SPARCL1 (SPARC like 1) - Rat Genome Database

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Gene: SPARCL1 (SPARC like 1) Homo sapiens
Analyze
Symbol: SPARCL1
Name: SPARC like 1
RGD ID: 736595
HGNC Page HGNC:11220
Description: Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Predicted to be involved in regulation of synapse organization. Located in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hevin; high endothelial venule protein; MAST 9; mast9; PIG33; proliferation-inducing protein 33; SC1; sparc-like 1; SPARC-like 1 (hevin); SPARC-like 1 (mast9, hevin); SPARC-like protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,473,335 - 87,529,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,473,335 - 87,531,061 (-)EnsemblGRCh38hg38GRCh38
GRCh37488,394,487 - 88,450,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,613,511 - 88,669,530 (-)NCBINCBI36Build 36hg18NCBI36
Build 34488,751,668 - 88,807,685NCBI
Celera485,683,694 - 85,739,861 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,140,423 - 84,196,598 (-)NCBIHuRef
CHM1_1488,371,316 - 88,427,455 (-)NCBICHM1_1
T2T-CHM13v2.0490,802,350 - 90,858,405 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (EXP)
chitosan  (EXP)
choline  (ISO)
chrysene  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
dichloroacetic acid  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fentin chloride  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
inulin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lead(0)  (EXP)
leflunomide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
miconazole  (ISO)
N-nitrosodiethylamine  (ISO)
nitrofen  (ISO)
O-methyleugenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP,ISO)
undecane  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7600298   PMID:8488563   PMID:8626806   PMID:10735494   PMID:12477932   PMID:12538579   PMID:15146195   PMID:15231748   PMID:16316624   PMID:16335952   PMID:16344560   PMID:16502470  
PMID:16844696   PMID:17043677   PMID:17825989   PMID:18381651   PMID:18384059   PMID:19834535   PMID:20029029   PMID:20237496   PMID:20926826   PMID:21528083   PMID:21653829   PMID:21873635  
PMID:21887554   PMID:22161898   PMID:22891198   PMID:22909274   PMID:22927397   PMID:23376485   PMID:23916135   PMID:24121790   PMID:24412244   PMID:24661672   PMID:26294211   PMID:26490986  
PMID:27068509   PMID:27357901   PMID:27721236   PMID:28543098   PMID:28944877   PMID:29084211   PMID:29102542   PMID:29154276   PMID:30639238   PMID:30656447   PMID:30883351   PMID:30964161  
PMID:30987093   PMID:31154721   PMID:31675488   PMID:31830525   PMID:32248722   PMID:32437418   PMID:33535026   PMID:33961781   PMID:34033869   PMID:34435512   PMID:34921028   PMID:35111844  
PMID:35136209   PMID:35549806   PMID:35914814   PMID:36830603   PMID:37180578   PMID:38762489  


Genomics

Comparative Map Data
SPARCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,473,335 - 87,529,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,473,335 - 87,531,061 (-)EnsemblGRCh38hg38GRCh38
GRCh37488,394,487 - 88,450,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,613,511 - 88,669,530 (-)NCBINCBI36Build 36hg18NCBI36
Build 34488,751,668 - 88,807,685NCBI
Celera485,683,694 - 85,739,861 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,140,423 - 84,196,598 (-)NCBIHuRef
CHM1_1488,371,316 - 88,427,455 (-)NCBICHM1_1
T2T-CHM13v2.0490,802,350 - 90,858,405 (-)NCBIT2T-CHM13v2.0
Sparcl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,226,974 - 104,261,954 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,226,977 - 104,261,599 (-)EnsemblGRCm39 Ensembl
GRCm385104,079,108 - 104,114,088 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,079,111 - 104,113,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv375104,508,127 - 104,543,107 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,319,413 - 104,354,006 (-)NCBIMGSCv36mm8
Celera5101,385,822 - 101,420,665 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.55NCBI
Sparcl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,937,484 - 5,968,532 (+)NCBIGRCr8
mRatBN7.2145,632,816 - 5,663,866 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,632,569 - 5,663,865 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,601,783 - 5,632,794 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,902,017 - 6,933,024 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,600,631 - 5,631,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,994,261 - 7,025,309 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,994,190 - 7,025,308 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,985,394 - 7,016,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,766,347 - 6,797,581 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,766,346 - 6,797,580 (+)NCBI
Celera145,771,812 - 5,802,805 (+)NCBICelera
Cytogenetic Map14p22NCBI
Sparcl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554742,370,237 - 2,391,285 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554742,352,662 - 2,387,237 (+)NCBIChiLan1.0ChiLan1.0
SPARCL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,482,960 - 85,539,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,745,304 - 85,802,172 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,769,085 - 79,825,430 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,495,769 - 90,551,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,498,810 - 90,521,665 (-)Ensemblpanpan1.1panPan2
SPARCL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13210,900,072 - 10,944,392 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3210,900,283 - 10,944,449 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3231,007,287 - 31,054,380 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03210,952,571 - 11,000,120 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3210,951,778 - 11,075,914 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,033,129 - 11,080,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,861,716 - 10,909,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03229,049,580 - 29,093,862 (+)NCBIUU_Cfam_GSD_1.0
Sparcl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052852,115,830 - 2,154,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936905535,355 - 574,734 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936905535,589 - 574,719 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPARCL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,386,973 - 131,431,200 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,386,804 - 131,431,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,599,058 - 140,643,513 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPARCL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,858,402 - 35,914,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl735,857,559 - 35,915,115 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603714,558,006 - 14,615,157 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sparcl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248723,981,072 - 3,997,533 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248723,981,166 - 4,015,843 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SPARCL1
32 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3		 pathogenic
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
Chr4:4q13.3-22.1		 pathogenic
GRCh38/hg38 4q21.21-22.1(chr4:79575748-92412449)x1 copy number loss See cases [RCV000053297] Chr4:79575748..92412449 [GRCh38]
Chr4:80496902..93333600 [GRCh37]
Chr4:80715926..93552623 [NCBI36]
Chr4:4q21.21-22.1		 pathogenic
NM_001128310.2(SPARCL1):c.1736G>A (p.Arg579Lys) single nucleotide variant Malignant melanoma [RCV000066567] Chr4:87480453 [GRCh38]
Chr4:88401605 [GRCh37]
Chr4:88620629 [NCBI36]
Chr4:4q22.1		 not provided
NM_001128310.2(SPARCL1):c.1570C>T (p.Pro524Ser) single nucleotide variant Malignant melanoma [RCV000066568] Chr4:87482522 [GRCh38]
Chr4:88403674 [GRCh37]
Chr4:88622698 [NCBI36]
Chr4:4q22.1		 not provided
GRCh38/hg38 4q21.3-22.1(chr4:87067415-88158276)x3 copy number gain See cases [RCV000134183] Chr4:87067415..88158276 [GRCh38]
Chr4:87988567..89079428 [GRCh37]
Chr4:88207591..89298452 [NCBI36]
Chr4:4q21.3-22.1		 uncertain significance
GRCh38/hg38 4q21.21-22.3(chr4:80879777-94809447)x1 copy number loss See cases [RCV000134977] Chr4:80879777..94809447 [GRCh38]
Chr4:81800931..95730598 [GRCh37]
Chr4:82019955..95949621 [NCBI36]
Chr4:4q21.21-22.3		 pathogenic
GRCh38/hg38 4q21.23-22.1(chr4:84329551-87679204)x1 copy number loss See cases [RCV000136623] Chr4:84329551..87679204 [GRCh38]
Chr4:85250704..88600356 [GRCh37]
Chr4:85469728..88819380 [NCBI36]
Chr4:4q21.23-22.1		 pathogenic
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1 copy number loss See cases [RCV000137269] Chr4:80427023..100855441 [GRCh38]
Chr4:81348177..101776598 [GRCh37]
Chr4:81567201..101995621 [NCBI36]
Chr4:4q21.21-24		 pathogenic
GRCh38/hg38 4q21.23-22.2(chr4:84329551-93654474)x1 copy number loss See cases [RCV000139231] Chr4:84329551..93654474 [GRCh38]
Chr4:85250704..94575625 [GRCh37]
Chr4:85469728..94794648 [NCBI36]
Chr4:4q21.23-22.2		 likely benign
GRCh38/hg38 4q21.23-22.2(chr4:85449365-93973194)x1 copy number loss See cases [RCV000141424] Chr4:85449365..93973194 [GRCh38]
Chr4:86370518..94894345 [GRCh37]
Chr4:86589542..95113368 [NCBI36]
Chr4:4q21.23-22.2		 pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3		 pathogenic
GRCh37/hg19 4q21.23-22.1(chr4:85839771-93071150)x1 copy number loss See cases [RCV000446648] Chr4:85839771..93071150 [GRCh37]
Chr4:4q21.23-22.1		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q21.23-24(chr4:85805268-103678797)x1 copy number loss See cases [RCV000445741] Chr4:85805268..103678797 [GRCh37]
Chr4:4q21.23-24		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:82283358-90341831)x1 copy number loss See cases [RCV000447691] Chr4:82283358..90341831 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_004684.6(SPARCL1):c.1453C>A (p.Leu485Ile) single nucleotide variant not specified [RCV004329089] Chr4:87490351 [GRCh38]
Chr4:88411503 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1130T>C (p.Ile377Thr) single nucleotide variant not specified [RCV004321222] Chr4:87493670 [GRCh38]
Chr4:88414822 [GRCh37]
Chr4:4q22.1		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q22.1(chr4:88397372-88453911)x1 copy number loss not provided [RCV000682432] Chr4:88397372..88453911 [GRCh37]
Chr4:4q22.1		 uncertain significance
GRCh37/hg19 4q21.21-22.3(chr4:81314915-96636651)x1 copy number loss not provided [RCV000682426] Chr4:81314915..96636651 [GRCh37]
Chr4:4q21.21-22.3		 pathogenic
GRCh37/hg19 4q21.3-22.1(chr4:87984263-89193590)x3 copy number gain not provided [RCV000682431] Chr4:87984263..89193590 [GRCh37]
Chr4:4q21.3-22.1		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:80482400-92572499)x1 copy number loss See cases [RCV000790579] Chr4:80482400..92572499 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
NM_004684.6(SPARCL1):c.1198G>C (p.Glu400Gln) single nucleotide variant not specified [RCV004287734] Chr4:87493602 [GRCh38]
Chr4:88414754 [GRCh37]
Chr4:4q22.1		 uncertain significance
Single allele deletion Autosomal dominant polycystic kidney disease [RCV001254217] Chr4:88075149..90714489 [GRCh37]
Chr4:4q22.1		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q21.23-22.1(chr4:85839771-93071150) copy number loss not specified [RCV002053440] Chr4:85839771..93071150 [GRCh37]
Chr4:4q21.23-22.1		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:80467886-93362064)x1 copy number loss not provided [RCV001829208] Chr4:80467886..93362064 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
GRCh37/hg19 4q13.3-22.1(chr4:75737340-91131156) copy number gain not specified [RCV002053429] Chr4:75737340..91131156 [GRCh37]
Chr4:4q13.3-22.1		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:81054789-90667421) copy number loss not specified [RCV002053435] Chr4:81054789..90667421 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
GRCh37/hg19 4q22.1(chr4:88063686-88517522)x3 copy number gain not provided [RCV001836531] Chr4:88063686..88517522 [GRCh37]
Chr4:4q22.1		 uncertain significance
GRCh37/hg19 4q21.21-22.2(chr4:79780152-94873225) copy number loss not specified [RCV002053432] Chr4:79780152..94873225 [GRCh37]
Chr4:4q21.21-22.2		 pathogenic
NM_004684.6(SPARCL1):c.1534A>G (p.Ile512Val) single nucleotide variant not specified [RCV004322653] Chr4:87482558 [GRCh38]
Chr4:88403710 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1462A>T (p.Thr488Ser) single nucleotide variant not specified [RCV004083191] Chr4:87490342 [GRCh38]
Chr4:88411494 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.515A>G (p.His172Arg) single nucleotide variant not specified [RCV004202640] Chr4:87494285 [GRCh38]
Chr4:88415437 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.917G>C (p.Ser306Thr) single nucleotide variant not specified [RCV004150885] Chr4:87493883 [GRCh38]
Chr4:88415035 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.891G>T (p.Glu297Asp) single nucleotide variant not specified [RCV004150884] Chr4:87493909 [GRCh38]
Chr4:88415061 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1627T>A (p.Ser543Thr) single nucleotide variant not specified [RCV004147401] Chr4:87482465 [GRCh38]
Chr4:88403617 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.536G>C (p.Ser179Thr) single nucleotide variant not specified [RCV004184564] Chr4:87494264 [GRCh38]
Chr4:88415416 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.982G>A (p.Gly328Ser) single nucleotide variant not specified [RCV004191890] Chr4:87493818 [GRCh38]
Chr4:88414970 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1427A>G (p.Asn476Ser) single nucleotide variant not specified [RCV004137519] Chr4:87490377 [GRCh38]
Chr4:88411529 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.295G>A (p.Asp99Asn) single nucleotide variant not specified [RCV004117000] Chr4:87494505 [GRCh38]
Chr4:88415657 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1045G>A (p.Gly349Ser) single nucleotide variant not specified [RCV004174271] Chr4:87493755 [GRCh38]
Chr4:88414907 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.325G>A (p.Val109Met) single nucleotide variant not specified [RCV004101246] Chr4:87494475 [GRCh38]
Chr4:88415627 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.850G>A (p.Val284Ile) single nucleotide variant not specified [RCV004204034] Chr4:87493950 [GRCh38]
Chr4:88415102 [GRCh37]
Chr4:4q22.1		 likely benign
NM_004684.6(SPARCL1):c.1696A>G (p.Arg566Gly) single nucleotide variant not specified [RCV004268882] Chr4:87480493 [GRCh38]
Chr4:88401645 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.481G>A (p.Glu161Lys) single nucleotide variant not specified [RCV004250911] Chr4:87494319 [GRCh38]
Chr4:88415471 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1469G>A (p.Cys490Tyr) single nucleotide variant not specified [RCV004275185] Chr4:87490335 [GRCh38]
Chr4:88411487 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1205G>C (p.Gly402Ala) single nucleotide variant not specified [RCV004254593] Chr4:87493595 [GRCh38]
Chr4:88414747 [GRCh37]
Chr4:4q22.1		 uncertain significance
GRCh37/hg19 4q22.1(chr4:88344058-89061168)x1 copy number loss not provided [RCV003223175] Chr4:88344058..89061168 [GRCh37]
Chr4:4q22.1		 pathogenic
NM_004684.6(SPARCL1):c.1052A>C (p.Asp351Ala) single nucleotide variant not specified [RCV004282994] Chr4:87493748 [GRCh38]
Chr4:88414900 [GRCh37]
Chr4:4q22.1		 uncertain significance
GRCh38/hg38 4q21.21-23(chr4:79123548-99457773)x1 copy number loss Chromosome 4q21 deletion syndrome [RCV003327709] Chr4:79123548..99457773 [GRCh38]
Chr4:4q21.21-23		 pathogenic
NM_004684.6(SPARCL1):c.625G>T (p.Gly209Cys) single nucleotide variant SPARCL1-related condition [RCV003408343] Chr4:87494175 [GRCh38]
Chr4:88415327 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.971C>T (p.Pro324Leu) single nucleotide variant SPARCL1-related condition [RCV003410464] Chr4:87493829 [GRCh38]
Chr4:88414981 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1025ATG[2] (p.Asp344del) microsatellite SPARCL1-related condition [RCV003393121] Chr4:87493767..87493769 [GRCh38]
Chr4:88414919..88414921 [GRCh37]
Chr4:4q22.1		 uncertain significance
GRCh37/hg19 4q21.21-22.3(chr4:81558759-95965995)x1 copy number loss not specified [RCV003986493] Chr4:81558759..95965995 [GRCh37]
Chr4:4q21.21-22.3		 pathogenic
GRCh37/hg19 4q21.23-22.3(chr4:85139670-96295033)x3 copy number gain not specified [RCV003986489] Chr4:85139670..96295033 [GRCh37]
Chr4:4q21.23-22.3		 likely pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_004684.6(SPARCL1):c.1804C>T (p.His602Tyr) single nucleotide variant not specified [RCV004460059] Chr4:87480385 [GRCh38]
Chr4:88401537 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1205G>A (p.Gly402Glu) single nucleotide variant not specified [RCV004460057] Chr4:87493595 [GRCh38]
Chr4:88414747 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.590T>C (p.Ile197Thr) single nucleotide variant not specified [RCV004460064] Chr4:87494210 [GRCh38]
Chr4:88415362 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.692G>A (p.Ser231Asn) single nucleotide variant not specified [RCV004460065] Chr4:87494108 [GRCh38]
Chr4:88415260 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.1576C>T (p.Arg526Trp) single nucleotide variant not specified [RCV004460058] Chr4:87482516 [GRCh38]
Chr4:88403668 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.193C>T (p.His65Tyr) single nucleotide variant not specified [RCV004460061] Chr4:87494989 [GRCh38]
Chr4:88416141 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.298C>A (p.Gln100Lys) single nucleotide variant not specified [RCV004460062] Chr4:87494502 [GRCh38]
Chr4:88415654 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.568A>G (p.Asn190Asp) single nucleotide variant not specified [RCV004460063] Chr4:87494232 [GRCh38]
Chr4:88415384 [GRCh37]
Chr4:4q22.1		 uncertain significance
NM_004684.6(SPARCL1):c.815C>A (p.Ser272Tyr) single nucleotide variant not specified [RCV004460066] Chr4:87493985 [GRCh38]
Chr4:88415137 [GRCh37]
Chr4:4q22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:972
Count of miRNA genes:358
Interacting mature miRNAs:393
Transcripts:ENST00000282470, ENST00000418378, ENST00000434434, ENST00000458304, ENST00000503414, ENST00000509407, ENST00000512317, ENST00000535835, ENST00000541496, ENST00000543631
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-59409  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37488,394,499 - 88,394,680UniSTSGRCh37
Build 36488,613,523 - 88,613,704RGDNCBI36
Celera485,683,706 - 85,683,887RGD
Cytogenetic Map4q22.1UniSTS
HuRef484,140,435 - 84,140,616UniSTS
GeneMap99-GB4 RH Map4457.21UniSTS
Whitehead-RH Map4503.9UniSTS
SPARCL1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37488,400,588 - 88,400,683UniSTSGRCh37
Build 36488,619,612 - 88,619,707RGDNCBI36
Celera485,689,795 - 85,689,890RGD
HuRef484,146,526 - 84,146,621UniSTS
WI-21135  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37488,399,224 - 88,399,356UniSTSGRCh37
Build 36488,618,248 - 88,618,380RGDNCBI36
Celera485,688,431 - 85,688,563RGD
Cytogenetic Map4q22.1UniSTS
HuRef484,145,162 - 84,145,294UniSTS
GeneMap99-GB4 RH Map4455.93UniSTS
Whitehead-RH Map4498.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 993 1316 121 3 19 4 1086 649 854 40 265 313 638 734
Medium 1311 929 1354 383 539 221 3013 1490 2794 313 1068 1081 166 1 566 2054 3
Low 33 673 225 223 761 221 182 18 22 30 55 80 3 2 2
Below cutoff 55 64 19 14 477 15 56 25 38 20 42 93 5 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001128310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC112250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF321976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY513278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA442598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA283085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC403565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC421365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000282470   ⟹   ENSP00000282470
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,473,335 - 87,529,376 (-)Ensembl
RefSeq Acc Id: ENST00000418378   ⟹   ENSP00000414856
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,473,348 - 87,529,503 (-)Ensembl
RefSeq Acc Id: ENST00000434434   ⟹   ENSP00000416971
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,494,376 - 87,529,457 (-)Ensembl
RefSeq Acc Id: ENST00000458304   ⟹   ENSP00000406251
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,495,013 - 87,529,372 (-)Ensembl
RefSeq Acc Id: ENST00000503414   ⟹   ENSP00000422903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,473,418 - 87,529,092 (-)Ensembl
RefSeq Acc Id: ENST00000509407   ⟹   ENSP00000423483
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,494,369 - 87,531,061 (-)Ensembl
RefSeq Acc Id: ENST00000512317   ⟹   ENSP00000423448
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,494,440 - 87,531,049 (-)Ensembl
RefSeq Acc Id: ENST00000535835   ⟹   ENSP00000438188
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,494,417 - 87,528,619 (-)Ensembl
RefSeq Acc Id: ENST00000541496   ⟹   ENSP00000445678
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,494,369 - 87,529,404 (-)Ensembl
RefSeq Acc Id: ENST00000543631   ⟹   ENSP00000444832
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl487,494,533 - 87,529,241 (-)Ensembl
RefSeq Acc Id: NM_001128310   ⟹   NP_001121782
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38487,473,335 - 87,529,376 (-)NCBI
GRCh37488,394,483 - 88,450,798 (-)NCBI
HuRef484,140,423 - 84,196,598 (-)ENTREZGENE
CHM1_1488,371,311 - 88,427,455 (-)NCBI
T2T-CHM13v2.0490,802,350 - 90,858,405 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291976   ⟹   NP_001278905
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38487,473,335 - 87,529,376 (-)NCBI
CHM1_1488,371,311 - 88,427,455 (-)NCBI
T2T-CHM13v2.0490,802,350 - 90,858,405 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291977   ⟹   NP_001278906
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38487,473,335 - 87,529,376 (-)NCBI
CHM1_1488,371,311 - 88,427,455 (-)NCBI
T2T-CHM13v2.0490,802,350 - 90,858,405 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004684   ⟹   NP_004675
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38487,473,335 - 87,529,376 (-)NCBI
GRCh37488,394,483 - 88,450,798 (-)NCBI
Build 36488,613,511 - 88,669,530 (-)NCBI Archive
HuRef484,140,423 - 84,196,598 (-)ENTREZGENE
CHM1_1488,371,311 - 88,427,455 (-)NCBI
T2T-CHM13v2.0490,802,350 - 90,858,405 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_004675   ⟸   NM_004684
- Peptide Label: isoform 1 precursor
- UniProtKB: E7ESU2 (UniProtKB/Swiss-Prot),   B4E2Z0 (UniProtKB/Swiss-Prot),   Q14800 (UniProtKB/Swiss-Prot),   Q14515 (UniProtKB/Swiss-Prot),   Q8N4S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001121782   ⟸   NM_001128310
- Peptide Label: isoform 1 precursor
- UniProtKB: E7ESU2 (UniProtKB/Swiss-Prot),   B4E2Z0 (UniProtKB/Swiss-Prot),   Q14800 (UniProtKB/Swiss-Prot),   Q14515 (UniProtKB/Swiss-Prot),   Q8N4S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278905   ⟸   NM_001291976
- Peptide Label: isoform 2
- UniProtKB: B7ZB68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278906   ⟸   NM_001291977
- Peptide Label: isoform 2
- UniProtKB: B7ZB68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000445678   ⟸   ENST00000541496
RefSeq Acc Id: ENSP00000422903   ⟸   ENST00000503414
RefSeq Acc Id: ENSP00000444832   ⟸   ENST00000543631
RefSeq Acc Id: ENSP00000282470   ⟸   ENST00000282470
RefSeq Acc Id: ENSP00000423483   ⟸   ENST00000509407
RefSeq Acc Id: ENSP00000438188   ⟸   ENST00000535835
RefSeq Acc Id: ENSP00000414856   ⟸   ENST00000418378
RefSeq Acc Id: ENSP00000406251   ⟸   ENST00000458304
RefSeq Acc Id: ENSP00000423448   ⟸   ENST00000512317
RefSeq Acc Id: ENSP00000416971   ⟸   ENST00000434434
Protein Domains
EF-hand   Follistatin-like   Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14515-F1-model_v2 AlphaFold Q14515 1-664 view protein structure

Promoters
RGD ID:6867972
Promoter ID:EPDNEW_H7151
Type:initiation region
Name:SPARCL1_1
Description:SPARC like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7152  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38487,529,209 - 87,529,269EPDNEW
RGD ID:6867974
Promoter ID:EPDNEW_H7152
Type:initiation region
Name:SPARCL1_2
Description:SPARC like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7151  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38487,529,404 - 87,529,464EPDNEW
RGD ID:6853296
Promoter ID:EP74470
Type:initiation region
Name:HS_SPARCL1_2
Description:SPARC-like 1 (mast9, hevin).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #2 of 2; 5' exon 1; site 2; major promoter.; see alsoEP74469  
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36488,669,385 - 88,669,445EPD
RGD ID:6853294
Promoter ID:EP74469
Type:initiation region
Name:HS_SPARCL1_1
Description:SPARC-like 1 (mast9, hevin).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 2; 5' exon 1; site 1.; see alsoEP74470  
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36488,669,574 - 88,669,634EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11220 AgrOrtholog
COSMIC SPARCL1 COSMIC
Ensembl Genes ENSG00000152583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000282470 ENTREZGENE
  ENST00000282470.11 UniProtKB/Swiss-Prot
  ENST00000418378 ENTREZGENE
  ENST00000418378.5 UniProtKB/Swiss-Prot
  ENST00000434434.5 UniProtKB/TrEMBL
  ENST00000458304.2 UniProtKB/TrEMBL
  ENST00000503414 ENTREZGENE
  ENST00000503414.5 UniProtKB/Swiss-Prot
  ENST00000509407.5 UniProtKB/TrEMBL
  ENST00000512317.5 UniProtKB/TrEMBL
  ENST00000535835.5 UniProtKB/TrEMBL
  ENST00000541496.1 UniProtKB/TrEMBL
  ENST00000543631.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000152583 GTEx
HGNC ID HGNC:11220 ENTREZGENE
Human Proteome Map SPARCL1 Human Proteome Map
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Osteonectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC-like_p1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC/Testican_Ca-bd-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8404 UniProtKB/Swiss-Prot
NCBI Gene 8404 ENTREZGENE
OMIM 606041 OMIM
PANTHER SPARC OSTEONECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC-LIKE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC_Ca_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36056 PharmGKB
PIRSF SPARC-like_p1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4E2Z0 ENTREZGENE
  B7ZB68 ENTREZGENE, UniProtKB/TrEMBL
  C9JJR8_HUMAN UniProtKB/TrEMBL
  D6RA29_HUMAN UniProtKB/TrEMBL
  E7ESU2 ENTREZGENE
  E7EU82_HUMAN UniProtKB/TrEMBL
  E9PC64_HUMAN UniProtKB/TrEMBL
  F5H1Y9_HUMAN UniProtKB/TrEMBL
  F5H331_HUMAN UniProtKB/TrEMBL
  F5H4Y3_HUMAN UniProtKB/TrEMBL
  Q14515 ENTREZGENE
  Q14800 ENTREZGENE
  Q8N4S1 ENTREZGENE, UniProtKB/TrEMBL
  SPRL1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B4E2Z0 UniProtKB/Swiss-Prot
  E7ESU2 UniProtKB/Swiss-Prot
  Q14800 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 SPARCL1  SPARC like 1    SPARC-like 1 (hevin)  Symbol and/or name change 5135510 APPROVED