Krt18 (keratin 18) - Rat Genome Database

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Gene: Krt18 (keratin 18) Rattus norvegicus
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Symbol: Krt18
Name: keratin 18
RGD ID: 619935
Description: Predicted to enable scaffold protein binding activity. Involved in several processes, including cholangiocyte apoptotic process; hepatocyte differentiation; and response to fructose. Located in external side of plasma membrane; extracellular space; and keratin filament. Part of protein-containing complex. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in liver cirrhosis and metabolic dysfunction-associated steatohepatitis. Orthologous to human KRT18 (keratin 18); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CK-18; cytokeratin-18; K18; keratin 18, type I; keratin complex 1, acidic, gene 18; keratin, type I cytoskeletal 18; keratin-18; Krt1-18; MGC109143
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,036,168 - 135,039,844 (+)NCBIGRCr8
mRatBN7.27133,157,486 - 133,161,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1064,877,631 - 64,879,869 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7133,157,475 - 133,161,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,918,930 - 134,922,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,148,293 - 137,152,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,127,118 - 137,130,838 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,629,455 - 143,633,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,425,684 - 141,429,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1279,988,565 - 79,989,008 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Krt18RatAcute Liver Failure  ISOKRT18 (Homo sapiens)18337491protein:increased degradation:serum (human)RGD 
Krt18RatChemical and Drug Induced Liver Injury  ISOKrt18 (Mus musculus)18337498mRNA and protein:increased expression:liver (mouse)RGD 
Krt18RatChronic Hepatitis B severityISOKRT18 (Homo sapiens)18337494protein:increased degradation:serum (human)RGD 
Krt18RatChronic Hepatitis B disease_progressionISOKRT18 (Homo sapiens)18337487protein:increased phosphorylation:liver (human)RGD 
Krt18RatChronic Hepatitis C disease_progressionISOKRT18 (Homo sapiens)18337496protein:increased degradation:serum (human)RGD 
Krt18RatChronic Hepatitis C disease_progressionISOKRT18 (Homo sapiens)18337500protein:increased expression:liver and serum (human)RGD 
Krt18RatChronic Hepatitis C disease_progressionISOKRT18 (Homo sapiens)18337481protein:increased expression:serum (human)RGD 
Krt18RatChronic Hepatitis C severityISOKRT18 (Homo sapiens)18337493protein:increased degradation:serum (human)RGD 
Krt18RatExperimental Liver Cirrhosis  IEP 27226809protein:increased expression:liver and plasma membrane (rat)RGD 
Krt18Rathepatosplenic schistosomiasis disease_progressionISOKrt18 (Mus musculus) and KRT18 (Homo sapiens)21406434 protein:increased expression:serum (mouse and human)RGD 
Krt18Ratliver cancer severityISOKrt18 (Mus musculus)18337485associated with fatty liver diseaseRGD 
Krt18Ratliver cirrhosis  ISOKRT18 (Homo sapiens)1624318 RGD 
Krt18Ratliver cirrhosis severityISOKRT18 (Homo sapiens)18337484protein:increased expression: serum (human)RGD 
Krt18Ratliver disease severityISOKRT18 (Homo sapiens)18337488protein:increased degradation:serum (human)RGD 
Krt18RatLiver Injury susceptibilityISOKRT18 (Homo sapiens)18337486DNA:missense mutations:cds:p.D238E and p.D397E (human)RGD 
Krt18Ratmetabolic dysfunction-associated steatohepatitis  ISOKRT18 (Homo sapiens)18337493protein:increased degradation:serum (human)RGD 
Krt18Ratmetabolic dysfunction-associated steatohepatitis severityIEP 27226810protein:altered degradation:liver and serum (rat)RGD 
Krt18Ratmetabolic dysfunction-associated steatohepatitis severityISOKRT18 (Homo sapiens)18337499protein:increased expression:serum (human)RGD 
Krt18Ratmetabolic dysfunction-associated steatohepatitis severityISOKRT18 (Homo sapiens)18337495associated with morbid obesity and protein:increased degradation: plasma(human)RGD 
Krt18Ratmetabolic dysfunction-associated steatohepatitis severityISOKRT18 (Homo sapiens)18337489protein:increased degradation:plasma (human)RGD 
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Original Reference(s)
Krt18RatCryptogenic Cirrhosis  ISOKRT18 (Homo sapiens)8554872ClinVar Annotator: match by term: Cirrhosis and cryptogenicClinVarPMID:12724528 and PMID:9011570
Krt18RatFamilial Cirrhosis  ISOKRT18 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12724528 more ...
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Krt18RatAcute Liver Failure  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20538000
Krt18RatBreast Neoplasms  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20061804 and PMID:25330770
Krt18RatChemical and Drug Induced Liver Injury  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19783637 more ...
Krt18RatExperimental Liver Cirrhosis  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15999547 more ...
Krt18RatFamilial Cirrhosis  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Krt18Ratliver cirrhosis  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20538000
Krt18RatLiver Neoplasms  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19409407 and PMID:19796649
Krt18RatNecrosis  ISOKRT18 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19783637
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Krt18Rathepatocellular carcinoma  ISSKrt18 (Mus musculus)13592920OMIM:114550MouseDO 
Krt18Ratmetabolic dysfunction-associated steatohepatitis  ISSKrt18 (Mus musculus)13592920 MouseDO 
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Original Reference(s)
Krt18RatFamilial Cirrhosis  ISOKRT18 (Homo sapiens)7240710 OMIM 

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Krt18Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of KRT18 mRNA]CTDPMID:31150632
Krt18Rat(1->4)-beta-D-glucan multiple interactionsISOKrt18 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of KRT18 mRNACTDPMID:36331819
Krt18Rat(S)-colchicine decreases expressionISOKRT18 (Homo sapiens)6480464Colchicine results in decreased expression of KRT18 proteinCTDPMID:11259854
Krt18Rat1,2-dichloroethane increases expressionISOKrt18 (Mus musculus)6480464ethylene dichloride results in increased expression of KRT18 mRNACTDPMID:28189721 and PMID:28960355
Krt18Rat1,2-dimethylhydrazine multiple interactionsISOKrt18 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KRT18 mRNACTDPMID:22206623
Krt18Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of KRT18 mRNACTDPMID:17522070 more ...
Krt18Rat1-naphthyl isothiocyanate multiple interactionsISOKrt18 (Mus musculus)6480464O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1 and 2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT18 mRNA]CTDPMID:15913567
Krt18Rat1-naphthyl isothiocyanate increases expressionISOKrt18 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of KRT18 mRNACTDPMID:15913567
Krt18Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of KRT18 mRNACTDPMID:12655037
Krt18Rat17beta-estradiol multiple interactionsISOKRT18 (Homo sapiens)64804643 more ...CTDPMID:11179685 more ...
Krt18Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of KRT18 mRNA and Estradiol results in decreased expression of KRT18 proteinCTDPMID:32145629
Krt18Rat17beta-estradiol increases expressionISOKrt18 (Mus musculus)6480464Estradiol results in increased expression of KRT18 mRNACTDPMID:19484750 and PMID:39298647
Krt18Rat17beta-estradiol increases expressionISOKRT18 (Homo sapiens)6480464Estradiol results in increased expression of KRT18 mRNACTDPMID:11179685 and PMID:19484750
Krt18Rat17beta-estradiol decreases expressionISOKRT18 (Homo sapiens)6480464Estradiol results in decreased expression of KRT18 mRNA and Estradiol results in decreased expression of KRT18 proteinCTDPMID:23019147 more ...
Krt18Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expressionISOKRT18 (Homo sapiens)6480464Metribolone results in increased expression of KRT18 proteinCTDPMID:17152098 and PMID:17541959
Krt18Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOKRT18 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of KRT18 mRNACTDPMID:29581250
Krt18Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOKrt18 (Mus musculus)64804642 more ...CTDPMID:30294300
Krt18Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:31826744
Krt18Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOKRT18 (Homo sapiens)6480464Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA]CTDPMID:11179685
Krt18Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOKRT18 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of KRT18 mRNACTDPMID:23152189

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Biological Process
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Original Reference(s)
Krt18Ratcholangiocyte apoptotic process  IEP 27226806 RGD 
Krt18Ratextrinsic apoptotic signaling pathway acts_upstream_of_or_withinISOKrt18 (Mus musculus)1624291MGI:2178045 PMID:10747083RGDPMID:10747083
Krt18RatGolgi to plasma membrane protein transport involved_inISOKRT18 (Homo sapiens)1624291 PMID:15529338RGDPMID:15529338
Krt18Rathepatocyte apoptotic process acts_upstream_of_or_withinISOKrt18 (Mus musculus)1624291MGI:2178045 PMID:10747083RGDPMID:10747083
Krt18Rathepatocyte differentiation  IEP 27226712 RGD 
Krt18Rathepatocyte differentiation  IEP 27226713 RGD 
Krt18Ratintermediate filament cytoskeleton organization involved_inISOKRT18 (Homo sapiens)1624291 PMID:20346438RGDPMID:20346438
Krt18Ratintermediate filament cytoskeleton organization involved_inIBAPANTHER:PTN002757475 and UniProtKB:P057831600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt18Ratmesenchymal stem cell differentiation  IEP 27226811 RGD 
Krt18Ratnegative regulation of apoptotic process involved_inISOKRT18 (Homo sapiens)1624291 PMID:11684708RGDPMID:11684708
Krt18Ratresponse to fructose  IEP 2688446035% fructose corn syrupRGD 
Krt18Ratresponse to nutrient levels  IEP 18337497high fat diet and sucroseRGD 
Krt18Ratresponse to nutrient levels  IEP 27226810high fat dietRGD 
Krt18Rattumor necrosis factor-mediated signaling pathway acts_upstream_of_or_withinISOKrt18 (Mus musculus)1624291MGI:96705 PMID:10747083RGDPMID:10747083
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Cellular Component
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Original Reference(s)
Krt18Ratcell periphery located_inISOKrt18 (Mus musculus)1624291 PMID:23284756RGDPMID:23284756
Krt18Ratcentriolar satellite located_inISOKRT18 (Homo sapiens)1624291 PMID:18000879RGDPMID:18000879
Krt18Ratcytoplasm located_inISOKRT18 (Homo sapiens)1624291 PMID:16424149 and PMID:20346438RGDPMID:16424149 and PMID:20346438
Krt18Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Krt18Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Krt18Ratcytoskeleton is_active_inIBAMGI:109364 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt18Ratcytosol located_inISOKRT18 (Homo sapiens)1624291 RGDGO_REF:0000052
Krt18Ratexternal side of plasma membrane  IDA 27226807MMO:0000679RGD 
Krt18Ratextracellular space  IDA 26884460MMO:0000669RGD 
Krt18Ratextracellular space  IDA 27226810MMO:0000712RGD 
Krt18Ratextracellular space  IDA 18337497MMO:0000075RGD 
Krt18Ratintermediate filament located_inISOKRT18 (Homo sapiens)1624291 PMID:10852826RGDPMID:10852826
Krt18Ratintermediate filament located_inISOKrt18 (Mus musculus)1624291 PMID:10747083RGDPMID:10747083
Krt18Ratintermediate filament located_inIEAUniProtKB-KW:KW-0403 and UniProtKB-KW:KW-04161600115GO_REF:0000043UniProtGO_REF:0000043
Krt18Ratkeratin filament  IDA 1624319 RGD 
Krt18Ratkeratin filament located_inISOKRT18 (Homo sapiens)1624291 PMID:10852826 and PMID:16424149RGDPMID:10852826 and PMID:16424149
Krt18Ratkeratin filament located_inISOKrt18 (Mus musculus)1624291 PMID:21930775RGDPMID:21930775
Krt18Ratkeratin filament is_active_inIBAMGI:96692 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt18Ratmicrotubule organizing center located_inISOKRT18 (Homo sapiens)1624291 PMID:18000879RGDPMID:18000879
Krt18Ratnuclear matrix located_inIEAUniProtKB-SubCell:SL-01811600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function

  


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Reference Title
Reference Citation
1. Evaluation of the diagnostic value of serum and tissue apoptotic cytokeratin-18 in patients with chronic hepatitis C. Abdel Haleem H, etal., Arab J Gastroenterol. 2013 Jun;14(2):68-72. doi: 10.1016/j.ajg.2013.03.004. Epub 2013 Apr 28.
2. Recovery of the Cholangiocytes After Ischemia and Reperfusion Injury: Ultra-Structural, Hystological and Molecular Assessment in Rats. Aloia TPA, etal., J Clin Exp Hepatol. 2018 Dec;8(4):380-389. doi: 10.1016/j.jceh.2018.01.003. Epub 2018 Feb 11.
3. Relationship between liver injury and serum cytokeratin 18 levels in asymptomatic hepatitis B virus carriers and in patients with chronic hepatitis B infection. Balkan A, etal., Arab J Gastroenterol. 2017 Jun;18(2):98-103. doi: 10.1016/j.ajg.2017.05.008. Epub 2017 Jun 1.
4. Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis. Bettermann K, etal., Oncotarget. 2016 Nov 8;7(45):73309-73322. doi: 10.18632/oncotarget.12325.
5. Association Between Serum CK-18 Levels and the Degree of Liver Damage in Fructose-Induced Metabolic Syndrome. Bratoeva K, etal., Metab Syndr Relat Disord. 2018 Sep;16(7):350-357. doi: 10.1089/met.2017.0162. Epub 2018 Jul 10.
6. In vitro and in vivo study of the application of volvox spheres to co-culture vehicles in liver tissue engineering. Chang SH, etal., Acta Biomater. 2017 Nov;63:261-273. doi: 10.1016/j.actbio.2017.09.028. Epub 2017 Sep 21.
7. Elevated serum cytokeratin-18 concentration in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease. Chang YH, etal., Ann Clin Biochem. 2019 Jan;56(1):141-147. doi: 10.1177/0004563218796259. Epub 2018 Aug 27.
8. Serum cytokeratin-18 and its relation to liver fibrosis and steatosis diagnosed by FibroScan and controlled attenuation parameter in nonalcoholic fatty liver disease and hepatitis C virus patients. Darweesh SK, etal., Eur J Gastroenterol Hepatol. 2019 May;31(5):633-641. doi: 10.1097/MEG.0000000000001385.
9. Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells. Deng X, etal., J Cell Physiol. 2008 Oct;217(1):138-44. doi: 10.1002/jcp.21481.
10. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Diab DL, etal., Clin Gastroenterol Hepatol. 2008 Nov;6(11):1249-54. doi: 10.1016/j.cgh.2008.07.016. Epub 2008 Jul 26.
11. Apoptotic and anti-apoptotic seromarkers for assessment of disease severity of non-alcoholic steatohepatitis. El Bassat H, etal., Arab J Gastroenterol. 2014 Mar;15(1):6-11. doi: 10.1016/j.ajg.2014.01.009. Epub 2014 Feb 7.
12. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Feldstein AE, etal., Hepatology. 2009 Oct;50(4):1072-8. doi: 10.1002/hep.23050.
13. Switch in the expression of the K19/K18 keratin genes as a very early evidence of testicular differentiation in the rat. Fridmacher V, etal., Mech Dev 1995 Aug;52(2-3):199-207.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression. Gonsebatt ME, etal., Arch Toxicol. 2007 Sep;81(9):619-26. doi: 10.1007/s00204-007-0192-7. Epub 2007 Mar 6.
17. Caspase-cleaved cytokeratin 18 and 20 S proteasome in liver degeneration. Hetz H, etal., J Clin Lab Anal. 2007;21(5):277-81. doi: 10.1002/jcla.20180.
18. Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis. Jazwinski AB, etal., J Viral Hepat. 2012 Apr;19(4):278-82. doi: 10.1111/j.1365-2893.2011.01546.x. Epub 2011 Nov 24.
19. [Subcellular proteome analysis of immune or alcohol induced rat liver fibrosis]. Jia XF, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Nov;18(11):826-30. doi: 10.3760/cma.j.issn.1007-3418.2010.11.009.
20. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Joka D, etal., Hepatology. 2012 Feb;55(2):455-64. doi: 10.1002/hep.24734. Epub 2011 Nov 29.
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PMID:10747083   PMID:10852826   PMID:11684708   PMID:12477932   PMID:15489334   PMID:15529338   PMID:16128803   PMID:16424149   PMID:16641100   PMID:18000879   PMID:19199708   PMID:19407366  
PMID:19409407   PMID:20346438   PMID:21930775   PMID:22658674   PMID:22685604   PMID:23284756   PMID:24625528   PMID:25468996   PMID:36395917  



Krt18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,036,168 - 135,039,844 (+)NCBIGRCr8
mRatBN7.27133,157,486 - 133,161,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1064,877,631 - 64,879,869 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7133,157,475 - 133,161,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,918,930 - 134,922,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,148,293 - 137,152,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,127,118 - 137,130,838 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,629,455 - 143,633,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,425,684 - 141,429,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1279,988,565 - 79,989,008 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)NCBICelera
Cytogenetic Map7q36NCBI
KRT18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,948,855 - 52,952,906 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,948,871 - 52,952,906 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,342,639 - 53,346,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,628,922 - 51,632,952 (+)NCBINCBI36Build 36hg18NCBI36
Build 341251,628,921 - 51,632,951NCBI
Celera1252,989,626 - 52,993,657 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,386,471 - 50,390,501 (+)NCBIHuRef
CHM1_11253,309,411 - 53,313,442 (+)NCBICHM1_1
T2T-CHM13v2.01252,913,414 - 52,917,465 (+)NCBIT2T-CHM13v2.0
Krt18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,936,651 - 101,940,461 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,936,615 - 101,940,462 (+)EnsemblGRCm39 Ensembl
GRCm3815102,028,216 - 102,032,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,028,180 - 102,032,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,858,647 - 101,862,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,856,259 - 101,860,055 (+)NCBIMGSCv36mm8
Celera15104,183,109 - 104,186,912 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.22NCBI
Krt18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458226,805 - 232,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458227,017 - 230,752 (+)NCBIChiLan1.0ChiLan1.0
KRT18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,240,278 - 41,244,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,237,041 - 41,241,089 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,807,660 - 35,811,691 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,587,149 - 36,591,196 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,587,149 - 36,591,196 (-)Ensemblpanpan1.1panPan2
KRT18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,189,269 - 2,193,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,189,269 - 2,193,368 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,058,883 - 44,062,982 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,190,002 - 2,194,108 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,189,986 - 2,194,112 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,207,095 - 2,210,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,193,381 - 2,197,266 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,457,950 - 44,461,835 (+)NCBIUU_Cfam_GSD_1.0
Krt18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,870,183 - 62,874,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,290,690 - 10,294,651 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,290,706 - 10,294,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,217,691 - 18,221,429 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,217,686 - 18,221,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,726,205 - 18,729,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,073,733 - 49,081,706 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037196,990,833 - 196,994,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,011,755 - 1,015,416 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,011,675 - 1,015,319 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Krt18
10 total Variants

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:43
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000073951
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat

1 to 10 of 15 rows
RH131703  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0825,170,981 - 25,171,164NCBIRnor5.0
Rnor_5.02100,546,425 - 100,546,621NCBIRnor5.0
RGSC_v3.4823,625,335 - 23,625,517UniSTSRGSC3.4
RGSC_v3.4280,044,296 - 80,044,491UniSTSRGSC3.4
Celera824,075,285 - 24,075,467UniSTS
Celera274,545,867 - 74,546,062UniSTS
RH 3.4 Map71065.8UniSTS
Cytogenetic Map7q36UniSTS
AA891608  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,039,313 - 135,039,801 (+)Marker Load Pipeline
mRatBN7.27133,160,631 - 133,161,119 (+)MAPPERmRatBN7.2
Rnor_6.07143,632,601 - 143,633,088NCBIRnor6.0
Rnor_5.07141,428,830 - 141,429,317UniSTSRnor5.0
Celera7129,597,185 - 129,597,672UniSTS
RH 3.4 Map2401.5UniSTS
Cytogenetic Map7q36UniSTS
Krt18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,910,620 - 78,911,453 (+)MAPPERmRatBN7.2
mRatBN7.2278,910,690 - 78,911,453 (+)MAPPERmRatBN7.2
Rnor_6.0280,878,793 - 80,879,555NCBIRnor6.0
Rnor_6.0280,878,570 - 80,879,555NCBIRnor6.0
Rnor_5.02100,545,637 - 100,546,399UniSTSRnor5.0
Rnor_5.02100,545,414 - 100,546,399UniSTSRnor5.0
RGSC_v3.4280,043,507 - 80,044,269UniSTSRGSC3.4
Celera274,545,078 - 74,545,840UniSTS
Cytogenetic Map7q36UniSTS
Krt18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,911,416 - 78,911,583 (+)MAPPERmRatBN7.2
mRatBN7.2822,497,552 - 22,497,716 (+)MAPPERmRatBN7.2
Rnor_6.0280,879,519 - 80,879,685NCBIRnor6.0
Rnor_6.0825,137,020 - 25,137,183NCBIRnor6.0
Rnor_5.0825,170,922 - 25,171,085UniSTSRnor5.0
Rnor_5.02100,546,363 - 100,546,529UniSTSRnor5.0
RGSC_v3.4823,625,275 - 23,625,438UniSTSRGSC3.4
RGSC_v3.4280,044,233 - 80,044,399UniSTSRGSC3.4
Celera824,075,225 - 24,075,388UniSTS
Celera274,545,804 - 74,545,970UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map8q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 49 113 91 90 59 25 59 6 215 94 93 45 59 31



Ensembl Acc Id: ENSRNOT00000073951   ⟹   ENSRNOP00000067234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,157,475 - 133,161,166 (+)Ensembl
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100179   ⟹   ENSRNOP00000084901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1064,877,631 - 64,879,869 (-)Ensembl
RefSeq Acc Id: NM_053976   ⟹   NP_446428
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,036,168 - 135,039,844 (+)NCBI
mRatBN7.27133,157,486 - 133,161,162 (+)NCBI
Rnor_6.07143,629,455 - 143,633,131 (+)NCBI
Rnor_5.07141,425,684 - 141,429,360 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)RGD
Sequence:
Protein RefSeqs NP_446428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB39618 (Get FASTA)   NCBI Sequence Viewer  
  AAH91275 (Get FASTA)   NCBI Sequence Viewer  
  CAA57204 (Get FASTA)   NCBI Sequence Viewer  
  EDL86867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067234.1
  ENSRNOP00000111587
GenBank Protein Q5BJY9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446428   ⟸   NM_053976
- UniProtKB: Q63278 (UniProtKB/Swiss-Prot),   Q5BJY9 (UniProtKB/Swiss-Prot),   A0A8I6A244 (UniProtKB/TrEMBL),   A6KCS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067234   ⟸   ENSRNOT00000073951
Ensembl Acc Id: ENSRNOP00000084901   ⟸   ENSRNOT00000100179
IF rod

Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJY9-F1-model_v2 AlphaFold Q5BJY9 1-423 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695686
Promoter ID:EPDNEW_R6211
Type:multiple initiation site
Name:Krt18_1
Description:keratin 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,629,441 - 143,629,501EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31953 BioCyc
Ensembl Genes ENSRNOG00000047393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000069468 Ensembl
Ensembl Transcript ENSRNOT00000073951.3 UniProtKB/Swiss-Prot
  ENSRNOT00000134417 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7383311 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_I UniProtKB/Swiss-Prot
KEGG Report rno:294853 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109143 IMAGE-MGC_LOAD
NCBI Gene Krt18 ENTREZGENE
PANTHER PTHR23239 UniProtKB/Swiss-Prot
  PTHR23239:SF349 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
PhenoGen Krt18 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047393 RatGTEx
  ENSRNOG00000069468 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt A0A8I6A244 ENTREZGENE, UniProtKB/TrEMBL
  A6KCS5 ENTREZGENE, UniProtKB/TrEMBL
  K1C18_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63278 ENTREZGENE
UniProt Secondary Q63278 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt18  keratin 18  Krt18  keratin 18, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt18  keratin 18, type I  Krt18  keratin 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Krt18  keratin 18  Krt1-18  keratin complex 1, acidic, gene 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Krt1-18  keratin complex 1, acidic, gene 18      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Krt1-18  keratin complex 1, acidic, gene 18      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression mRNA expressed at the onset of testicular differentiation and in male gonads 633091
gene_expression exclusively expressed in fetal Sertoli cells from 14.5 days of gestation 633091
gene_regulation expression regulated at the transcriptional level 633091