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ONTOLOGY REPORT - ANNOTATIONS


Term:macrophage differentiation
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Accession:GO:0030225 term browser browse the term
Definition:The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
Synonyms:exact_synonym: macrophage cell differentiation



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macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl2 ASXL transcriptional regulator 2 acts_upstream_of ISO (PMID:21490954) RGD PMID:21490954 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:21149635)
Ensembl
RGD
PMID:21149635 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Casp8 caspase 8 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:2176089 (PMID:15322156)
GO_Central
RGD
PMID:15322156 GO_REF:0000033 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cd4 Cd4 molecule involved_in ISO (PMID:24942581) RGD PMID:24942581 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha acts_upstream_of_or_within ISO MGI:2177135 (PMID:15073037) RGD PMID:15073037 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon acts_upstream_of_or_within ISO MGI:2178607 (PMID:11861297) RGD PMID:11861297 NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814
JBrowse link
G Csf1 colony stimulating factor 1 acts_upstream_of IEP
ISO
IDA
MGI:1856333 (PMID:9215625) RGD PMID:9215625 PMID:12379742 PMID:20628067 RGD:628338, RGD:5131511 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:24942581) RGD PMID:24942581 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Diaph3 diaphanous-related formin 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:26471482)
Ensembl
RGD
PMID:26471482 GO_REF:0000107 NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2679454 (PMID:17932563)
Ensembl
RGD
PMID:17932563 GO_REF:0000107 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:1857079 (PMID:23717624) RGD PMID:23717624 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3757560 (PMID:30181393), (PMID:31135379)
Ensembl
RGD
PMID:30181393 PMID:31135379 GO_REF:0000107 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Gata3 GATA binding protein 3 involved_in ISO (MGI:6856556|PMID:34644537) RGD PMID:34644537 MGI:6856556 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:30634164) RGD PMID:30634164 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ighe immunoglobulin heavy constant epsilon involved_in ISO (PMID:30956175) RGD PMID:30956175
G Il15 interleukin 15 involved_in ISO
IEA
(PMID:24942581)
GO_REF:0000107
RGD
Ensembl
PMID:24942581 GO_REF:0000107 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6856556|PMID:34644537)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:34644537 GO_REF:0000024 GO_REF:0000107 MGI:6856556 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il33 interleukin 33 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6856556|PMID:34644537)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:34644537 GO_REF:0000024 GO_REF:0000107 MGI:6856556 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 acts_upstream_of_or_within ISO MGI:3579468 (PMID:15889154) RGD PMID:15889154 NCBI chr 1:18,988,763...19,089,247
Ensembl chr 1:18,990,618...19,089,263
JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 acts_upstream_of_or_within ISO MGI:1856965 (PMID:25661440) RGD PMID:25661440 NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930
JBrowse link
G Nfix nuclear factor I X acts_upstream_of_or_within ISO MGI:3802570 (PMID:32183151) RGD PMID:32183151 NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265
JBrowse link
G Nkx2-3 NK2 homeobox 3 acts_upstream_of_or_within ISO MGI:2448069 (PMID:10926756) RGD PMID:10926756 NCBI chr 1:242,478,130...242,481,083
Ensembl chr 1:242,478,130...242,481,083
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:24942581) RGD PMID:24942581 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA
(MGI:5319292|PMID:22315447)
GO_REF:0000107
RGD
Ensembl
PMID:22315447 GO_REF:0000107 MGI:5319292 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO
IEA
(PMID:32634427)
GO_REF:0000107
RGD
Ensembl
PMID:32634427 GO_REF:0000107 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Spi1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO (PMID:11980719) RGD PMID:11980719 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
G Spib Spi-B transcription factor acts_upstream_of_or_within ISO (PMID:11980719) RGD PMID:11980719 NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780
JBrowse link
G Ucp2 uncoupling protein 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:6856556|PMID:34644537)
UniProt
RGD
PMID:34644537 GO_REF:0000024 MGI:6856556 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA
(PMID:21149635)
GO_REF:0000107
RGD
Ensembl
PMID:21149635 GO_REF:0000107 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of ISO MGI:5320483 (PMID:22615127) RGD PMID:22615127 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782
JBrowse link
microglia development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO
IEA
UniProtKB:P49768|UniProtKB:Q9QUN7 (PMID:22198949)
GO_REF:0000107
RGD
Ensembl
PMID:22198949 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:33450391 RGD:126781687 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Itgam integrin subunit alpha M acts_upstream_of_or_within ISO (PMID:20578039) RGD PMID:20578039 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Nrros negative regulator of reactive oxygen species involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:6141908|PMID:28459434), (MGI:6192878|PMID:29909984)
UniProt
Ensembl
RGD
PMID:28459434 PMID:29909984 GO_REF:0000024 GO_REF:0000107 MGI:6141908 MGI:6192878 NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142
JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:5307186|PMID:22198949) RGD PMID:22198949 MGI:5307186 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tspan2 tetraspanin 2 acts_upstream_of_or_within ISO MGI:5556057|MGI:97623 (PMID:24038504) RGD PMID:24038504 NCBI chr 2:190,177,717...190,234,994
Ensembl chr 2:190,177,741...190,219,660
JBrowse link
microglia differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:1857079 (PMID:23717624) RGD PMID:23717624 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Gba1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (PMID:17954912) RGD PMID:17954912 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO (PMID:27654426) RGD PMID:27654426 NCBI chr 2:123,822,042...123,847,808
Ensembl chr 2:123,816,614...123,857,971
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of_or_within ISO MGI:2385681 (PMID:18509511) RGD PMID:18509511 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (PMID:18509511) RGD PMID:18509511 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972
JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO MGI:2676199 (PMID:29654250) RGD PMID:29654250 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:29890290)
Ensembl
RGD
PMID:29890290 GO_REF:0000107 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6514532|PMID:33378678)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:33378678 GO_REF:0000024 GO_REF:0000107 MGI:6514532 NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1860885 (PMID:18509511)
Ensembl
RGD
PMID:18509511 GO_REF:0000107 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Vps13a vacuolar protein sorting 13 homolog A acts_upstream_of_or_within ISO (PMID:37714309) RGD PMID:37714309 NCBI chr 1:213,901,999...214,128,638
Ensembl chr 1:213,901,999...214,128,555
JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in IEA
ISO
GO_REF:0000107
MGI:1857091 (PMID:29890290)
Ensembl
RGD
PMID:29890290 GO_REF:0000107 NCBI chr14:95,378,821...95,455,871
Ensembl chr14:95,378,012...95,455,857
JBrowse link
negative regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS
(PMID:10961870)
GO_REF:0000024
RGD
UniProt
PMID:10961870 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA
(PMID:10961870)
GO_REF:0000107
RGD
Ensembl
PMID:10961870 GO_REF:0000107 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO (PMID:16254139) RGD PMID:16254139 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Mir486 microRNA 486 involved_in ISO (PMID:25857263) RGD PMID:25857263
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:3629372|PMID:16705167)
UniProt
Ensembl
RGD
PMID:16705167 GO_REF:0000024 GO_REF:0000107 MGI:3629372 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISS
ISO
GO_REF:0000024
(PMID:22398723)
UniProt
RGD
PMID:22398723 GO_REF:0000024 NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
JBrowse link
G Thoc5 THO complex subunit 5 acts_upstream_of_or_within ISO (PMID:10597251) RGD PMID:10597251 NCBI chr14:79,758,805...79,792,718
Ensembl chr14:79,758,917...79,792,718
JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (PMID:22615127) RGD PMID:22615127 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782
JBrowse link
positive regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl2 ASXL transcriptional regulator 2 acts_upstream_of_or_within ISO (PMID:21490954) RGD PMID:21490954 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477
JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10822112) RGD PMID:10822112 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp8 caspase 8 involved_in ISO (PMID:17047155) RGD PMID:17047155 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Csf1 colony stimulating factor 1 involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
(PMID:2460758)
MGI:1856333 (PMID:9215625)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:2460758 PMID:9215625 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf2 colony stimulating factor 2 TAS RGD PMID:14504066 RGD:727979 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Fadd Fas associated via death domain involved_in ISO (PMID:17047155) RGD PMID:17047155 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 involved_in ISO (MGI:5448611|PMID:23001182) RGD PMID:23001182 MGI:5448611 NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014
JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:24504023) RGD PMID:24504023 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:97874 (PMID:15616565) RGD PMID:15616565 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Il34 interleukin 34 involved_in ISO
IBA
IEA
(PMID:23409120)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:23409120 GO_REF:0000033 GO_REF:0000107 NCBI chr19:38,714,990...38,782,749
Ensembl chr19:38,714,991...38,764,000
JBrowse link
G Lif LIF, interleukin 6 family cytokine acts_upstream_of_or_within ISO (PMID:7957045) RGD PMID:7957045 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Mir145 microRNA 145 acts_upstream_of ISO (PMID:30634164) RGD PMID:30634164 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Prkca protein kinase C, alpha involved_in ISS
ISO
GO_REF:0000024
(MGI:5306334|PMID:9508782)
UniProt
RGD
PMID:9508782 GO_REF:0000024 MGI:5306334 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96397 (PMID:15616565)
Ensembl
RGD
PMID:15616565 GO_REF:0000107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:17047155) RGD PMID:17047155 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ror2 receptor tyrosine kinase-like orphan receptor 2 IMP RGD PMID:25749876 RGD:11537353 NCBI chr17:11,972,830...12,148,152
Ensembl chr17:11,972,830...12,148,152
JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) RGD PMID:23515163 MGI:5488531 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
positive regulation of microglia differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6192878|PMID:29909984)
UniProt
RGD
PMID:29909984 GO_REF:0000024 MGI:6192878 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Qki QKI, KH domain containing RNA binding involved_in IEA
ISO
GO_REF:0000107
(PMID:27029405)
Ensembl
RGD
PMID:27029405 GO_REF:0000107 NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      cellular developmental process 4695
        cell differentiation 4694
          myeloid cell differentiation 506
            myeloid leukocyte differentiation 280
              macrophage differentiation 67
                microglia differentiation + 18
                negative regulation of macrophage differentiation + 8
                positive regulation of macrophage differentiation + 19
                regulation of macrophage differentiation + 27
Path 2
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      cellular developmental process 4695
        cell differentiation 4694
          cell development 3269
            hemopoiesis 1061
              leukocyte differentiation 674
                myeloid leukocyte differentiation 280
                  macrophage differentiation 67
                    microglia differentiation + 18
                    negative regulation of macrophage differentiation + 8
                    positive regulation of macrophage differentiation + 19
                    regulation of macrophage differentiation + 27
paths to the root