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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elicitor
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Accession:CHEBI:192504 term browser browse the term
Definition:A chemical or biochemical compound that is introduced in small concentrations to a living system to promote the biosynthesis of the target bioactive compound.
Synonyms:related_synonym: elicitors
 xref: PMID:25969762;   Wikipedia:Elicitor


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chitosan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions ISO [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA] CTD PMID:28987369 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein]
Chitosan results in decreased phosphorylation of AKT1 protein		 CTD PMID:28732690 PMID:36706893 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein] CTD PMID:22704994 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated increases expression EXP Chitosan results in increased expression of ALPL mRNA; Chitosan results in increased expression of ALPL protein CTD PMID:25246786 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G AOX1 aldehyde oxidase 1 multiple interactions ISO [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA] CTD PMID:28987369 NCBI chr 2:200,586,014...200,682,241
Ensembl chr 2:200,586,014...200,677,064 		JBrowse link
G ARB2A ARB2 cotranscriptional regulator A multiple interactions
increases expression		 EXP ARB2A protein affects the reaction [Chitosan results in decreased expression of CPE protein]; ARB2A protein affects the reaction [Chitosan results in decreased expression of MMP9 protein]; ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK1 protein]; ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK3 protein]
Chitosan results in increased expression of ARB2A mRNA		 CTD PMID:36706893 NCBI chr 5:93,617,725...94,111,699
Ensembl chr 5:93,617,725...94,111,699 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in increased expression of BAX protein
Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of BAX protein]		 CTD PMID:18567086 PMID:30928397 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in decreased expression of BCL2 protein
[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]		 CTD PMID:18567086 PMID:28732690 PMID:30928397 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression EXP Chitosan results in increased expression of BGLAP mRNA CTD PMID:25246786 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO		 Chitosan metabolite inhibits the reaction [Copper results in increased activity of CASP3 protein]
Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Chitosan inhibits the reaction [carbendazim results in increased expression of CASP3 protein]		 CTD PMID:25542178 PMID:30928397 PMID:35705592 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions ISO Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:30928397 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO [Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; Chitosan inhibits the reaction [carbendazim results in decreased expression of CAT protein]; Chitosan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:12679053 PMID:22704994 PMID:27923682 PMID:30928397 PMID:35705592 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CLEC7A C-type lectin domain containing 7A multiple interactions
decreases expression		 EXP Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC7A mRNA]
Chitosan results in decreased expression of CLEC7A mRNA		 CTD PMID:21329777 NCBI chr12:10,116,777...10,130,304
Ensembl chr12:10,116,777...10,130,258 		JBrowse link
G COL15A1 collagen type XV alpha 1 chain decreases expression EXP Chitosan results in decreased expression of COL15A1 mRNA CTD PMID:36706893 NCBI chr 9:98,943,907...99,070,787
Ensembl chr 9:98,943,179...99,070,787 		JBrowse link
G CPE carboxypeptidase E multiple interactions
decreases expression		 EXP ARB2A protein affects the reaction [Chitosan results in decreased expression of CPE protein]
Chitosan results in decreased expression of CPE mRNA; Chitosan results in decreased expression of CPE protein		 CTD PMID:36706893 NCBI chr 4:165,379,008...165,498,547
Ensembl chr 4:165,361,194...165,498,547 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases activity EXP Chitosan analog results in increased activity of CYP3A4 protein CTD PMID:20831879 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Fish Oils promotes the reaction [Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]] CTD PMID:28987369 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 increases expression EXP Chitosan results in increased expression of DKK1 mRNA CTD PMID:36706893 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042 		JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA] CTD PMID:28987369 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FASN fatty acid synthase multiple interactions ISO [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:28987369 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FOXO3 forkhead box O3 decreases phosphorylation EXP Chitosan results in decreased phosphorylation of FOXO3 protein CTD PMID:36706893 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G GCG glucagon increases expression
increases secretion
multiple interactions		 EXP Chitosan results in increased expression of GCG mRNA
Chitosan results in increased secretion of GCG protein
SB 203580 inhibits the reaction [Chitosan results in increased expression of GCG mRNA]; SB 203580 inhibits the reaction [Chitosan results in increased secretion of GCG protein]		 CTD PMID:23611362 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO Chitosan inhibits the reaction [carbendazim results in increased secretion of GOT1 protein] CTD PMID:35705592 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Chitosan inhibits the reaction [carbendazim results in increased secretion of GPT protein] CTD PMID:35705592 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
increases expression		 ISO [Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]; [Chitosan analog co-treated with Quercetin] results in increased expression of GPX1 mRNA; Chitosan analog inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]
Chitosan analog results in increased expression of GPX1 mRNA		 CTD PMID:27923682 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA] CTD PMID:30928397 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:28987369 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP
ISO		 [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 mRNA; [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 protein
Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; Chitosan inhibits the reaction [carbendazim results in decreased expression of HMOX1 mRNA]		 CTD PMID:25542178 PMID:30928397 PMID:35705592 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL10 interleukin 10 multiple interactions
increases secretion		 EXP Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Chitosan results in increased secretion of IL10 protein		 CTD PMID:21329777 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL6 interleukin 6 increases secretion
multiple interactions		 EXP Chitosan results in increased secretion of IL6 protein
Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]		 CTD PMID:21329777 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO Chitosan inhibits the reaction [carbendazim results in increased expression of KEAP1 mRNA] CTD PMID:35705592 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation
multiple interactions		 EXP Chitosan results in decreased phosphorylation of MAPK1 protein
ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:36706893 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
Chitosan results in decreased phosphorylation of MAPK3 protein
ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:28732690 PMID:36706893 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO Chitosan inhibits the reaction [Aminolevulinic Acid analog results in increased activity of MMP2 protein] CTD PMID:18806744 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP Chitosan results in decreased expression of MMP9 mRNA; Chitosan results in decreased expression of MMP9 protein
ARB2A protein affects the reaction [Chitosan results in decreased expression of MMP9 protein]		 CTD PMID:36706893 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization		 EXP
ISO		 [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased phosphorylation of NFE2L2 protein
Chitosan analog affects the localization of NFE2L2 protein
Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]; Chitosan inhibits the reaction [carbendazim results in decreased expression of NFE2L2 mRNA]; pyrazolanthrone inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; SB 203580 inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]		 CTD PMID:25542178 PMID:30928397 PMID:35705592 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Chitosan inhibits the reaction [carbendazim results in increased expression of NOS2 protein] CTD PMID:35705592 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA] CTD PMID:30928397 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 multiple interactions ISO [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in increased expression of NR1H3 protein] CTD PMID:28987369 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha decreases phosphorylation EXP Chitosan results in decreased phosphorylation of PIK3CA protein CTD PMID:36706893 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation EXP Chitosan results in decreased phosphorylation of PIK3R1 protein CTD PMID:36706893 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein] CTD PMID:28987369 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP Chitosan results in increased expression of PPARGC1A mRNA CTD PMID:36706893 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression EXP Chitosan results in increased expression of RUNX2 mRNA; Chitosan results in increased expression of RUNX2 protein CTD PMID:25246786 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression
multiple interactions		 ISO Chitosan analog results in increased expression of SOD1 mRNA
[Chitosan analog co-treated with Quercetin] results in increased expression of SOD1 mRNA; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of SOD1 mRNA]		 CTD PMID:27923682 PMID:30928397 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SPARCL1 SPARC like 1 decreases expression EXP Chitosan results in decreased expression of SPARCL1 mRNA CTD PMID:36706893 NCBI chr 4:87,473,335...87,529,376
Ensembl chr 4:87,473,335...87,531,061 		JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression EXP Chitosan results in increased expression of SPP1 mRNA CTD PMID:25246786 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:28987369 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TLR2 toll like receptor 2 multiple interactions
decreases expression		 EXP Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]
Chitosan results in decreased expression of TLR2 mRNA		 CTD PMID:21329777 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260 		JBrowse link
G TLR4 toll like receptor 4 decreases expression
multiple interactions		 EXP Chitosan results in decreased expression of TLR4 mRNA
Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA]		 CTD PMID:21329777 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion		 EXP Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Chitosan results in increased secretion of TNF protein		 CTD PMID:21329777 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TPH1 tryptophan hydroxylase 1 multiple interactions ISO [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein] CTD PMID:22704994 NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,555...18,046,269 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        biochemical role 25168
          elicitor 56
            chitosan 56
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