Mpl (myeloproliferative leukemia virus oncogene) - Rat Genome Database

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Gene: Mpl (myeloproliferative leukemia virus oncogene) Mus musculus
Analyze
Symbol: Mpl
Name: myeloproliferative leukemia virus oncogene
RGD ID: 1322331
MGI Page MGI
Description: Predicted to enable thrombopoietin receptor activity. Involved in thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of stem cell division. Predicted to be located in several cellular components, including Golgi apparatus; neuronal cell body; and nuclear membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; hemolymphoid system; mesenchyme derived from splanchnopleure; spinal cord; and vestibulo-cochlear ganglion. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-m; c-mp; c-mpl; c-mpl-I; c-mpl-II; CD110; hlb21; hlb219; myeloproliferative leukemia protein; proto-oncogene c-Mpl; thrombopoietin receptor; TP; TPO-R
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,299,609 - 118,314,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,299,612 - 118,314,710 (-)EnsemblGRCm39 Ensembl
GRCm384118,442,412 - 118,457,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4118,442,415 - 118,457,513 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,115,022 - 118,130,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364117,940,347 - 117,955,403 (-)NCBIMGSCv36mm8
Celera4117,167,633 - 117,182,859 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map454.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal megakaryocyte differentiation  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal platelet morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal thrombopoiesis  (IAGP)
absent megakaryocytes  (IAGP)
anemia  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased megakaryocyte cell number  (IAGP)
decreased spleen B cell follicle size  (IAGP)
enlarged spleen  (IAGP)
increased bleeding time  (IAGP)
increased eosinophil cell number  (IAGP)
increased hematopoietic stem cell proliferation  (IAGP)
increased leukocyte cell number  (IAGP)
increased lymphocyte cell number  (IAGP)
increased mean platelet volume  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
thrombocytopenia  (IAGP)
thrombocytosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Alexander WS, etal., Blood. 1996 Mar 15;87(6):2162-70.
2. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Ding J, etal., Blood. 2004 Jun 1;103(11):4198-200. Epub 2004 Feb 5.
3. Molecular detection of c-mpl thrombopoietin receptor gene expression in chronic myeloproliferative disorders. Duensing S, etal., Mol Pathol. 1999 Jun;52(3):146-50.
4. Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene. El-Harith el-HA, etal., Br J Haematol. 2009 Jan;144(2):185-94. doi: 10.1111/j.1365-2141.2008.07430.x. Epub 2008 Nov 19.
5. Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gao W, etal., Gastroenterology. 2013 Sep;145(3):636-46.e5. doi: 10.1053/j.gastro.2013.05.049. Epub 2013 Jun 5.
6. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. Ihara K, etal., Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3132-6.
7. Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim. Kuter DJ, etal., Blood. 2009 Oct 29;114(18):3748-56. doi: 10.1182/blood-2009-05-224766. Epub 2009 Aug 11.
8. Autoantibody to c-Mpl (thrombopoietin receptor) in systemic lupus erythematosus: relationship to thrombocytopenia with megakaryocytic hypoplasia. Kuwana M, etal., Arthritis Rheum. 2002 Aug;46(8):2148-59.
9. The platelet thrombopoietin receptor number and function are markedly decreased in patients with essential thrombocythaemia. Li J, etal., Br J Haematol. 2000 Dec;111(3):943-53.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Decreased prothrombotic effects of pegylated recombinant human megakaryocyte growth and development factor in thrombocytopenic state in a rat thrombosis model. Nishiyama U, etal., J Thromb Haemost. 2005 Feb;3(2):355-60.
13. Effects of thrombopoietin on growth of hepatocellular carcinoma: Is thrombopoietin therapy for liver disease safe or not? Nozaki R, etal., Hepatol Res. 2013 Jun;43(6):610-20. doi: 10.1111/hepr.12006. Epub 2012 Nov 16.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease. Sano Y, etal., Digestion. 2020 Aug 25:1-9. doi: 10.1159/000509852.
21. CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis. Yan Z, etal., J Cancer Res Clin Oncol. 2019 May;145(5):1147-1164. doi: 10.1007/s00432-019-02860-z. Epub 2019 Feb 15.
Additional References at PubMed
PMID:2539212   PMID:7534285   PMID:7536928   PMID:7696972   PMID:7759951   PMID:7774011   PMID:7862460   PMID:8073287   PMID:8105016   PMID:8334987   PMID:8397366   PMID:8578519  
PMID:8630374   PMID:8661058   PMID:8704234   PMID:8799165   PMID:8843393   PMID:8943846   PMID:8954775   PMID:9108391   PMID:9345025   PMID:9427697   PMID:9448308   PMID:9474742  
PMID:9531584   PMID:9878243   PMID:9892696   PMID:10349636   PMID:10480432   PMID:10582337   PMID:10611229   PMID:10627458   PMID:10721728   PMID:10918061   PMID:10981960   PMID:11008012  
PMID:11042159   PMID:11071383   PMID:11076861   PMID:11217851   PMID:11238104   PMID:11493447   PMID:11967992   PMID:11980901   PMID:11997107   PMID:12006617   PMID:12130527   PMID:12393382  
PMID:12438747   PMID:12477932   PMID:12623841   PMID:14662325   PMID:15070672   PMID:15071178   PMID:15138166   PMID:15210714   PMID:15282311   PMID:15337790   PMID:15665109   PMID:16051888  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16648859   PMID:16702405   PMID:16757682   PMID:17347409   PMID:17548465   PMID:17634189   PMID:17637498   PMID:17693582   PMID:18218856  
PMID:18416604   PMID:18500345   PMID:18618018   PMID:18684867   PMID:18687690   PMID:18796624   PMID:18845793   PMID:19059699   PMID:19197068   PMID:19201855   PMID:19261614   PMID:19302922  
PMID:19624305   PMID:19633199   PMID:19809160   PMID:19880496   PMID:20059953   PMID:20086247   PMID:20298742   PMID:20538807   PMID:20643340   PMID:20667107   PMID:20711984   PMID:21115812  
PMID:21149592   PMID:21224471   PMID:21263445   PMID:21267068   PMID:21289307   PMID:21791880   PMID:21873635   PMID:21892137   PMID:22308484   PMID:22628264   PMID:22836751   PMID:23246483  
PMID:23359689   PMID:23990627   PMID:24043765   PMID:24184684   PMID:24438083   PMID:24615392   PMID:24711413   PMID:25298035   PMID:25339357   PMID:25468569   PMID:25636339   PMID:25865259  
PMID:25995324   PMID:26147434   PMID:26375403   PMID:26608331   PMID:26644453   PMID:26668133   PMID:26912146   PMID:26974155   PMID:27748371   PMID:28034873   PMID:28329764   PMID:28596376  
PMID:28622305   PMID:28744010   PMID:29097774   PMID:29212120   PMID:29454962   PMID:29802222   PMID:30005133   PMID:30104364   PMID:30106501   PMID:30209246   PMID:30683655   PMID:32417303  
PMID:32479500   PMID:32535617   PMID:32721504   PMID:32954656   PMID:32958856   PMID:35192546   PMID:36223471   PMID:37633268   PMID:38326297   PMID:38336176  


Genomics

Comparative Map Data
Mpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,299,609 - 118,314,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,299,612 - 118,314,710 (-)EnsemblGRCm39 Ensembl
GRCm384118,442,412 - 118,457,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4118,442,415 - 118,457,513 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,115,022 - 118,130,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364117,940,347 - 117,955,403 (-)NCBIMGSCv36mm8
Celera4117,167,633 - 117,182,859 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map454.61NCBI
MPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38143,337,818 - 43,354,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl143,337,818 - 43,354,466 (+)EnsemblGRCh38hg38GRCh38
GRCh37143,803,489 - 43,820,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,576,062 - 43,592,722 (+)NCBINCBI36Build 36hg18NCBI36
Build 34143,472,567 - 43,489,228NCBI
Celera142,085,625 - 42,102,280 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,923,380 - 41,939,975 (+)NCBIHuRef
CHM1_1143,919,946 - 43,936,585 (+)NCBICHM1_1
T2T-CHM13v2.0143,208,365 - 43,225,013 (+)NCBIT2T-CHM13v2.0
Mpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,259,288 - 137,281,540 (-)NCBIGRCr8
mRatBN7.25131,973,895 - 131,987,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5131,973,895 - 131,986,797 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05137,268,412 - 137,282,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,532,972 (-)NCBICelera
Cytogenetic Map5q36NCBI
Mpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,922,156 - 2,937,223 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,922,156 - 2,937,223 (+)NCBIChiLan1.0ChiLan1.0
MPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,455,594 - 183,472,256 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11182,596,971 - 182,613,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,639,191 - 42,654,738 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1144,018,395 - 44,034,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl144,018,395 - 44,034,492 (+)Ensemblpanpan1.1panPan2
MPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11516,815,102 - 16,825,321 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1516,815,294 - 16,825,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1516,937,406 - 16,953,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01516,977,122 - 16,993,028 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1516,978,816 - 16,993,003 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11516,769,591 - 16,785,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01516,838,589 - 16,854,485 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01516,912,170 - 16,928,047 (-)NCBIUU_Cfam_GSD_1.0
Mpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,919,891 - 58,932,407 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,744,673 - 24,757,085 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,744,673 - 24,757,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6167,896,287 - 167,908,625 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16167,896,191 - 167,908,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26155,334,350 - 155,335,846 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,457,549 - 89,474,756 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2089,459,493 - 89,474,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603327,447,284 - 27,462,737 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,656,260 - 2,669,946 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,656,260 - 2,671,455 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpl
462 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1141
Count of miRNA genes:369
Interacting mature miRNAs:425
Transcripts:ENSMUST00000006556, ENSMUST00000102671, ENSMUST00000106375, ENSMUST00000168404
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101574601123127211Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
13208565Bmiq6_mbody mass index QTL 6 (mouse)4110857197125893793Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115030777129465915Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301996Mmtg2_mmodifier of mammary tumor growth 2 (mouse)Not determined4116270979124055180Mouse
4141330Iva1_misovaleric acid smelling 1 (mouse)Not determined117071971120723203Mouse
12904006Cfq1_mconditioned fear QTL 1 (mouse)4117177646120107755Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse

Markers in Region
Mpl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv374118,128,369 - 118,129,416UniSTSGRCm37
Celera4117,181,128 - 117,182,175UniSTS
Cytogenetic Map4DUniSTS
cM Map456.5UniSTS
Mpl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384118,455,764 - 118,456,811UniSTSGRCm38
MGSCv374118,128,369 - 118,129,416UniSTSGRCm37
Celera4117,181,128 - 117,182,175UniSTS
Cytogenetic Map4DUniSTS
Mpl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4DUniSTS
Mpl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4DUniSTS
Mpl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4DUniSTS
Mpl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4DUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001122949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF360122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL627212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB850765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X73552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X73677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z22649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z22657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000006556   ⟹   ENSMUSP00000006556
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4118,300,469 - 118,314,692 (-)Ensembl
GRCm38.p6 Ensembl4118,443,272 - 118,457,495 (-)Ensembl
RefSeq Acc Id: ENSMUST00000102671   ⟹   ENSMUSP00000099732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4118,299,612 - 118,314,710 (-)Ensembl
GRCm38.p6 Ensembl4118,442,415 - 118,457,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106375   ⟹   ENSMUSP00000101983
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4118,300,626 - 118,314,647 (-)Ensembl
GRCm38.p6 Ensembl4118,443,429 - 118,457,450 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168404   ⟹   ENSMUSP00000130167
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4118,300,179 - 118,314,667 (-)Ensembl
GRCm38.p6 Ensembl4118,442,982 - 118,457,470 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216417
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4118,314,260 - 118,314,692 (-)Ensembl
GRCm38.p6 Ensembl4118,457,063 - 118,457,495 (-)Ensembl
RefSeq Acc Id: NM_001122949   ⟹   NP_001116421
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394118,299,609 - 118,314,685 (-)NCBI
GRCm384118,442,415 - 118,457,513 (-)NCBI
MGSCv374118,115,022 - 118,130,100 (-)RGD
Celera4117,167,631 - 117,182,877 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001285496   ⟹   NP_001272425
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394118,299,609 - 118,314,685 (-)NCBI
GRCm384118,442,415 - 118,457,513 (-)NCBI
Celera4117,167,631 - 117,182,877 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001285497   ⟹   NP_001272426
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394118,299,609 - 118,314,685 (-)NCBI
GRCm384118,442,415 - 118,457,513 (-)NCBI
Celera4117,167,631 - 117,182,877 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010823   ⟹   NP_034953
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394118,299,609 - 118,314,685 (-)NCBI
GRCm384118,442,415 - 118,457,513 (-)NCBI
MGSCv374118,115,022 - 118,130,100 (-)RGD
Celera4117,167,631 - 117,182,877 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240468   ⟹   XP_011238770
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394118,299,609 - 118,312,389 (-)NCBI
GRCm384118,442,412 - 118,455,193 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004941829
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394118,299,609 - 118,314,771 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034953   ⟸   NM_010823
- Peptide Label: isoform 2 precursor
- UniProtKB: A6H8H6 (UniProtKB/Swiss-Prot),   Q8BRX0 (UniProtKB/Swiss-Prot),   Q08351 (UniProtKB/Swiss-Prot),   Q3ZB69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001116421   ⟸   NM_001122949
- Peptide Label: isoform 1 precursor
- UniProtKB: A2A9D4 (UniProtKB/TrEMBL),   Q3ZB68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272425   ⟸   NM_001285496
- Peptide Label: isoform 3 precursor
- UniProtKB: Q925F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272426   ⟸   NM_001285497
- Peptide Label: isoform 4 precursor
- UniProtKB: E9Q7U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238770   ⟸   XM_011240468
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000006556   ⟸   ENSMUST00000006556
RefSeq Acc Id: ENSMUSP00000101983   ⟸   ENSMUST00000106375
RefSeq Acc Id: ENSMUSP00000130167   ⟸   ENSMUST00000168404
RefSeq Acc Id: ENSMUSP00000099732   ⟸   ENSMUST00000102671
Protein Domains
Fibronectin type-III   Growth hormone/erythropoietin receptor ligand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08351-F1-model_v2 AlphaFold Q08351 1-625 view protein structure

Promoters
RGD ID:6884414
Promoter ID:EPDNEW_M5658
Type:multiple initiation site
Name:Mpl_1
Description:Mus musculus myeloproliferative leukemia virus oncogene , transcriptvariant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384118,457,488 - 118,457,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97076 AgrOrtholog
Ensembl Genes ENSMUSG00000006389 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006556 ENTREZGENE
  ENSMUST00000006556.11 UniProtKB/TrEMBL
  ENSMUST00000102671 ENTREZGENE
  ENSMUST00000102671.10 UniProtKB/Swiss-Prot
  ENSMUST00000106375 ENTREZGENE
  ENSMUST00000106375.2 UniProtKB/TrEMBL
  ENSMUST00000168404 ENTREZGENE
  ENSMUST00000168404.9 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Long_hematopoietin_rcpt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17480 UniProtKB/Swiss-Prot
MGD MGI:97076 ENTREZGENE
NCBI Gene 17480 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THROMBOPOIETIN RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mpl PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A9D4 ENTREZGENE, UniProtKB/TrEMBL
  A6H8H6 ENTREZGENE
  A6QL55_MOUSE UniProtKB/TrEMBL
  E9Q7U5 ENTREZGENE, UniProtKB/TrEMBL
  Q08351 ENTREZGENE
  Q3ZB68 ENTREZGENE, UniProtKB/TrEMBL
  Q3ZB69 ENTREZGENE, UniProtKB/TrEMBL
  Q8BRX0 ENTREZGENE
  Q925F5 ENTREZGENE, UniProtKB/TrEMBL
  TPOR_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A6H8H6 UniProtKB/Swiss-Prot
  Q8BRX0 UniProtKB/Swiss-Prot