VAMP8 (vesicle associated membrane protein 8) - Rat Genome Database

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Gene: VAMP8 (vesicle associated membrane protein 8) Homo sapiens
Analyze
Symbol: VAMP8
Name: vesicle associated membrane protein 8
RGD ID: 1347649
HGNC Page HGNC:12647
Description: Enables chloride channel inhibitor activity. Involved in several processes, including autophagosome membrane docking; mucus secretion; and regulation of secretion by cell. Acts upstream of or within symbiont entry into host cell. Located in several cellular components, including cytoplasmic vesicle; cytosol; and perinuclear region of cytoplasm. Part of SNARE complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EDB; VAMP-8; vesicle-associated membrane protein 8; vesicle-associated membrane protein 8 (endobrevin)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,577,586 - 85,582,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,561,562 - 85,582,031 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,804,709 - 85,809,154 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,658,228 - 85,662,665 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,716,374 - 85,720,811NCBI
Celera285,632,880 - 85,637,440 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,701,916 - 85,706,329 (+)NCBIHuRef
CHM1_1285,734,420 - 85,738,962 (+)NCBICHM1_1
T2T-CHM13v2.0285,579,646 - 85,584,091 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
3-Nitrobenzanthrone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
aconitine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
chloropicrin  (EXP)
cisplatin  (EXP)
clothianidin  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (EXP)
elemental selenium  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
ethyl methanesulfonate  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
gentamycin  (ISO)
ivermectin  (EXP)
ketoconazole  (ISO)
mercury dibromide  (EXP)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (ISO)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (EXP)
potassium chromate  (EXP)
rac-lactic acid  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sulfadimethoxine  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
toluene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9144278   PMID:9614193   PMID:9878266   PMID:10336434   PMID:10601239   PMID:10820264   PMID:11029036   PMID:11031247   PMID:11101518   PMID:11112705   PMID:11252894  
PMID:11278762   PMID:11694590   PMID:11786915   PMID:11839770   PMID:12130530   PMID:12477932   PMID:12828989   PMID:15489334   PMID:15815621   PMID:16110299   PMID:16195891   PMID:16677249  
PMID:16690874   PMID:17255364   PMID:17975119   PMID:17979178   PMID:18073581   PMID:18253931   PMID:18388320   PMID:18570918   PMID:19023099   PMID:19056867   PMID:19282863   PMID:19374688  
PMID:19557002   PMID:19738201   PMID:19738360   PMID:19752551   PMID:19913121   PMID:19943878   PMID:20089838   PMID:20458337   PMID:20533276   PMID:20628086   PMID:20706999   PMID:20877624  
PMID:21486954   PMID:21674799   PMID:21743467   PMID:21873635   PMID:21988832   PMID:22118466   PMID:22144578   PMID:22192511   PMID:22589474   PMID:22623428   PMID:23217709   PMID:23376485  
PMID:24550300   PMID:25209430   PMID:25419848   PMID:25648148   PMID:25686604   PMID:25748427   PMID:26124288   PMID:26186194   PMID:26191281   PMID:26496610   PMID:26553929   PMID:26638075  
PMID:27791468   PMID:28514442   PMID:29360461   PMID:29568061   PMID:30165196   PMID:30442766   PMID:30584088   PMID:30630984   PMID:30639242   PMID:30659120   PMID:30742775   PMID:30945947  
PMID:31251111   PMID:31594818   PMID:31694946   PMID:31806350   PMID:31871319   PMID:32556890   PMID:32817423   PMID:33060197   PMID:33144569   PMID:33422265   PMID:33947832   PMID:33957083  
PMID:33961781   PMID:34042162   PMID:34079125   PMID:34432599   PMID:34597346   PMID:34645799   PMID:34672954   PMID:34702444   PMID:34709727   PMID:34752845   PMID:34785650   PMID:35271311  
PMID:35748872   PMID:35944360   PMID:36300783   PMID:36328496   PMID:36610398   PMID:37405957   PMID:37827155   PMID:38182888  


Genomics

Comparative Map Data
VAMP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,577,586 - 85,582,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,561,562 - 85,582,031 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,804,709 - 85,809,154 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,658,228 - 85,662,665 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,716,374 - 85,720,811NCBI
Celera285,632,880 - 85,637,440 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,701,916 - 85,706,329 (+)NCBIHuRef
CHM1_1285,734,420 - 85,738,962 (+)NCBICHM1_1
T2T-CHM13v2.0285,579,646 - 85,584,091 (+)NCBIT2T-CHM13v2.0
Vamp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,362,204 - 72,367,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,362,206 - 72,367,686 (-)EnsemblGRCm39 Ensembl
GRCm38672,385,221 - 72,390,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,385,223 - 72,390,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,335,215 - 72,340,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,314,732 - 72,320,090 (-)NCBIMGSCv36mm8
Celera674,475,546 - 74,480,987 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Vamp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,000,570 - 106,011,081 (-)NCBIGRCr8
mRatBN7.24104,442,383 - 104,452,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,442,393 - 104,452,897 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,822,062 - 109,827,133 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,597,175 - 105,602,246 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,210,202 - 104,215,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,250,301 - 100,252,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,250,301 - 100,252,755 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,020,594 - 165,023,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,692,451 - 105,694,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,936,931 - 105,939,387 (-)NCBI
Celera493,595,511 - 93,597,967 (-)NCBICelera
Cytogenetic Map4q32NCBI
Vamp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,923,092 - 1,926,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,922,830 - 1,926,844 (-)NCBIChiLan1.0ChiLan1.0
VAMP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,800,606 - 40,805,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,803,367 - 40,807,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,627,678 - 85,632,205 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,180,681 - 87,185,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,180,681 - 87,185,195 (+)Ensemblpanpan1.1panPan2
VAMP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,497,628 - 39,501,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,497,785 - 39,501,739 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,169,004 - 39,173,102 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,244,282 - 40,248,381 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,244,432 - 40,248,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,373,788 - 39,377,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,445,831 - 39,449,930 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,845,443 - 39,849,546 (-)NCBIUU_Cfam_GSD_1.0
Vamp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,167,736 - 79,170,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,688,093 - 1,689,816 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,688,126 - 1,689,742 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAMP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,185,735 - 59,193,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,187,900 - 59,193,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,249,017 - 62,254,147 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAMP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,575,057 - 21,580,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,575,161 - 21,579,820 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604590,888,891 - 90,893,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vamp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,558,429 - 17,562,723 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,558,429 - 17,562,765 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VAMP8
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p12-11.2(chr2:77025216-90282666)x3 copy number gain See cases [RCV000134786] Chr2:77025216..90282666 [GRCh38]
Chr2:77252342..91619262 [GRCh37]
Chr2:77105850..90982989 [NCBI36]
Chr2:2p12-11.2
pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p11.2(chr2:85014686-88826619)x1 copy number loss See cases [RCV000141948] Chr2:85014686..88826619 [GRCh38]
Chr2:85241809..89126132 [GRCh37]
Chr2:85095320..88907247 [NCBI36]
Chr2:2p11.2
pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh37/hg19 2p11.2(chr2:85598271-85843453)x3 copy number gain Ductal breast carcinoma [RCV000207275] Chr2:85598271..85843453 [GRCh37]
Chr2:2p11.2
uncertain significance
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p13.1-11.2(chr2:74365484-89129064)x1 copy number loss See cases [RCV000510763] Chr2:74365484..89129064 [GRCh37]
Chr2:2p13.1-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p12-11.2(chr2:82517612-86262705)x3 copy number gain not provided [RCV000682150] Chr2:82517612..86262705 [GRCh37]
Chr2:2p12-11.2
uncertain significance
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2p13.1-11.2(chr2:74527522-89125488)x1 copy number loss not provided [RCV000682167] Chr2:74527522..89125488 [GRCh37]
Chr2:2p13.1-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p12-11.2(chr2:77907114-87330965)x1 copy number loss not provided [RCV000846587] Chr2:77907114..87330965 [GRCh37]
Chr2:2p12-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p11.2(chr2:85786006-86559358)x3 copy number gain not provided [RCV001259609] Chr2:85786006..86559358 [GRCh37]
Chr2:2p11.2
uncertain significance
GRCh37/hg19 2p12-11.2(chr2:81209244-86688030)x1 copy number loss not provided [RCV001537915] Chr2:81209244..86688030 [GRCh37]
Chr2:2p12-11.2
pathogenic
NM_003761.5(VAMP8):c.*143T>C single nucleotide variant not provided [RCV001539917] Chr2:85581859 [GRCh38]
Chr2:85808982 [GRCh37]
Chr2:2p11.2
benign
GRCh37/hg19 2p12-11.2(chr2:82486900-87322042) copy number loss not specified [RCV002053172] Chr2:82486900..87322042 [GRCh37]
Chr2:2p12-11.2
pathogenic
NC_000002.11:g.(?_85766411)_(86564633_?)del deletion Hereditary spastic paraplegia 31 [RCV003111516] Chr2:85766411..86564633 [GRCh37]
Chr2:2p11.2
pathogenic
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13
pathogenic
NM_003761.5(VAMP8):c.271A>G (p.Ile91Val) single nucleotide variant Inborn genetic diseases [RCV002689333] Chr2:85581684 [GRCh38]
Chr2:85808807 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_003761.5(VAMP8):c.29A>G (p.Asn10Ser) single nucleotide variant Inborn genetic diseases [RCV002683996] Chr2:85579034 [GRCh38]
Chr2:85806157 [GRCh37]
Chr2:2p11.2
uncertain significance
GRCh37/hg19 2p11.2(chr2:85786007-86559358)x3 copy number gain not provided [RCV002475677] Chr2:85786007..86559358 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_003761.5(VAMP8):c.133C>T (p.Arg45Cys) single nucleotide variant Inborn genetic diseases [RCV002784424] Chr2:85579138 [GRCh38]
Chr2:85806261 [GRCh37]
Chr2:2p11.2
uncertain significance
NM_003761.5(VAMP8):c.119A>T (p.Asn40Ile) single nucleotide variant Inborn genetic diseases [RCV003358948] Chr2:85579124 [GRCh38]
Chr2:85806247 [GRCh37]
Chr2:2p11.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1015
Count of miRNA genes:320
Interacting mature miRNAs:345
Transcripts:ENST00000263864, ENST00000409760, ENST00000432071
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D2S2607  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37285,808,692 - 85,809,028UniSTSGRCh37
Build 36285,662,203 - 85,662,539RGDNCBI36
Celera285,636,976 - 85,637,312RGD
Cytogenetic Map2p12-p11.2UniSTS
HuRef285,705,865 - 85,706,201UniSTS
Whitehead-YAC Contig Map2 UniSTS
RH98261  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37285,808,692 - 85,808,820UniSTSGRCh37
Build 36285,662,203 - 85,662,331RGDNCBI36
Celera285,636,976 - 85,637,104RGD
Cytogenetic Map2p12-p11.2UniSTS
HuRef285,705,865 - 85,705,993UniSTS
GeneMap99-GB4 RH Map2292.55UniSTS
G59843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37285,808,798 - 85,809,003UniSTSGRCh37
Build 36285,662,309 - 85,662,514RGDNCBI36
Celera285,637,082 - 85,637,287RGD
Cytogenetic Map2p12-p11.2UniSTS
HuRef285,705,971 - 85,706,176UniSTS
TNG Radiation Hybrid Map253778.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 2 10 2 3 59 10
Medium 2291 2165 1700 620 1928 461 3512 1090 1516 411 1283 1542 174 1 1202 1989 6 2
Low 147 826 22 2 12 2 839 1104 2211 3 117 56 1 2 799
Below cutoff 1 1 1 5 3 7 1 1 5

Sequence


RefSeq Acc Id: ENST00000263864   ⟹   ENSP00000263864
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,577,586 - 85,582,031 (+)Ensembl
RefSeq Acc Id: ENST00000409760   ⟹   ENSP00000387094
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,577,593 - 85,582,031 (+)Ensembl
RefSeq Acc Id: ENST00000432071   ⟹   ENSP00000407984
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,561,562 - 85,581,997 (+)Ensembl
RefSeq Acc Id: NM_003761   ⟹   NP_003752
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,577,586 - 85,582,031 (+)NCBI
GRCh37285,804,614 - 85,809,156 (+)ENTREZGENE
Build 36285,658,228 - 85,662,665 (+)NCBI Archive
HuRef285,701,916 - 85,706,329 (+)ENTREZGENE
CHM1_1285,734,420 - 85,738,962 (+)NCBI
T2T-CHM13v2.0285,579,646 - 85,584,091 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017005170   ⟹   XP_016860659
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,577,586 - 85,582,031 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054344328   ⟹   XP_054200303
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,579,646 - 85,584,091 (+)NCBI
RefSeq Acc Id: NP_003752   ⟸   NM_003761
- UniProtKB: Q53SP9 (UniProtKB/Swiss-Prot),   O60625 (UniProtKB/Swiss-Prot),   Q6IB09 (UniProtKB/Swiss-Prot),   Q9BV40 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016860659   ⟸   XM_017005170
- Peptide Label: isoform X1
- UniProtKB: B8ZZT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000407984   ⟸   ENST00000432071
RefSeq Acc Id: ENSP00000387094   ⟸   ENST00000409760
RefSeq Acc Id: ENSP00000263864   ⟸   ENST00000263864
RefSeq Acc Id: XP_054200303   ⟸   XM_054344328
- Peptide Label: isoform X1
- UniProtKB: B8ZZT4 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BV40-F1-model_v2 AlphaFold Q9BV40 1-100 view protein structure

Promoters
RGD ID:6860896
Promoter ID:EPDNEW_H3613
Type:initiation region
Name:VAMP8_1
Description:vesicle associated membrane protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,577,586 - 85,577,646EPDNEW
RGD ID:6798432
Promoter ID:HG_KWN:33554
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000409760,   OTTHUMT00000252498
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,658,066 - 85,658,566 (+)MPROMDB
RGD ID:6852462
Promoter ID:EP74040
Type:initiation region
Name:HS_VAMP8
Description:Vesicle-associated membrane protein 8 (endobrevin).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,658,220 - 85,658,280EPD
RGD ID:6811996
Promoter ID:HG_ACW:44858
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:VAMP8ANDVAMP5.FAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 36285,659,096 - 85,659,596 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12647 AgrOrtholog
COSMIC VAMP8 COSMIC
Ensembl Genes ENSG00000118640 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000263864 ENTREZGENE
  ENST00000263864.10 UniProtKB/Swiss-Prot
  ENST00000409760 ENTREZGENE
  ENST00000409760.1 UniProtKB/TrEMBL
  ENST00000432071.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000118640 GTEx
HGNC ID HGNC:12647 ENTREZGENE
Human Proteome Map VAMP8 Human Proteome Map
InterPro Synaptobrevin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptobrevin/VAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8673 UniProtKB/Swiss-Prot
NCBI Gene 8673 ENTREZGENE
OMIM 603177 OMIM
PANTHER PTHR45701 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VESICLE-ASSOCIATED MEMBRANE PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Synaptobrevin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37271 PharmGKB
PIRSF Synaptobrevin_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SYNAPTOBREVN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SYNAPTOBREVIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B8ZZT4 ENTREZGENE, UniProtKB/TrEMBL
  C9JXZ5_HUMAN UniProtKB/TrEMBL
  O60625 ENTREZGENE
  Q53SP9 ENTREZGENE
  Q6IB09 ENTREZGENE
  Q9BV40 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O60625 UniProtKB/Swiss-Prot
  Q53SP9 UniProtKB/Swiss-Prot
  Q6IB09 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-10 VAMP8  vesicle associated membrane protein 8    vesicle-associated membrane protein 8  Symbol and/or name change 5135510 APPROVED
2012-10-23 VAMP8  vesicle-associated membrane protein 8    vesicle-associated membrane protein 8 (endobrevin)  Symbol and/or name change 5135510 APPROVED