Myo5a (myosin VA) - Rat Genome Database

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Gene: Myo5a (myosin VA) Rattus norvegicus
Analyze
Symbol: Myo5a
Name: myosin VA
RGD ID: 3143
Description: Enables several functions, including ATP binding activity; ATP-dependent protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including cytoskeleton-dependent intracellular transport; positive regulation of cytochrome-c oxidase activity; and regulation of secretion by cell. Acts upstream of or within pigmentation. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Part of actomyosin, myosin complex part and ribonucleoprotein complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D; dilute myosin heavy chain, non-muscle; Dilute-opisthotonus; Dop; Myh12; myosin 5a; myosin-Va; unconventional myosin-Va
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Myo5am1Stc  
Is Marker For: Strains:   DOP/Nem  
Candidate Gene For: Vetf5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8884,692,524 - 84,860,564 (+)NCBIGRCr8
mRatBN7.2875,811,985 - 75,980,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl875,812,412 - 75,975,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,318,987 - 81,482,100 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,584,646 - 79,746,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,418,315 - 77,581,426 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,038,966 - 82,156,507 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,037,977 - 82,156,617 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0881,641,953 - 81,759,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4879,909,224 - 80,027,290 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1879,928,282 - 80,046,341 (+)NCBI
Celera875,604,281 - 75,764,672 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
flavone  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fructose  (ISO)
geldanamycin  (ISO)
glucose  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
mercury dichloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IBA)
actin filament-based movement  (IDA,ISO)
axo-dendritic protein transport  (IMP)
cellular response to insulin stimulus  (ISO,ISS)
chemical synaptic transmission  (ISO)
developmental pigmentation  (ISO)
dopamine metabolic process  (IMP)
endoplasmic reticulum localization  (ISO)
establishment of endoplasmic reticulum localization to postsynapse  (ISO)
exocytosis  (ISO)
hair follicle maturation  (ISO)
insulin secretion  (ISO)
locomotion involved in locomotory behavior  (ISO)
long-chain fatty acid biosynthetic process  (ISO)
macroautophagy  (IMP)
melanin biosynthetic process  (ISO)
melanin metabolic process  (ISO)
melanocyte differentiation  (ISO)
melanosome localization  (ISO)
melanosome transport  (ISO)
myelination  (ISO)
negative regulation of dopamine secretion  (IMP)
negative regulation of synaptic transmission, glutamatergic  (IMP)
neuromuscular process controlling balance  (ISO)
odontogenesis  (ISO)
pigmentation  (IMP,ISO)
positive regulation of cellular response to insulin stimulus  (IMP)
positive regulation of cytochrome-c oxidase activity  (IMP)
positive regulation of protein localization to plasma membrane  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
post-Golgi vesicle-mediated transport  (IEA,ISO)
protein localization to plasma membrane  (ISO,ISS)
protein transport  (IEA)
protein-containing complex assembly  (IMP)
reactive gliosis  (IMP)
regulation of exocytosis  (IMP)
regulation of Golgi organization  (ISO)
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity  (ISO)
regulation of postsynaptic cytosolic calcium ion concentration  (ISO)
secretory granule localization  (IDA,IMP,ISO)
synapse organization  (ISO)
vesicle transport along actin filament  (IBA,IEA,IMP,ISO)
vesicle-mediated transport  (ISO,ISS)
visual perception  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A. Anikster Y, etal., Am J Hum Genet. 2002 Aug;71(2):407-14. Epub 2002 Jun 7.
2. Actin and myosin-dependent localization of mRNA to dendrites. Balasanyan V and Arnold DB, PLoS One. 2014 Mar 17;9(3):e92349. doi: 10.1371/journal.pone.0092349. eCollection 2014.
3. Myosin Va is locally synthesized following nerve injury. Calliari A, etal., Cell Motil Cytoskeleton 2002 Apr;51(4):169-76.
4. Myosin Va associates with mRNA in ribonucleoprotein particles present in myelinated peripheral axons and in the central nervous system. Calliari A, etal., Dev Neurobiol. 2014 Mar;74(3):382-96. doi: 10.1002/dneu.22155. Epub 2014 Jan 27.
5. Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. Correia SS, etal., Nat Neurosci. 2008 Apr;11(4):457-66. doi: 10.1038/nn2063. Epub 2008 Mar 2.
6. Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus. Futaki S, etal., Mamm Genome 2000 Aug;11(8):649-55
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats. Guatteo E, etal., Exp Neurol. 2017 Jan;287(Pt 1):21-33. doi: 10.1016/j.expneurol.2016.10.009. Epub 2016 Oct 20.
10. Myosin 5a controls insulin granule recruitment during late-phase secretion. Ivarsson R, etal., Traffic. 2005 Nov;6(11):1027-35.
11. Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Landrock KK, etal., Brain Res. 2018 Jan 15;1679:155-170. doi: 10.1016/j.brainres.2017.11.029. Epub 2017 Dec 5.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Pastural E, etal., Nat Genet. 1997 Jul;16(3):289-92.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Myosin Va facilitates the distribution of secretory granules in the F-actin rich cortex of PC12 cells. Rudolf R, etal., J Cell Sci 2003 Apr 1;116(Pt 7):1339-48.
20. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
21. Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Schumacher-Bass SM, etal., Circ Res. 2014 Mar 14;114(6):982-92. doi: 10.1161/CIRCRESAHA.114.302711. Epub 2014 Feb 7.
22. TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5. Selamat W, etal., Neurosci Lett. 2009 Jan 30;450(2):163-6. doi: 10.1016/j.neulet.2008.12.014. Epub 2008 Dec 16.
23. Real-time visualization of processive myosin 5a-mediated vesicle movement in living astrocytes. Stachelek SJ, etal., J Biol Chem. 2001 Sep 21;276(38):35652-9. Epub 2001 Aug 9.
24. Potential role of α-synuclein in neurodegeneration: studies in a rat animal model. Stoica G, etal., J Neurochem. 2012 Aug;122(4):812-22. doi: 10.1111/j.1471-4159.2012.07805.x. Epub 2012 Jun 22.
25. Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells. Sun Y, etal., Mol Biol Cell. 2014 Apr;25(7):1159-70. doi: 10.1091/mbc.E13-08-0493. Epub 2014 Jan 29.
26. Myosin Va mutation in rats is an animal model for the human hereditary neurological disease, Griscelli syndrome type 1. Takagishi Y and Murata Y, Ann N Y Acad Sci. 2006 Nov;1086:66-80.
27. Localization of myosin II and V isoforms in cultured rat sympathetic neurones and their potential involvement in presynaptic function. Takagishi Y, etal., J Physiol. 2005 Nov 15;569(Pt 1):195-208. Epub 2005 Sep 15.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Immunohistochemical localization of myosin Va in the adult rat brain. Tilelli CQ, etal., Neuroscience. 2003;121(3):573-86.
30. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Ultanir SK, etal., Neuron. 2014 Dec 3;84(5):968-82. doi: 10.1016/j.neuron.2014.10.025. Epub 2014 Nov 13.
31. Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A. Watanabe M, etal., Mol Biol Cell. 2005 Oct;16(10):4519-30. Epub 2005 Jul 19.
32. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
33. BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin Va via Erk signaling. Zhang M, etal., Oxid Med Cell Longev. 2014;2014:294150. doi: 10.1155/2014/294150. Epub 2014 Mar 20.
Additional References at PubMed
PMID:1150661   PMID:1298991   PMID:1996138   PMID:2379821   PMID:3141922   PMID:3422417   PMID:6098826   PMID:6305507   PMID:7665913   PMID:7774591   PMID:7828830   PMID:8188282  
PMID:8899740   PMID:8962090   PMID:9133672   PMID:9548375   PMID:9560408   PMID:9560409   PMID:9852149   PMID:10536275   PMID:10749990   PMID:11086997   PMID:11266470   PMID:11266473  
PMID:11432975   PMID:11706052   PMID:11886590   PMID:11887186   PMID:11980908   PMID:12403814   PMID:13880466   PMID:14724135   PMID:14730011   PMID:14978221   PMID:15007063   PMID:15316067  
PMID:15357836   PMID:15550542   PMID:15788565   PMID:16025302   PMID:16137617   PMID:16247022   PMID:17247639   PMID:17513864   PMID:18568366   PMID:19214741   PMID:19787448   PMID:19812310  
PMID:19946888   PMID:20018767   PMID:20124353   PMID:20131911   PMID:20133809   PMID:21080055   PMID:21151132   PMID:21349835   PMID:21700703   PMID:21842169   PMID:21985333   PMID:22437832  
PMID:22681889   PMID:22908308   PMID:23533145   PMID:23626749   PMID:24006491   PMID:24625528   PMID:24721909   PMID:25260918   PMID:25340873   PMID:29476059   PMID:30053369   PMID:30320552  
PMID:32412091  


Genomics

Comparative Map Data
Myo5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8884,692,524 - 84,860,564 (+)NCBIGRCr8
mRatBN7.2875,811,985 - 75,980,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl875,812,412 - 75,975,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,318,987 - 81,482,100 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,584,646 - 79,746,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,418,315 - 77,581,426 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,038,966 - 82,156,507 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,037,977 - 82,156,617 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0881,641,953 - 81,759,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4879,909,224 - 80,027,290 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1879,928,282 - 80,046,341 (+)NCBI
Celera875,604,281 - 75,764,672 (+)NCBICelera
Cytogenetic Map8q24NCBI
MYO5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381552,307,283 - 52,529,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1552,307,281 - 52,529,132 (-)EnsemblGRCh38hg38GRCh38
GRCh371552,599,480 - 52,821,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361550,386,770 - 50,608,539 (-)NCBINCBI36Build 36hg18NCBI36
Build 341550,392,601 - 50,608,539NCBI
Celera1529,494,500 - 29,716,298 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1529,430,131 - 29,652,241 (-)NCBIHuRef
CHM1_11552,717,420 - 52,939,199 (-)NCBICHM1_1
T2T-CHM13v2.01550,115,562 - 50,337,348 (-)NCBIT2T-CHM13v2.0
Myo5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39974,975,183 - 75,130,970 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl974,978,297 - 75,130,970 (+)EnsemblGRCm39 Ensembl
GRCm38975,069,799 - 75,223,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl975,071,015 - 75,223,688 (+)EnsemblGRCm38mm10GRCm38
MGSCv37974,919,013 - 75,071,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36974,858,205 - 75,005,381 (+)NCBIMGSCv36mm8
Celera972,225,104 - 72,382,491 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map942.26NCBI
Myo5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554092,428,815 - 2,530,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554092,409,503 - 2,530,539 (+)NCBIChiLan1.0ChiLan1.0
MYO5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21641,541,713 - 41,765,479 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11545,722,108 - 45,945,837 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01531,246,192 - 31,470,040 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11549,572,084 - 49,699,507 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1549,578,491 - 49,704,319 (-)Ensemblpanpan1.1panPan2
MYO5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13017,990,521 - 18,122,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3017,888,419 - 18,213,061 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3017,917,091 - 18,108,854 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03018,136,193 - 18,328,524 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3018,141,754 - 18,328,530 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13018,055,372 - 18,247,165 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03018,173,117 - 18,365,153 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03018,280,846 - 18,470,667 (-)NCBIUU_Cfam_GSD_1.0
Myo5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864096,257,769 - 96,409,323 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647114,111,841 - 14,254,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647114,105,832 - 14,257,386 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,165,942 - 119,394,725 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,165,751 - 119,398,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21132,234,339 - 132,481,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12630,865,947 - 31,085,184 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048110,145,270 - 110,364,249 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247318,113,715 - 8,280,823 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247318,114,557 - 8,280,586 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo5a
554 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat

Markers in Region
RH139301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2875,974,311 - 75,974,491 (+)MAPPERmRatBN7.2
Rnor_6.0882,156,261 - 82,156,440NCBIRnor6.0
Rnor_5.0881,759,749 - 81,759,928UniSTSRnor5.0
RGSC_v3.4880,027,044 - 80,027,223UniSTSRGSC3.4
Celera875,764,426 - 75,764,605UniSTS
RH 3.4 Map8925.79UniSTS
Cytogenetic Map8q24UniSTS


Related Rat Strains
The following Strains have been annotated to Myo5a
DOP/Nem    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000079535   ⟹   ENSRNOP00000075167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl875,855,941 - 75,974,555 (+)Ensembl
Rnor_6.0 Ensembl882,038,967 - 82,156,504 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082288   ⟹   ENSRNOP00000073223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl875,856,305 - 75,974,555 (+)Ensembl
Rnor_6.0 Ensembl882,037,977 - 82,156,419 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091789   ⟹   ENSRNOP00000075108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl875,812,412 - 75,974,555 (+)Ensembl
Rnor_6.0 Ensembl882,043,403 - 82,156,617 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102636   ⟹   ENSRNOP00000088028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl875,812,421 - 75,975,918 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109142   ⟹   ENSRNOP00000076388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl875,812,421 - 75,975,918 (+)Ensembl
RefSeq Acc Id: NM_022178   ⟹   NP_071514
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,692,949 - 84,855,073 (+)NCBI
mRatBN7.2875,812,412 - 75,974,558 (+)NCBI
Rnor_6.0882,038,966 - 82,156,507 (+)NCBI
Rnor_5.0881,641,953 - 81,759,995 (+)NCBI
RGSC_v3.4879,909,224 - 80,027,290 (+)RGD
Celera875,604,281 - 75,764,672 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080847   ⟹   XP_038936775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,692,524 - 84,860,564 (+)NCBI
mRatBN7.2875,811,985 - 75,980,049 (+)NCBI
RefSeq Acc Id: XM_039080851   ⟹   XP_038936779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,692,526 - 84,860,564 (+)NCBI
mRatBN7.2875,811,986 - 75,974,470 (+)NCBI
RefSeq Acc Id: XM_039080852   ⟹   XP_038936780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,692,526 - 84,860,564 (+)NCBI
mRatBN7.2875,811,986 - 75,980,049 (+)NCBI
RefSeq Acc Id: XM_063264937   ⟹   XP_063121007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,692,527 - 84,860,564 (+)NCBI
RefSeq Acc Id: XM_063264938   ⟹   XP_063121008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,741,671 - 84,860,564 (+)NCBI
RefSeq Acc Id: NP_071514   ⟸   NM_022178
- UniProtKB: A0A0G2K9X3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075167   ⟸   ENSRNOT00000079535
Ensembl Acc Id: ENSRNOP00000073223   ⟸   ENSRNOT00000082288
Ensembl Acc Id: ENSRNOP00000075108   ⟸   ENSRNOT00000091789
RefSeq Acc Id: XP_038936775   ⟸   XM_039080847
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJ51 (UniProtKB/TrEMBL),   A0A8I6A732 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936780   ⟸   XM_039080852
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K9S4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936779   ⟸   XM_039080851
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A732 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088028   ⟸   ENSRNOT00000102636
Ensembl Acc Id: ENSRNOP00000076388   ⟸   ENSRNOT00000109142
RefSeq Acc Id: XP_063121007   ⟸   XM_063264937
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063121008   ⟸   XM_063264938
- Peptide Label: isoform X5
Protein Domains
Dilute   IQ   Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYF3-F1-model_v2 AlphaFold Q9QYF3 1-1828 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3143 AgrOrtholog
BioCyc Gene G2FUF-29825 BioCyc
Ensembl Genes ENSRNOG00000058866 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079535.2 UniProtKB/TrEMBL
  ENSRNOT00000082288.2 UniProtKB/TrEMBL
  ENSRNOT00000091789.2 UniProtKB/TrEMBL
  ENSRNOT00000102636.1 UniProtKB/TrEMBL
  ENSRNOT00000109142.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.1590 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dilute_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myo5a_CBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYSc_Myo5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vascular_dev_regulator UniProtKB/TrEMBL
KEGG Report rno:25017 UniProtKB/Swiss-Prot
NCBI Gene 25017 ENTREZGENE
PANTHER DILUTE DOMAIN-CONTAINING PROTEIN YPR089W UniProtKB/TrEMBL
  MYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOSIN VB UniProtKB/TrEMBL
  UNCONVENTIONAL MYOSIN-VA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DIL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myo5a PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DILUTE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058866 RatGTEx
SMART DIL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Myosin S1 fragment, N-terminal domain UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206609
UniProt A0A0G2K4Y7_RAT UniProtKB/TrEMBL
  A0A0G2K9S4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K9X3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZJ51 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A732 ENTREZGENE, UniProtKB/TrEMBL
  A6I1B4_RAT UniProtKB/TrEMBL
  A6I1B5_RAT UniProtKB/TrEMBL
  A6I1B6_RAT UniProtKB/TrEMBL
  MYO5A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Myo5a  myosin VA   Myo5a  myosin Va  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Myo5a  myosin Va      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Myo5a  myosin 5a      Name updated 70585 PROVISIONAL
2001-04-06 Myo5a  Dilute-opisthotonus      Name withdran - does not match symbol 61478 WITHDRAWN
2001-04-06 Myo5a  Myosin 5a      Name changed to match symbol 61478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deletions and decreased expression are detected in the ataxic dilute-opisthotonus rat 61493
gene_function may function as a actin-dependent organelle transporter 61493