ACVR1 (activin A receptor type 1)

Gene: ACVR1 (activin A receptor type 1) Canis lupus familiaris

Analyze

Symbol:

ACVR1

Name:

activin A receptor type 1

RGD ID:

12191404

Description:

ENCODES a protein that exhibits activin receptor activity, type I (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); cellular response to glucocorticoid stimulus (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); autism spectrum disorder (ortholog); bicuspid aortic valve disease (ortholog); FOUND IN activin receptor complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

activin receptor type-1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACVR1 (activin A receptor type 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Acvr1 (activin A receptor, type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Acvr1 (activin A receptor type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acvr1 (activin A receptor type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACVR1 (activin A receptor type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acvr1 (activin A receptor type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACVR1 (activin A receptor type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACVR1 (activin A receptor type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acvr1 (activin A receptor type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	3,743,257 - 3,818,659 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	3,744,163 - 3,818,652 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	3,880,162 - 4,006,562 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	3,865,484 - 3,991,973 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	3,865,493 - 3,946,584 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	3,867,397 - 3,993,826 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	3,927,214 - 4,053,637 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	3,965,356 - 4,091,837 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

autism spectrum disorder (ISO)

bicuspid aortic valve disease (ISO)

Breast Neoplasms (ISO)

Carotid Artery Injuries (ISO)

cataract (ISO)

congenital heart disease (ISO)

Diabetic Nephropathies (ISO)

exfoliation syndrome (ISO)

Eye Neoplasms (ISO)

fibrodysplasia ossificans progressiva (ISO)

gastric adenocarcinoma (ISO)

genetic disease (ISO)

high grade glioma (ISO)

malignant astrocytoma (ISO)

middle cerebral artery infarction (ISO)

myositis ossificans (ISO)

pancreatic cancer (ISO)

primary angle-closure glaucoma (ISO)

primary open angle glaucoma (ISO)

severe pre-eclampsia (ISO)

ventricular septal defect (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activin receptor signaling pathway (IEA)

acute inflammatory response (IEA)

atrial septum primum morphogenesis (IEA)

atrioventricular valve morphogenesis (IEA)

BMP signaling pathway (IEA)

branching involved in blood vessel morphogenesis (IEA,ISO)

cardiac muscle cell fate commitment (IEA)

cell surface receptor protein serine/threonine kinase signaling pathway (IEA,ISO)

cellular response to BMP stimulus (IEA)

cellular response to glucocorticoid stimulus (ISO)

cellular response to growth factor stimulus (IEA)

determination of left/right symmetry (IEA,ISO)

embryonic heart tube morphogenesis (IEA)

endocardial cushion cell fate commitment (IEA)

endocardial cushion formation (IEA)

endocardial cushion fusion (IEA)

gastrulation (IEA,ISO)

gastrulation with mouth forming second (IEA,ISO)

germ cell development (IEA,ISO)

heart development (IEA,ISO)

in utero embryonic development (IEA,ISO)

mesoderm development (IEA,ISO)

mesoderm formation (IEA,ISO)

mitral valve morphogenesis (IEA)

negative regulation of activin receptor signaling pathway (IEA)

negative regulation of extrinsic apoptotic signaling pathway (IEA)

negative regulation of G1/S transition of mitotic cell cycle (IEA)

negative regulation of signal transduction (IEA)

neural crest cell migration (IEA,ISO)

outflow tract septum morphogenesis (ISO)

pharyngeal system development (IEA,ISO)

positive regulation of bone mineralization (IEA)

positive regulation of cardiac epithelial to mesenchymal transition (IEA)

positive regulation of cell migration (IEA)

positive regulation of determination of dorsal identity (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of osteoblast differentiation (IEA)

positive regulation of peptidyl-tyrosine phosphorylation (IEA)

positive regulation of SMAD protein signal transduction (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of ossification (IEA)

regulation of skeletal muscle tissue development (ISO)

smooth muscle cell differentiation (IEA,ISO)

transforming growth factor beta receptor signaling pathway (IEA,ISO)

urogenital system development (ISO)

ventricular septum morphogenesis (IEA)

Cellular Component

activin receptor complex (IEA,ISO)

apical part of cell (IEA)

BMP receptor complex (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

activin binding (IEA)

activin receptor activity, type I (IEA,ISO)

ATP binding (IEA)

BMP receptor activity (IEA)

cadherin binding (IEA)

growth factor binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

protein kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

protein tyrosine kinase binding (IEA)

SMAD binding (IEA)

transforming growth factor beta binding (IEA)

transforming growth factor beta receptor activity, type I (IEA)

transmembrane receptor protein serine/threonine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

activin signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ACVR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	3,743,257 - 3,818,659 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	3,744,163 - 3,818,652 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	3,880,162 - 4,006,562 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	3,865,484 - 3,991,973 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	3,865,493 - 3,946,584 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	3,867,397 - 3,993,826 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	3,927,214 - 4,053,637 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	3,965,356 - 4,091,837 (-)	NCBI		UU_Cfam_GSD_1.0

ACVR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	157,736,446 - 157,876,330 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	157,736,251 - 157,876,330 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	158,592,958 - 158,732,842 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	158,301,207 - 158,403,036 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	158,418,468 - 158,520,298	NCBI
Celera	2	152,206,070 - 152,344,336 (-)	NCBI		Celera
Cytogenetic Map	2	q24.1	NCBI
HuRef	2	150,478,249 - 150,616,526 (-)	NCBI		HuRef
CHM1_1	2	158,598,894 - 158,738,243 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	158,189,880 - 158,329,404 (-)	NCBI		T2T-CHM13v2.0

Acvr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	58,336,450 - 58,456,840 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	58,278,656 - 58,457,169 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	58,446,438 - 58,566,828 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	58,388,644 - 58,567,157 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	58,298,849 - 58,419,239 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	58,261,824 - 58,331,545 (-)	NCBI		MGSCv36	mm8
Celera	2	60,202,316 - 60,294,260 (-)	NCBI		Celera
Cytogenetic Map	2	C1.1	NCBI
cM Map	2	33.05	NCBI

Acvr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	63,387,378 - 63,506,980 (-)	NCBI		GRCr8
mRatBN7.2	3	42,978,558 - 43,097,892 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	42,978,561 - 43,098,241 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	46,318,305 - 46,385,863 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	54,907,442 - 54,974,813 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	52,686,046 - 52,753,663 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	44,432,476 - 44,539,680 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	44,432,471 - 44,522,930 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	49,551,411 - 49,641,517 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	40,191,727 - 40,260,488 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	40,088,098 - 40,156,860 (-)	NCBI
Celera	3	41,046,965 - 41,113,654 (-)	NCBI		Celera
Cytogenetic Map	3	q21	NCBI

Acvr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	15,640,230 - 15,708,694 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	15,587,958 - 15,706,432 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACVR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	60,399,806 - 60,481,894 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	60,414,781 - 60,553,730 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	44,994,175 - 45,133,490 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	162,234,823 - 162,372,533 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	162,234,823 - 162,297,805 (-)	Ensembl	panpan1.1		panPan2

Acvr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	120,806,153 - 120,874,529 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	20,743,213 - 20,811,569 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	20,743,195 - 20,811,567 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACVR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	64,750,796 - 64,891,544 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	64,749,478 - 64,891,653 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	71,681,467 - 71,823,490 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACVR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	43,139,396 - 43,281,024 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	43,139,528 - 43,281,177 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	156,293,920 - 156,435,319 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acvr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	7,929,583 - 8,005,072 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	7,929,997 - 8,004,235 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ACVR1
546 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	4	3	17	6	3	6	6		12		10	5
Low	1	2	5		3			6		8		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005640196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022414922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038446783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038446784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038446785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038446786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038463296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038463297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038463298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038520885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038520886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038520887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038520888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038648973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038648974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038648975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038648976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000014782 ⟹ ENSCAFP00000013675

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	36	3,744,163 - 3,818,652 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000088744 ⟹ ENSCAFP00000046780

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	36	3,744,163 - 3,818,652 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845046412 ⟹ ENSCAFP00845036443

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	36	3,865,493 - 3,946,584 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845046496 ⟹ ENSCAFP00845036501

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	36	3,865,493 - 3,946,584 (-)	Ensembl

RefSeq Acc Id:

XM_005640196 ⟹ XP_005640253

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	36	3,743,257 - 3,818,649 (-)	NCBI
Dog10K_Boxer_Tasha	36	3,880,162 - 3,962,137 (-)	NCBI

Sequence:

show sequence

CCTGAGCCGCCTGCGAGCAGAACTGCTGGAGAGCTTCTCCTGGTTCCCGGAGCGCCTGCCAGCC
TCCCAGCCCCCCGTCTCCGTGCCCGGGACCCGTGACCTCGGCCTGCGGGAGCCGGGACCCGCCG
TGGGAAGGCATGATGCGGCGCCAGGCCCAAGGGAGCTGAGTCAGCCTGCCCGCGCCCGAGCAGC
TGCCACTGCGGCCCCAGAGCCGTTGCAACAAATCACCTCTTTTAATGCTCTTTGGCAGAGATCA
AATCTACACGTGAAAAGACAAGGACATACGGTTGGAGACTGTCATCAGGATTCAGTGGCGTGGA
GGAGGGGTCGATATGAGTAAAGAACAGTCGTACAATGGTAGATGGAGTGATGATGCTTCCTGTG
CTAATGATGATCGCCTTCCCTTCCCCTAGTATGGAAGATGAGAAGCCCAAGGTAAACCCCAAAC
TTTACATGTGTGTGTGTGAAGGCCTCTCCTGTGGGAACGAGGACCATTGTGAAGGCCAGCAGTG
CTTTTCCTCATTGAGCATAAACGATGGCTTCCATGTCTACCAGAAAGGCTGCTTCCAGGTCTAC
GAGCAGGGGAAGATGACCTGTAAGACCCCGCCATCACCTGGCCAAGCTGTGGAGTGCTGCCAAG
GGGACTGGTGTAACAGGAACATCACGGCCCAGCTGCCCACTAAAGGGAAATCCTTTCCTGAAAC
ACAGAATTTCCACTTGGAGGTCGGCCTCATTATTCTGTCCGTAGTATTTGCAGTATGCCTTCTA
GCTTGCCTACTGGGAGTCGCTCTCCGAAAATTTAAAAGGCGCAATCAAGAACGCCTCAATCCCA
GAGATGTGGAGTACGGCACCATCGAAGGGCTCATCACCACCAATGTTGGAGACAGCACTCTAGC
AGATTTATTGGATCATTCGTGTACATCAGGAAGTGGCTCTGGTCTCCCTTTTCTGGTACAAAGA
ACAGTGGCTCGTCAGATCACACTGTTGGAGTGTGTCGGGAAAGGCAGGTATGGTGAGGTGTGGA
GGGGCAGCTGGCAAGGGGAGAACGTTGCTGTGAAGATCTTCTCCTCCCGGGATGAGAAGTCGTG
GTTCAGGGAAACAGAATTGTACAACACTGTGATGCTGAGGCATGAAAATATTTTAGGTTTTATT
GCTTCAGACATGACATCAAGACACTCCAGTACCCAGTTGTGGTTAATCACACATTATCATGAAA
TGGGATCGTTGTACGACTATCTTCAGCTTACTACTCTGGATACTGTTAGCTGCCTGCGAATAGT
GCTGTCCATAGCTAGTGGTCTTGCACATTTGCACATAGAGATATTTGGGACCCAAGGAAAGCCA
GCCATTGCTCATCGAGATTTAAAGAGCAAAAACATCCTGGTTAAGAAGAATGGACAGTGTTGCA
TAGCAGATTTGGGCCTGGCAGTCATGCATTCCCAGAGTACCAATCAGCTCGATGTGGGGAACAA
CCCCCGTGTGGGCACCAAACGCTACATGGCTCCTGAAGTTCTAGATGAAACCATCCAGGTGGAC
TGTTTCGATTCTTACAAGAGAGTTGATATTTGGGCCTTTGGTCTTGTCTTGTGGGAAGTGGCCA
GGCGTATGGTAAGCAACGGTATTGTGGAGGATTACAAGCCACCATTTTACGATGTGGTCCCCAA
TGACCCAAGTTTTGAAGATATGAGAAAGGTGGTCTGTGTGGATCAACAGAGGCCAAACATACCC
AATAGGTGGTTCTCAGACCCGACATTAACCTCTCTGGCTAAGCTGATGAAAGAATGCTGGTATC
AGAATCCATCTGCAAGACTCACAGCTCTGCGTATCAAAAAGACTTTGACCAAAATTGATAATTC
CCTAGACAAATTGAAAACTGACTGTTGACATTTTCATGGAGTCAAGAAGGAAGATTTGACGTTG
TCATTGTCCAGCTGGGACCTAATGCTGGCCTGACTGGTTGTCAGAACAGAATCCATCTGTCTCC
CTCCGCAAATGGCTGCTTTGCCAAGGCAGACATCCTACCCAGCCGTGTGTTGGGGAGACACCAA
AACCACCCTAACCTCGCTCAATGACTGTGACCTGGGCATTTCACAAACTGTTCACACTGCAGAG
ACTAATGTCGGACAGACACTGTTGCAAAGGTAGGGGAACTGGAGGAACACAGAGAAATCCTAAA
AGAGATCTGGGCATTAAGACAGTGGCTTTGCATATCTTTCACAGGTCTCCTAGACTCTCCCCAT
GGGAAACTCAAGGAGGTGGTGAATTTTTATCAGCAATATTGCCTGTGCTTCTCTTCTTTATTGC
ACTAGGAATTCTTTGCATTCCTTACTTGCACTGTTACTCTTAATTTTAAAGACCCAACTTGCCA
AAACGTTGGCTGCGTACTCCACTGGTCTGTCTTTGGATAATAGGAATTCAATTTGGCAAAACAA
AATGTAATGTCAGACTTTGCTGCATTTTACACATGTGCTGATGTTTACAATGATGCTGAAACAT
TAGGAATTGTTTATACACAACTTTGCAAATTATTTATTACTTGTGCACTTAGCAGTTTTTACAA
AACTGCTTCGCGCATATGTTAAAGCTTATTTTTATGTGGTCTTATGATTTTATTACTGAAATGT
TTTTAACACTATACTCTGAAATGGACATTTTTCTTTTATTATCAGTTAAATTCACATTTTAAGT
GCTTCACATTTGTATGTGTGTAGACTGTAACTTTTTTCAGTTCATATGCAGAAATGTATTTAGC
CATTACCCATGTGACACCACCGAATATATTACTGATTTAGAAGCAAAGATTTCAGTAGAATTTT
AGTCCTGAACGCTGTGGGGAAAATGCATTTTCTTCGGAATTATCCATTATGTGCATTTAAACTC
TGCCAGAAAAAAAATAACTATTTTGTTTTAATCTACTTTTTGTATTTAGTAGTTATTTGTATAA
ATTAAATAAAAGGTTTTCAAGTCAAAGTGAA

hide sequence

RefSeq Acc Id:

XM_038446783 ⟹ XP_038302711

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	36	3,865,484 - 3,947,481 (-)	NCBI

RefSeq Acc Id:

XM_038446784 ⟹ XP_038302712

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	36	3,865,484 - 3,991,973 (-)	NCBI

RefSeq Acc Id:

XM_038446785 ⟹ XP_038302713

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	36	3,865,484 - 3,946,994 (-)	NCBI

RefSeq Acc Id:

XM_038446786 ⟹ XP_038302714

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	36	3,865,484 - 3,947,481 (-)	NCBI

RefSeq Acc Id:

XM_038463296 ⟹ XP_038319224

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	36	3,880,162 - 3,962,137 (-)	NCBI

RefSeq Acc Id:

XM_038463297 ⟹ XP_038319225

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	36	3,880,162 - 4,006,562 (-)	NCBI

RefSeq Acc Id:

XM_038463298 ⟹ XP_038319226

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	36	3,880,162 - 3,961,650 (-)	NCBI

RefSeq Acc Id:

XM_038520885 ⟹ XP_038376813

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	36	3,867,397 - 3,949,407 (-)	NCBI

RefSeq Acc Id:

XM_038520886 ⟹ XP_038376814

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	36	3,867,397 - 3,993,826 (-)	NCBI

RefSeq Acc Id:

XM_038520887 ⟹ XP_038376815

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	36	3,867,397 - 3,948,921 (-)	NCBI

RefSeq Acc Id:

XM_038520888 ⟹ XP_038376816

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	36	3,867,397 - 3,949,407 (-)	NCBI

RefSeq Acc Id:

XM_038584554 ⟹ XP_038440482

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	36	3,965,356 - 4,047,356 (-)	NCBI

RefSeq Acc Id:

XM_038584555 ⟹ XP_038440483

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	36	3,965,356 - 4,091,837 (-)	NCBI

RefSeq Acc Id:

XM_038584556 ⟹ XP_038440484

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	36	3,965,356 - 4,046,869 (-)	NCBI

RefSeq Acc Id:

XM_038584557 ⟹ XP_038440485

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	36	3,965,356 - 4,047,356 (-)	NCBI

RefSeq Acc Id:

XM_038648973 ⟹ XP_038504901

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	36	3,927,214 - 4,009,144 (-)	NCBI

RefSeq Acc Id:

XM_038648974 ⟹ XP_038504902

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	36	3,927,214 - 4,053,637 (-)	NCBI

RefSeq Acc Id:

XM_038648975 ⟹ XP_038504903

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	36	3,927,214 - 4,008,657 (-)	NCBI

RefSeq Acc Id:

XM_038648976 ⟹ XP_038504904

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	36	3,927,214 - 4,009,144 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005640253	(Get FASTA)	NCBI Sequence Viewer
	XP_038302711	(Get FASTA)	NCBI Sequence Viewer
	XP_038302712	(Get FASTA)	NCBI Sequence Viewer
	XP_038302713	(Get FASTA)	NCBI Sequence Viewer
	XP_038302714	(Get FASTA)	NCBI Sequence Viewer
	XP_038319224	(Get FASTA)	NCBI Sequence Viewer
	XP_038319225	(Get FASTA)	NCBI Sequence Viewer
	XP_038319226	(Get FASTA)	NCBI Sequence Viewer
	XP_038376813	(Get FASTA)	NCBI Sequence Viewer
	XP_038376814	(Get FASTA)	NCBI Sequence Viewer
	XP_038376815	(Get FASTA)	NCBI Sequence Viewer
	XP_038376816	(Get FASTA)	NCBI Sequence Viewer
	XP_038440482	(Get FASTA)	NCBI Sequence Viewer
	XP_038440483	(Get FASTA)	NCBI Sequence Viewer
	XP_038440484	(Get FASTA)	NCBI Sequence Viewer
	XP_038440485	(Get FASTA)	NCBI Sequence Viewer
	XP_038504901	(Get FASTA)	NCBI Sequence Viewer
	XP_038504902	(Get FASTA)	NCBI Sequence Viewer
	XP_038504903	(Get FASTA)	NCBI Sequence Viewer
	XP_038504904	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000046780.1
	ENSCAFP00000069681.1
	ENSCAFP00030014928.1
	ENSCAFP00030015035.1
	ENSCAFP00030015127.1
	ENSCAFP00030015180.1
	ENSCAFP00040023373.1
	ENSCAFP00040023449.1
	ENSCAFP00040023512.1
	ENSCAFP00040023572.1
	ENSCAFP00040023634.1
	ENSCAFP00845036443
	ENSCAFP00845036443.1
	ENSCAFP00845036501.1

RefSeq Acc Id:

XP_005640253 ⟸ XM_005640196

- UniProtKB:

A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVDGVMMLPVLMMIAFPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFH
VYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPETQNFHLEVGLII
LSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGS
GSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVM
LRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLH
IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAP
EVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVV
CVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

hide sequence

RefSeq Acc Id:

ENSCAFP00000046780 ⟸ ENSCAFT00000088744

RefSeq Acc Id:

ENSCAFP00000013675 ⟸ ENSCAFT00000014782

RefSeq Acc Id:

XP_038376814 ⟸ XM_038520886

RefSeq Acc Id:

XP_038376813 ⟸ XM_038520885

RefSeq Acc Id:

XP_038376816 ⟸ XM_038520888

RefSeq Acc Id:

XP_038376815 ⟸ XM_038520887

RefSeq Acc Id:

XP_038504902 ⟸ XM_038648974

RefSeq Acc Id:

XP_038504901 ⟸ XM_038648973

RefSeq Acc Id:

XP_038504904 ⟸ XM_038648976

RefSeq Acc Id:

XP_038504903 ⟸ XM_038648975

RefSeq Acc Id:	XP_038302712 ⟸ XM_038446784
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038302711 ⟸ XM_038446783
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038302714 ⟸ XM_038446786
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038302713 ⟸ XM_038446785
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038319225 ⟸ XM_038463297
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038319224 ⟸ XM_038463296
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038319226 ⟸ XM_038463298
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038440483 ⟸ XM_038584555
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038440482 ⟸ XM_038584554
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038440485 ⟸ XM_038584557
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038440484 ⟸ XM_038584556
- UniProtKB:	A0A8C0KA33 (UniProtKB/TrEMBL), A0A8C0MPL7 (UniProtKB/TrEMBL), A0A8C0MQ83 (UniProtKB/TrEMBL), A0A8I3PSN0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845036443 ⟸ ENSCAFT00845046412

RefSeq Acc Id:

ENSCAFP00845036501 ⟸ ENSCAFT00845046496

Protein Domains

GS Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000009287	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030009212	UniProtKB/TrEMBL
	ENSCAFG00040014602	UniProtKB/TrEMBL
	ENSCAFG00845026311	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000088744.2	UniProtKB/TrEMBL
	ENSCAFT00000097279.1	UniProtKB/TrEMBL
	ENSCAFT00030017082.1	UniProtKB/TrEMBL
	ENSCAFT00030017218.1	UniProtKB/TrEMBL
	ENSCAFT00030017321.1	UniProtKB/TrEMBL
	ENSCAFT00030017382.1	UniProtKB/TrEMBL
	ENSCAFT00040026896.1	UniProtKB/TrEMBL
	ENSCAFT00040026981.1	UniProtKB/TrEMBL
	ENSCAFT00040027052.1	UniProtKB/TrEMBL
	ENSCAFT00040027123.1	UniProtKB/TrEMBL
	ENSCAFT00040027197.1	UniProtKB/TrEMBL
	ENSCAFT00845046412	ENTREZGENE
	ENSCAFT00845046412.1	UniProtKB/TrEMBL
	ENSCAFT00845046496.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.60.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Activin_recp	UniProtKB/TrEMBL
	GS_dom	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	Snake_toxin-like_sf	UniProtKB/TrEMBL
	TGFB_receptor	UniProtKB/TrEMBL
KEGG Report	cfa:478757	UniProtKB/TrEMBL
NCBI Gene	ACVR1	ENTREZGENE
PANTHER	ACTIVIN RECEPTOR TYPE-1	UniProtKB/TrEMBL
	PTHR23255	UniProtKB/TrEMBL
Pfam	Activin_recp	UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
	TGF_beta_GS	UniProtKB/TrEMBL
PRINTS	ACTIVIN2R	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	PS51256	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
	SM00467	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
	SSF57302	UniProtKB/TrEMBL
UniProt	A0A8C0KA33	ENTREZGENE
	A0A8C0MPL7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0MQ83	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0MT88_CANLF	UniProtKB/TrEMBL
	A0A8C0SLM2_CANLF	UniProtKB/TrEMBL
	A0A8C0SPE5_CANLF	UniProtKB/TrEMBL
	A0A8I3PSN0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PXV6_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:37561	ENTREZGENE

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)