CRADD (CASP2 and RIPK1 domain containing adaptor with death domain) - Rat Genome Database

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Gene: CRADD (CASP2 and RIPK1 domain containing adaptor with death domain) Chlorocebus sabaeus
Analyze
Symbol: CRADD
Name: CASP2 and RIPK1 domain containing adaptor with death domain
RGD ID: 18359369
Description: ENCODES a protein that exhibits death domain binding (inferred); protease binding (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN positive regulation of apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; ASSOCIATED WITH autosomal recessive intellectual developmental disorder 34 (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN endopeptidase complex (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: death domain-containing protein CRADD; LOC103238872; uncharacterized LOC103238872
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11189,066,952 - 89,246,177 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037155,916,158 - 156,095,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
endopeptidase complex  (IEA,ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CRADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11189,066,952 - 89,246,177 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037155,916,158 - 156,095,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CRADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381293,677,375 - 93,894,840 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1293,677,375 - 93,894,840 (+)EnsemblGRCh38hg38GRCh38
GRCh371294,071,151 - 94,288,616 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361292,595,282 - 92,768,663 (+)NCBINCBI36Build 36hg18NCBI36
Build 341292,573,618 - 92,746,997NCBI
Celera1293,741,644 - 93,915,013 (+)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1291,137,880 - 91,311,191 (+)NCBIHuRef
CHM1_11294,036,232 - 94,209,574 (+)NCBICHM1_1
T2T-CHM13v2.01293,658,870 - 93,876,341 (+)NCBIT2T-CHM13v2.0
Cradd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391095,010,601 - 95,160,000 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1095,010,608 - 95,159,995 (-)EnsemblGRCm39 Ensembl
GRCm381095,174,739 - 95,324,138 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1095,174,746 - 95,324,133 (-)EnsemblGRCm38mm10GRCm38
MGSCv371094,637,380 - 94,786,731 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361094,604,434 - 94,753,785 (-)NCBIMGSCv36mm8
Celera1097,149,089 - 97,298,972 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1049.26NCBI
Cradd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8731,827,131 - 31,839,796 (-)NCBIGRCr8
mRatBN7.2729,940,240 - 29,952,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl729,798,586 - 29,952,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx731,927,620 - 31,940,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0734,100,876 - 34,113,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0733,869,731 - 33,882,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0736,395,665 - 36,408,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl736,395,665 - 36,408,588 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0736,457,911 - 36,470,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,504,279 - 32,517,581 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1732,379,423 - 32,536,642 (-)NCBI
Celera727,014,185 - 27,026,498 (-)NCBICelera
Cytogenetic Map7q13NCBI
CRADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210101,720,799 - 102,094,687 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112101,717,193 - 101,937,321 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01291,220,813 - 91,593,799 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11294,619,877 - 94,836,970 (+)NCBIpanpan1.1PanPan1.1panPan2
CRADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11533,873,600 - 34,052,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1533,878,467 - 34,092,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1534,323,893 - 34,502,937 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01534,542,199 - 34,714,967 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1534,546,434 - 34,754,560 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11533,815,780 - 33,988,870 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01533,905,303 - 34,078,557 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01534,174,303 - 34,346,975 (+)NCBIUU_Cfam_GSD_1.0
Cradd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494525,972,089 - 26,167,311 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650710,098,171 - 10,264,716 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650710,077,345 - 10,264,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Cradd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475013,063,009 - 13,254,499 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475013,065,300 - 13,309,439 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_008004254   ⟹   XP_008002445
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11189,066,952 - 89,246,177 (+)NCBI
Vero_WHO_p1.0NW_023666037155,916,158 - 156,095,333 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037996710   ⟹   XP_037852638
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037156,029,414 - 156,095,333 (-)NCBI
RefSeq Acc Id: XM_037996711   ⟹   XP_037852639
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037156,029,414 - 156,095,333 (-)NCBI
RefSeq Acc Id: XM_037996712   ⟹   XP_037852640
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037156,029,414 - 156,095,333 (-)NCBI
RefSeq Acc Id: XM_037996713   ⟹   XP_037852641
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037156,029,414 - 156,095,333 (-)NCBI
RefSeq Acc Id: XR_005239907
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037156,031,205 - 156,095,333 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008002445 (Get FASTA)   NCBI Sequence Viewer  
  XP_037852638 (Get FASTA)   NCBI Sequence Viewer  
  XP_037852639 (Get FASTA)   NCBI Sequence Viewer  
  XP_037852640 (Get FASTA)   NCBI Sequence Viewer  
  XP_037852641 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000069.1
Reference Protein Sequences
RefSeq Acc Id: XP_008002445   ⟸   XM_008004254
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037852641   ⟸   XM_037996713
- Peptide Label: isoform X5
- UniProtKB: A0A0D9QUN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037852640   ⟸   XM_037996712
- Peptide Label: isoform X4
- UniProtKB: A0A0D9QUN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037852639   ⟸   XM_037996711
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037852638   ⟸   XM_037996710
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003700 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001729.1 UniProtKB/TrEMBL
Gene3D-CATH Death Domain, Fas UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD_RAIDD UniProtKB/TrEMBL
  CRADD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
NCBI Gene CRADD ENTREZGENE
PANTHER DEATH DOMAIN-CONTAINING PROTEIN CRADD UniProtKB/TrEMBL
  DEATH DOMAIN-CONTAINING PROTEIN CRADD UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
SMART CARD UniProtKB/TrEMBL
Superfamily-SCOP DEATH domain UniProtKB/TrEMBL
UniProt A0A0D9QUN0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 CRADD  CASP2 and RIPK1 domain containing adaptor with death domain  LOC103238872  uncharacterized LOC103238872  Data merged from RGD:18589022 737654 PROVISIONAL