RGD Reference Report - Arginine methylation an emerging regulator of protein function. - Rat Genome Database

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Arginine methylation an emerging regulator of protein function.

Authors: Bedford, MT  Richard, S 
Citation: Bedford MT and Richard S, Mol Cell 2005 Apr 29;18(3):263-72.
RGD ID: 1359044
Pubmed: PMID:15866169   (View Abstract at PubMed)
DOI: DOI:10.1016/j.molcel.2005.04.003   (Journal Full-text)

Arginine methylation is now coming out of the shadows of protein phosphorylation and entering the mainstream, largely due to the identification of the family of enzymes that lay down this modification. In addition, modification-specific antibodies and proteomic approaches have facilitated the identification of an array of substrates for the protein arginine methyltransferases. This review describes recent insights into the molecular processes regulated by arginine methylation in normal and diseased cells.

Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Carm1  (coactivator-associated arginine methyltransferase 1)
Prmt1  (protein arginine methyltransferase 1)
Prmt3  (protein arginine methyltransferase 3)
Prmt5  (protein arginine methyltransferase 5)
Prmt6  (protein arginine methyltransferase 6)

Genes (Homo sapiens)
CARM1  (coactivator associated arginine methyltransferase 1)
PRMT1  (protein arginine methyltransferase 1)
PRMT5  (protein arginine methyltransferase 5)
PRMT6  (protein arginine methyltransferase 6)

Additional Information