RGD Reference Report - Intestinal epithelial cells both express and respond to interleukin 15. - Rat Genome Database

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Intestinal epithelial cells both express and respond to interleukin 15.

Authors: Reinecker, HC  MacDermott, RP  Mirau, S  Dignass, A  Podolsky, DK 
Citation: Reinecker HC, etal., Gastroenterology. 1996 Dec;111(6):1706-13.
RGD ID: 5024920
Pubmed: PMID:8942753   (View Abstract at PubMed)

BACKGROUND & AIMS: Interleukin (IL)-15 exerts functional effects on lymphocytes similar to those of IL-2. IL-15 is expressed by nonlymphoid cells and may integrate these cells into classical immune responses. The aim of this study was to characterize the expression of IL-15 by intestinal epithelial cells and determine the functional roles of IL-15 within the mucosal immune system. METHODS: Rat IL-15 was cloned from a rat jejunal library. Expression of IL-15 in rat and human intestinal epithelial cells was assessed by Northern and Western blotting. Tyrosine kinase activation in response to IL-15 in intestinal epithelial cells was determined by immunoprecipitation. RESULTS: Rat and human intestinal epithelial cells express IL-15 messenger RNA. IL-15 activates Stat3 and stimulates the proliferation of intestinal epithelial cells. The relevance of the observations for intestinal epithelial cell function in vivo was supported by the demonstration of transcripts for IL-15 in primary human intestinal epithelial cells. CONCLUSIONS: IL-15 is expressed by intestinal epithelial cells function. These experiments suggest that IL-15 is an important mediator that could integrate intestinal epithelial cell function with the intestinal immune system.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of tyrosine phosphorylation of STAT protein  IDA 5024920 RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Jak-Stat signaling pathway   ISOIl15 (Rattus norvegicus)5024920; 5024920 RGD 
Jak-Stat signaling pathway   IDA 5024920 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Il15  (interleukin 15)

Genes (Mus musculus)
Il15  (interleukin 15)

Genes (Homo sapiens)
IL15  (interleukin 15)


Additional Information