KANK2 (KN motif and ankyrin repeat domains 2) - Rat Genome Database

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Gene: KANK2 (KN motif and ankyrin repeat domains 2) Chlorocebus sabaeus
Analyze
Symbol: KANK2
Name: KN motif and ankyrin repeat domains 2
RGD ID: 18338046
Description: INVOLVED IN apoptotic process (inferred); kidney epithelium development (inferred); negative regulation of actin filament polymerization (inferred); ASSOCIATED WITH alpha-mannosidosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate B (ortholog); diastolic heart failure (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: KN motif and ankyrin repeat domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,095,319 - 10,131,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,095,246 - 10,131,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,755,298 - 9,792,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KANK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,095,319 - 10,131,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,095,246 - 10,131,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,755,298 - 9,792,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KANK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,164,270 - 11,197,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,164,270 - 11,197,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371911,274,946 - 11,308,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,135,946 - 11,167,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341911,135,946 - 11,167,496NCBI
Celera1911,169,761 - 11,203,056 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,851,580 - 10,884,321 (-)NCBIHuRef
CHM1_11911,276,193 - 11,309,454 (-)NCBICHM1_1
T2T-CHM13v2.01911,291,296 - 11,324,866 (-)NCBIT2T-CHM13v2.0
Kank2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,678,069 - 21,709,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,678,080 - 21,710,040 (-)EnsemblGRCm39 Ensembl
GRCm38921,766,773 - 21,798,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,766,784 - 21,798,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,571,217 - 21,602,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,518,479 - 21,548,919 (-)NCBIMGSCv36mm8
Celera919,036,363 - 19,068,137 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.88NCBI
Kank2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,587,770 - 28,617,212 (-)NCBIGRCr8
mRatBN7.2820,311,676 - 20,341,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,311,676 - 20,340,900 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,347,039 - 24,376,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,642,587 - 22,671,915 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,541,282 - 20,570,501 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,792,000 - 22,821,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,791,995 - 22,821,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,846,154 - 22,875,574 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,865,615 - 20,892,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,702,311 - 21,731,556 (-)NCBICelera
Cytogenetic Map8q13NCBI
Kank2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554952,168,992 - 2,173,581 (-)NCBIChiLan1.0ChiLan1.0
KANK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,080,285 - 16,113,351 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,078,983 - 15,111,807 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,713,582 - 10,746,371 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,426,149 - 11,457,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,426,149 - 11,457,359 (-)Ensemblpanpan1.1panPan2
KANK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,067,749 - 50,093,377 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,067,760 - 50,091,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,941,266 - 49,966,898 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,588,664 - 50,614,343 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,588,642 - 50,614,335 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,798,849 - 49,824,490 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,225,723 - 50,251,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,468,431 - 50,494,081 (+)NCBIUU_Cfam_GSD_1.0
Kank2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,015,097 - 209,034,537 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,321,980 - 1,337,746 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,320,169 - 1,340,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KANK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,896,120 - 69,924,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,896,116 - 69,925,194 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Kank2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,041,991 - 3,062,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,039,871 - 3,060,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 1 31
Low 19 29
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000004893   ⟹   ENSCSAP00000003135
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl610,095,246 - 10,131,946 (-)Ensembl
RefSeq Acc Id: XM_007995271   ⟹   XP_007993462
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1610,095,319 - 10,131,985 (-)NCBI
Vero_WHO_p1.0NW_0236660749,755,618 - 9,792,353 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007995272   ⟹   XP_007993463
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1610,095,319 - 10,131,927 (-)NCBI
Vero_WHO_p1.0NW_0236660749,755,616 - 9,792,353 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007995273   ⟹   XP_007993464
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1610,095,319 - 10,131,985 (-)NCBI
Vero_WHO_p1.0NW_0236660749,755,618 - 9,792,353 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037992445   ⟹   XP_037848373
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,711 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992446   ⟹   XP_037848374
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,616 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992447   ⟹   XP_037848375
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,618 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992448   ⟹   XP_037848376
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,711 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992449   ⟹   XP_037848377
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,630 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992451   ⟹   XP_037848379
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,618 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992452   ⟹   XP_037848380
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,559 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992453   ⟹   XP_037848381
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,711 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992454   ⟹   XP_037848382
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,298 - 9,792,353 (+)NCBI
RefSeq Acc Id: XM_037992455   ⟹   XP_037848383
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660749,755,711 - 9,792,353 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007993464   ⟸   XM_007995273
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R3E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993462   ⟸   XM_007995271
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R3E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993463   ⟸   XM_007995272
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R3E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000003135   ⟸   ENSCSAT00000004893
RefSeq Acc Id: XP_037848382   ⟸   XM_037992454
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R3E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848380   ⟸   XM_037992452
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037848374   ⟸   XM_037992446
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037848375   ⟸   XM_037992447
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037848379   ⟸   XM_037992451
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037848377   ⟸   XM_037992449
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037848373   ⟸   XM_037992445
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037848381   ⟸   XM_037992453
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R3E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848376   ⟸   XM_037992448
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037848383   ⟸   XM_037992455
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R3E6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006850 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004893.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  KANK1-4 UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
KEGG Report csab:103233918 UniProtKB/TrEMBL
NCBI Gene KANK2 ENTREZGENE
PANTHER KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING UniProtKB/TrEMBL
  KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A0D9R3E6 ENTREZGENE, UniProtKB/TrEMBL