RPA2 (replication protein A2) - Rat Genome Database

Name: RPA2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: RPA2 (replication protein A2) Chlorocebus sabaeus

Analyze

Symbol:

RPA2

Name:

replication protein A2

RGD ID:

18767941

Description:

ENCODES a protein that exhibits damaged DNA binding (ortholog); DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA replication (ortholog); double-strand break repair via homologous recombination (ortholog); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); DNA replication factor A complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

replication protein A 32 kDa subunit

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RPA2 (replication protein A2)	NCBI	Ortholog
Mus musculus (house mouse):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RPA2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RPA2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RPA2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	104,882,739 - 104,904,612 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	11,565,047 - 11,586,556 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (ISO)

DNA replication (ISO)

double-strand break repair via homologous recombination (ISO)

mismatch repair (ISO)

mitotic G1 DNA damage checkpoint signaling (ISO)

nucleotide-excision repair (ISO)

protein localization to chromosome (ISO)

regulation of DNA damage checkpoint (ISO)

regulation of double-strand break repair via homologous recombination (ISO)

telomere maintenance (ISO)

Cellular Component

chromatin (ISO)

chromosome, telomeric region (ISO)

DNA replication factor A complex (ISO)

nuclear body (ISO)

nucleoplasm (ISO)

nucleus (ISO)

PML body (ISO)

site of double-strand break (ISO)

Molecular Function

damaged DNA binding (ISO)

DNA binding (ISO)

enzyme binding (ISO)

G-rich strand telomeric DNA binding (ISO)

protein binding (ISO)

protein phosphatase binding (ISO)

single-stranded DNA binding (ISO)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mismatch repair pathway (ISO)

nucleotide excision repair pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

RPA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	104,882,739 - 104,904,612 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	11,565,047 - 11,586,556 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

RPA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	27,891,524 - 27,914,797 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	27,891,524 - 27,914,746 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	28,218,035 - 28,241,308 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	28,090,636 - 28,113,823 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	27,902,191 - 27,925,378	NCBI
Celera	1	26,613,902 - 26,637,086 (-)	NCBI		Celera
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	26,473,870 - 26,497,363 (-)	NCBI		HuRef
CHM1_1	1	28,333,548 - 28,356,736 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	27,733,626 - 27,756,900 (-)	NCBI		T2T-CHM13v2.0

Rpa2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	132,495,671 - 132,506,057 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	132,495,643 - 132,506,063 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	132,768,360 - 132,778,746 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	132,768,332 - 132,778,752 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	132,324,275 - 132,334,661 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	132,040,437 - 132,050,559 (+)	NCBI		MGSCv36	mm8
Celera	4	130,929,794 - 130,940,162 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	65.88	NCBI

Rpa2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	150,260,668 - 150,271,329 (+)	NCBI		GRCr8
mRatBN7.2	5	144,976,789 - 144,989,445 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,976,748 - 144,987,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	147,676,577 - 147,687,100 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	149,446,166 - 149,456,689 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	149,434,752 - 149,445,307 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	150,957,041 - 150,967,597 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,957,001 - 150,968,269 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	154,623,986 - 154,634,568 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	152,369,550 - 152,380,370 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	152,379,590 - 152,390,409 (-)	NCBI
Celera	5	143,400,981 - 143,411,495 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Rpa2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	7,080,579 - 7,097,742 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	7,080,641 - 7,098,009 (-)	NCBI	ChiLan1.0	ChiLan1.0

RPA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	198,938,671 - 198,961,968 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	198,055,633 - 198,078,934 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	27,151,784 - 27,175,110 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	28,191,726 - 28,214,665 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	28,191,731 - 28,214,666 (-)	Ensembl	panpan1.1		panPan2

RPA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	72,463,951 - 72,479,864 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	72,419,459 - 72,479,227 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	69,041,511 - 69,057,436 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	73,023,824 - 73,039,936 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	73,023,798 - 73,039,932 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	69,851,237 - 69,867,152 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	70,861,509 - 70,877,423 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	71,857,687 - 71,874,007 (+)	NCBI		UU_Cfam_GSD_1.0

Rpa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	46,302,244 - 46,322,308 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	12,126,245 - 12,147,130 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	12,127,026 - 12,147,120 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	85,031,582 - 85,045,915 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	85,032,604 - 85,045,899 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	78,572,938 - 78,586,231 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Rpa2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	11,736,129 - 11,764,080 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	11,737,234 - 11,763,862 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007979803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007979803 ⟹ XP_007977994

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	104,882,739 - 104,904,612 (+)	NCBI
Vero_WHO_p1.0	NW_023666033	11,565,047 - 11,586,556 (-)	NCBI

Sequence:

show sequence

GAGGGTTTTGCCCTTCGTAAAGATGGCCGCGGAGGCCAACTGGGAGCGCAGTGTGCGTTTTCTG
GAGCATGGGCAGAGAAGACAGGAACAAGCGTAGCATTCGTGAGCACGGATTGGCTGAAGCGAGA
AGCTCCCCGGAGCTGACTGGCTCCGTCATTCGCGCGAAGGAGTTTGTGGCGCCAGAGAAAAGTA
GCTAGAGCGGCGCAGTAGGGGCCGCGTTCTGTGGTTTTCCTTGATTGCCCCAGACCCGAACCTT
CTCGGCCTCTTTGCGGAAAATCGCGACCAAGATGTGGAACAGTGGATTCGAAAGCTATGGCAGC
TCCTCATATGGGGGAGCCGGCGGCTACACGCAGTCCCCGGGGGGCTTTGGATCGCCCGCACCTT
CTCAGGCCGAAAAGAAATCAAGAGCCCGAGCCCAGCACATTGTACCCTGTACTATATCTCAGCT
GCTTTCTGCCACTTTGGTTGATGAAGTGTTCAGAATTGGGAATGTTGAGATTTCACAGGTCACT
ATTGTGGGGATCATTAGACATGCAGAGAAGGCTCCAACCAACATTGTTTACAAAATAGATGACA
TGACAGCTGCACCCATGGATGTTCGCCAGTGGGTTGACACAGATGACGCCAGCAGTGAAAACAC
CGTGGTTCCTCCAGAAACATATGTGAAAGTGGCAGGCCACCTGAGATCTTTTCAGAACAAAAAG
AGCCTGGTAGCCTTTAAGATCATGCCCCTGGAGGATATGAATGAGTTCACCACACATATTCTGG
AAGTGATCAATGCACACATGGTACTAAGCAAAGCCAACAGCCAGTCCTCAGCAGGGAGAGCACC
TATCAGCAGTCCAGGAATGAGTGAAGCAGGGAACTTCGGTGGGAATAGCTTCATGCCAGCAAAT
GGCCTCACTGTGGCCCAAAACCAGGTGTTGAATTTGATTAAGGCTTGTCCAAGACCTGAAGGGT
TGAACTTTCAGGATCTCAAGAACCAGCTGAAACACATGTCTGTATCTTCAATCAAGCAAGCTGT
GGATTTTCTGAGCAATGAGGGGCACATCTATTCTACTGTGGATGATGACCATTTTAAATCCACA
GATGCAGAATAACTGGATCTAATTGGGTACCTGAGATATTTTACAGCTGGACCTAGTTTCACAA
TCTATTGTCTCCGGCTCTGCATATGTTTGGCCACGTGGCTTCTAGAAAGTAGGTTTCATCTATC
TAAAGGTCTCCTCTGACATCCTTTTGAAACTTACTGCTCTTCTGTTTTGTTTTGTTTTGTTTGA
AGCTCAGAGGGAGATGGGCAATTGACAGGGATGCAATCCAGGGTGGGATTTCTTGAGGAAGTTA
CAAATAAGCTTGTTACCACAGCAAGATAGATGGAATTGGAAGGATGCTACCAGGAGAGTACTTA
CATAGTGCTCGGGAGTTTCTCTTCTTAAAATGTTTGCTGCTGAAAGATGAGCAGGACCAGGGCC
TTGTAGGCAGAGCCCTAGCTGAGAAACCTGCTGGCCTCTGCCTGTTTTTGTTTCCCACTTTGGT
TGTGTGGCATTACTTTCAGAATTGCACTTTCCTGCTTGTCATGACTGCTTGACACACTTGTCAT
GACGTGTGTTTCTGTGAACATGAAGTTCTGCGGTGGTGGCCTCCAGGGGCAGAGGAAAGGAAGA
AGTGTTACTGCGTTTTGTACAAAATAAGTACATTCGTATGTTTAATAAAACAGTTCTATTGTAG
CAACTTGTAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007977994	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_007977994 ⟸ XM_007979803

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	RPA2	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

RGD Manual Annotations