Hrk (harakiri, BCL2 interacting protein) - Rat Genome Database

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Gene: Hrk (harakiri, BCL2 interacting protein) Rattus norvegicus
Analyze
Symbol: Hrk
Name: harakiri, BCL2 interacting protein
RGD ID: 70549
Description: Involved in cellular response to potassium ion starvation and positive regulation of neuron apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human HRK (harakiri, BCL2 interacting protein); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activator of apoptosis harakiri; BH3 interacting (with BCL2 family) domain apoptosis agonist; BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3 interacting domain 3; BH3-interacting domain-containing protein 3; Bid3; Dp5; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: NM_057130.4 is based on transcript and protein alignment data, and may not be a true representation of the structure of GeneID 117271 due to the incomplete nature of the assembly in this region of the genome. [10 Oct 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,048,402 - 44,070,561 (-)NCBIGRCr8
mRatBN7.21238,387,484 - 38,409,652 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1239,562,829 - 39,584,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,176,631 - 40,198,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,229,587 - 39,251,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,008,879 - 44,029,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,839,708 - 45,861,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,520,265 - 39,543,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,383,652 - 39,407,289 (-)NCBI
Celera1240,046,737 - 40,068,164 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-carnitine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3'-diindolylmethane  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gentamycin  (ISO)
glycidol  (EXP)
inulin  (ISO)
isoflurane  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel dichloride  (EXP)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
pyrethrins  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (EXP)
sphingosine 1-phosphate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrion  (IBA,ISO,ISS)

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Duval N, etal., Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. Harris CA and Johnson EM Jr, J Biol Chem 2001 Oct 12;276(41):37754-60.
5. Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. Imaizumi K, etal., J Biol Chem 1997 Jul 25;272(30):18842-8.
6. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. Imaizumi K, etal., J Biol Chem 1999 Mar 19;274(12):7975-81.
7. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
8. dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons. Ma C, etal., J Biol Chem. 2007 Oct 19;282(42):30901-9. Epub 2007 Apr 11.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release. Polster BM, etal., Cell Death Differ 2003 Mar;10(3):365-70.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:15031724   PMID:16005241   PMID:17690097   PMID:19304750   PMID:19629134   PMID:21041309   PMID:33603338  


Genomics

Comparative Map Data
Hrk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,048,402 - 44,070,561 (-)NCBIGRCr8
mRatBN7.21238,387,484 - 38,409,652 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1239,562,829 - 39,584,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,176,631 - 40,198,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,229,587 - 39,251,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,008,879 - 44,029,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,839,708 - 45,861,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,520,265 - 39,543,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,383,652 - 39,407,289 (-)NCBI
Celera1240,046,737 - 40,068,164 (-)NCBICelera
Cytogenetic Map12q16NCBI
HRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812116,856,144 - 116,881,441 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12116,856,144 - 116,881,441 (-)EnsemblGRCh38hg38GRCh38
GRCh3712117,293,949 - 117,319,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612115,783,410 - 115,803,615 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412115,761,747 - 115,781,952NCBI
Celera12116,928,567 - 116,948,765 (-)NCBICelera
Cytogenetic Map12q24.22NCBI
HuRef12114,307,719 - 114,328,689 (-)NCBIHuRef
CHM1_112117,265,885 - 117,286,893 (-)NCBICHM1_1
T2T-CHM13v2.012116,837,255 - 116,862,509 (-)NCBIT2T-CHM13v2.0
Hrk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,307,829 - 118,327,543 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5118,302,713 - 118,327,543 (+)EnsemblGRCm39 Ensembl
GRCm385118,169,764 - 118,189,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5118,164,648 - 118,189,478 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,619,773 - 118,639,487 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365118,430,794 - 118,450,508 (+)NCBIMGSCv36mm8
Celera5115,265,345 - 115,284,637 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map558.16NCBI
HRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210124,917,453 - 124,942,735 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112124,913,835 - 124,939,116 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012114,432,755 - 114,458,044 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,481,095 - 13,501,276 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,475,701 - 13,495,708 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02613,741,064 - 13,761,072 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12613,702,735 - 13,722,722 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02613,780,661 - 13,800,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02613,815,015 - 13,835,046 (-)NCBIUU_Cfam_GSD_1.0
HRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1435,613,075 - 35,613,350 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11435,612,920 - 35,632,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,832,636 - 37,849,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HRK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,171,912 - 112,195,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11112,193,561 - 112,193,836 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037132,884,361 - 132,909,787 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hrk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474716,366,080 - 16,387,840 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474716,365,938 - 16,387,841 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hrk
126 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
D12Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,388,124 - 38,388,298 (+)MAPPERmRatBN7.2
Rnor_6.01244,009,520 - 44,009,693NCBIRnor6.0
Rnor_5.01245,840,351 - 45,840,524UniSTSRnor5.0
RGSC_v3.41239,520,906 - 39,521,079UniSTSRGSC3.4
Celera1240,047,378 - 40,047,551UniSTS
Cytogenetic Map12q16UniSTS
D12Wox24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,388,089 - 38,388,262 (+)MAPPERmRatBN7.2
Rnor_6.01244,009,485 - 44,009,657NCBIRnor6.0
Rnor_5.01245,840,316 - 45,840,488UniSTSRnor5.0
RGSC_v3.41239,520,871 - 39,521,043UniSTSRGSC3.4
Celera1240,047,343 - 40,047,515UniSTS
Cytogenetic Map12q16UniSTS
RH132357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,387,072 - 38,387,256 (+)MAPPERmRatBN7.2
Rnor_6.01244,008,468 - 44,008,651NCBIRnor6.0
Rnor_5.01245,839,299 - 45,839,482UniSTSRnor5.0
RGSC_v3.41239,519,854 - 39,520,037UniSTSRGSC3.4
Celera1240,046,326 - 40,046,509UniSTS
RH 3.4 Map12703.7UniSTS
Cytogenetic Map12q16UniSTS
AI102299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,390,675 - 38,390,845 (+)MAPPERmRatBN7.2
Rnor_6.01244,012,071 - 44,012,240NCBIRnor6.0
Rnor_5.01245,842,902 - 45,843,071UniSTSRnor5.0
RGSC_v3.41239,523,457 - 39,523,626UniSTSRGSC3.4
Celera1240,049,929 - 40,050,098UniSTS
RH 3.4 Map12724.01UniSTS
Cytogenetic Map12q16UniSTS
RH139521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,387,668 - 38,387,871 (+)MAPPERmRatBN7.2
Rnor_6.01244,009,064 - 44,009,266NCBIRnor6.0
Rnor_5.01245,839,895 - 45,840,097UniSTSRnor5.0
RGSC_v3.41239,520,450 - 39,520,652UniSTSRGSC3.4
Celera1240,046,922 - 40,047,124UniSTS
RH 3.4 Map12703.3UniSTS
Cytogenetic Map12q16UniSTS
RH140359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,387,566 - 38,387,790 (+)MAPPERmRatBN7.2
Rnor_6.01244,008,962 - 44,009,185NCBIRnor6.0
Rnor_5.01245,839,793 - 45,840,016UniSTSRnor5.0
RGSC_v3.41239,520,348 - 39,520,571UniSTSRGSC3.4
Celera1240,046,820 - 40,047,043UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NM_057130   ⟹   NP_476471
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,048,402 - 44,070,561 (-)NCBI
mRatBN7.21238,387,484 - 38,409,652 (-)NCBI
Rnor_6.01244,008,879 - 44,029,211 (-)NCBI
Rnor_5.01245,839,708 - 45,861,437 (-)NCBI
RGSC_v3.41239,520,265 - 39,543,901 (-)RGD
Celera1240,046,737 - 40,068,164 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_476471 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA12065 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00055018910
  ENSRNOP00060002751
  ENSRNOP00065005978
GenBank Protein P62817 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476471   ⟸   NM_057130
- UniProtKB: P62817 (UniProtKB/Swiss-Prot)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62817-F1-model_v2 AlphaFold P62817 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70549 AgrOrtholog
BioCyc Gene G2FUF-19078 BioCyc
Ensembl Genes ENSRNOG00055013589 UniProtKB/Swiss-Prot
  ENSRNOG00060002446 UniProtKB/Swiss-Prot
  ENSRNOG00065005694 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00055023296 UniProtKB/Swiss-Prot
  ENSRNOT00060003898 UniProtKB/Swiss-Prot
  ENSRNOT00065008490 UniProtKB/Swiss-Prot
InterPro Apoptosis_activator_harakiri UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot
KEGG Report rno:117271 UniProtKB/Swiss-Prot
NCBI Gene 117271 ENTREZGENE
PANTHER ACTIVATOR OF APOPTOSIS HARAKIRI UniProtKB/Swiss-Prot
  PTHR15056 UniProtKB/Swiss-Prot
Pfam Harakiri UniProtKB/Swiss-Prot
PhenoGen Hrk PhenoGen
PIRSF BID3 UniProtKB/Swiss-Prot
PROSITE BH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00055013589 RatGTEx
  ENSRNOG00060002446 RatGTEx
  ENSRNOG00065005694 RatGTEx
UniProt HRK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70678 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-12 Hrk  harakiri, BCL2 interacting protein  Hrk  harakiri, BCL2 interacting protein (contains only BH3 domain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Hrk  harakiri, BCL2 interacting protein (contains only BH3 domain)  Bid3  BH3 interacting (with BCL2 family) domain, apoptosis agonist  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Bid3  BH3 interacting (with BCL2 family) domain, apoptosis agonist    BH3 interacting domain 3  Name updated 1299863 APPROVED
2002-06-10 Bid3  BH3 interacting domain 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may be associated with Alzheimers disease 70303
gene_disease may be associated with Alzheimers disease 70326
gene_function binds Bcl2, Bcl-xl through its BH3 domain 70303
gene_function binds Bcl2, Bcl-xl through its BH3 domain 70326
gene_function binds Bcl2, Bcl-xl through its BH3 domain 70327
gene_mutations_overexpression overexpression induces apoptosis 70327
gene_process may have a role in cerebellar granule neuronal apoptosis, perhaps through calcium release from the endoplasmic reticulum 70303
gene_process may have a role in cerebellar granule neuronal apoptosis, perhaps through calcium release from the endoplasmic reticulum 70326
gene_process may have a role in neuronal apoptosis, perhaps through calcium release from the endoplasmic reticulum 70327
gene_protein 92 amino acid protein 70303
gene_protein 92 amino acid protein 70326
gene_protein 92 amino acid protein 70327
gene_regulation induced in neurons undergoing programmed cell death after treatment with amyloid beta protein and deprivation of nerve growth factor 70326
gene_regulation induced in neurons undergoing programmed cell death after treatment with amyloid beta protein and deprivation of nerve growth factor 70327
gene_regulation mRNA increased after NGF withdrawal of sympathetic neurons 70326
gene_regulation mRNA increased after NGF withdrawal of sympathetic neurons 70327
gene_transcript 5.5 kb mRNA 70326
gene_transcript 5.5 kb mRNA 70327