DACT1 (dishevelled binding antagonist of beta catenin 1) - Rat Genome Database

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Gene: DACT1 (dishevelled binding antagonist of beta catenin 1) Chlorocebus sabaeus
Analyze
Symbol: DACT1
Name: dishevelled binding antagonist of beta catenin 1
RGD ID: 18536583
Description: ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-Rieger syndrome (ortholog); Colorectal Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN beta-catenin destruction complex (ortholog); glutamatergic synapse (ortholog); postsynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dapper homolog 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12435,821,518 - 35,832,486 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2435,821,990 - 35,832,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605324,088,036 - 24,098,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DACT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12435,821,518 - 35,832,486 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2435,821,990 - 35,832,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605324,088,036 - 24,098,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DACT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381458,634,061 - 58,648,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1458,633,967 - 58,648,321 (+)EnsemblGRCh38hg38GRCh38
GRCh371459,100,779 - 59,115,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361458,174,510 - 58,184,792 (+)NCBINCBI36Build 36hg18NCBI36
Build 341458,174,611 - 58,184,789NCBI
Celera1439,154,745 - 39,165,027 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1439,264,994 - 39,279,247 (+)NCBIHuRef
CHM1_11459,039,260 - 59,053,513 (+)NCBICHM1_1
T2T-CHM13v2.01452,841,138 - 52,855,396 (+)NCBIT2T-CHM13v2.0
Dact1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391271,356,658 - 71,366,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1271,356,658 - 71,366,881 (+)EnsemblGRCm39 Ensembl
GRCm381271,309,884 - 71,320,107 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1271,309,884 - 71,320,107 (+)EnsemblGRCm38mm10GRCm38
MGSCv371272,410,871 - 72,421,094 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361272,228,589 - 72,237,499 (+)NCBIMGSCv36mm8
Celera1272,410,534 - 72,420,756 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1229.39NCBI
Dact1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8695,526,645 - 95,538,625 (+)NCBIGRCr8
mRatBN7.2689,790,676 - 89,818,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl689,790,644 - 89,817,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx690,174,745 - 90,185,345 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0690,474,205 - 90,484,805 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0689,913,716 - 89,924,316 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0693,740,440 - 93,751,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl693,740,586 - 93,749,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06103,201,826 - 103,212,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4693,402,304 - 93,411,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera688,272,055 - 88,282,541 (+)NCBICelera
Cytogenetic Map6q24NCBI
Dact1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546612,367,775 - 12,373,036 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546612,367,760 - 12,374,141 (+)NCBIChiLan1.0ChiLan1.0
DACT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21559,761,876 - 59,772,346 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11458,978,423 - 58,988,860 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01439,231,910 - 39,242,353 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11457,498,901 - 57,510,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1457,499,906 - 57,510,019 (+)Ensemblpanpan1.1panPan2
DACT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1833,950,016 - 33,959,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl833,949,926 - 33,958,449 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha833,710,858 - 33,719,128 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0834,191,432 - 34,199,711 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl834,191,432 - 34,199,675 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1833,803,264 - 33,811,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0833,871,726 - 33,879,997 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0834,246,058 - 34,254,343 (+)NCBIUU_Cfam_GSD_1.0
Dact1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864071,165,976 - 71,174,693 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364953,017,150 - 3,025,684 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364953,017,029 - 3,026,759 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DACT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1187,719,290 - 187,729,422 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11187,719,391 - 187,729,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Dact1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248843,739,334 - 3,948,621 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248843,733,648 - 3,750,207 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 4 2
Low 32 20 58
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012429   ⟹   ENSCSAP00000010467
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2435,821,990 - 35,832,712 (+)Ensembl
RefSeq Acc Id: XM_007986816   ⟹   XP_007985007
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12435,821,518 - 35,832,486 (+)NCBI
Vero_WHO_p1.0NW_02366605324,088,036 - 24,098,815 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007986817   ⟹   XP_007985008
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12435,821,520 - 35,832,486 (+)NCBI
Vero_WHO_p1.0NW_02366605324,088,036 - 24,098,815 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007985007 (Get FASTA)   NCBI Sequence Viewer  
  XP_007985008 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010467.1
Reference Protein Sequences
RefSeq Acc Id: XP_007985007   ⟸   XM_007986816
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007985008   ⟸   XM_007986817
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RPC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010467   ⟸   ENSCSAT00000012429


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014335 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012429.1 UniProtKB/TrEMBL
InterPro Dapper UniProtKB/TrEMBL
NCBI Gene DACT1 ENTREZGENE
PANTHER PTHR15919 UniProtKB/TrEMBL
  PTHR15919:SF12 UniProtKB/TrEMBL
Pfam Dapper UniProtKB/TrEMBL
UniProt A0A0D9RPC8 ENTREZGENE, UniProtKB/TrEMBL