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Gene: DHPS (deoxyhypusine synthase) Homo sapiens
Symbol: DHPS
Name: deoxyhypusine synthase
Description: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DHS; DS; MIG13; migration-inducing gene 13; NEDSSWI
Mus musculus (house mouse) : Dhps (deoxyhypusine synthase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dhps (deoxyhypusine synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhps (deoxyhypusine synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHPS (deoxyhypusine synthase)
Canis lupus familiaris (dog) : DHPS (deoxyhypusine synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhps (deoxyhypusine synthase)
Sus scrofa (pig) : DHPS (deoxyhypusine synthase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381912,672,470 - 12,681,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,786,531 - 12,792,701 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,647,534 - 12,653,677 (-)NCBINCBI36hg18NCBI36
Celera1912,676,248 - 12,682,391 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,359,566 - 12,365,756 (-)NCBIHuRef
CHM1_11912,787,036 - 12,793,200 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DHPS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1602903
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.