Ifnab (interferon alpha B) - Rat Genome Database

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Gene: Ifnab (interferon alpha B) Mus musculus
Analyze
No known orthologs.
Symbol: Ifnab
Name: interferon alpha B
RGD ID: 1621617
MGI Page MGI
Description: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA4 (interferon alpha 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: If1ai8; interferon 1ai8; interferon alpha family, gene B
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39488,608,836 - 88,609,505 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl488,608,539 - 88,609,596 (-)EnsemblGRCm39 Ensembl
GRCm38488,690,599 - 88,691,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl488,690,302 - 88,691,359 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,336,503 - 88,337,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36488,161,886 - 88,162,458 (-)NCBIMGSCv36mm8
Celera487,199,721 - 87,200,390 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:6094686   PMID:7530016   PMID:7684767   PMID:8245849   PMID:8786318   PMID:12205107   PMID:12477932   PMID:14983024   PMID:15240719   PMID:15684736   PMID:17277142   PMID:18726328  
PMID:21873635  


Genomics

Variants

.
Variants in Ifnab
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:196
Interacting mature miRNAs:203
Transcripts:ENSMUST00000105146
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094788237Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
10043964Obq26_mobesity QTL 26 (mouse)Not determined45904725193047251Mouse
1357507Synch2_msynechia 2 (mouse)Not determined46014527794145424Mouse
1301190Cd4ts2_mCD4 T cell subset 2 (mouse)Not determined46014527794145424Mouse
1357870Pfat1_mpredicted fat percentage 1 (mouse)Not determined46361952697619685Mouse
12879903Berr8_mberghei resistance locus 8 (mouse)46422246098222460Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
13506251Cytrq1_mcytokine response QTL 1 (mouse)46571808699718086Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12880404Embq1_memotional behavior QTL 1 (mouse)46575720395921546Mouse
27095938Ulnl6_mulna length 6, 10 week (mouse)46671823798588237Mouse
1301757Tlsr4_mthymic lymphoma suppressor region 4 (mouse)Not determined466757130100757258Mouse
1357561Mbsyd_mmetabolic syndrome (mouse)Not determined466888445100888588Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468018237107157197Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1302057Pgia27_mproteoglycan induced arthritis 27 (mouse)Not determined470067227104067464Mouse
12879897Berr4_mberghei resistance locus 4 (mouse)471982069105982216Mouse
1302044Nss1_mNOD Sjogren's syndrome 1 (mouse)Not determined471982069105982216Mouse
1301739Pitm2_mprion incubation time 2 (mouse)Not determined471982069105982216Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474033887108034029Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474444699108444983Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474444699108444983Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474444699108444983Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474444699108444983Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474444699108444983Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474444699108444983Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474444699108444983Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474444699108444983Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474444699108444983Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474444699108444983Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474718237108357197Mouse
26884406Huml3_mhumerus length 3, 10 week (mouse)475618237100157197Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
4142203Lyr_mlymphoma resistance (mouse)Not determined8075244588769188Mouse
12904738Idohtq_miris defect with ocular hypertension QTL (mouse)48075246793112991Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483118237108357197Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
10412176Habiir3_mhyperoxic acute lung injury imprinted region 3 (mouse)Not determined48375713094293740Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)484918237107157197Mouse
26884435Zlq4_mzygomatic length QTL 4, 10 week (mouse)485118237104957197Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
27226801Feml6_mfemur length 6, 5 week (mouse)487518237103257197Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487518237107157197Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487518237108357197Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488118237108357197Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488518237108357197Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488518237108457197Mouse
1300601Tlsr1_mthymic lymphoma suppressor region 1 (mouse)Not determined48860115894957775Mouse

Markers in Region
L38698  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38488,816,851 - 88,816,926UniSTSGRCm38
GRCm38488,690,530 - 88,690,605UniSTSGRCm38
MGSCv37488,462,755 - 88,462,830UniSTSGRCm37
MGSCv37488,336,434 - 88,336,509UniSTSGRCm37
Celera487,199,652 - 87,199,727UniSTS
Celera487,298,536 - 87,298,612UniSTS
Cytogenetic Map4C4UniSTS
cM Map442.6UniSTS
Whitehead_YAC4 UniSTS
Ifna1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C4UniSTS
cM Map442.6UniSTS
UniSTS:491243  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38488,690,599 - 88,691,268UniSTSGRCm38
MGSCv37488,336,503 - 88,337,172UniSTSGRCm37
Celera487,297,869 - 87,298,542UniSTS
Celera487,199,721 - 87,200,390UniSTS
Cytogenetic Map4C4UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000071378   ⟹   ENSMUSP00000071333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl488,608,539 - 88,609,596 (-)Ensembl
GRCm38.p6 Ensembl488,690,302 - 88,691,359 (-)Ensembl
RefSeq Acc Id: NM_008336   ⟹   NP_032362
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39488,608,836 - 88,609,505 (-)NCBI
GRCm38488,690,599 - 88,691,268 (-)ENTREZGENE
MGSCv37488,336,503 - 88,337,172 (-)RGD
Celera487,199,721 - 87,200,390 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032362 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA58254 (Get FASTA)   NCBI Sequence Viewer  
  AAI16863 (Get FASTA)   NCBI Sequence Viewer  
  AAI16865 (Get FASTA)   NCBI Sequence Viewer  
  CAB0000147 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000071333
  ENSMUSP00000071333.6
RefSeq Acc Id: NP_032362   ⟸   NM_008336
- Peptide Label: precursor
- UniProtKB: L7MTU6 (UniProtKB/TrEMBL),   Q61719 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071333   ⟸   ENSMUST00000071378

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-L7MTU6-F1-model_v2 AlphaFold L7MTU6 1-190 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1097683 AgrOrtholog
Ensembl Genes ENSMUSG00000100079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071378 ENTREZGENE
  ENSMUST00000071378.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Interferon_alpha/beta/delta UniProtKB/TrEMBL
KEGG Report mmu:15974 UniProtKB/TrEMBL
MGD MGI:1097683 ENTREZGENE
NCBI Gene 15974 ENTREZGENE
PANTHER ALPHA-INTERFERON-RELATED UniProtKB/TrEMBL
  Interferon_abd UniProtKB/TrEMBL
Pfam Interferon UniProtKB/TrEMBL
PhenoGen Ifnab PhenoGen
PRINTS INTERFERONAB UniProtKB/TrEMBL
PROSITE INTERFERON_A_B_D UniProtKB/TrEMBL
SMART IFabd UniProtKB/TrEMBL
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt L7MTU6 ENTREZGENE, UniProtKB/TrEMBL
  Q61719 ENTREZGENE, UniProtKB/TrEMBL