CASP2 (caspase 2) - Rat Genome Database

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Gene: CASP2 (caspase 2) Chlorocebus sabaeus
Analyze
Symbol: CASP2
Name: caspase 2
RGD ID: 18712886
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity involved in apoptotic process (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to mechanical stimulus (ortholog); DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Autosomal Recessive Intellectual Developmental Disorder 80 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); endopeptidase complex (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,172,614 - 112,189,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,172,733 - 112,188,744 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660728,895,441 - 8,914,545 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CASP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,172,614 - 112,189,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,172,733 - 112,188,744 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660728,895,441 - 8,914,545 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CASP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,288,351 - 143,307,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,288,215 - 143,307,696 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,985,444 - 143,004,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,695,524 - 142,714,907 (+)NCBINCBI36Build 36hg18NCBI36
Celera7137,822,267 - 137,841,650 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7137,322,670 - 137,342,153 (+)NCBIHuRef
CHM1_17142,922,195 - 142,941,676 (+)NCBICHM1_1
T2T-CHM13v2.07144,643,759 - 144,663,112 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,387,424 - 142,406,906 (+)NCBI
Casp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,241,942 - 42,259,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,241,919 - 42,259,442 (+)EnsemblGRCm39 Ensembl
GRCm38642,264,902 - 42,282,508 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,264,985 - 42,282,508 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,215,038 - 42,232,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,194,646 - 42,212,103 (+)NCBIMGSCv36mm8
Celera642,209,337 - 42,226,794 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
Casp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,116,265 - 72,134,023 (+)NCBIGRCr8
mRatBN7.2471,149,632 - 71,167,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx476,069,535 - 76,087,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,982,792 - 72,000,428 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,402,261 - 70,419,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,652,358 - 71,670,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,454,723 - 136,474,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,029,728 - 70,047,164 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1470,305,857 - 70,323,294 (+)NCBI
Celera466,080,364 - 66,098,003 (+)NCBICelera
Cytogenetic Map4q24NCBI
Casp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494353,310 - 368,873 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955494353,572 - 369,207 (-)NCBIChiLan1.0ChiLan1.0
CASP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,141,294 - 180,166,578 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,151,551 - 32,176,835 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,283,072 - 135,307,855 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,773,749 - 147,792,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,773,749 - 147,792,958 (+)Ensemblpanpan1.1panPan2
CASP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,378,447 - 6,396,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,379,913 - 6,396,646 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,368,808 - 7,385,123 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,232,171 - 6,251,272 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,232,210 - 6,250,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,181,045 - 6,197,357 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,032,942 - 6,049,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,108,280 - 6,124,667 (-)NCBIUU_Cfam_GSD_1.0
Casp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,149,166 - 12,164,126 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527739,281 - 754,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936527739,325 - 754,259 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,941,937 - 6,966,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,946,432 - 6,966,088 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,183,208 - 7,206,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Casp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,451,038 - 11,468,205 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480011,451,784 - 11,468,791 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 18 12 26
Low 18 8 34
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000005306   ⟹   ENSCSAP00000003529
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl21112,172,733 - 112,188,744 (+)Ensembl
RefSeq Acc Id: XM_037991194   ⟹   XP_037847122
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660728,895,441 - 8,914,545 (+)NCBI
RefSeq Acc Id: XM_037991195   ⟹   XP_037847123
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660728,896,961 - 8,914,545 (+)NCBI
RefSeq Acc Id: XM_037991196   ⟹   XP_037847124
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660728,897,813 - 8,914,545 (+)NCBI
RefSeq Acc Id: XR_005238168
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660728,895,713 - 8,913,306 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037847122 (Get FASTA)   NCBI Sequence Viewer  
  XP_037847123 (Get FASTA)   NCBI Sequence Viewer  
  XP_037847124 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003529.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000003529   ⟸   ENSCSAT00000005306
RefSeq Acc Id: XP_037847122   ⟸   XM_037991194
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037847123   ⟸   XM_037991195
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R4J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037847124   ⟸   XM_037991196
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R4J0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007289 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005306.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
  Caspase-like UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
NCBI Gene CASP2 ENTREZGENE
PANTHER CASPASE 2 UniProtKB/TrEMBL
  CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PIRSF Caspase_ICE UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A0D9R4J0 ENTREZGENE, UniProtKB/TrEMBL