Gene: Jak3 (Janus kinase 3)
Rattus norvegicus
Symbol:
Jak3
Name:
Janus kinase 3
Description:
ENCODES a protein that exhibits protein tyrosine kinase activity; INVOLVED IN cytokine-mediated signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of activated T cell proliferation; PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Severe Combined Immunodeficiency (ortholog); Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative (ortholog); FOUND IN cytoplasm; INTERACTS WITH cadmium dichloride; 17beta-estradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
JAK-3; Janus kinase 3; Janus kinase 3 protein-tyrosine kinase; Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; RATJAK3; tyrosine-protein kinase JAK3
Orthologs:
Homo sapiens : JAK3
(Janus kinase 3)
HGNC
Jak3
(Janus kinase 3)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 16 p14 NCBI RGSC Genome Assembly v5.0 16 19,969,814 - 19,981,132 + NCBI RGSC Genome Assembly v3.4 16 18,878,139 - 18,889,441 + NCBI Rat Celera Assembly 16 18,589,820 - 18,601,138 + NCBI Genome Assembly 3.1 16 18,878,136 - 18,889,439 + NCBI RH 3.4 16 181.8 RGD
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17beta-estradiol increases expression ISO RGD:10824 6480464 Estradiol results in increased expression of JAK3 mRNA CTD PMID:15289156 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10824 6480464 Tetrachlorodibenzodioxin affects the expression of JAK3 mRNA CTD PMID:21570461 afimoxifene decreases response to substance ISO RGD:737593 6480464 JAK3 results in decreased susceptibility to 4-hydroxytamoxifen CTD PMID:21233418 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of JAK3 promoter CTD PMID:22457795 cadmium dichloride increases expression ISO RGD:737593 6480464 Cadmium Chloride results in increased expression of JAK3 mRNA CTD PMID:12160620 curcumin decreases activity ISO RGD:737593 6480464 Curcumin results in decreased activity of JAK3 protein CTD PMID:16932349 diethylstilbestrol increases expression ISO RGD:737593 6480464 Diethylstilbestrol results in increased expression of JAK3 mRNA CTD PMID:15766595 diethylstilbestrol increases expression ISO RGD:10824 6480464 Diethylstilbestrol results in increased expression of JAK3 mRNA CTD PMID:15289156 genistein increases expression ISO RGD:10824 6480464 Genistein results in increased expression of JAK3 mRNA CTD PMID:15289156 hypochlorous acid decreases expression ISO RGD:10824 6480464 Hypochlorous Acid results in decreased expression of JAK3 mRNA CTD PMID:19376150 methotrexate decreases expression ISO RGD:737593 6480464 Methotrexate results in decreased expression of JAK3 mRNA CTD PMID:17400583 methylphenidate decreases expression ISO RGD:10824 6480464 Methylphenidate results in decreased expression of JAK3 mRNA CTD PMID:22470460 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:10824 6480464 Ethylnitrosourea results in increased mutagenesis of JAK3 gene CTD PMID:16724327 paracetamol affects expression ISO RGD:10824 6480464 Acetaminophen affects the expression of JAK3 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:737593 6480464 Acetaminophen results in increased expression of JAK3 mRNA CTD PMID:22230336 pirinixic acid multiple interactions ISO RGD:10824 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of JAK3 mRNA CTD PMID:19710929 prostaglandin E2 multiple interactions ISO RGD:737593 6480464 Dinoprostone results in decreased phosphorylation of and results in decreased activity of JAK3 protein CTD PMID:19812686 tamibarotene decreases expression ISO RGD:10824 6480464 Am 80 results in decreased expression of JAK3 mRNA; more ... CTD PMID:20861477 tamoxifen increases expression ISO RGD:10824 6480464 Tamoxifen results in increased expression of JAK3 mRNA CTD PMID:19031437 vanadium atom decreases expression ISO RGD:737593 6480464 Vanadium results in decreased expression of JAK3 mRNA CTD PMID:19000753 vanadium(0) decreases expression ISO RGD:737593 6480464 Vanadium results in decreased expression of JAK3 mRNA CTD PMID:19000753 zinc atom increases expression ISO RGD:737593 6480464 Zinc results in increased expression of JAK3 mRNA CTD PMID:19071009 zinc(0) increases expression ISO RGD:737593 6480464 Zinc results in increased expression of JAK3 mRNA CTD PMID:19071009 zoledronic acid increases expression ISO RGD:737593 6480464 zoledronic acid results in increased expression of JAK3 mRNA CTD PMID:20977926
1600369 Hcas8 Hepatocarcinoma susceptibility QTL 8 Liver tumor susceptibility nodule number 16 1 24132402 Rat 631830 Alc7 Alcohol consumption QTL 7 2.9 Consumption level alcohol preference 16 1 26804456 Rat 634355 Rends4 Renal damage susceptibility QTL 4 .05 Renal histology renal lesion severity 16 1 26804456 Rat 1582235 Insul8 Insulin level QTL 8 3.3 .0063 Insulin level 16 1 26804456 Rat 2302380 Slep6 Serum leptin concentration QTL 6 3.36 Hormone level leptin 16 1 32464321 Rat 2307172 Activ4 Activity QTL 4 3.71 .00023 Activity level Locomotor activity 16 1 33735317 Rat 1354584 Despr6 Despair related QTL 6 .0067 Activity level immobility level 16 1 40096603 Rat 2303566 Bw90 Body weight QTL 90 2 Body weight 16 1 40096603 Rat 631561 Hcuc2 Hepatic copper content QTL 2 2.8 Copper level hepatic 16 1 40096622 Rat 6903319 Bw114 Body weight QTL 114 2.7 .0037 Body weight 16 172013 45172013 Rat 1600378 Arunc4 Aerobic running capacity QTL 4 .03 Aerobic running capacity best distance run to exhaustion 16 350121 85734479 Rat 2293343 Glom16 Glomerulus QTL 16 9.1 Renal pathology glomerulus inflammation 16 819225 49333382 Rat 2312660 Bw95 Body weight QTL 95 .05 Body weight adiposity index 16 819225 63306215 Rat 2312663 Slep9 Serum leptin concentration QTL 9 .001 Hormone level leptin 16 819225 63306215 Rat 2312666 Insul16 Insulin level QTL 16 .01 Insulin level serum 16 819225 63306215 Rat 2312669 Stl23 Serum triglyceride level QTL 23 .01 Lipid level triglyceride 16 819225 63306215 Rat 1354625 Despr7 Despair related QTL 7 .016 Activity level immobility and climbing levels 16 1632183 46632183 Rat 1300133 Rf24 Renal function QTL 24 3.64 Renal function salt-loaded creatinine clearance 16 3464719 22979073 Rat 2306902 Bp339 Blood pressure QTL 339 .01 Blood pressure salt-loaded systolic 16 3464719 46137590 Rat 70183 BpQTLcluster13 Blood pressure QTL cluster 13 3.325 Blood pressure 16 4304396 46137590 Rat 61338 Bp23 Blood pressure QTL 23 4.3 Blood pressure salt-loaded systolic 16 4304396 49304396 Rat 737819 Hcas4 Hepatocarcinoma susceptibility QTL 4 4.43 Liver tumor susceptibility nodule number 16 4304396 50266190 Rat 61405 Niddm6 Non-insulin dependent diabetes mellitus QTL 6 3.66 .001 Glucose level 16 4304396 52304351 Rat 737826 Alc11 Alcohol consumption QTL 11 3.2 Consumption level alcohol preference 16 4304396 64081533 Rat 1357403 Slep4 Serum leptin concentration QTL 4 3.91 Hormone level leptin 16 9964433 30560825 Rat 631517 Scl9 Serum cholesterol level QTL 9 3.3 Lipid level cholesterol 16 16194598 22671959 Rat 70205 Gcr3 Gastric cancer resistance QTL 3 2.2 Gastric tumor resistance tumor invasions depth 16 18121291 70196694 Rat
Gene-Chemical Interaction Annotations
