProtKB/Swiss-Prot | |
| PI3Ka | UniProtKB/Swiss-Prot | |
| PIRSF | PI3K_Vps34 | UniProtKB/Swiss-Prot |
| PROSITE | PI3_4_KINASE_1 | UniProtKB/Swiss-Prot |
| PI3_4_KINASE_2 | UniProtKB/Swiss-Prot | |
| PI3_4_KINASE_3 | UniProtKB/Swiss-Prot | |
| PI3K_C2; FALSE_NEG | UniProtKB/Swiss-Prot | |
| PIK_HELICAL | UniProtKB/Swiss-Prot | |
| SMART | PI3K_C2 | UniProtKB/Swiss-Prot |
| PI3Ka | UniProtKB/Swiss-Prot | |
| PI3Kc | UniProtKB/Swiss-Prot | |
| SM00239 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | ARM-type_fold | UniProtKB/Swiss-Prot |
| C2_CaLB | UniProtKB/Swiss-Prot | |
| Kinase_like | UniProtKB/Swiss-Prot | |
| UniGene | Rn.30010 | ENTREZGENE |
| UniProt | PK3C3_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-10-10 | Pik3c3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | Pik3c3 | phosphoinositide-3-kinase, class 3 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-09-10 | Pik3c3 | phosphoinositide-3-kinase, class 3 | phosphatidylinositol 3-kinase | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Pik3c3 | phosphatidylinositol 3-kinase | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_drugs | inhibitors act on one transport step | 628447 |
| gene_process | helps in the delivery of newly synthesized lysosomal hydrolases to lysosomes | 628447 |
| More on Pik3c3 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620899 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.