Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2) - Rat Genome Database

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Gene: Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2) Mus musculus
Analyze
Symbol: Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
RGD ID: 68479
MGI Page MGI
Description: Enables phosphatidylinositol 3-kinase regulatory subunit binding activity and protein heterodimerization activity. Involved in several processes, including insulin receptor signaling pathway; intracellular glucose homeostasis; and positive regulation of protein import into nucleus. Acts upstream of or within positive regulation of cell adhesion; regulation of actin filament organization; and regulation of protein localization to plasma membrane. Located in focal adhesion and nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; musculature; and spleen. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p85be; p85beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,220,820 - 71,229,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,220,820 - 71,229,357 (-)EnsemblGRCm39 Ensembl
GRCm38870,768,176 - 70,776,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,768,176 - 70,776,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,292,080 - 73,300,611 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,697,168 - 73,705,670 (-)NCBIMGSCv36mm8
Celera873,329,482 - 73,338,028 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
antimonite  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
folic acid  (EXP)
genistein  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
N-nitrosodiethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nickel dichloride  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
phenobarbital  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. p85ß phosphoinositide 3-kinase subunit regulates tumor progression. Cortés I, etal., Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11318-23. doi: 10.1073/pnas.1118138109. Epub 2012 Jun 25.
2. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Guo C, etal., Genes Chromosomes Cancer. 2008 Nov;47(11):939-46. doi: 10.1002/gcc.20596.
3. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. MicroRNA126 inhibits proliferation and metastasis by targeting pik3r2 in prostate cancer. Song L, etal., Mol Med Rep. 2016 Feb;13(2):1204-10. doi: 10.3892/mmr.2015.4661. Epub 2015 Dec 9.
14. Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer. Stoll V, etal., Gut. 2005 Jan;54(1):109-16. doi: 10.1136/gut.2004.046706.
15. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
Additional References at PubMed
PMID:7542745   PMID:8663140   PMID:9062339   PMID:9582025   PMID:9624169   PMID:10349636   PMID:10620012   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11752399   PMID:12052866  
PMID:12466851   PMID:12477932   PMID:14681479   PMID:15102471   PMID:15153476   PMID:15385169   PMID:15489334   PMID:15767666   PMID:15782199   PMID:16006513   PMID:16141072   PMID:16141073  
PMID:16227599   PMID:16239435   PMID:16679292   PMID:16679293   PMID:16944949   PMID:17071741   PMID:17074976   PMID:17164340   PMID:17360811   PMID:17846664   PMID:18382766   PMID:18453570  
PMID:18534979   PMID:18621722   PMID:18704194   PMID:18981154   PMID:19029981   PMID:19074768   PMID:19190244   PMID:19635806   PMID:19747165   PMID:19811262   PMID:20348926   PMID:20697350  
PMID:21109194   PMID:21367821   PMID:21383062   PMID:21677750   PMID:21731673   PMID:21873635   PMID:21946561   PMID:22378846   PMID:22378847   PMID:22493067   PMID:22806988   PMID:22867989  
PMID:23077605   PMID:23315073   PMID:23330804   PMID:23951027   PMID:25217619   PMID:25754093   PMID:27381007   PMID:27799550   PMID:30973865   PMID:31924648   PMID:32203420   PMID:32325033  
PMID:32856318   PMID:32895527   PMID:34193412   PMID:35429500   PMID:38310234  


Genomics

Comparative Map Data
Pik3r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,220,820 - 71,229,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,220,820 - 71,229,357 (-)EnsemblGRCm39 Ensembl
GRCm38870,768,176 - 70,776,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,768,176 - 70,776,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,292,080 - 73,300,611 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,697,168 - 73,705,670 (-)NCBIMGSCv36mm8
Celera873,329,482 - 73,338,028 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
PIK3R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,153,163 - 18,170,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,153,163 - 18,170,532 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,263,973 - 18,281,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,125,016 - 18,142,343 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,125,015 - 18,142,343NCBI
Celera1918,165,735 - 18,183,085 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,827,466 - 17,844,856 (+)NCBIHuRef
CHM1_11918,263,528 - 18,280,901 (+)NCBICHM1_1
T2T-CHM13v2.01918,287,263 - 18,304,664 (+)NCBIT2T-CHM13v2.0
Pik3r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,699,389 - 18,708,045 (+)NCBIGRCr8
mRatBN7.21618,665,517 - 18,674,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,665,457 - 18,674,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,707,923 - 18,716,460 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,840,602 - 19,849,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,760,867 - 18,769,404 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,415,109 - 20,424,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,416,432 - 20,424,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,273,500 - 20,282,051 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,171,101 - 19,179,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,171,098 - 19,179,648 (+)NCBI
Celera1618,857,756 - 18,866,282 (+)NCBICelera
Cytogenetic Map16p14NCBI
Pik3r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,234,111 - 3,241,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,234,111 - 3,241,445 (-)NCBIChiLan1.0ChiLan1.0
PIK3R2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,013,784 - 23,031,178 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,022,130 - 22,039,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,632,265 - 17,649,664 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,608,470 - 18,624,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,611,179 - 18,624,177 (+)Ensemblpanpan1.1panPan2
PIK3R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,826,037 - 44,838,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,826,339 - 44,836,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,739,520 - 44,751,946 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,311,340 - 45,323,770 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,311,351 - 45,321,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,548,506 - 44,560,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,958,996 - 44,971,420 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,234,496 - 45,247,145 (-)NCBIUU_Cfam_GSD_1.0
Pik3r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,461,387 - 203,472,734 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,010,488 - 3,021,920 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,010,526 - 3,021,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,637,371 - 59,652,073 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,637,363 - 59,652,075 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,195,762 - 59,210,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,620,673 - 16,637,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,621,606 - 16,636,937 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,738,902 - 2,757,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3r2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,513,969 - 1,523,295 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,513,916 - 1,523,723 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3r2
201 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1501
Count of miRNA genes:610
Interacting mature miRNAs:743
Transcripts:ENSMUST00000034296, ENSMUST00000142370, ENSMUST00000143785, ENSMUST00000146707, ENSMUST00000152545, ENSMUST00000154685
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse

Markers in Region
Y13569  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,768,215 - 70,768,361UniSTSGRCm38
MGSCv37873,292,114 - 73,292,260UniSTSGRCm37
Celera873,329,516 - 73,329,662UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8743.32UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001424805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC162446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY193286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LS482402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034296   ⟹   ENSMUSP00000034296
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,220,820 - 71,229,357 (-)Ensembl
GRCm38.p6 Ensembl870,768,176 - 70,776,713 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,227,653 - 71,229,323 (-)Ensembl
GRCm38.p6 Ensembl870,775,009 - 70,776,679 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143785   ⟹   ENSMUSP00000122065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,221,105 - 71,222,032 (-)Ensembl
GRCm38.p6 Ensembl870,768,461 - 70,769,388 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,221,284 - 71,222,308 (-)Ensembl
GRCm38.p6 Ensembl870,768,640 - 70,769,664 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,224,638 - 71,225,808 (-)Ensembl
GRCm38.p6 Ensembl870,771,994 - 70,773,164 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154685   ⟹   ENSMUSP00000121463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,225,018 - 71,227,331 (-)Ensembl
GRCm38.p6 Ensembl870,772,374 - 70,774,687 (-)Ensembl
RefSeq Acc Id: NM_001424805   ⟹   NP_001411734
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,220,823 - 71,229,348 (-)NCBI
RefSeq Acc Id: NM_001424806   ⟹   NP_001411735
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,220,823 - 71,229,348 (-)NCBI
RefSeq Acc Id: NM_008841   ⟹   NP_032867
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,220,820 - 71,229,356 (-)NCBI
GRCm38870,768,176 - 70,776,712 (-)NCBI
MGSCv37873,292,080 - 73,300,611 (-)RGD
Celera873,329,482 - 73,338,028 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032867   ⟸   NM_008841
- Peptide Label: isoform 1
- UniProtKB: Q5U3K7 (UniProtKB/Swiss-Prot),   O08908 (UniProtKB/Swiss-Prot),   A0A2X0SZ21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000122065   ⟸   ENSMUST00000143785
RefSeq Acc Id: ENSMUSP00000034296   ⟸   ENSMUST00000034296
RefSeq Acc Id: ENSMUSP00000121463   ⟸   ENSMUST00000154685
RefSeq Acc Id: NP_001411735   ⟸   NM_001424806
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001411734   ⟸   NM_001424805
- Peptide Label: isoform 2
Protein Domains
Rho-GAP   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08908-F1-model_v2 AlphaFold O08908 1-722 view protein structure

Promoters
RGD ID:8667347
Promoter ID:EPDNEW_M11705
Type:initiation region
Name:Pik3r2_1
Description:Mus musculus phosphoinositide-3-kinase regulatory subunit 2 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,776,704 - 70,776,764EPDNEW
RGD ID:6843606
Promoter ID:MM_KWN:54741
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Spleen
Transcripts:OTTMUST00000080760,   OTTMUST00000080761
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,293,154 - 73,293,654 (-)MPROMDB
RGD ID:6848893
Promoter ID:MM_TRO:9547
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver
Transcripts:MTR018653.8.1220.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,294,389 - 73,294,889 (-)MPROMDB
RGD ID:6843604
Promoter ID:MM_KWN:54744
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Spleen
Transcripts:OTTMUST00000080756
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,298,436 - 73,298,936 (-)MPROMDB
RGD ID:6843637
Promoter ID:MM_KWN:54745
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NR_029440,   OTTMUST00000080755,   OTTMUST00000080757
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,300,306 - 73,302,002 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098772 AgrOrtholog
Ensembl Genes ENSMUSG00000031834 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034296 ENTREZGENE
  ENSMUST00000034296.15 UniProtKB/Swiss-Prot
  ENSMUST00000143785.2 UniProtKB/TrEMBL
  ENSMUST00000154685.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85beta_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18709 UniProtKB/Swiss-Prot
MGD MGI:1098772 ENTREZGENE
NCBI Gene 18709 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K21B, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPPRESSOR OF CYTOKINE SIGNALING 6 UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3r2 PhenoGen
PRINTS PI3KINASEP85 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2X0SZ21 ENTREZGENE, UniProtKB/TrEMBL
  F6R2V5_MOUSE UniProtKB/TrEMBL
  F7CB91_MOUSE UniProtKB/TrEMBL
  O08908 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UK33_MOUSE UniProtKB/TrEMBL
  Q5U3K7 ENTREZGENE
UniProt Secondary Q5U3K7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pik3r2  phosphoinositide-3-kinase regulatory subunit 2    phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)  Symbol and/or name change 5135510 APPROVED