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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of G1/S transition of mitotic cell cycle
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Accession:GO:2000134 term browser browse the term
Definition:Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.

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negative regulation of G1/S transition of mitotic cell cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in ISO (PMID:9884026) HGNC-UCL PMID:9884026 NCBI chr10:43,139,396...43,281,024
Ensembl chr10:43,139,528...43,281,177 		JBrowse link
G APC APC regulator of WNT signaling pathway involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:15,992,437...16,135,117
Ensembl chr23:16,042,287...16,137,067 		JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within ISO (PMID:12855558), (PMID:14660795)
(PMID:14660795)		 MGI PMID:12855558 PMID:14660795 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G BRD7 bromodomain containing 7 involved_in ISO (PMID:16265664) UniProt PMID:16265664 NCBI chr 5:36,114,951...36,168,786
Ensembl chr 5:36,112,289...36,168,728 		JBrowse link
G BTN2A2 butyrophilin subfamily 2 member A2 acts_upstream_of_or_within ISO (PMID:23589618) MGI PMID:23589618 NCBI chr17:45,857,898...45,869,901
Ensembl chr17:45,744,451...45,868,941 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:28587927 RGD:13515054 NCBI chr10:37,240,749...37,518,174
Ensembl chr10:37,246,991...37,388,059 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CDC73 cell division cycle 73 involved_in ISO (PMID:16989776) UniProt PMID:16989776 NCBI chr25:36,167,482...36,302,918
Ensembl chr25:36,170,134...36,302,812 		JBrowse link
G CDK2AP2 cyclin dependent kinase 2 associated protein 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:6,756,853...6,759,087
Ensembl chr 1:6,756,909...6,759,090 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21628527) MGI
Ensembl		 PMID:21628527 GO_REF:0000107 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G CRLF3 cytokine receptor like factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:25,485,440...25,533,769 JBrowse link
G CTDSP1 CTD small phosphatase 1 acts_upstream_of_or_within ISO (PMID:22210897) MGI PMID:22210897 NCBI chr10:104,291,494...104,298,982
Ensembl chr10:104,293,073...104,299,258 		JBrowse link
G CTDSP2 CTD small phosphatase 2 acts_upstream_of_or_within ISO (PMID:22210897) MGI PMID:22210897 NCBI chr11:53,733,041...53,759,809
Ensembl chr11:53,736,699...53,742,750 		JBrowse link
G CTDSPL CTD small phosphatase like involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22210897) Ensembl
MGI		 PMID:22210897 GO_REF:0000107 NCBI chr15:1,418,855...1,536,527
Ensembl chr15:1,418,848...1,536,457 		JBrowse link
G DACT1 dishevelled binding antagonist of beta catenin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:35,821,518...35,832,486
Ensembl chr24:35,821,990...35,832,712 		JBrowse link
G DCUN1D3 defective in cullin neddylation 1 domain containing 3 involved_in ISO (PMID:18823379) UniProt PMID:18823379 NCBI chr 5:18,987,962...19,036,304
Ensembl chr 5:18,992,923...18,995,317 		JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 involved_in ISO (PMID:10656683) UniProt PMID:10656683 NCBI chr15:89,937,900...90,214,976
Ensembl chr15:90,055,964...90,215,652 		JBrowse link
G E2F7 E2F transcription factor 7 involved_in ISO (MGI:5448509|PMID:22180533) UniProt PMID:22180533 MGI:5448509 NCBI chr11:72,598,220...72,642,366
Ensembl chr11:72,599,353...72,641,420 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19303854) Ensembl
MGI		 PMID:19303854 GO_REF:0000107 NCBI chr21:117,380,518...117,515,224
Ensembl chr21:117,380,361...117,421,573 		JBrowse link
G FAM107A family with sequence similarity 107 member A involved_in ISO (PMID:28604741) UniProt PMID:28604741 NCBI chr22:19,859,853...19,923,256
Ensembl chr22:19,859,809...19,923,487 		JBrowse link
G FBXO7 F-box protein 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21652635) Ensembl
MGI		 PMID:21652635 GO_REF:0000107 NCBI chr19:15,300,135...15,324,256
Ensembl chr19:15,300,158...15,323,956 		JBrowse link
G FHL1 four and a half LIM domains 1 involved_in ISO (PMID:21702045) UniProt PMID:21702045 NCBI chr  X:111,160,389...111,226,713
Ensembl chr  X:111,211,911...111,226,841 		JBrowse link
G GJC2 gap junction protein gamma 2 ISO RGD PMID:28278052 RGD:13208599 NCBI chr25:1,568,664...1,579,279
Ensembl chr25:1,569,427...1,570,752 		JBrowse link
G GPNMB glycoprotein nmb involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:35,037,197...35,066,143
Ensembl chr21:35,037,001...35,066,171 		JBrowse link
G HASPIN histone H3 associated protein kinase acts_upstream_of_or_within ISO (PMID:10358056) MGI PMID:10358056 NCBI chr16:3,226,292...3,229,349
Ensembl chr16:3,226,582...3,228,978 		JBrowse link
G INHBA inhibin subunit beta A involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:16,936,054...16,951,430
Ensembl chr21:16,936,175...16,946,880 		JBrowse link
G JADE1 jade family PHD finger 1 acts_upstream_of_or_within ISO (PMID:23001567) MGI PMID:23001567 NCBI chr 7:75,926,199...75,993,381
Ensembl chr 7:75,926,616...75,995,327 		JBrowse link
G KANK2 KN motif and ankyrin repeat domains 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:10,095,319...10,131,985
Ensembl chr 6:10,095,246...10,131,946 		JBrowse link
G KLF4 KLF transcription factor 4 involved_in ISO (PMID:23867820) BHF-UCL PMID:23867820 NCBI chr12:32,045,690...32,050,531
Ensembl chr12:32,045,609...32,050,703 		JBrowse link
G LOC103247740 retinoblastoma-like protein 1 involved_in IEA TreeGrafter GO_REF:0000118
G MYO16 myosin XVI involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:86,850,362...87,550,840 JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16311606) Ensembl
BHF-UCL		 PMID:16311606 GO_REF:0000107 NCBI chr 7:36,369,226...36,445,713
Ensembl chr 7:36,369,524...36,443,612 		JBrowse link
G PPP2R3B protein phosphatase 2 regulatory subunit B''beta acts_upstream_of_or_within ISO (PMID:9927208) MGI PMID:9927208
G PRMT2 protein arginine methyltransferase 2 involved_in ISO (MGI:3653799|PMID:16616919) UniProt PMID:16616919 MGI:3653799 NCBI chr 2:90,225,051...90,256,541
Ensembl chr 2:90,225,346...90,256,558 		JBrowse link
G PTEN phosphatase and tensin homolog involved_in ISO (PMID:21241890) BHF-UCL PMID:21241890 NCBI chr 9:81,308,058...81,412,386
Ensembl chr 9:81,309,099...81,409,146 		JBrowse link
G RB1 RB transcriptional corepressor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7958874) TreeGrafter
MGI		 PMID:7958874 GO_REF:0000118 NCBI chr 3:26,220,783...26,393,671
Ensembl chr 3:26,220,803...26,394,546 		JBrowse link
G RBL2 RB transcriptional corepressor like 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:39,225,797...39,283,550
Ensembl chr 5:39,225,844...39,282,190 		JBrowse link
G SLFN11 schlafen family member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:28,819,647...28,842,121
Ensembl chr16:28,817,666...28,842,065 		JBrowse link
G TFDP3 transcription factor Dp family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:108,356,281...108,358,019
Ensembl chr  X:108,356,662...108,357,879 		JBrowse link
G ZC3H12D zinc finger CCCH-type containing 12D involved_in ISO (PMID:19531561) UniProt PMID:19531561 NCBI chr13:22,152,938...22,195,470
Ensembl chr13:22,158,259...22,194,514 		JBrowse link
G ZNF655 zinc finger protein 655 involved_in ISO (PMID:15558030) UniProt PMID:15558030 NCBI chr28:13,588,503...13,608,647
Ensembl chr28:13,588,032...13,605,131 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP2 caspase 2 involved_in ISO (PMID:21726810) UniProt PMID:21726810 NCBI chr21:112,172,614...112,189,574
Ensembl chr21:112,172,733...112,188,744 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:89,066,952...89,246,177 JBrowse link
G E2F7 E2F transcription factor 7 involved_in ISO (PMID:22802528) UniProt PMID:22802528 NCBI chr11:72,598,220...72,642,366
Ensembl chr11:72,599,353...72,641,420 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:64,434,203...64,465,490
Ensembl chr11:64,434,261...64,469,890 		JBrowse link
G MUC1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962 		JBrowse link
G PCBP4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chr22:13,326,069...13,336,474
Ensembl chr22:13,325,551...13,329,903 		JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:602,594...609,388
Ensembl chr 1:602,721...607,893 		JBrowse link
G PML PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) UniProt PMID:15626733 MGI:3580934 NCBI chr26:9,441,998...9,494,949
Ensembl chr26:9,451,112...9,494,931 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chr24:79,703,316...79,875,379
Ensembl chr24:79,703,312...79,875,389 		JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in ISO (PMID:23235459) UniProt PMID:23235459 NCBI chr26:53,195,600...53,201,846 JBrowse link
G RBM38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chr 2:6,709,975...6,727,534
Ensembl chr 2:6,711,458...6,727,353 		JBrowse link
G RPL26 ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:7,733,652...7,740,384
Ensembl chr16:7,732,921...7,740,325 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16107883) Ensembl
MGI		 PMID:16107883 GO_REF:0000107 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357 		JBrowse link
G DGKZ diacylglycerol kinase zeta involved_in ISO (PMID:16286473) UniProt PMID:16286473 NCBI chr 1:18,949,360...18,997,957
Ensembl chr 1:18,948,425...18,982,354 		JBrowse link
G FBXO31 F-box protein 31 involved_in ISO (PMID:19412162) UniProt PMID:19412162 NCBI chr 5:72,696,868...72,752,480
Ensembl chr 5:72,701,136...72,752,989 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19744960) Ensembl
MGI		 PMID:19744960 GO_REF:0000107 NCBI chr10:118,720,668...118,883,299
Ensembl chr10:118,720,690...118,874,162 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:53,045,408...53,092,214
Ensembl chr 5:53,045,465...53,092,494 		JBrowse link
G RPA2 replication protein A2 involved_in ISO (PMID:21731742) UniProt PMID:21731742 NCBI chr20:104,882,739...104,904,612 JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr20:104,883,027...104,904,951 JBrowse link
G RPS27L ribosomal protein S27 like involved_in ISO (PMID:18056458) UniProt PMID:18056458 NCBI chr26:20,385,684...20,389,351 JBrowse link
G SDE2 SDE2 telomere maintenance homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:3,779,561...3,793,496
Ensembl chr25:3,779,560...3,795,893 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16107883) Ensembl
MGI		 PMID:16107883 GO_REF:0000107 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO (PMID:23993650)
(PMID:18045533)		 MGI PMID:18045533 PMID:23993650 NCBI chr22:9,869,502...9,871,659 JBrowse link
G WAC WW domain containing adaptor with coiled-coil involved_in ISO (PMID:21329877) UniProt PMID:21329877 NCBI chr 9:28,131,774...28,222,501
Ensembl chr 9:28,131,769...28,219,134 		JBrowse link
mitotic G1/S transition checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLK3 polo like kinase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:87,989,573...87,995,396
Ensembl chr20:87,989,574...87,994,478 		JBrowse link
G PLK5 polo like kinase 5 (inactive) involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 6:1,303,105...1,309,523 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16925
    cellular process 15870
      cell cycle process 1306
        cell cycle phase transition 528
          mitotic cell cycle phase transition 420
            G1/S transition of mitotic cell cycle 198
              negative regulation of G1/S transition of mitotic cell cycle 67
                mitotic G1 cell size control checkpoint signaling 0
                mitotic G1/S transition checkpoint signaling + 28
Path 2
Term Annotations click to browse term
  biological_process 16925
    biological regulation 11599
      regulation of biological process 11243
        regulation of cellular process 10711
          regulation of cell cycle 1042
            regulation of cell cycle process 734
              negative regulation of cell cycle process 298
                negative regulation of cell cycle phase transition 249
                  negative regulation of mitotic cell cycle phase transition 175
                    negative regulation of G1/S transition of mitotic cell cycle 67
                      mitotic G1 cell size control checkpoint signaling 0
                      mitotic G1/S transition checkpoint signaling + 28
paths to the root