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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Jak-Stat signaling pathway
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Accession:PW:0000209 term browser browse the term
Definition:The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand- triggered signaling through the various receptors.
Synonyms:related_synonym: receptor signaling pathway via JAK-STAT
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Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 IEA KEGG mmu:04630 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 IEA KEGG mmu:04630 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251 		JBrowse link
G Akt3 thymoma viral proto-oncogene 3 IEA KEGG mmu:04630 NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769 		JBrowse link
G Bcl2l1 BCL2-like 1 IEA KEGG mmu:04630 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Cbl Casitas B-lineage lymphoma IEA KEGG mmu:04630 NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346 		JBrowse link
G Cblb Casitas B-lineage lymphoma b IEA KEGG mmu:04630 NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411 		JBrowse link
G Cblc Casitas B-lineage lymphoma c IEA KEGG mmu:04630 NCBI chr 7:19,513,643...19,530,734
Ensembl chr 7:19,512,806...19,530,734 		JBrowse link
G Ccnd1 cyclin D1 IEA KEGG mmu:04630 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccnd2 cyclin D2 IEA KEGG mmu:04630 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156 		JBrowse link
G Ccnd3 cyclin D3 IEA KEGG mmu:04630 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616 		JBrowse link
G Cish cytokine inducible SH2-containing protein IEA KEGG mmu:04630 NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983 		JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 IEA KEGG mmu:04630 NCBI chr19:4,264,479...4,273,548
Ensembl chr19:4,264,292...4,273,544 		JBrowse link
G Cntf ciliary neurotrophic factor IEA KEGG mmu:04630 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996 		JBrowse link
G Cntfr ciliary neurotrophic factor receptor IEA KEGG mmu:04630 NCBI chr 4:41,657,498...41,697,091
Ensembl chr 4:41,657,498...41,697,089 		JBrowse link
G Crebbp CREB binding protein IEA KEGG mmu:04630 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 IEA KEGG mmu:04630 NCBI chr 5:109,702,575...109,707,301
Ensembl chr 5:109,702,575...109,706,859 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) IEA KEGG mmu:04630 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) IEA KEGG mmu:04630 NCBI chr19:61,205,629...61,221,141
Ensembl chr19:61,212,395...61,216,867 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) IEA KEGG mmu:04630 NCBI chr15:78,210,000...78,235,201
Ensembl chr15:78,209,952...78,238,047 		JBrowse link
G Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) IEA KEGG mmu:04630 NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) IEA KEGG mmu:04630 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Csf3r colony stimulating factor 3 receptor IEA KEGG mmu:04630 NCBI chr 4:125,917,241...125,938,233
Ensembl chr 4:125,918,343...125,938,233 		JBrowse link
G Ctf1 cardiotrophin 1 IEA KEGG mmu:04630 NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364 		JBrowse link
G Ep300 E1A binding protein p300 IEA KEGG mmu:04630 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epo erythropoietin IEA KEGG mmu:04630 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Epor erythropoietin receptor IEA KEGG mmu:04630 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802 		JBrowse link
G Gh growth hormone IEA KEGG mmu:04630 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691 		JBrowse link
G Ghr growth hormone receptor IEA KEGG mmu:04630 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG mmu:04630 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423 		JBrowse link
G Ifna1 interferon alpha 1 IEA KEGG mmu:04630 NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893 		JBrowse link
G Ifna11 interferon alpha 11 IEA KEGG mmu:04630 NCBI chr 4:88,738,156...88,738,802
Ensembl chr 4:88,738,196...88,738,768 		JBrowse link
G Ifna12 interferon alpha 12 IEA KEGG mmu:04630 NCBI chr 4:88,520,817...88,521,613
Ensembl chr 4:88,520,817...88,521,613 		JBrowse link
G Ifna13 interferon alpha 13 IEA KEGG mmu:04630 NCBI chr 4:88,561,878...88,562,696
Ensembl chr 4:88,561,878...88,562,696 		JBrowse link
G Ifna14 interferon alpha 14 IEA KEGG mmu:04630 NCBI chr 4:88,489,466...88,490,035
Ensembl chr 4:88,489,466...88,490,035 		JBrowse link
G Ifna15 interferon alpha 15 IEA KEGG mmu:04630 NCBI chr 4:88,475,910...88,476,482
Ensembl chr 4:88,475,910...88,476,482 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG mmu:04630 NCBI chr 4:88,601,444...88,602,016
Ensembl chr 4:88,601,118...88,602,149 		JBrowse link
G Ifna4 interferon alpha 4 IEA KEGG mmu:04630 NCBI chr 4:88,760,032...88,761,009
Ensembl chr 4:88,760,098...88,760,658 		JBrowse link
G Ifna5 interferon alpha 5 IEA KEGG mmu:04630 NCBI chr 4:88,753,762...88,754,331
Ensembl chr 4:88,753,762...88,754,331 		JBrowse link
G Ifna6 interferon alpha 6 IEA KEGG mmu:04630 NCBI chr 4:88,745,627...88,746,269
Ensembl chr 4:88,745,653...88,746,222 		JBrowse link
G Ifna7 interferon alpha 7 IEA KEGG mmu:04630 NCBI chr 4:88,734,462...88,735,037
Ensembl chr 4:88,734,465...88,735,037 		JBrowse link
G Ifna9 interferon alpha 9 IEA KEGG mmu:04630 NCBI chr 4:88,510,050...88,510,622
Ensembl chr 4:88,510,050...88,510,622 		JBrowse link
G Ifnab interferon alpha B IEA KEGG mmu:04630 NCBI chr 4:88,608,836...88,609,505
Ensembl chr 4:88,608,539...88,609,596 		JBrowse link
G Ifnar1 interferon (alpha and beta) receptor 1 IEA KEGG mmu:04630 NCBI chr16:91,281,016...91,307,411
Ensembl chr16:91,282,126...91,304,329 		JBrowse link
G Ifnar2 interferon (alpha and beta) receptor 2 IEA KEGG mmu:04630 NCBI chr16:91,166,517...91,202,477
Ensembl chr16:91,169,671...91,202,477 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast IEA KEGG mmu:04630 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifne interferon epsilon IEA KEGG mmu:04630 NCBI chr 4:88,797,775...88,798,438
Ensembl chr 4:88,797,775...88,798,438 		JBrowse link
G Ifng interferon gamma IEA KEGG mmu:04630 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ifngr1 interferon gamma receptor 1 IEA KEGG mmu:04630 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Ifngr2 interferon gamma receptor 2 IEA KEGG mmu:04630 NCBI chr16:91,343,947...91,360,895
Ensembl chr16:91,343,960...91,362,511 		JBrowse link
G Ifnk interferon kappa IEA KEGG mmu:04630 NCBI chr 4:35,152,055...35,154,019
Ensembl chr 4:35,152,056...35,154,005 		JBrowse link
G Ifnl2 interferon lambda 2 IEA KEGG mmu:04630 NCBI chr 7:28,208,209...28,209,957
Ensembl chr 7:28,208,261...28,209,880 		JBrowse link
G Ifnl3 interferon lambda 3 IEA KEGG mmu:04630 NCBI chr 7:28,222,251...28,223,826
Ensembl chr 7:28,222,261...28,223,747 		JBrowse link
G Ifnlr1 interferon lambda receptor 1 IEA KEGG mmu:04630 NCBI chr 4:135,413,513...135,435,492
Ensembl chr 4:135,413,598...135,435,492 		JBrowse link
G Il10 interleukin 10 IEA KEGG mmu:04630 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il10ra interleukin 10 receptor, alpha IEA KEGG mmu:04630 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447 		JBrowse link
G Il10rb interleukin 10 receptor, beta IEA KEGG mmu:04630 NCBI chr16:91,203,166...91,222,718
Ensembl chr16:91,203,052...91,222,722 		JBrowse link
G Il11 interleukin 11 IEA KEGG mmu:04630 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 IEA KEGG mmu:04630 NCBI chr 4:41,760,443...41,769,473
Ensembl chr 4:41,699,989...41,769,474 		JBrowse link
G Il11ra2 interleukin 11 receptor subunit alpha 2 IEA KEGG mmu:04630 NCBI chr 4:42,656,001...42,665,744
Ensembl chr 4:42,656,001...42,665,763 		JBrowse link
G Il12a interleukin 12a IEA KEGG mmu:04630 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880 		JBrowse link
G Il12b interleukin 12b IEA KEGG mmu:04630 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il12rb1 interleukin 12 receptor, beta 1 IEA KEGG mmu:04630 NCBI chr 8:71,261,005...71,276,186
Ensembl chr 8:71,261,093...71,274,068 		JBrowse link
G Il12rb2 interleukin 12 receptor, beta 2 IEA KEGG mmu:04630 NCBI chr 6:67,263,914...67,353,277
Ensembl chr 6:67,268,302...67,353,172 		JBrowse link
G Il13 interleukin 13 IEA KEGG mmu:04630 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il13ra1 interleukin 13 receptor, alpha 1 IEA KEGG mmu:04630 NCBI chr  X:35,375,761...35,434,915
Ensembl chr  X:35,375,763...35,434,912 		JBrowse link
G Il13ra2 interleukin 13 receptor, alpha 2 IEA KEGG mmu:04630 NCBI chr  X:146,166,474...146,214,982
Ensembl chr  X:146,166,472...146,212,188 		JBrowse link
G Il15 interleukin 15 ISO
IEA		 KEGG
RGD		 PMID:8942753 mmu:04630, RGD:5024920 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il15ra interleukin 15 receptor, alpha chain ISO
IEA		 KEGG
RGD		 PMID:19747902 mmu:04630, RGD:5001122 NCBI chr 2:11,709,992...11,739,129
Ensembl chr 2:11,710,101...11,739,128 		JBrowse link
G Il19 interleukin 19 IEA KEGG mmu:04630 NCBI chr 1:130,860,393...130,873,194
Ensembl chr 1:130,860,393...130,867,852 		JBrowse link
G Il2 interleukin 2 IEA KEGG mmu:04630 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il20 interleukin 20 IEA KEGG mmu:04630 NCBI chr 1:130,834,722...130,839,033
Ensembl chr 1:130,834,722...130,839,188 		JBrowse link
G Il20ra interleukin 20 receptor, alpha IEA KEGG mmu:04630 NCBI chr10:19,587,421...19,635,801
Ensembl chr10:19,588,318...19,635,801 		JBrowse link
G Il20rb interleukin 20 receptor beta IEA KEGG mmu:04630 NCBI chr 9:100,339,772...100,368,526
Ensembl chr 9:100,339,772...100,368,841 		JBrowse link
G Il21 interleukin 21 IEA KEGG mmu:04630 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il21r interleukin 21 receptor IEA KEGG mmu:04630 NCBI chr 7:125,202,424...125,232,742
Ensembl chr 7:125,202,601...125,232,742 		JBrowse link
G Il22 interleukin 22 IEA KEGG mmu:04630 NCBI chr10:118,040,456...118,045,952
Ensembl chr10:118,040,847...118,045,952 		JBrowse link
G Il22ra1 interleukin 22 receptor, alpha 1 IEA KEGG mmu:04630 NCBI chr 4:135,455,470...135,482,694
Ensembl chr 4:135,455,483...135,479,451 		JBrowse link
G Il22ra2 interleukin 22 receptor, alpha 2 IEA KEGG mmu:04630 NCBI chr10:19,497,776...19,510,429
Ensembl chr10:19,497,746...19,510,429 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 IEA KEGG mmu:04630 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Il23r interleukin 23 receptor IEA KEGG mmu:04630 NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839 		JBrowse link
G Il24 interleukin 24 IEA KEGG mmu:04630 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain IEA KEGG mmu:04630 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il2rb interleukin 2 receptor, beta chain IEA KEGG mmu:04630 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471 		JBrowse link
G Il2rg interleukin 2 receptor, gamma chain IEA KEGG mmu:04630 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861 		JBrowse link
G Il3 interleukin 3 IEA KEGG mmu:04630 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il3ra interleukin 3 receptor, alpha chain IEA KEGG mmu:04630 NCBI chr14:8,114,270...8,123,851
Ensembl chr14:8,113,752...8,123,488 		JBrowse link
G Il4 interleukin 4 IEA KEGG mmu:04630 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il4ra interleukin 4 receptor, alpha IEA KEGG mmu:04630 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Il5 interleukin 5 IEA KEGG mmu:04630 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il5ra interleukin 5 receptor, alpha IEA KEGG mmu:04630 NCBI chr 6:106,687,336...106,725,998
Ensembl chr 6:106,687,318...106,725,998 		JBrowse link
G Il6 interleukin 6 IEA KEGG mmu:04630 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha IEA KEGG mmu:04630 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Il6st interleukin 6 signal transducer IEA KEGG mmu:04630 NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620 		JBrowse link
G Il7 interleukin 7 IEA KEGG mmu:04630 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820 		JBrowse link
G Il7r interleukin 7 receptor IEA KEGG mmu:04630 NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262 		JBrowse link
G Il9 interleukin 9 IEA KEGG mmu:04630 NCBI chr13:56,627,090...56,630,070
Ensembl chr13:56,627,090...56,630,059 		JBrowse link
G Il9r interleukin 9 receptor IEA KEGG mmu:04630 NCBI chr11:32,137,544...32,155,283
Ensembl chr11:32,137,541...32,150,279 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO RGD PMID:20980260 RGD:5128774 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Irf9 interferon regulatory factor 9 IEA KEGG mmu:04630 NCBI chr14:55,841,442...55,847,487
Ensembl chr14:55,841,028...55,847,487 		JBrowse link
G Jak1 Janus kinase 1 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Jak2 Janus kinase 2 ISO
TAS
IEA		 KEGG
RGD		 PMID:11064147 PMID:17312100 mmu:04630, RGD:1624963, RGD:1625126 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jak3 Janus kinase 3 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219 		JBrowse link
G Lep leptin IEA KEGG mmu:04630 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor IEA KEGG mmu:04630 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lif leukemia inhibitory factor IEA KEGG mmu:04630 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Lifr LIF receptor alpha IEA KEGG mmu:04630 NCBI chr15:7,120,091...7,226,970
Ensembl chr15:7,120,095...7,226,970 		JBrowse link
G Mpl myeloproliferative leukemia virus oncogene IEA KEGG mmu:04630 NCBI chr 4:118,299,609...118,314,771
Ensembl chr 4:118,299,612...118,314,710 		JBrowse link
G Myc myelocytomatosis oncogene IEA KEGG mmu:04630 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Osm oncostatin M IEA KEGG mmu:04630 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026 		JBrowse link
G Osmr oncostatin M receptor IEA KEGG mmu:04630 NCBI chr15:6,843,049...6,904,434
Ensembl chr15:6,843,058...6,904,450 		JBrowse link
G Pias1 protein inhibitor of activated STAT 1 ISO
IEA		 KEGG
RGD		 PMID:16426581 mmu:04630, RGD:2290530 NCBI chr 9:62,785,648...62,888,161
Ensembl chr 9:62,785,650...62,895,206 		JBrowse link
G Pias2 protein inhibitor of activated STAT 2 ISO
IEA		 KEGG
RGD		 PMID:16426581 mmu:04630, RGD:2290530 NCBI chr18:77,152,883...77,243,406
Ensembl chr18:77,152,904...77,241,496 		JBrowse link
G Pias3 protein inhibitor of activated STAT 3 ISO
IEA		 KEGG
RGD		 PMID:16426581 mmu:04630, RGD:2290530 NCBI chr 3:96,603,679...96,613,386
Ensembl chr 3:96,603,700...96,613,386 		JBrowse link
G Pias4 protein inhibitor of activated STAT 4 ISO
IEA		 KEGG
RGD		 PMID:16426581 mmu:04630, RGD:2290530 NCBI chr10:80,989,795...81,003,554
Ensembl chr10:80,989,100...81,003,757 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IEA KEGG mmu:04630 NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IEA KEGG mmu:04630 NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IEA KEGG mmu:04630 NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IEA KEGG mmu:04630 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG mmu:04630 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG mmu:04630 NCBI chr 8:71,220,820...71,229,356
Ensembl chr 8:71,220,820...71,229,357 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG mmu:04630 NCBI chr 4:116,078,593...116,160,253
Ensembl chr 4:116,078,815...116,160,253
Ensembl chr 4:116,078,815...116,160,253 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 IEA KEGG mmu:04630 NCBI chr11:68,322,951...68,388,675
Ensembl chr11:68,322,947...68,388,675 		JBrowse link
G Pim1 proviral integration site 1 IEA KEGG mmu:04630 NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086 		JBrowse link
G Prl prolactin IEA KEGG mmu:04630 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Prlr prolactin receptor IEA KEGG mmu:04630 NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta ISO RGD PMID:11818507 RGD:633057 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO RGD PMID:16426581 RGD:2290530 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO
IEA		 KEGG
RGD		 PMID:16426581 mmu:04630, RGD:2290530 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO RGD PMID:16426581 RGD:2290530 NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO
IEA		 KEGG
RGD		 PMID:16426581 mmu:04630, RGD:2290530 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 IEA KEGG mmu:04630 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 IEA KEGG mmu:04630 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 IEA KEGG mmu:04630 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 IEA KEGG mmu:04630 NCBI chr14:47,514,377...47,533,559
Ensembl chr14:47,514,388...47,533,559 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO
IEA		 KEGG
RGD		 PMID:14607831 mmu:04630, RGD:1357941 NCBI chr17:87,414,707...87,445,153
Ensembl chr17:87,415,107...87,445,267 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 ISO RGD PMID:14607831 RGD:1357941 NCBI chr18:88,883,293...88,912,623
Ensembl chr18:88,683,348...88,945,605 		JBrowse link
G Socs7 suppressor of cytokine signaling 7 IEA KEGG mmu:04630 NCBI chr11:97,253,044...97,289,368
Ensembl chr11:97,253,261...97,289,368 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG mmu:04630 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG mmu:04630 NCBI chr12:69,630,535...69,728,626
Ensembl chr12:69,630,536...69,728,626 		JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IEA KEGG mmu:04630 NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760 		JBrowse link
G Spred2 sprouty-related EVH1 domain containing 2 IEA KEGG mmu:04630 NCBI chr11:19,874,442...19,974,026
Ensembl chr11:19,874,375...19,974,026 		JBrowse link
G Spred3 sprouty-related EVH1 domain containing 3 IEA KEGG mmu:04630 NCBI chr 7:28,857,208...28,869,286
Ensembl chr 7:28,858,254...28,869,836 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 IEA KEGG mmu:04630 NCBI chr 3:37,694,096...37,698,748
Ensembl chr 3:37,694,096...37,698,747 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 IEA KEGG mmu:04630 NCBI chr14:106,129,381...106,134,559
Ensembl chr14:106,129,381...106,134,253 		JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 IEA KEGG mmu:04630
G Spry4 sprouty RTK signaling antagonist 4 IEA KEGG mmu:04630 NCBI chr18:38,719,300...38,734,400
Ensembl chr18:38,719,300...38,734,468 		JBrowse link
G Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 IEA KEGG mmu:04630 NCBI chr 2:14,078,912...14,152,351
Ensembl chr 2:14,078,909...14,154,445 		JBrowse link
G Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 IEA KEGG mmu:04630 NCBI chr 2:52,582,213...52,632,212
Ensembl chr 2:52,581,676...52,632,293 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO
IEA
TAS		 KEGG
RGD		 PMID:11064147 PMID:17312100 mmu:04630, RGD:1624963, RGD:1625126 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO
IEA
TAS		 KEGG
RGD		 PMID:11064147 PMID:17312100 mmu:04630, RGD:1624963, RGD:1625126 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Tpo thyroid peroxidase IEA KEGG mmu:04630 NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623 		JBrowse link
G Tslp thymic stromal lymphopoietin IEA KEGG mmu:04630 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850 		JBrowse link
G Tyk2 tyrosine kinase 2 TAS
IEA		 KEGG
RGD		 PMID:17312100 mmu:04630, RGD:1625126 NCBI chr 9:21,015,364...21,042,689
Ensembl chr 9:21,015,364...21,042,539 		JBrowse link
altered Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 ISO RGD PMID:12032773 RGD:1357939 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jak3 Janus kinase 3 ISO RGD PMID:12032773 RGD:1357939 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6070
    signaling pathway 2498
      signaling pathway pertinent to immunity 602
        Jak-Stat signaling pathway 158
          altered Jak-Stat signaling pathway 2
Path 2
Term Annotations click to browse term
  pathway 6070
    signaling pathway 2498
      kinase mediated signaling pathway 617
        tyrosine-specific protein kinase mediated signaling pathway 158
          Jak-Stat signaling pathway 158
            altered Jak-Stat signaling pathway 2
paths to the root