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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:extrinsic apoptotic signaling pathway in absence of ligand
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Accession:GO:0097192 term browser browse the term
Definition:The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
Comment:For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154).
Synonyms:exact_synonym: extrinsic apoptotic signalling pathway in absence of ligand
 narrow_synonym: extrinsic apoptosis in absence of ligand
 related_synonym: dependence receptor signaling pathway


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extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1890081 (PMID:12115603), (PMID:12431371), (PMID:12944463), (PMID:14967141)		 Ensembl
RGD		 PMID:12115603 PMID:12431371 PMID:12944463 PMID:14967141 GO_REF:0000107 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bag3 BAG cochaperone 3 acts_upstream_of_or_within ISO (PMID:11527400) RGD PMID:11527400 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1197519|MGI:99702 (PMID:15680329), (PMID:15967824)		 GO_Central
RGD		 PMID:15680329 PMID:15967824 GO_REF:0000033 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1097161|MGI:1197519 (PMID:15680329), (PMID:15967824)		 GO_Central
RGD		 PMID:15680329 PMID:15967824 GO_REF:0000033 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:1309517 (PMID:12082633)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:12082633 GO_REF:0000033 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:12115603)		 GO_Central
RGD		 PMID:12115603 GO_REF:0000033 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 involved_in
acts_upstream_of		 IBA
ISO		 GO_REF:0000033
(PMID:9878060)		 GO_Central
RGD		 PMID:9878060 GO_REF:0000033 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:1097161|MGI:2156498|MGI:99702 (PMID:15967824) RGD PMID:15967824 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:12115603)		 GO_Central
RGD		 PMID:12115603 GO_REF:0000033 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp2 caspase 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2159368 (PMID:11536012)		 GO_Central
RGD		 PMID:11536012 GO_REF:0000033 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Col2a1 collagen type II alpha 1 chain involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2152978 (PMID:9299161)		 Ensembl
RGD		 PMID:9299161 GO_REF:0000107 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Ctnna1 catenin alpha 1 acts_upstream_of ISO MGI:2677796 (PMID:22411810) RGD PMID:22411810 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 acts_upstream_of ISO (PMID:18322241), (PMID:18971423) RGD PMID:18322241 PMID:18971423 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 involved_in ISO
IEA		 (PMID:17701904)
GO_REF:0000107		 RGD
Ensembl		 PMID:17701904 GO_REF:0000107 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of ISO MGI:1857803 (PMID:15817220) RGD PMID:15817220 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (PMID:11700312) RGD PMID:11700312 NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793 		JBrowse link
G Fadd Fas associated via death domain acts_upstream_of_or_within ISO (PMID:13679421) RGD PMID:13679421 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1856334|MGI:1861923 (PMID:13679421)		 GO_Central
RGD		 PMID:13679421 GO_REF:0000033 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of ISO MGI:1859647 (PMID:16956603) RGD PMID:16956603 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Foxo3 forkhead box O3 acts_upstream_of_or_within ISO MGI:1096330 (PMID:12431371) RGD PMID:12431371 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5514334|PMID:16543145)		 UniProt
Ensembl
RGD		 PMID:16543145 GO_REF:0000024 GO_REF:0000107 MGI:5514334 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
ISO		 GO_REF:0000024
(MGI:5514334|PMID:16543145)		 UniProt
RGD		 PMID:16543145 GO_REF:0000024 MGI:5514334 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO (PMID:12431371) RGD PMID:12431371 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1a interleukin 1 alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2157371 (PMID:11536012)		 Ensembl
RGD		 PMID:11536012 GO_REF:0000107 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2157396 (PMID:11536012)		 Ensembl
RGD		 PMID:11536012 GO_REF:0000107 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO (PMID:12082633) RGD PMID:12082633 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il3 interleukin 3 acts_upstream_of_or_within ISO (PMID:11527400), (PMID:12124386), (PMID:12944463), (PMID:14967141), (PMID:15231831), (PMID:15680329) RGD PMID:11527400 PMID:12124386 PMID:12944463 PMID:14967141 PMID:15231831 More... NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12115603) RGD PMID:12115603 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (MGI:3530680|PMID:15591537) RGD PMID:15591537 MGI:3530680 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Kitlg KIT ligand acts_upstream_of_or_within ISO (PMID:15039234) RGD PMID:15039234 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Lcn2 lipocalin 2 acts_upstream_of_or_within ISO (PMID:16377569) RGD PMID:16377569 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:5514334|PMID:16543145)
(PMID:16543145)		 UniProt
GO_Central
RGD		 PMID:16543145 GO_REF:0000024 GO_REF:0000033 MGI:5514334 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 acts_upstream_of_or_within ISO MGI:3052673|MGI:894279 (PMID:17903173) RGD PMID:17903173 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3052675|MGI:894316 (PMID:17903173)		 Ensembl
RGD		 PMID:17903173 GO_REF:0000107 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827 		JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643 		JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:1857478 (PMID:15039234)		 Ensembl
RGD		 PMID:15039234 GO_REF:0000107 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Ngf nerve growth factor acts_upstream_of_or_within ISO (PMID:14623868) RGD PMID:14623868 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of ISO (PMID:8206089) RGD PMID:8206089 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 involved_in IMP PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:99702 (PMID:8358790)
GO_REF:0000107		 RGD
Ensembl		 PMID:8358790 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l10 Bcl2-like 10 acts_upstream_of_or_within ISO (PMID:9878060) RGD PMID:9878060 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Col2a1 collagen type II alpha 1 chain involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2152978 (PMID:9299161)		 Ensembl
RGD		 PMID:9299161 GO_REF:0000107 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO MGI:2677796 (PMID:22411810) RGD PMID:22411810 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 acts_upstream_of_or_within ISO (PMID:18322241), (PMID:18971423) RGD PMID:18322241 PMID:18971423 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1857803 (PMID:15817220)		 GO_Central
RGD		 PMID:15817220 GO_REF:0000033 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793 		JBrowse link
G Eya3 EYA transcriptional coactivator and phosphatase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:144,806,523...144,934,522
Ensembl chr 5:144,806,577...144,934,518 		JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647 (PMID:16956603) RGD PMID:16956603 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gas1 growth arrest-specific 1 acts_upstream_of_or_within ISO (PMID:15070677) RGD PMID:15070677 NCBI chr17:4,482,168...4,485,153 JBrowse link
G Gata1 GATA binding protein 1 involved_in ISO (PMID:17167422) RGD PMID:17167422 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Gdnf glial cell derived neurotrophic factor involved_in ISO
IEA		 (PMID:10921886)
GO_REF:0000107		 RGD
Ensembl		 PMID:10921886 GO_REF:0000107 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfral GDNF family receptor alpha like involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:16086688)		 Ensembl
RGD		 PMID:16086688 GO_REF:0000107 NCBI chr 8:76,917,894...76,963,258
Ensembl chr 8:76,918,657...76,959,425 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:17167422) RGD PMID:17167422 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:17167422) RGD PMID:17167422 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:10748004) RGD PMID:10748004 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:8950980)		 Ensembl
RGD		 PMID:8950980 GO_REF:0000107 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 involved_in IMP PMID:20551324 BHF-UCL PMID:20551324 RGD:8553940 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 involved_in ISO
IEA		 UniProtKB:Q62862 (PMID:20551324)
GO_REF:0000107		 RGD
Ensembl		 PMID:20551324 GO_REF:0000107 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISO (PMID:20921992) RGD PMID:20921992 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Nrg1 neuregulin 1 involved_in ISO (PMID:9553078) RGD PMID:9553078 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:9115640)		 Ensembl
RGD		 PMID:9115640 GO_REF:0000107 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:5306563|PMID:20125124) RGD PMID:20125124 MGI:5306563 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:11050396)		 Ensembl
RGD		 PMID:11050396 GO_REF:0000107 NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476 		JBrowse link
G Snai2 snail family transcriptional repressor 2 acts_upstream_of_or_within ISO (PMID:10518215) RGD PMID:10518215 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Stradb STE20 related adaptor beta acts_upstream_of_or_within ISO (PMID:12574163) RGD PMID:12574163 NCBI chr 9:60,414,182...60,433,084
Ensembl chr 9:60,414,182...60,433,084 		JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:10449030) RGD PMID:10449030 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:10666185), (PMID:10748004) RGD PMID:10666185 PMID:10748004 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Unc5b unc-5 netrin receptor B involved_in ISO
IEA		 (PMID:18469807)
GO_REF:0000107		 RGD
Ensembl		 PMID:18469807 GO_REF:0000107 NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537 		JBrowse link
G Zc3hc1 zinc finger, C3HC-type containing 1 acts_upstream_of_or_within ISO (PMID:12748172) RGD PMID:12748172 NCBI chr 4:58,989,989...59,011,925
Ensembl chr 4:58,989,987...59,011,933 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO MGI:2677796 (PMID:22411810) RGD PMID:22411810 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Dapk3 death-associated protein kinase 3 involved_in IMP PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558 		JBrowse link
G Htra2 HtrA serine peptidase 2 involved_in ISO (PMID:20125124) RGD PMID:20125124 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Inhba inhibin subunit beta A involved_in ISO
ISS		 (PMID:8267637)
GO_REF:0000024		 RGD
UniProt		 PMID:8267637 GO_REF:0000024 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) RGD PMID:16020505 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857478 (PMID:15039234)		 Ensembl
RGD		 PMID:15039234 GO_REF:0000107 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha acts_upstream_of_or_within ISO (PMID:12115603) RGD PMID:12115603 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha acts_upstream_of_or_within ISO (PMID:12944463) RGD PMID:12944463 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta involved_in ISO
IEA		 (PMID:21172653)
GO_REF:0000107		 RGD
Ensembl		 PMID:21172653 GO_REF:0000107 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Ret ret proto-oncogene involved_in ISO (PMID:10921886) RGD PMID:10921886 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Srpx sushi-repeat-containing protein, X-linked acts_upstream_of_or_within ISO MGI:3706175 (PMID:17088259) RGD PMID:17088259 NCBI chr  X:12,676,984...12,751,296
Ensembl chr  X:12,566,645...12,747,882 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of_or_within ISO (PMID:8206089) RGD PMID:8206089 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Unc5b unc-5 netrin receptor B involved_in IMP PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537 		JBrowse link
G Wwox WW domain-containing oxidoreductase acts_upstream_of_or_within ISO (PMID:19366691) RGD PMID:19366691 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391 		JBrowse link
regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO MGI:2176216|MGI:2181474 (PMID:16207751), (PMID:18191119) RGD PMID:16207751 PMID:18191119 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    cellular process 18196
      signal transduction 7020
        signal transduction in absence of ligand 78
          extrinsic apoptotic signaling pathway in absence of ligand 76
            negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 35
            positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 14
            regulation of extrinsic apoptotic signaling pathway in absence of ligand + 48
Path 2
Term Annotations click to browse term
  biological_process 19694
    biological regulation 13309
      regulation of biological process 12906
        signaling 7595
          signal transduction 7020
            apoptotic signaling pathway 671
              extrinsic apoptotic signaling pathway 243
                extrinsic apoptotic signaling pathway in absence of ligand 76
                  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 35
                  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 14
                  regulation of extrinsic apoptotic signaling pathway in absence of ligand + 48
paths to the root