Notch4 (notch receptor 4) - Rat Genome Database

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Gene: Notch4 (notch receptor 4) Rattus norvegicus
Analyze
Symbol: Notch4
Name: notch receptor 4
RGD ID: 1303282
Description: Predicted to enable Notch binding activity and transcription coactivator activity. Involved in endothelial cell morphogenesis and luteolysis. Predicted to be located in cell surface; cytoplasmic vesicle; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including alopecia areata; ductal carcinoma in situ; multiple sclerosis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human NOTCH4 (notch receptor 4); PARTICIPATES IN Notch signaling pathway; altered Notch signaling pathway; Notch signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylfuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neurogenic locus notch homolog protein 4; notch 4; Notch homolog 4; Notch homolog 4 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,164,969 - 4,189,072 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,161,730 - 4,189,072 (-)EnsemblGRCr8
mRatBN7.2204,160,362 - 4,184,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx204,867,047 - 4,890,265 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,228,799 - 4,252,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,759,694 - 4,786,711 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,329,794 - 4,353,868 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)Ensemblrn6Rnor6.0
Rnor_5.0206,409,125 - 6,433,141 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,263,205 - 4,287,312 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera203,846,498 - 3,869,836 (+)NCBICelera
RGSC_v3.1204,263,431 - 4,287,539 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-methylfuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
androgen antagonist  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
atropine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
DAPT  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
isoprenaline  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
linuron  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
nickel atom  (ISO)
nicotine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
prostaglandin F2alpha  (EXP)
quercetin  (EXP)
ritonavir  (EXP)
saquinavir  (EXP)
simvastatin  (EXP)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
tremolite asbestos  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic association of sequence variants near AGER/NOTCH4 and dementia. Bennet AM, etal., J Alzheimers Dis. 2011;24(3):475-84.
2. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. Farnie G, etal., J Natl Cancer Inst. 2007 Apr 18;99(8):616-27.
3. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. Gorlova O, etal., PLoS Genet. 2011 Jul;7(7):e1002178. Epub 2011 Jul 14.
7. Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat. Hernandez F, etal., Biol Reprod. 2011 May;84(5):859-65. doi: 10.1095/biolreprod.110.088708. Epub 2011 Jan 5.
8. Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis. Jiao Z, etal., Scand J Rheumatol. 2010;39(1):26-32.
9. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
10. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Luo X, etal., Biol Psychiatry 2004 Jan 15;55(2):112-7.
11. SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. McElroy JP, etal., Genes Immun. 2011 Oct;12(7):523-30. doi: 10.1038/gene.2011.25. Epub 2011 Jun 9.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. Murphy PA, etal., Lab Invest. 2009 Sep;89(9):971-82. Epub 2009 Jun 22.
14. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
15. Study of angiogenic signaling pathways in hemangioblastoma. Pierscianek D, etal., Neuropathology. 2017 Feb;37(1):3-11. doi: 10.1111/neup.12316. Epub 2016 Jul 7.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis. Quillard T, etal., Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2258-65. Epub 2008 Sep 18.
19. Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh). Raafat A, etal., Oncogene. 2004 Dec 16;23(58):9401-7.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Insertional mutation of int protooncogenes in the mammary tumors of a new strain of mice derived from the wild in China: normal- and tumor-tissue-specific expression of int-3 transcripts. Sarkar NH, etal., Virology. 1994 Aug 15;203(1):52-62.
24. Activation of Notch signaling pathway in HIV-associated nephropathy. Sharma M, etal., AIDS. 2010 Sep 10;24(14):2161-70.
25. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Suzuki T, etal., Int J Oncol. 2000 Dec;17(6):1131-9.
26. Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. Tazi-Ahnini R, etal., Hum Genet. 2003 Apr;112(4):400-3. Epub 2003 Feb 14.
27. Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population. Tochigi M, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):37-40.
28. Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells. Uyttendaele H, etal., Microvasc Res 2000 Sep;60(2):91-103.
29. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Valdes AM and Thomson G, Diabetes Obes Metab. 2009 Feb;11 Suppl 1:46-52.
30. A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia. Wang Z, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):902-6.
31. Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages. Xia Z, etal., Braz J Med Biol Res. 2021 Jul 23;54(8):e11184. doi: 10.1590/1414-431X2021e11184. eCollection 2021.
Additional References at PubMed
PMID:9576833   PMID:11344305   PMID:11823422   PMID:17984306   PMID:18952909   PMID:20643108   PMID:21872265   PMID:24563863   PMID:24667410   PMID:29754932   PMID:35016680  


Genomics

Comparative Map Data
Notch4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,164,969 - 4,189,072 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl204,161,730 - 4,189,072 (-)EnsemblGRCr8
mRatBN7.2204,160,362 - 4,184,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx204,867,047 - 4,890,265 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,228,799 - 4,252,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,759,694 - 4,786,711 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,329,794 - 4,353,868 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)Ensemblrn6Rnor6.0
Rnor_5.0206,409,125 - 6,433,141 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4204,263,205 - 4,287,312 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera203,846,498 - 3,869,836 (+)NCBICelera
RGSC_v3.1204,263,431 - 4,287,539 (-)NCBI
Cytogenetic Map20p12NCBI
NOTCH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,194,843 - 32,224,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,194,843 - 32,224,111 (-)Ensemblhg38GRCh38
GRCh37632,162,620 - 32,191,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,270,598 - 32,299,822 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34632,270,598 - 32,299,822NCBI
Celera633,729,664 - 33,758,884 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef631,916,815 - 31,946,041 (-)NCBIHuRef
CHM1_1632,165,104 - 32,194,322 (-)NCBICHM1_1
T2T-CHM13v2.0632,048,032 - 32,077,265 (-)NCBIT2T-CHM13v2.0
Notch4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,783,257 - 34,807,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,783,242 - 34,807,477 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381734,564,286 - 34,588,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)Ensemblmm10GRCm38
MGSCv371734,701,240 - 34,725,488 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361734,172,386 - 34,196,552 (+)NCBIMGSCv36mm8
Celera1737,659,444 - 37,683,703 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.15NCBI
Notch4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437657,837 - 678,460 (-)Ensembl
ChiLan1.0NW_004955437658,076 - 679,338 (-)NCBIChiLan1.0ChiLan1.0
NOTCH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,657,915 - 46,687,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,619,989 - 42,648,574 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,722,112 - 32,750,978 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,722,112 - 32,750,978 (-)EnsemblpanPan2panpan1.1
NOTCH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,585,249 - 1,608,721 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,587,918 - 1,607,760 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha121,720,443 - 1,742,455 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0121,724,977 - 1,746,984 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1121,587,999 - 1,609,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,653,597 - 1,675,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,719,919 - 1,741,905 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Notch4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,152,409 - 36,174,550 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,386,953 - 1,408,397 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,386,842 - 1,409,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,231,293 - 24,256,281 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1724,231,293 - 24,256,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,052,185 - 28,077,374 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,806,864 - 39,837,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,808,035 - 39,837,365 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604432,094,646 - 32,124,232 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notch4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,108,661 - 24,128,053 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Notch4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1187,248,399 - 7,271,499 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Notch4
368 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:41
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000000513
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
D20Yum63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,171,433 - 4,171,590 (-)MAPPERmRatBN7.2
Rnor_6.0204,342,640 - 4,342,796NCBIRnor6.0
Rnor_5.0206,421,996 - 6,422,152UniSTSRnor5.0
RGSC_v3.4204,274,327 - 4,274,483UniSTSRGSC3.4
Celera203,858,677 - 3,858,833UniSTS
Cytogenetic Map20p12UniSTS
BE113482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,180,709 - 4,180,860 (-)MAPPERmRatBN7.2
Rnor_6.0204,333,399 - 4,333,549NCBIRnor6.0
Rnor_5.0206,412,755 - 6,412,905UniSTSRnor5.0
RGSC_v3.4204,283,559 - 4,283,709UniSTSRGSC3.4
Celera203,850,103 - 3,850,253UniSTS
RH 3.4 Map2052.4UniSTS
Cytogenetic Map20p12UniSTS
RH139089  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8204,165,945 - 4,166,320 (+)Marker Load Pipeline
mRatBN7.2204,161,338 - 4,161,713 (-)MAPPERmRatBN7.2
Rnor_6.0204,352,517 - 4,352,891NCBIRnor6.0
Rnor_5.0206,431,873 - 6,432,247UniSTSRnor5.0
RGSC_v3.4204,264,099 - 4,264,473UniSTSRGSC3.4
Celera203,868,568 - 3,868,942UniSTS
RH 3.4 Map2052.0UniSTS
Cytogenetic Map20p12UniSTS
AA799611  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map2052.5UniSTS
Cytogenetic Map20p12UniSTS
UniSTS:465467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,161,676 - 4,162,237 (-)MAPPERmRatBN7.2
Rnor_6.0204,351,993 - 4,352,553NCBIRnor6.0
Rnor_5.0206,431,349 - 6,431,909UniSTSRnor5.0
RGSC_v3.4204,264,437 - 4,265,274UniSTSRGSC3.4
Celera203,868,044 - 3,868,604UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 88 59 6 352 188 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000510   ⟹   ENSRNOP00000000510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl204,161,730 - 4,163,591 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000000513   ⟹   ENSRNOP00000000513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl204,161,730 - 4,189,072 (-)Ensembl
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)Ensembl
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)Ensembl
RefSeq Acc Id: NM_001002827   ⟹   NP_001002827
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,165,052 - 4,189,072 (-)NCBI
mRatBN7.2204,160,445 - 4,184,465 (-)NCBI
Rnor_6.0204,329,794 - 4,353,785 (+)NCBI
Rnor_5.0206,409,125 - 6,433,141 (+)NCBI
RGSC_v3.4204,263,205 - 4,287,312 (-)RGD
Celera203,846,498 - 3,869,836 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098926   ⟹   XP_038954854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,166,331 - 4,189,069 (-)NCBI
mRatBN7.2204,161,711 - 4,184,466 (-)NCBI
RefSeq Acc Id: XM_039098927   ⟹   XP_038954855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,164,969 - 4,185,137 (-)NCBI
mRatBN7.2204,160,362 - 4,180,530 (-)NCBI
RefSeq Acc Id: XM_039098928   ⟹   XP_038954856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,167,333 - 4,189,070 (-)NCBI
mRatBN7.2204,162,726 - 4,184,466 (-)NCBI
RefSeq Acc Id: XM_039098929   ⟹   XP_038954857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,164,969 - 4,185,137 (-)NCBI
mRatBN7.2204,160,362 - 4,180,530 (-)NCBI
RefSeq Acc Id: XM_039098930   ⟹   XP_038954858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,164,969 - 4,185,127 (-)NCBI
mRatBN7.2204,160,362 - 4,180,519 (-)NCBI
RefSeq Acc Id: XM_039098931   ⟹   XP_038954859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,168,464 - 4,189,070 (-)NCBI
mRatBN7.2204,163,857 - 4,184,466 (-)NCBI
RefSeq Acc Id: NP_001002827   ⟸   NM_001002827
- Peptide Label: precursor
- UniProtKB: Q6MG89 (UniProtKB/TrEMBL),   A6KTE6 (UniProtKB/TrEMBL),   A6KTE7 (UniProtKB/TrEMBL),   F7EQS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000513   ⟸   ENSRNOT00000000513
RefSeq Acc Id: XP_038954857   ⟸   XM_039098929
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038954855   ⟸   XM_039098927
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954858   ⟸   XM_039098930
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038954854   ⟸   XM_039098926
- Peptide Label: isoform X1
- UniProtKB: A6KTE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954856   ⟸   XM_039098928
- Peptide Label: isoform X3
- UniProtKB: A6KTE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954859   ⟸   XM_039098931
- Peptide Label: isoform X6
- UniProtKB: A6KTE8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000000510   ⟸   ENSRNOT00000000510
Protein Domains
EGF-like   LNR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG89-F1-model_v2 AlphaFold Q6MG89 1-1961 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701337
Promoter ID:EPDNEW_R11861
Type:single initiation site
Name:Notch4_1
Description:notch 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,329,821 - 4,329,881EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303282 AgrOrtholog
BioCyc Gene G2FUF-4581 BioCyc
Ensembl Genes ENSRNOG00000000442 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000513 ENTREZGENE
  ENSRNOT00000000513.6 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  3.30.300.320 UniProtKB/TrEMBL
  3.30.70.3310 UniProtKB/TrEMBL
  4.10.470.20 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  EGF-like_reg_CS UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_Ca_bd UniProtKB/TrEMBL
  EGF_Ca_bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch/Slit_guidance UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  Notch_4 UniProtKB/TrEMBL
  Notch_Cell-Fate_Det UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_dom_like UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
KEGG Report rno:406162 UniProtKB/TrEMBL
NCBI Gene 406162 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/TrEMBL
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/TrEMBL
  SLIT HOMOLOG UniProtKB/TrEMBL
  UNINFLATABLE, ISOFORM C UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  EGF_TEN UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PharmGKB NOTCH4 RGD
PhenoGen Notch4 PhenoGen
PIRSF Notch UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
  NOTCH UniProtKB/TrEMBL
  NOTCH UniProtKB/TrEMBL
  NOTCH4 UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000442 RatGTEx
SMART ANK UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  Notch_region UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0ABZ3NN75_RAT UniProtKB/TrEMBL
  A6KTE6 ENTREZGENE, UniProtKB/TrEMBL
  A6KTE7 ENTREZGENE, UniProtKB/TrEMBL
  A6KTE8 ENTREZGENE, UniProtKB/TrEMBL
  A6KTE9_RAT UniProtKB/TrEMBL
  A6KTF0_RAT UniProtKB/TrEMBL
  A6KTF1_RAT UniProtKB/TrEMBL
  A6KTF2_RAT UniProtKB/TrEMBL
  A6KTF3_RAT UniProtKB/TrEMBL
  F7EQS6 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG89 ENTREZGENE
UniProt Secondary Q6MG89 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Notch4  notch receptor 4  Notch4  notch 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Notch4  notch 4  Notch4  Notch homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Notch4  Notch homolog 4 (Drosophila)  Notch4  Notch homolog 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Notch4        Symbol and Name status set to provisional 70820 PROVISIONAL