Vamp8 (vesicle-associated membrane protein 8) - Rat Genome Database

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Gene: Vamp8 (vesicle-associated membrane protein 8) Rattus norvegicus
Analyze
Symbol: Vamp8
Name: vesicle-associated membrane protein 8
RGD ID: 620421
Description: Enables SNAP receptor activity and syntaxin binding activity. Involved in protein-containing complex assembly and vesicle fusion. Located in endosome; lysosomal membrane; and midbody. Part of SNARE complex. Orthologous to human VAMP8 (vesicle associated membrane protein 8); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EDB; endobrevin; VAMP-8; vesicle-associated membrane protein 8 (endobrevin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,000,570 - 106,011,081 (-)NCBIGRCr8
mRatBN7.24104,442,383 - 104,452,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,442,393 - 104,452,897 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,822,062 - 109,827,133 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,597,175 - 105,602,246 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,210,202 - 104,215,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,250,301 - 100,252,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,250,301 - 100,252,755 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,020,594 - 165,023,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,692,451 - 105,694,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,936,931 - 105,939,387 (-)NCBI
Celera493,595,511 - 93,597,967 (-)NCBICelera
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
camptothecin  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
Nutlin-3  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Antonin W, etal., Nat Struct Biol 2002 Feb;9(2):107-11.
2. Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. Fasshauer D, etal., J Biol Chem 1999 May 28;274(22):15440-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Low SH, etal., Dev Cell 2003 May;4(5):753-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. Pryor PR, etal., EMBO Rep. 2004 Jun;5(6):590-5. Epub 2004 May 7.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Richardson SC, etal., Mol Biol Cell 2004 Mar;15(3):1197-210. Epub 2003 Dec 10.
11. Membrane fusion between liposomes containing SNARE proteins involved in mast cell exocytosis. Sakiyama H, etal., Inflamm Res. 2009 Mar;58(3):139-42.
12. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51.
Additional References at PubMed
PMID:9614193   PMID:11029036   PMID:11101518   PMID:11208143   PMID:12130530   PMID:12414999   PMID:16677249   PMID:17272274   PMID:17618625   PMID:18227281   PMID:18253931   PMID:18321981  
PMID:18535671   PMID:18570918   PMID:18614015   PMID:19056867   PMID:19144319   PMID:20458337   PMID:21151919   PMID:22144578   PMID:22589474   PMID:23217709   PMID:23376485   PMID:24550300  
PMID:25686604   PMID:27402227   PMID:27628032   PMID:28242757  


Genomics

Comparative Map Data
Vamp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,000,570 - 106,011,081 (-)NCBIGRCr8
mRatBN7.24104,442,383 - 104,452,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,442,393 - 104,452,897 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,822,062 - 109,827,133 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,597,175 - 105,602,246 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,210,202 - 104,215,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,250,301 - 100,252,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,250,301 - 100,252,755 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,020,594 - 165,023,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,692,451 - 105,694,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,936,931 - 105,939,387 (-)NCBI
Celera493,595,511 - 93,597,967 (-)NCBICelera
Cytogenetic Map4q32NCBI
VAMP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,577,586 - 85,582,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,561,562 - 85,582,031 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,804,709 - 85,809,154 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,658,228 - 85,662,665 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,716,374 - 85,720,811NCBI
Celera285,632,880 - 85,637,440 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,701,916 - 85,706,329 (+)NCBIHuRef
CHM1_1285,734,420 - 85,738,962 (+)NCBICHM1_1
T2T-CHM13v2.0285,579,646 - 85,584,091 (+)NCBIT2T-CHM13v2.0
Vamp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,362,204 - 72,367,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,362,206 - 72,367,686 (-)EnsemblGRCm39 Ensembl
GRCm38672,385,221 - 72,390,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,385,223 - 72,390,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,335,215 - 72,340,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,314,732 - 72,320,090 (-)NCBIMGSCv36mm8
Celera674,475,546 - 74,480,987 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Vamp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,923,092 - 1,926,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,922,830 - 1,926,844 (-)NCBIChiLan1.0ChiLan1.0
VAMP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,800,606 - 40,805,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,803,367 - 40,807,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,627,678 - 85,632,205 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,180,681 - 87,185,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,180,681 - 87,185,195 (+)Ensemblpanpan1.1panPan2
VAMP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,497,628 - 39,501,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,497,785 - 39,501,739 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,169,004 - 39,173,102 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,244,282 - 40,248,381 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,244,432 - 40,248,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,373,788 - 39,377,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,445,831 - 39,449,930 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,845,443 - 39,849,546 (-)NCBIUU_Cfam_GSD_1.0
Vamp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,167,736 - 79,170,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,688,093 - 1,689,816 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,688,126 - 1,689,742 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAMP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,185,735 - 59,193,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,187,900 - 59,193,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,249,017 - 62,254,147 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAMP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,575,057 - 21,580,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,575,161 - 21,579,820 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604590,888,891 - 90,893,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vamp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,558,429 - 17,562,723 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,558,429 - 17,562,765 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vamp8
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:61
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000017301
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4103194805112478794Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017301   ⟹   ENSRNOP00000017301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,442,393 - 104,452,897 (-)Ensembl
Rnor_6.0 Ensembl4100,250,301 - 100,252,755 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096938   ⟹   ENSRNOP00000083978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,442,393 - 104,447,514 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115330   ⟹   ENSRNOP00000088625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,442,393 - 104,445,670 (-)Ensembl
RefSeq Acc Id: NM_031827   ⟹   NP_114015
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,000,570 - 106,005,642 (-)NCBI
mRatBN7.24104,442,383 - 104,447,457 (-)NCBI
Rnor_6.04100,250,301 - 100,252,756 (-)NCBI
Rnor_5.04165,020,594 - 165,023,049 (-)NCBI
RGSC_v3.44105,692,451 - 105,694,908 (-)RGD
Celera493,595,511 - 93,597,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108449   ⟹   XP_038964377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,000,574 - 106,011,081 (-)NCBI
mRatBN7.24104,442,387 - 104,452,884 (-)NCBI
RefSeq Acc Id: NP_114015   ⟸   NM_031827
- UniProtKB: Q9WUF4 (UniProtKB/Swiss-Prot),   A6IAB7 (UniProtKB/TrEMBL),   A0A8I6AB54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017301   ⟸   ENSRNOT00000017301
RefSeq Acc Id: XP_038964377   ⟸   XM_039108449
- Peptide Label: isoform X1
- UniProtKB: F1LNT8 (UniProtKB/TrEMBL),   A0A8I6AB54 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083978   ⟸   ENSRNOT00000096938
Ensembl Acc Id: ENSRNOP00000088625   ⟸   ENSRNOT00000115330
Protein Domains
v-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUF4-F1-model_v2 AlphaFold Q9WUF4 1-100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620421 AgrOrtholog
BioCyc Gene G2FUF-44148 BioCyc
Ensembl Genes ENSRNOG00000012748 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055020802 UniProtKB/Swiss-Prot
  ENSRNOG00060015579 UniProtKB/Swiss-Prot
  ENSRNOG00065005266 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017301.5 UniProtKB/TrEMBL
  ENSRNOT00000096938.1 UniProtKB/Swiss-Prot
  ENSRNOT00000115330.1 UniProtKB/TrEMBL
  ENSRNOT00055035532 UniProtKB/Swiss-Prot
  ENSRNOT00060026683 UniProtKB/Swiss-Prot
  ENSRNOT00065007759 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Synaptobrevin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptobrevin/VAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 83730 ENTREZGENE
PANTHER PTHR45701 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VESICLE-ASSOCIATED MEMBRANE PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Synaptobrevin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vamp8 PhenoGen
PIRSF Synaptobrevin_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SYNAPTOBREVN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SYNAPTOBREVIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012748 RatGTEx
  ENSRNOG00055020802 RatGTEx
  ENSRNOG00060015579 RatGTEx
  ENSRNOG00065005266 RatGTEx
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AB54 ENTREZGENE, UniProtKB/TrEMBL
  A6IAB7 ENTREZGENE, UniProtKB/TrEMBL
  F1LNT8 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUF4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Vamp8  vesicle-associated membrane protein 8    vesicle-associated membrane protein 8 (endobrevin)  Name updated 1299863 APPROVED
2002-08-07 Vamp8  vesicle-associated membrane protein 8 (endobrevin)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with other SNARE proteins and forms stable ternary complex, reversibly dissociated by the soluble ATPase NSF 634238