Il6ra (interleukin 6 receptor, alpha) - Rat Genome Database

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Gene: Il6ra (interleukin 6 receptor, alpha) Mus musculus
Analyze
Symbol: Il6ra
Name: interleukin 6 receptor, alpha
RGD ID: 10803
MGI Page MGI
Description: Enables interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD126; I; IL; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; Il6r; interleukin-6 receptor subunit alpha; MGC30256
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,776,631 - 89,820,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,771,366 - 89,820,503 (-)EnsemblGRCm39 Ensembl
GRCm38389,869,324 - 89,913,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,864,059 - 89,913,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,673,246 - 89,717,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,962,736 - 89,998,969 (-)NCBIMGSCv36mm8
Celera389,906,161 - 89,949,620 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (EXP)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
asperentin  (EXP)
azathioprine  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
Brevianamide A  (EXP)
bromobenzene  (ISO)
buspirone  (ISO)
butanal  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP)
Cannabidivarin  (EXP)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
cephaeline  (ISO)
choline  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
daunorubicin  (ISO)
dequalinium  (ISO)
dexamethasone  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dichloroacetic acid  (EXP)
digitoxigenin  (ISO)
digoxigenin  (ISO)
digoxin  (ISO)
dimethyl fumarate  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emetine  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenbendazole  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
glucose  (EXP)
glycidol  (ISO)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
L-methionine  (EXP)
lanatoside C  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
leflunomide  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
mebendazole  (ISO)
meclocycline  (ISO)
melittin  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methionine sulfoximine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
Methylbenzethonium chloride  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
minocycline  (ISO)
mitomycin C  (ISO)
mycophenolic acid  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nocodazole  (ISO)
obeticholic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxytetracycline  (ISO)
ozone  (EXP)
palmatine  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
puromycin  (ISO)
pyrvinium  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sotorasib  (ISO)
succimer  (EXP)
tamibarotene  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thymoquinone  (EXP)
TMC-120A  (EXP)
tofacitinib  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal circulating serum amyloid protein level  (IAGP)
abnormal emotion/affect behavior  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal head movements  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal wound healing  (IAGP)
decreased acute inflammation  (IAGP)
decreased adipocyte glucose uptake  (IAGP)
decreased circulating interleukin-1 beta level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver glycogen level  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased susceptibility to parasitic infection induced morbidity/mortality  (IAGP)
decreased tumor growth/size  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
impaired glucose tolerance  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased glycogen catabolism rate  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased insulin secretion  (IAGP)
increased plasma cell number  (IAGP)
increased red blood cell distribution width  (IEA)
increased spleen weight  (IAGP)
increased spleen white pulp amount  (IAGP)
insulin resistance  (IAGP)
liver inflammation  (IAGP)
no abnormal phenotype detected  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. Abbatecola AM, etal., J Am Geriatr Soc. 2004 Mar;52(3):399-404.
2. Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy. Asimaki A, etal., Circ Arrhythm Electrophysiol. 2011 Oct;4(5):743-52. doi: 10.1161/CIRCEP.111.964890. Epub 2011 Aug 22.
3. Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study. Bagli M, etal., Eur Arch Psychiatry Clin Neurosci. 2003 Feb;253(1):44-8.
4. Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor. Baumann M, etal., J Biol Chem 1990 Nov 15;265(32):19853-62.
5. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome. Bensadoun JC, etal., Eur J Neurosci. 2001 Dec;14(11):1753-61.
6. [Serum levels of interleukin 6 (IL-6) and soluble IL-6 receptor (sIL-6R) in children and adolescents with Graves-Basedow disease]. Bossowski A, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 1999;5(2):85-93.
7. Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain. Brazda V, etal., Mol Pain. 2013 Aug 16;9:42. doi: 10.1186/1744-8069-9-42.
8. Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women. Bustamante M, etal., Eur J Endocrinol. 2007 Nov;157(5):677-84.
9. Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T Cells. Chen X, etal., Am J Respir Crit Care Med. 2010 Apr 1;181(7):734-42. Epub 2009 Dec 17.
10. Interleukin-6 receptor blockade suppresses subretinal fibrosis in a mouse model. Cui W, etal., Int J Ophthalmol. 2014 Apr 18;7(2):194-7. doi: 10.3980/j.issn.2222-3959.2014.02.02. eCollection 2014.
11. Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. Deten A, etal., Cardiovasc Res. 2002 Aug 1;55(2):329-40.
12. Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model. Dubovy P, etal., Neuron Glia Biol. 2010 Feb;6(1):73-83. Epub 2010 Jun 2.
13. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Escobar-Morreale HF, etal., Obes Res. 2003 Aug;11(8):987-96.
14. Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome. Esteve E, etal., Clin Endocrinol (Oxf). 2006 Jul;65(1):88-91.
15. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Finotto S, etal., Int Immunol. 2007 Jun;19(6):685-93. Epub 2007 May 11.
16. Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure. Helwig BG, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1165-73. Epub 2006 Nov 9.
17. CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease. Joetham A, etal., J Immunol. 2011 Jan 1;186(1):113-20. Epub 2010 Nov 29.
18. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
19. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
20. Soluble IL-6 receptor in vitreous fluid of patients with proliferative diabetic retinopathy. Kawashima M, etal., Jpn J Ophthalmol. 2007 Mar-Apr;51(2):100-4. Epub 2007 Apr 6.
21. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Lehtimaki KA, etal., Brain Res Mol Brain Res. 2003 Feb 20;110(2):253-60.
22. [Determination of serum soluble interleukin-6 receptor and soluble gp130 levels in patient with pregnancy induced hypertension and its significance] Li Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2001 Jan;36(1):18-9.
23. Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity: relationship with abdominal fat deposition. Malavazos AE, etal., Nutr Metab Cardiovasc Dis. 2007 May;17(4):294-302. Epub 2006 Mar 31.
24. Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis. Matsushita K, etal., Lab Invest. 2005 Oct;85(10):1210-23.
25. Soluble interleukin 6 receptor: A novel marker of moderate to severe sleep-related breathing disorder. Mehra R, etal., Arch Intern Med. 2006 Sep 18;166(16):1725-31.
26. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
27. MGDs mouse GO annotations MGD data from the GO Consortium
28. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
29. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
30. Interleukin 6 and its soluble receptor are elevated in aqueous humor of patients with uveitis. Petrinovic-Doresic J, etal., Ocul Immunol Inflamm. 1999 Jun;7(2):75-84.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. Association of IL-6 and IL-6R gene polymorphisms with susceptibility to respiratory tract infections in young Finnish men. Rantala A, etal., Hum Immunol. 2011 Jan;72(1):63-8. Epub 2010 Oct 15.
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis. Rival C, etal., J Reprod Immunol. 2006 Jun;70(1-2):43-58. Epub 2006 Feb 3.
37. Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han. Wang M, etal., Brain Res. 2010 Apr 23;1327:1-5. doi: 10.1016/j.brainres.2010.02.067. Epub 2010 Mar 1.
38. Inhibition of interleukin-6 attenuates erectile dysfunction in a rat model of nerve-sparing radical prostatectomy. Yamashita S, etal., J Sex Med. 2011 Jul;8(7):1957-64. doi: 10.1111/j.1743-6109.2011.02283.x. Epub 2011 Apr 14.
39. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Yokota S, etal., Lancet. 2008 Mar 22;371(9617):998-1006. doi: 10.1016/S0140-6736(08)60454-7.
40. Association of genetic variations in IL-6/IL-6R pathway genes with gastric cancer risk in a Chinese population. Zhang JZ, etal., Gene. 2017 Aug 5;623:1-4. doi: 10.1016/j.gene.2017.04.038. Epub 2017 Apr 23.
41. Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model. Zhang L, etal., Dig Dis Sci. 2013 Aug;58(8):2187-96. doi: 10.1007/s10620-013-2656-3. Epub 2013 Apr 16.
Additional References at PubMed
PMID:1312474   PMID:2051018   PMID:2112585   PMID:7621883   PMID:8392875   PMID:8477802   PMID:8499630   PMID:8676083   PMID:8770556   PMID:8797792   PMID:8836549   PMID:9034153  
PMID:9324354   PMID:9659221   PMID:9708822   PMID:9743535   PMID:9874564   PMID:10349636   PMID:10521784   PMID:11042159   PMID:11073809   PMID:11076861   PMID:11197687   PMID:11275690  
PMID:11937300   PMID:12058253   PMID:12370259   PMID:12413742   PMID:12429018   PMID:12477932   PMID:12643284   PMID:14610273   PMID:14960573   PMID:15073037   PMID:15191552   PMID:15457342  
PMID:16034137   PMID:16141072   PMID:16141073   PMID:16435023   PMID:16602821   PMID:17202339   PMID:17567983   PMID:18156493   PMID:18555695   PMID:19420002   PMID:19714627   PMID:19933857  
PMID:20026129   PMID:20042582   PMID:20083667   PMID:20351184   PMID:20483735   PMID:20691261   PMID:20816090   PMID:20817879   PMID:20861861   PMID:21267068   PMID:21454673   PMID:21464300  
PMID:21511185   PMID:21873635   PMID:21960530   PMID:21990364   PMID:22295972   PMID:22467660   PMID:22758208   PMID:23085146   PMID:23209286   PMID:23297399   PMID:23378927   PMID:23564454  
PMID:23696660   PMID:23935104   PMID:23954788   PMID:24021059   PMID:24047696   PMID:24194600   PMID:24209760   PMID:24412616   PMID:24681566   PMID:24842874   PMID:24993179   PMID:25127137  
PMID:25234944   PMID:25326801   PMID:25429137   PMID:25491772   PMID:25607885   PMID:26010074   PMID:26026268   PMID:26143620   PMID:26201536   PMID:26253200   PMID:26273529   PMID:26329582  
PMID:26359498   PMID:26431949   PMID:26601142   PMID:26705936   PMID:26739431   PMID:26764350   PMID:26839965   PMID:26999594   PMID:27086282   PMID:27096320   PMID:27097661   PMID:27479084  
PMID:27563728   PMID:27626380   PMID:27662015   PMID:27694478   PMID:27838335   PMID:27869785   PMID:27893700   PMID:27936014   PMID:28087239   PMID:28188245   PMID:28235765   PMID:28402851  
PMID:28456715   PMID:28466852   PMID:28502470   PMID:28683285   PMID:28882904   PMID:29024103   PMID:29123149   PMID:29398651   PMID:29453398   PMID:29628394   PMID:29629897   PMID:29695802  
PMID:29770132   PMID:29784660   PMID:29987839   PMID:30169526   PMID:30224299   PMID:30315140   PMID:30374128   PMID:30674283   PMID:30890796   PMID:31165501   PMID:31259624   PMID:31311828  
PMID:31413107   PMID:31515941   PMID:31685531   PMID:31776260   PMID:31924653   PMID:32027619   PMID:32142677   PMID:32242005   PMID:32399548   PMID:32471947   PMID:32610084   PMID:32643523  
PMID:32929274   PMID:33001866   PMID:33414408   PMID:33476547   PMID:33691135   PMID:33941650   PMID:34301846   PMID:34446580   PMID:34570961   PMID:34626614   PMID:34747340   PMID:35258174  
PMID:35470093   PMID:36271280   PMID:36343752   PMID:36387898   PMID:36787740   PMID:37018396   PMID:37248420   PMID:37586472   PMID:37734370   PMID:38038619   PMID:38165930  


Genomics

Comparative Map Data
Il6ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,776,631 - 89,820,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,771,366 - 89,820,503 (-)EnsemblGRCm39 Ensembl
GRCm38389,869,324 - 89,913,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,864,059 - 89,913,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,673,246 - 89,717,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,962,736 - 89,998,969 (-)NCBIMGSCv36mm8
Celera389,906,161 - 89,949,620 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.19NCBI
IL6R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381154,405,343 - 154,469,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1154,405,193 - 154,469,450 (+)EnsemblGRCh38hg38GRCh38
GRCh371154,377,819 - 154,441,926 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361152,644,293 - 152,706,812 (+)NCBINCBI36Build 36hg18NCBI36
Build 341151,190,741 - 151,253,261NCBI
Celera1127,449,298 - 127,511,851 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1125,740,964 - 125,805,584 (+)NCBIHuRef
CHM1_11155,774,020 - 155,838,256 (+)NCBICHM1_1
T2T-CHM13v2.01153,542,427 - 153,606,601 (+)NCBIT2T-CHM13v2.0
Il6r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,582,020 - 177,646,705 (-)NCBIGRCr8
mRatBN7.22175,289,157 - 175,347,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,298,686 - 175,347,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2182,447,296 - 182,496,140 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,469,671 - 180,518,517 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,070,810 - 175,119,703 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,196,180 - 189,255,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,205,701 - 189,254,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,619,391 - 208,679,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,078,049 - 182,128,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12182,028,156 - 182,078,238 (-)NCBI
Celera2169,240,233 - 169,289,575 (-)NCBICelera
Cytogenetic Map2q34NCBI
Il6r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955545950,765 - 981,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955545932,814 - 979,359 (+)NCBIChiLan1.0ChiLan1.0
IL6R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2195,364,609 - 95,427,592 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,099,912 - 95,162,870 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01129,761,914 - 129,824,386 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,374,078 - 133,433,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,374,078 - 133,433,089 (+)Ensemblpanpan1.1panPan2
IL6R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,877,731 - 42,920,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,880,885 - 42,920,090 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,368,082 - 42,410,484 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,747,387 - 42,789,817 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,747,374 - 42,790,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,526,574 - 42,569,177 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,580,411 - 42,622,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,864,074 - 42,906,503 (-)NCBIUU_Cfam_GSD_1.0
Il6r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,027,301 - 25,051,502 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,057,771 - 4,081,885 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,055,438 - 4,081,876 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl495,322,433 - 95,381,282 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1495,322,426 - 95,381,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,202,230 - 104,250,108 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL6R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1209,345,723 - 9,418,963 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl209,361,152 - 9,396,610 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,700,264 - 8,762,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,910,112 - 2,946,886 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,910,367 - 2,946,916 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il6ra
1409 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:808
Count of miRNA genes:444
Interacting mature miRNAs:538
Transcripts:ENSMUST00000029559
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse

Markers in Region
X51975  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,870,910 - 89,870,999UniSTSGRCm38
MGSCv37389,674,832 - 89,674,921UniSTSGRCm37
Celera389,907,747 - 89,907,836UniSTS
Cytogenetic Map3F1UniSTS
cM Map342.1UniSTS
Whitehead/MRC_RH3900.6UniSTS
px-50g7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map7B5UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map3B-DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map4C1UniSTS
Cytogenetic Map18CUniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map2F2UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map9A1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map74.0UniSTS
cM Map1718.88UniSTS
cM Map241.25UniSTS
cM Map727.0UniSTS
cM Map342.1UniSTS
cM Map275.0UniSTS
cM Map153.6UniSTS
cM Map91.0UniSTS
Il6ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
cM Map342.1UniSTS
Il6ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029559   ⟹   ENSMUSP00000029559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,776,631 - 89,820,469 (-)Ensembl
GRCm38.p6 Ensembl389,869,324 - 89,913,162 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197679   ⟹   ENSMUSP00000143541
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,771,366 - 89,820,503 (-)Ensembl
GRCm38.p6 Ensembl389,864,059 - 89,913,196 (-)Ensembl
RefSeq Acc Id: NM_001310676   ⟹   NP_001297605
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,776,631 - 89,820,503 (-)NCBI
GRCm38389,869,324 - 89,913,196 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010559   ⟹   NP_034689
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,776,631 - 89,820,503 (-)NCBI
GRCm38389,869,324 - 89,913,196 (-)NCBI
MGSCv37389,673,246 - 89,717,084 (-)RGD
Celera389,906,161 - 89,949,620 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034689   ⟸   NM_010559
- Peptide Label: isoform 1 precursor
- UniProtKB: P22272 (UniProtKB/Swiss-Prot),   Q3URV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001297605   ⟸   NM_001310676
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0G2JGF1 (UniProtKB/TrEMBL),   Q3URV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000143541   ⟸   ENSMUST00000197679
RefSeq Acc Id: ENSMUSP00000029559   ⟸   ENSMUST00000029559
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22272-F1-model_v2 AlphaFold P22272 1-460 view protein structure

Promoters
RGD ID:6833978
Promoter ID:MM_KWN:34985
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_010559,   UC008QAG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36389,716,726 - 89,717,512 (-)MPROMDB
RGD ID:6881290
Promoter ID:EPDNEW_M4096
Type:initiation region
Name:Il6ra_1
Description:Mus musculus interleukin 6 receptor, alpha , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38389,913,160 - 89,913,220EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105304 AgrOrtholog
Ensembl Genes ENSMUSG00000027947 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029559 ENTREZGENE
  ENSMUST00000029559.7 UniProtKB/Swiss-Prot
  ENSMUST00000197679 ENTREZGENE
  ENSMUST00000197679.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_L_F3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TypeI_recpt_CBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16194 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105304 ENTREZGENE
NCBI Gene 16194 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL6Ra-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il6ra PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JGF1 ENTREZGENE, UniProtKB/TrEMBL
  IL6RA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3URV7 ENTREZGENE, UniProtKB/TrEMBL
  V9H161_MOUSE UniProtKB/TrEMBL