Gene: Pik3cb (phosphatidylinositol 3-kinase, catalytic, beta polypeptide)
Mus musculus |
| Symbol: |
Pik3cb
|
| Name: |
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
|
| Description: |
ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding; INVOLVED IN cellular calcium ion homeostasis; embryonic cleavage; homophilic cell adhesion; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH abnormal cell physiology; abnormal gluconeogenesis; abnormal platelet physiology; ASSOCIATED WITH Thrombosis (ortholog); FOUND IN brush border membrane (ortholog); phosphatidylinositol 3-kinase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal; benzo[a]pyrene |
| Type: |
protein-coding
|
| RefSeq Status: |
VALIDATED
|
| Also known as: |
1110001J02Rik; AI447572; MGC150132; OTTMUSP00000023176; p110beta; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta
|
| Orthologs: |
Homo sapiens : PIK3CB
(phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta)
HGNC
Rattus norvegicus : Pik3cb
(phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta)
|
| Related Pseudogenes: |
Gm12978
|
| Latest Assembly: |
Mouse Genome Assembly Build 37
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Mouse Genome Assembly GRCm38 | 9 | 99,038,402 - 99,140,211 | - | NCBI | Mouse cM Map | 9 | | - | NCBI | Mouse Celera Assembly | 9 | 98,576,088 - 98,662,033 | - | NCBI | Mouse Genome Assembly Build 37 | 9 | 98,938,821 - 99,040,630 | - | NCBI | Mouse Genome Assembly Build 36.1 | 9 | 98,938,821 - 99,040,506 | - | NCBI | Mouse Cytogenetic Map | 9 | E4 | | NCBI |
|
| Model |
|
 Disease Annotations |
 Gene-Chemical Interaction Annotations
| (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:732496 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PIK3CB mRNA | CTD | PMID:22079256 | | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PIK3CB promoter] | CTD | PMID:19654925 | | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732496 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PIK3CB mRNA | CTD | PMID:21632981 | | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PIK3CB mRNA | CTD | PMID:21570461 | | 2,6-dinitrotoluene | affects expression | ISO | RGD:620917 | 6480464 | 2,6-dinitrotoluene affects the expression of PIK3CB mRNA | CTD | PMID:21346803 | | 4-hydroxynon-2-enal | increases expression | EXP | | 6480464 | 4-hydroxy-2-nonenal results in increased expression of PIK3CB mRNA | CTD | PMID:19191707 | | all-trans-retinoic acid | multiple interactions | ISO | RGD:732496 | 6480464 | LE 540 inhibits the reaction [Tretinoin results in increased expression of and results in increased activity of PIK3CB protein] | CTD | PMID:16043647 | | all-trans-retinoic acid | decreases expression | ISO | RGD:732496 | 6480464 | Tretinoin results in decreased expression of PIK3CB mRNA | CTD | PMID:15498508 | | all-trans-retinoic acid | increases expression | ISO | RGD:732496 | 6480464 | Tretinoin results in increased expression of PIK3CB mRNA | CTD | PMID:16043647 | | benzo[a]pyrene | decreases expression | ISO | RGD:732496 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3CB mRNA | CTD | PMID:20106945 PMID:20064835 | | benzo[a]pyrene | decreases expression | ISO | RGD:732496 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3CB mRNA | CTD | PMID:20064835 more ... | | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PIK3CB mRNA | CTD | PMID:21715664 | | benzo[a]pyrene | decreases expression | ISO | RGD:732496 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3CB mRNA | CTD | PMID:20064835 PMID:20106945 | | calcium atom | affects transport | ISO | RGD:620917 | 6480464 | PIK3CB protein affects the transport of Calcium | CTD | PMID:11597992 | | calcium(0) | affects transport | ISO | RGD:620917 | 6480464 | PIK3CB protein affects the transport of Calcium | CTD | PMID:11597992 | | copper(2+) sulfate | decreases expression | ISO | RGD:732496 | 6480464 | Copper Sulfate results in decreased expression of PIK3CB mRNA | CTD | PMID:19549813 | | crocidolite asbestos | affects expression | ISO | RGD:732496 | 6480464 | Asbestos, Crocidolite affects the expression of PIK3CB mRNA | CTD | PMID:17331233 | | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PIK3CB mRNA | CTD | PMID:21266533 | | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PIK3CB mRNA | CTD | PMID:17361019 PMID:21266533 | | ethanol | increases expression | ISO | RGD:620917 | 6480464 | Ethanol results in increased expression of PIK3CB mRNA | CTD | PMID:20655511 | | LY294002 | decreases activity | EXP | | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CB protein | CTD | PMID:16179367 | | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of PIK3CB mRNA | CTD | PMID:23091169 | | resveratrol | multiple interactions | ISO | RGD:732496 | 6480464 | resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CB protein] | CTD | PMID:17550345 | | tamibarotene | affects expression | ISO | RGD:732496 | 6480464 | Am 80 affects the expression of PIK3CB mRNA; more ... | CTD | PMID:15498508 | | tetracycline | increases expression | EXP | | 6480464 | Tetracycline results in increased expression of PIK3CB mRNA | CTD | PMID:16917069 | | trans-resveratrol | multiple interactions | ISO | RGD:732496 | 6480464 | resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CB protein] | CTD | PMID:17550345 | | wortmannin | decreases activity | ISO | RGD:732496 | 6480464 | wortmannin results in decreased activity of PIK3CB protein | CTD | PMID:11931710 | |
Biological Process
| autophagy | | IEA | UniProtKB-KW:KW-0072 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| cell adhesion | | IEA | UniProtKB-KW:KW-0130 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| cellular calcium ion homeostasis | | IMP | | 2290270 | MGI:MGI:3577829|PMID:15834429 | MGI | MGI:MGI:3577829 PMID:15834429 |
| embryonic cleavage | | IMP | MGI:MGI:2180703 | 2290270 | MGI:MGI:2177130|PMID:11919689 | MGI | MGI:MGI:2177130 PMID:11919689 |
| endocytosis | | IEA | UniProtKB-KW:KW-0254 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| homophilic cell adhesion | | IMP | | 2290270 | MGI:MGI:3577829|PMID:15834429 | MGI | MGI:MGI:3577829 PMID:15834429 |
| phosphatidylinositol phosphorylation | | IEA | EC:2.7.1.153 | 2290270 | MGI:MGI:2152096 | GOC | MGI:MGI:2152096 |
| phosphatidylinositol phosphorylation | | ISO | UniProtKB:Q9Z1L0 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| phosphatidylinositol-3-phosphate biosynthetic process | | ISO | UniProtKB:Q9Z1L0 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| phosphatidylinositol-mediated signaling | | IEA | InterPro:IPR015433 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| phosphorylation | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| platelet activation | | IMP | | 2290270 | MGI:MGI:3577829|PMID:15834429 | MGI | MGI:MGI:3577829 PMID:15834429 |
| regulation of cell-matrix adhesion | | IMP | | 2290270 | MGI:MGI:3577829|PMID:15834429 | MGI | MGI:MGI:3577829 PMID:15834429 |
Cellular Component
| brush border membrane | | ISO | UniProtKB:Q9Z1L0 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| cytoplasm | | IEA | UniProtKB-KW:KW-0963 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| nucleus | | IEA | UniProtKB-KW:KW-0539 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| phosphatidylinositol 3-kinase complex | | IBA | PANTHER:PTN000005674 | 2290270 | MGI:MGI:4459044 | RefGenome | MGI:MGI:4459044 |
| phosphatidylinositol 3-kinase complex | | ISO | UniProtKB:Q9Z1L0 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| plasma membrane | | IBA | PANTHER:PTN000005674 | 2290270 | MGI:MGI:4459044 | RefGenome | MGI:MGI:4459044 |
Molecular Function
| 1-phosphatidylinositol-3-kinase activity | | IMP | | 2290270 | MGI:MGI:3625596|PMID:16625210 | MGI | MGI:MGI:3625596 PMID:16625210 |
| 1-phosphatidylinositol-3-kinase activity | | ISO | UniProtKB:Q9Z1L0 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| 1-phosphatidylinositol-3-kinase activity | | IMP | | 2290270 | MGI:MGI:3577829|PMID:15834429 | MGI | MGI:MGI:3577829 PMID:15834429 |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | | IBA | PANTHER:PTN000005674 | 2290270 | MGI:MGI:4459044 | RefGenome | MGI:MGI:4459044 |
| ATP binding | | IEA | UniProtKB-KW:KW-0067 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| insulin receptor substrate binding | | IPI | UniProtKB:P35569|UniProtKB:Q3U2I0 | 2290270 | MGI:MGI:3625596|PMID:16625210 | MGI | MGI:MGI:3625596 PMID:16625210 |
| kinase activity | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| nucleotide binding | | IEA | UniProtKB-KW:KW-0547 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | | IBA | PANTHER:PTN000005743 | 2290270 | MGI:MGI:4459044 | RefGenome | MGI:MGI:4459044 |
| phosphotransferase activity, alcohol group as acceptor | | IEA | InterPro:IPR000403|InterPro:IPR018936 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| protein binding | | IPI | UniProtKB:P26450 | 2290270 | MGI:MGI:3688344|PMID:15102471 | IntAct | MGI:MGI:3688344 PMID:15102471 |
| transferase activity | | IEA | UniProtKB-KW:KW-0808 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| transferase activity, transferring phosphorus-containing groups | | IEA | InterPro:IPR011009 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| 1301636 | Lith5_m | lithogenic gene 5 (mouse) | | | Not determined | | 9 | 66100631 | 100100729 | Mouse |
| 1301475 | Tnbs1_m | tri-nitrobenzene sulfonic acid susceptible 1 (mouse) | | | Not determined | | 9 | 68791117 | 102791259 | Mouse |
| 1301924 | Bmd10_m | bone mineral density 10 (mouse) | | | Not determined | | 9 | 68791117 | 102791259 | Mouse |
| 1357610 | Vtbt8_m | vertebral trabecular bone trait 8 (mouse) | | | Not determined | | 9 | 68791117 | 102791259 | Mouse |
| 1301302 | Pas4_m | pulmonary adenoma susceptibility 4 (mouse) | | | Not determined | | 9 | 69133452 | 103133527 | Mouse |
| 1301621 | Hpic1_m | haloperidol-induced catalepsy 1 (mouse) | | | Not determined | | 9 | 69440120 | 103440252 | Mouse |
| 1357497 | Stzid2_m | streptozotocin induced diabetes susceptibility 2 (mouse) | | | Not determined | | 9 | 69542264 | 103542401 | Mouse |
| 1301573 | Etohcta8_m | ethanol conditioned taste aversion 8 (mouse) | | | Not determined | | 9 | 72871843 | 106871990 | Mouse |
| 4141460 | Vmmt16_m | vertebral morphology and mechanical traits 16 (mouse) | | | Not determined | | 9 | 74263015 | 108263163 | Mouse |
| 1301725 | Lifespan1_m | life span 1 (mouse) | | | Not determined | | 9 | 74263015 | 108263163 | Mouse |
| 1357774 | Fmgty8_m | femur geometry 8 (mouse) | | | Not determined | | 9 | 74263015 | 108263163 | Mouse |
| 1301192 | Skts6_m | skin tumor susceptibility 6 (mouse) | | | Not determined | | 9 | 78541064 | 112541174 | Mouse |
| 1301290 | Smgd1_m | submucosal gland distribution 1 (mouse) | | | Not determined | | 9 | 81698687 | 115698811 | Mouse |
| 1301732 | Char1_m | P. chabaudi malaria resistance QTL 1 (mouse) | | | Not determined | | 9 | 81698687 | 115698811 | Mouse |
| 4141569 | Vmmt17_m | vertebral morphology and mechanical traits 17 (mouse) | | | Not determined | | 9 | 82810752 | 116810847 | Mouse |
| 1357560 | Alcrsp4_m | alcohol response 4 (mouse) | | | Not determined | | 9 | 82810752 | 116810847 | Mouse |
| 1300884 | Sluc11_m | susceptibility to lung cancer 11 (mouse) | | | Not determined | | 9 | 82810752 | 116810847 | Mouse |
| 1357461 | Idd2_m | insulin dependent diabetes susceptibility 2 (mouse) | | | Not determined | | 9 | 82810752 | 116810847 | Mouse |
| 1300868 | Tlf_m | T lymphocyte fraction (mouse) | | | Not determined | | 9 | 82810752 | 116810847 | Mouse |
| 4140998 | Dbsq8_m | diabetes susceptibility QTL 8 (mouse) | | | Not determined | | 9 | 84431148 | 118431251 | Mouse |
| 1301487 | Nociq1_m | nociceptive sensitivity inflammatory QTL 1 (mouse) | | | Not determined | | 9 | 84431148 | 118431251 | Mouse |
| 1301396 | Apmt2_m | accelerator of polyoma-induced mammary tumors 2 (mouse) | | | Not determined | | 9 | 84431148 | 118431251 | Mouse |
| 4141552 | Nhil5_m | non-heme iron levels 5 (mouse) | | | Not determined | | 9 | 84431148 | 118431251 | Mouse |
| 1300549 | Bbaa17_m | B. burgdorferi-associated arthritis 17 (mouse) | | | Not determined | | 9 | 86132731 | 120132860 | Mouse |
| 1357657 | Pymr_m | Plasmodium yoelli malaria resistance (mouse) | | | Not determined | | 9 | 86503469 | 120503544 | Mouse |
| 1300673 | Cosz1_m | cocaine seizure 1 (mouse) | | | Not determined | | 9 | 89314608 | 123314727 | Mouse |
| 1301649 | Psl1_m | promotion susceptibility QTL 1 (mouse) | | | Not determined | | 9 | 89314608 | 123314727 | Mouse |
| 1302103 | Dob2_m | dietary obesity 2 (mouse) | | | Not determined | | 9 | 91316210 | 124041922 | Mouse |
| 1302001 | Bdln5_m | body length 5 (mouse) | | | Not determined | | 9 | 93665094 | 124041922 | Mouse |
| 1301484 | Bwq6_m | body weight (mouse) | | | Not determined | | 9 | 93665094 | 124041922 | Mouse |
| 1357826 | Arti1_m | age related thymic involution 1 (mouse) | | | Not determined | | 9 | 96554297 | 124041922 | Mouse |