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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | mammary gland alveolus development | | ISO | RGD:1619007 | 1624291 | MGI:MGI:4439325 | RGD | MGI:MGI:4438668 PMID:20075866 | mammary gland alveolus development | | IEA | Ensembl:ENSMUSP00000043466 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of apoptotic process | | ISO | RGD:1619007 | 1624291 | MGI:MGI:3775717|PMID:16841086 | RGD | MGI:MGI:3775717 PMID:16841086 | negative regulation of apoptotic process | | IEA | Ensembl:ENSMUSP00000043466 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | negative regulation of apoptotic process | | ISO | RGD:1619007 | 1624291 | MGI:MGI:4439325 | RGD | MGI:MGI:4438668 PMID:20075866 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | | IMP | | | PMID:18469807 | UniProtKB | PMID:18469807 | negative regulation of neuron apoptotic process | | ISO | RGD:1349110 | 1624291 | UniProtKB:Q01105 | RGD | PMID:18374643 | negative regulation of protein catabolic process | | ISO | RGD:1349110 | 1624291 | PMID:18374643 | RGD | PMID:18374643 | positive regulation of JAK-STAT cascade | | ISO | RGD:1619007 | 1624291 | MGI:MGI:4438668|PMID:20075866 | RGD | MGI:MGI:4438668 PMID:20075866 | positive regulation of JAK-STAT cascade | | IEA | Ensembl:ENSMUSP00000043466 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of mammary gland epithelial cell proliferation | | ISO | RGD:1619007 | 1624291 | MGI:MGI:4438668|PMID:20075866 | RGD | MGI:MGI:4438668 PMID:20075866 | positive regulation of mammary gland epithelial cell proliferation | | IEA | Ensembl:ENSMUSP00000043466 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of protein kinase activity | | IDA | | 632423 | PMID:11136977 | GOC | | positive regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1619007 | 1624291 | MGI:MGI:4438668|PMID:20075866 | RGD | MGI:MGI:4438668 PMID:20075866 | positive regulation of transcription from RNA polymerase II promoter | | IEA | Ensembl:ENSMUSP00000043466 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of ARF GTPase activity | | IEA | InterPro:IPR001164 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | small GTPase mediated signal transduction | | IEA | InterPro:IPR013684 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Endocytosis |
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gamma (PID:200214) |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Endocytosis |
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gamma (PID:200214) |
References - curated| 1. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 2. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 3. |
RGD automated data pipeline |
| 4. |
RGD automated import pipeline for gene-chemical interactions |
| 5. |
Ye K, etal., Cell 2000 Dec 8;103(6):919-30. |
References - uncurated
RGD Disease Portals| Agap2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Agap2 (Rattus norvegicus) |
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| AGAP2 (Homo sapiens) |
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| Agap2 (Mus musculus) |
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Position Markers| RH132545 |
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| RH140015 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_023026 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06050234 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01049869 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01049870 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF280816 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY128688 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473950 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_023026 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_075415 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_075415 | (Get FASTA) |
| GenBank Protein | AAF97595 | (Get FASTA) |
| AAM97539 | (Get FASTA) | |
| EDM16498 | (Get FASTA) | |
| Q8CGU4 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000025584 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000029533 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000031230 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 65218 | ENTREZGENE |
| Gene3D-CATH | ANK | UniProtKB/Swiss-Prot |
| PH_type | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000025584 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 86815 | ENTREZGENE |
| InterPro | Ankyrin_rpt | UniProtKB/Swiss-Prot |
| Ankyrin_rpt-contain_dom | UniProtKB/Swiss-Prot | |
| ArfGAP | UniProtKB/Swiss-Prot | |
| MIRO-like | UniProtKB/Swiss-Prot | |
| PH_type | UniProtKB/Swiss-Prot | |
| Pleckstrin_homology | UniProtKB/Swiss-Prot | |
| IPI | IPI00768248 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:65218 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Ank_2 | UniProtKB/Swiss-Prot |
| ArfGap | UniProtKB/Swiss-Prot | |
| Miro | UniProtKB/Swiss-Prot | |
| PF00169 | UniProtKB/Swiss-Prot | |
| PRINTS | REVINTRACTNG | UniProtKB/Swiss-Prot |
| PROSITE | ANK_REP_REGION | UniProtKB/Swiss-Prot |
| ANK_REPEAT | UniProtKB/Swiss-Prot | |
| ARFGAP | UniProtKB/Swiss-Prot | |
| PH_DOMAIN | UniProtKB/Swiss-Prot | |
| RAB | UniProtKB/Swiss-Prot | |
| SMART | ANK | UniProtKB/Swiss-Prot |
| ArfGap | UniProtKB/Swiss-Prot | |
| SM00233 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | ANK | UniProtKB/Swiss-Prot |
| UniGene | Rn.91094 | ENTREZGENE |
| UniProt | AGAP2_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-10-15 | Agap2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | Centg1 | centaurin, gamma 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2003-04-09 | Centg1 | centaurin, gamma 1 | Symbol and Name updated | 2574 | APPROVED | ||
| 2003-03-06 | Centg1 | centaurin, gamma 1 | Pike | nuclear GTPase PIKE | Data Merged | 2447 | PROVISIONAL |
| 2003-02-27 | Centg1 | centaurin, gamma 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2002-08-07 | Pike | nuclear GTPase PIKE | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_process | enhances PI3kinase activity | 632423 |
| gene_protein | 753 amino acid | 632423 |
| More on Agap2 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 628844 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




