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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:corticotropin-releasing hormone signaling pathway
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Accession:PW:0000493 term browser browse the term
Definition:Corticotropin-releasing hormone is secreted by the hypothalamus in response to stress or fear and signaling through its receptors stimulates secretion of corticotropic (adrenocorticotropic, ACTH) hormone by the anterior pituitary. ACTH is one of the cleavage products of pro-opiomelanocortin (POMC).
Synonyms:related_synonym: CRH
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corticotropin-releasing hormone signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO RGD PMID:16918397 RGD:5147673 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16918397 RGD:5147673 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487 		JBrowse link
G Crh corticotropin releasing hormone TAS
ISO 		RGD PMID:12942143 PMID:16484629 RGD:1358326, RGD:5147387 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein ISO RGD PMID:16484629 RGD:5147387 NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:28,427,139...28,439,446 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 TAS
ISO 		RGD PMID:12942143 PMID:16484629 RGD:1358326, RGD:5147387 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 TAS
ISO 		RGD PMID:12942143 PMID:16484629 RGD:1358326, RGD:5147387 NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:85,554,268...85,596,318 		JBrowse link
G Gnas GNAS complex locus ISO RGD PMID:16484629 RGD:5147387 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16484629 RGD:5147387 NCBI chr12:49,285,228...49,395,803
Ensembl chr12:49,285,263...49,395,802 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16484629 RGD:5147387 NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954 		JBrowse link
G Ucn urocortin ISO RGD PMID:16484629 RGD:5147387 NCBI chr 6:30,958,086...30,958,916
Ensembl chr 6:30,957,383...30,959,422 		JBrowse link
G Ucn2 urocortin 2 ISO RGD PMID:16484629 RGD:5147387 NCBI chr 8:118,516,111...118,517,660
Ensembl chr 8:118,483,364...118,517,439 		JBrowse link
G Ucn3 urocortin 3 ISO RGD PMID:16484629 RGD:5147387 NCBI chr17:71,219,611...71,225,904
Ensembl chr17:71,215,720...71,225,861 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      hormone signaling pathway 623
        peptide and protein hormone signaling pathway 438
          corticotropin-releasing hormone signaling pathway 12
paths to the root