ACVR1 (activin A receptor type 1) - Rat Genome Database

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Pathways
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Gene: ACVR1 (activin A receptor type 1) Chlorocebus sabaeus
Analyze
Symbol: ACVR1
Name: activin A receptor type 1
RGD ID: 18783214
Description: ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity, type I (ortholog); BMP receptor activity (ortholog); INVOLVED IN activin receptor signaling pathway (ortholog); acute inflammatory response (ortholog); atrial septum primum morphogenesis (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); autism spectrum disorder (ortholog); bicuspid aortic valve disease (ortholog); FOUND IN activin receptor complex (ortholog); apical part of cell (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: activin receptor type-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11043,139,396 - 43,281,024 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1043,139,528 - 43,281,177 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040156,293,920 - 156,435,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (ISO)
acute inflammatory response  (ISO)
atrial septum primum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
BMP signaling pathway  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
cardiac muscle cell fate commitment  (ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA,ISO)
cellular response to BMP stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to growth factor stimulus  (IEA)
determination of left/right symmetry  (ISO)
embryonic heart tube morphogenesis  (ISO)
endocardial cushion cell fate commitment  (ISO)
endocardial cushion formation  (ISO)
endocardial cushion fusion  (ISO)
gastrulation  (ISO)
gastrulation with mouth forming second  (ISO)
germ cell development  (ISO)
heart development  (IEA,ISO)
in utero embryonic development  (ISO)
mesoderm development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of activin receptor signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of signal transduction  (ISO)
neural crest cell migration  (ISO)
outflow tract septum morphogenesis  (ISO)
pharyngeal system development  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of multicellular organismal process  (IEA)
regulation of ossification  (ISO)
regulation of skeletal muscle tissue development  (ISO)
smooth muscle cell differentiation  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
transforming growth factor beta receptor superfamily signaling pathway  (IEA)
urogenital system development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ACVR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11043,139,396 - 43,281,024 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1043,139,528 - 43,281,177 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040156,293,920 - 156,435,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ACVR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382157,736,446 - 157,876,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2157,736,251 - 157,876,330 (-)EnsemblGRCh38hg38GRCh38
GRCh372158,592,958 - 158,732,842 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362158,301,207 - 158,403,036 (-)NCBINCBI36Build 36hg18NCBI36
Build 342158,418,468 - 158,520,298NCBI
Celera2152,206,070 - 152,344,336 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2150,478,249 - 150,616,526 (-)NCBIHuRef
CHM1_12158,598,894 - 158,738,243 (-)NCBICHM1_1
T2T-CHM13v2.02158,189,880 - 158,329,404 (-)NCBIT2T-CHM13v2.0
Acvr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39258,336,450 - 58,456,840 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl258,278,656 - 58,457,169 (-)EnsemblGRCm39 Ensembl
GRCm38258,446,438 - 58,566,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl258,388,644 - 58,567,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv37258,298,849 - 58,419,239 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36258,261,824 - 58,331,545 (-)NCBIMGSCv36mm8
Celera260,202,316 - 60,294,260 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map233.05NCBI
Acvr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,387,378 - 63,506,980 (-)NCBIGRCr8
mRatBN7.2342,978,558 - 43,097,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,978,561 - 43,098,241 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx346,318,305 - 46,385,863 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,907,442 - 54,974,813 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,686,046 - 52,753,663 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,432,476 - 44,539,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,432,471 - 44,522,930 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0349,551,411 - 49,641,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4340,191,727 - 40,260,488 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1340,088,098 - 40,156,860 (-)NCBI
Celera341,046,965 - 41,113,654 (-)NCBICelera
Cytogenetic Map3q21NCBI
Acvr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544915,640,230 - 15,708,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544915,587,958 - 15,706,432 (+)NCBIChiLan1.0ChiLan1.0
ACVR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21360,399,806 - 60,481,894 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B60,414,781 - 60,553,730 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B44,994,175 - 45,133,490 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B162,234,823 - 162,372,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B162,234,823 - 162,297,805 (-)Ensemblpanpan1.1panPan2
ACVR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1363,743,257 - 3,818,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl363,744,163 - 3,818,652 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,880,162 - 4,006,562 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0363,865,484 - 3,991,973 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl363,865,493 - 3,946,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1363,867,397 - 3,993,826 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0363,927,214 - 4,053,637 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0363,965,356 - 4,091,837 (-)NCBIUU_Cfam_GSD_1.0
Acvr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303120,806,153 - 120,874,529 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646920,743,213 - 20,811,569 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646920,743,195 - 20,811,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1564,750,796 - 64,891,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11564,749,478 - 64,891,653 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21571,681,467 - 71,823,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Acvr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247327,929,583 - 8,005,072 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247327,929,997 - 8,004,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 57
Low 20 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000014025   ⟹   ENSCSAP00000012006
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1043,139,528 - 43,281,177 (-)Ensembl
RefSeq Acc Id: XM_007965024   ⟹   XP_007963215
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11043,139,396 - 43,281,024 (-)NCBI
Vero_WHO_p1.0NW_023666040156,293,920 - 156,435,319 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007965025   ⟹   XP_007963216
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11043,139,396 - 43,280,940 (-)NCBI
Vero_WHO_p1.0NW_023666040156,294,376 - 156,435,319 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007965026   ⟹   XP_007963217
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11043,139,396 - 43,224,635 (-)NCBI
Vero_WHO_p1.0NW_023666040156,294,169 - 156,435,319 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038002097   ⟹   XP_037858025
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040156,294,376 - 156,435,319 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007963215 (Get FASTA)   NCBI Sequence Viewer  
  XP_007963216 (Get FASTA)   NCBI Sequence Viewer  
  XP_007963217 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858025 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012006
  ENSCSAP00000012006.1
Reference Protein Sequences
RefSeq Acc Id: XP_007963215   ⟸   XM_007965024
- UniProtKB: A0A0D9RTR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007963216   ⟸   XM_007965025
- UniProtKB: A0A0D9RTR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007963217   ⟸   XM_007965026
- UniProtKB: A0A0D9RTR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000012006   ⟸   ENSCSAT00000014025
RefSeq Acc Id: XP_037858025   ⟸   XM_038002097
- UniProtKB: A0A0D9RTR7 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015925 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014025.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/TrEMBL
  GS_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
KEGG Report csab:103217143 UniProtKB/TrEMBL
NCBI Gene ACVR1 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-1 UniProtKB/TrEMBL
  PTHR23255 UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/TrEMBL
PRINTS ACTIVIN2R UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS51256 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00467 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
  SSF57302 UniProtKB/TrEMBL
UniProt A0A0D9RTR7 ENTREZGENE, UniProtKB/TrEMBL