Prmt1 (protein arginine methyltransferase 1) - Rat Genome Database

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Gene: Prmt1 (protein arginine methyltransferase 1) Rattus norvegicus
Analyze
Symbol: Prmt1
Name: protein arginine methyltransferase 1
RGD ID: 62020
Description: Enables several functions, including S-adenosyl-L-methionine binding activity; identical protein binding activity; and protein methyltransferase activity. Involved in several processes, including liver regeneration; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in cytosol. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT1 (protein arginine methyltransferase 1); PARTICIPATES IN androgen signaling pathway; estrogen signaling pathway; histone modification pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae); histone-arginine N-methyltransferase PRMT1; Hrmt1l2; protein arginine N-methyltransferase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,595,339 - 104,605,552 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,595,335 - 104,604,827 (-)EnsemblGRCr8
mRatBN7.2195,458,853 - 95,468,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,458,850 - 95,468,345 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,844,258 - 100,853,464 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,316,924 - 109,326,130 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,607,317 - 102,616,523 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,971,132 - 100,980,411 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,971,273 - 100,980,340 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,035,572 - 102,044,849 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,449,061 - 95,458,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,720,386 - 89,729,592 (-)NCBICelera
RGSC_v3.1195,527,171 - 95,536,378 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
cyclosporin A  (ISO)
dapsone  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
melatonin  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
ribavirin  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-adenosyl-L-homocysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IDA,IEA)
lysosomal membrane  (IEA,ISO)
methylosome  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Arginine methylation an emerging regulator of protein function. Bedford MT and Richard S, Mol Cell 2005 Apr 29;18(3):263-72.
2. Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. Bonham K, etal., FEBS J. 2010 May;277(9):2096-108. doi: 10.1111/j.1742-4658.2010.07623.x. Epub 2010 Mar 22.
3. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
4. Histone arginine methylation in cocaine action in the nucleus accumbens. Damez-Werno DM, etal., Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.
5. Histone arginine methylation. Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
6. The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. Gary JD, etal., J Biol Chem 1996 May 24;271(21):12585-94.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Readers of histone methylarginine marks. Gayatri S and Bedford MT, Biochim Biophys Acta. 2014 Aug;1839(8):702-710. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
11. Protein arginine methyltransferase 1 interacts with and activates p38alpha to facilitate erythroid differentiation. Hua WK, etal., PLoS One. 2013;8(3):e56715. doi: 10.1371/journal.pone.0056715. Epub 2013 Mar 6.
12. Involvement of PRMT1 in hnRNPQ activation and internalization of insulin receptor. Iwasaki H Biochem Biophys Res Commun. 2008 Jul 25;372(2):314-9. doi: 10.1016/j.bbrc.2008.05.051. Epub 2008 May 19.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Lakowski TM and Frankel A, Biochem J. 2009 Jun 26;421(2):253-61. doi: 10.1042/BJ20090268.
15. Multimerization of expressed protein-arginine methyltransferases during the growth and differentiation of rat liver. Lim Y, etal., Biochim Biophys Acta. 2005 May 25;1723(1-3):240-7. Epub 2005 Mar 17.
16. Arginine methylation of recombinant murine fibrillarin by protein arginine methyltransferase. Lin CH, etal., J Protein Chem 2002 Oct;21(7):447-53.
17. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Lin WJ, etal., Biochem J 2001 Mar 15;354(Pt 3):635-43.
18. The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. Lin WJ, etal., J Biol Chem 1996 Jun 21;271(25):15034-44.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression. Ojima A, etal., Am J Pathol. 2013 Jan;182(1):132-41. doi: 10.1016/j.ajpath.2012.09.016. Epub 2012 Nov 14.
22. Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable. Pawlak MR, etal., Mol Cell Biol 2000 Jul;20(13):4859-69.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. [Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma]. Sun QZ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):716-9.
27. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. Tang J, etal., J Biol Chem 1998 Jul 3;273(27):16935-45.
28. Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. Tang J, etal., J Biol Chem 2000 Jun 30;275(26):19866-76.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding. Wei HM, etal., FEBS Lett. 2014 May 2;588(9):1542-8. doi: 10.1016/j.febslet.2014.03.052. Epub 2014 Apr 12.
31. Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Zhang X and Cheng X, Structure. 2003 May;11(5):509-20. doi: 10.1016/s0969-2126(03)00071-6.
32. Crystal structure of the conserved core of protein arginine methyltransferase PRMT3. Zhang X, etal., EMBO J. 2000 Jul 17;19(14):3509-19.
Additional References at PubMed
PMID:10772824   PMID:11448779   PMID:12397599   PMID:15489334   PMID:16169070   PMID:16682010   PMID:18316480   PMID:18495660   PMID:18657504   PMID:18773938   PMID:19124016   PMID:19460357  
PMID:19467247   PMID:20442406   PMID:21080372   PMID:21652632   PMID:21736313   PMID:22082260   PMID:22387551   PMID:22681889   PMID:22697391   PMID:22785485   PMID:23214442   PMID:23455924  
PMID:23977297   PMID:24478314   PMID:25284789   PMID:25416956   PMID:25865156   PMID:26026059   PMID:26575292   PMID:26876602   PMID:28040436   PMID:28131823   PMID:29119338   PMID:29128891  
PMID:31160378   PMID:31787756   PMID:31813251   PMID:33826088   PMID:34688662   PMID:34715362  


Genomics

Comparative Map Data
Prmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,595,339 - 104,605,552 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,595,335 - 104,604,827 (-)EnsemblGRCr8
mRatBN7.2195,458,853 - 95,468,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,458,850 - 95,468,345 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,844,258 - 100,853,464 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,316,924 - 109,326,130 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,607,317 - 102,616,523 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,971,132 - 100,980,411 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,971,273 - 100,980,340 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,035,572 - 102,044,849 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,449,061 - 95,458,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,720,386 - 89,729,592 (-)NCBICelera
RGSC_v3.1195,527,171 - 95,536,378 (-)NCBI
Cytogenetic Map1q22NCBI
PRMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,676,153 - 49,688,447 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,675,786 - 49,689,029 (+)Ensemblhg38GRCh38
GRCh371950,180,528 - 50,191,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,872,308 - 54,883,516 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341954,872,354 - 54,883,516NCBI
Celera1947,049,830 - 47,061,036 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,557,181 - 46,568,351 (+)NCBIHuRef
CHM1_11950,182,198 - 50,193,506 (+)NCBICHM1_1
T2T-CHM13v2.01952,677,341 - 52,688,515 (+)NCBIT2T-CHM13v2.0
Prmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,626,179 - 44,635,844 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,625,413 - 44,635,992 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38744,976,755 - 44,986,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,975,989 - 44,986,568 (-)Ensemblmm10GRCm38
MGSCv37752,232,128 - 52,241,702 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36744,844,800 - 44,854,374 (-)NCBIMGSCv36mm8
Celera740,428,328 - 40,437,891 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.07NCBI
Prmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,203,283 - 1,215,021 (-)Ensembl
ChiLan1.0NW_0049555591,205,340 - 1,215,672 (-)NCBIChiLan1.0ChiLan1.0
PRMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,794,221 - 55,805,705 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,714,976 - 57,726,452 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,691,795 - 46,705,179 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,610,938 - 55,623,135 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,610,938 - 55,623,135 (+)EnsemblpanPan2panpan1.1
PRMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,849,864 - 106,859,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,849,864 - 106,874,075 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1106,433,570 - 106,443,601 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01107,371,449 - 107,381,481 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,371,449 - 107,381,410 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,043,700 - 107,053,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,685,774 - 106,695,794 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,526,251 - 107,536,278 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,873,842 - 21,884,543 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,491,920 - 3,504,667 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,492,032 - 3,502,738 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,714,157 - 54,732,574 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,718,845 - 54,730,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,447,908 - 50,459,466 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,854,873 - 42,863,113 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,854,918 - 42,863,014 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607322,796,021 - 22,808,631 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,589,743 - 4,602,402 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248324,593,594 - 4,602,514 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prmt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,558,695 - 154,568,650 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prmt1
80 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:94
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000064272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
BI285876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,458,857 - 95,459,077 (+)MAPPERmRatBN7.2
mRatBN7.21487,551,063 - 87,551,283 (+)MAPPERmRatBN7.2
Rnor_6.01100,971,137 - 100,971,356NCBIRnor6.0
Rnor_6.01493,040,983 - 93,041,202NCBIRnor6.0
Rnor_5.01492,831,791 - 92,832,010UniSTSRnor5.0
Rnor_5.01102,035,577 - 102,035,796UniSTSRnor5.0
RGSC_v3.4195,449,062 - 95,449,281UniSTSRGSC3.4
RGSC_v3.41493,881,141 - 93,881,360UniSTSRGSC3.4
Celera1486,680,959 - 86,681,178UniSTS
Celera189,720,387 - 89,720,606UniSTS
RH 3.4 Map14654.09UniSTS
Cytogenetic Map1q22UniSTS
Hrmt1l2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21767,626,147 - 67,626,358 (+)MAPPERmRatBN7.2
mRatBN7.21487,552,031 - 87,552,243 (+)MAPPERmRatBN7.2
Rnor_6.01493,041,951 - 93,042,162NCBIRnor6.0
Rnor_6.01771,397,715 - 71,397,925NCBIRnor6.0
Rnor_5.01773,092,124 - 73,092,334UniSTSRnor5.0
Rnor_5.01492,832,759 - 92,832,970UniSTSRnor5.0
RGSC_v3.41493,882,109 - 93,882,320UniSTSRGSC3.4
RGSC_v3.41778,879,926 - 78,880,136UniSTSRGSC3.4
Celera1767,123,381 - 67,123,591UniSTS
Celera1486,681,927 - 86,682,138UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000064272   ⟹   ENSRNOP00000063624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,602,575 (-)Ensembl
mRatBN7.2 Ensembl195,458,850 - 95,466,093 (-)Ensembl
Rnor_6.0 Ensembl1100,971,273 - 100,980,340 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098850   ⟹   ENSRNOP00000084758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,604,591 (-)Ensembl
mRatBN7.2 Ensembl195,458,857 - 95,468,078 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100032   ⟹   ENSRNOP00000087098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,604,543 (-)Ensembl
mRatBN7.2 Ensembl195,458,850 - 95,468,061 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103705   ⟹   ENSRNOP00000096484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,604,543 (-)Ensembl
mRatBN7.2 Ensembl195,458,850 - 95,468,061 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113175   ⟹   ENSRNOP00000078126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,602,489 (-)Ensembl
mRatBN7.2 Ensembl195,458,850 - 95,468,224 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115255   ⟹   ENSRNOP00000087248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,604,827 (-)Ensembl
mRatBN7.2 Ensembl195,458,853 - 95,468,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138194   ⟹   ENSRNOP00000100024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,604,827 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140432   ⟹   ENSRNOP00000101567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,476 - 104,604,543 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173579   ⟹   ENSRNOP00000105021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,595,335 - 104,602,489 (-)Ensembl
RefSeq Acc Id: NM_024363   ⟹   NP_077339
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,604,545 (-)NCBI
mRatBN7.2195,458,857 - 95,468,063 (-)NCBI
Rnor_6.01100,971,136 - 100,980,342 (-)NCBI
Rnor_5.01102,035,572 - 102,044,849 (-)NCBI
RGSC_v3.4195,449,061 - 95,458,267 (-)RGD
Celera189,720,386 - 89,729,592 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229144   ⟹   XP_006229206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,605,552 (-)NCBI
mRatBN7.2195,458,853 - 95,468,176 (-)NCBI
Rnor_6.01100,971,132 - 100,980,411 (-)NCBI
Rnor_5.01102,035,572 - 102,044,849 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272501   ⟹   XP_063128571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,602,243 (-)NCBI
RefSeq Acc Id: XM_063272507   ⟹   XP_063128577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,602,249 (-)NCBI
RefSeq Acc Id: NP_077339   ⟸   NM_024363
- UniProtKB: Q63009 (UniProtKB/Swiss-Prot),   A6JAU8 (UniProtKB/TrEMBL),   A0A8L2QUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229206   ⟸   XM_006229144
- Peptide Label: isoform X1
- UniProtKB: A6JAU9 (UniProtKB/TrEMBL),   A0A8L2QUM0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063624   ⟸   ENSRNOT00000064272
Ensembl Acc Id: ENSRNOP00000084758   ⟸   ENSRNOT00000098850
Ensembl Acc Id: ENSRNOP00000087248   ⟸   ENSRNOT00000115255
Ensembl Acc Id: ENSRNOP00000096484   ⟸   ENSRNOT00000103705
Ensembl Acc Id: ENSRNOP00000078126   ⟸   ENSRNOT00000113175
Ensembl Acc Id: ENSRNOP00000087098   ⟸   ENSRNOT00000100032
RefSeq Acc Id: XP_063128577   ⟸   XM_063272507
- Peptide Label: isoform X3
- UniProtKB: A6JAV0 (UniProtKB/TrEMBL),   A0A8L2QUM0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128571   ⟸   XM_063272501
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QUM0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105021   ⟸   ENSRNOT00000173579
Ensembl Acc Id: ENSRNOP00000100024   ⟸   ENSRNOT00000138194
Ensembl Acc Id: ENSRNOP00000101567   ⟸   ENSRNOT00000140432
Protein Domains
Methyltransferase   Protein arginine N-methyltransferase   SAM-dependent MTase PRMT-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63009-F1-model_v2 AlphaFold Q63009 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690016
Promoter ID:EPDNEW_R541
Type:multiple initiation site
Name:Prmt1_1
Description:protein arginine methyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,980,357 - 100,980,417EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62020 AgrOrtholog
BIND 130433
  130434
BioCyc Gene G2FUF-59737 BioCyc
Ensembl Genes ENSRNOG00000026109 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000098850 ENTREZGENE
  ENSRNOT00000113175 ENTREZGENE
  ENSRNOT00000138194 ENTREZGENE
  ENSRNOT00000173579 ENTREZGENE
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot
  Hnrnp arginine n-methyltransferase1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106257 IMAGE-MGC_LOAD
InterPro Arg_MeTrfase UniProtKB/Swiss-Prot
  Methyltransf_25 UniProtKB/Swiss-Prot
  PRMT_dom UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report rno:60421 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93411 IMAGE-MGC_LOAD
NCBI Gene 60421 ENTREZGENE
PANTHER PROTEIN ARGININE N-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR11006 UniProtKB/Swiss-Prot
Pfam Methyltransf_25 UniProtKB/Swiss-Prot
  PRMT_C UniProtKB/Swiss-Prot
PhenoGen Prmt1 PhenoGen
PROSITE SAM_MT_PRMT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026109 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
TIGR TC228983
UniProt A0A8I5Y864_RAT UniProtKB/TrEMBL
  A0A8I5ZYM2_RAT UniProtKB/TrEMBL
  A0A8I6A3L2_RAT UniProtKB/TrEMBL
  A0A8I6A3V3_RAT UniProtKB/TrEMBL
  A0A8I6GM37_RAT UniProtKB/TrEMBL
  A0A8L2QUM0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L0H6_RAT UniProtKB/TrEMBL
  A0ABK0LT45_RAT UniProtKB/TrEMBL
  A6JAU8 ENTREZGENE, UniProtKB/TrEMBL
  A6JAU9 ENTREZGENE, UniProtKB/TrEMBL
  A6JAV0 ENTREZGENE, UniProtKB/TrEMBL
  ANM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Prmt1  protein arginine methyltransferase 1  Prmt1  protein arginine N-methyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Prmt1  protein arginine N-methyltransferase 1  Hrmt1l2  heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hrmt1l2  heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds immediate early protein TIS21 and the leukemia-associated protein BTG1 in vitro 61630