Hdac8 (histone deacetylase 8) - Rat Genome Database

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Gene: Hdac8 (histone deacetylase 8) Rattus norvegicus
Analyze
Symbol: Hdac8
Name: histone deacetylase 8
RGD ID: 1562895
Description: Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to forskolin; cellular response to trichostatin A; and negative regulation of macromolecule metabolic process. Predicted to be located in chromosome and cytoplasm. Predicted to be active in nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HD8; LOC103690124; LOC363481; RGD1562895; similar to Histone deacetylase 8 (HD8); uncharacterized LOC103690124
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X71,425,240 - 71,632,865 (-)NCBIGRCr8
mRatBN7.2X67,385,288 - 67,593,014 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX67,385,289 - 67,592,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,868,650 - 69,076,271 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X72,368,892 - 72,576,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,930,041 - 70,137,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X72,163,777 - 72,370,058 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX72,163,777 - 72,370,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X73,566,613 - 73,589,000 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X73,694,610 - 73,698,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X90,336,001 - 90,544,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX67,738,891 - 67,946,303 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
cytoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone deacetylase 8 suppresses osteogenic differentiation of bone marrow stromal cells by inhibiting histone H3K9 acetylation and RUNX2 activity. Fu Y, etal., Int J Biochem Cell Biol. 2014 Sep;54:68-77. doi: 10.1016/j.biocel.2014.07.003. Epub 2014 Jul 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face. Harakalova M, etal., J Med Genet. 2012 Aug;49(8):539-43. doi: 10.1136/jmedgenet-2012-100921.
4. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. Ito K, etal., N Engl J Med. 2005 May 12;352(19):1967-76.
5. Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance. Kaiser FJ, etal., Hum Mol Genet. 2014 Jun 1;23(11):2888-900. doi: 10.1093/hmg/ddu002. Epub 2014 Jan 8.
6. HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity. Kee HJ, etal., Kidney Blood Press Res. 2013;37(4-5):229-39. doi: 10.1159/000350148. Epub 2013 Jul 8.
7. Expression of Class I and Class II a/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models. Kee HJ, etal., Korean Circ J. 2017 May;47(3):392-400. doi: 10.4070/kcj.2016.0266. Epub 2017 May 12.
8. Roles of HDAC2 and HDAC8 in Cardiac Remodeling in Renovascular Hypertensive Rats and the Effects of Valproic Acid Sodium. Li RF, etal., Pharmacology. 2017;99(1-2):27-39. doi: 10.1159/000449467. Epub 2016 Sep 27.
9. Transcription regulation mechanism of the syntaxin 1A gene via protein kinase A. Nakayama T and Akagawa K, Biochem J. 2017 Jul 11;474(14):2465-2473. doi: 10.1042/BCJ20170249.
10. The cell- and tissue-specific transcription mechanism of the TATA-less syntaxin 1A gene. Nakayama T, etal., FASEB J. 2016 Feb;30(2):525-43. doi: 10.1096/fj.15-275529. Epub 2015 Sep 21.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum. Omonijo O, etal., Neurotoxicology. 2014 Oct 27;45C:178-184. doi: 10.1016/j.neuro.2014.10.008.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Wedel T, etal., Neurogastroenterol Motil. 2006 Jul;18(7):526-38.
17. miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8. Yan M, etal., Cardiovasc Res. 2015 Mar 1;105(3):340-52. doi: 10.1093/cvr/cvu254. Epub 2014 Dec 10.
Additional References at PubMed
PMID:12477932   PMID:16809764   PMID:21151613   PMID:22885700   PMID:29393346  


Genomics

Comparative Map Data
Hdac8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X71,425,240 - 71,632,865 (-)NCBIGRCr8
mRatBN7.2X67,385,288 - 67,593,014 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX67,385,289 - 67,592,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,868,650 - 69,076,271 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X72,368,892 - 72,576,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,930,041 - 70,137,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X72,163,777 - 72,370,058 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX72,163,777 - 72,370,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X73,566,613 - 73,589,000 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X73,694,610 - 73,698,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X90,336,001 - 90,544,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX67,738,891 - 67,946,303 (-)NCBICelera
Cytogenetic MapXq22NCBI
HDAC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X72,329,516 - 72,572,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX72,329,516 - 72,573,101 (-)EnsemblGRCh38hg38GRCh38
GRCh37X71,549,366 - 71,792,693 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X71,466,091 - 71,709,378 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X71,332,387 - 71,575,674NCBI
CeleraX71,892,584 - 72,136,175 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX65,303,729 - 65,547,461 (-)NCBIHuRef
CHM1_1X71,442,370 - 71,685,931 (-)NCBICHM1_1
T2T-CHM13v2.0X70,762,405 - 71,005,758 (-)NCBIT2T-CHM13v2.0
Hdac8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X101,328,244 - 101,549,005 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX101,328,245 - 101,548,965 (-)EnsemblGRCm39 Ensembl
GRCm38X102,284,638 - 102,505,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX102,284,639 - 102,505,359 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X99,479,979 - 99,700,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X98,487,359 - 98,707,867 (-)NCBIMGSCv36mm8
CeleraX89,195,856 - 89,416,063 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX45.28NCBI
Hdac8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547511,748,365 - 12,013,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547511,748,502 - 12,012,884 (-)NCBIChiLan1.0ChiLan1.0
HDAC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X72,002,591 - 72,248,461 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X72,006,198 - 72,252,066 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X61,565,790 - 61,811,588 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X71,649,178 - 71,894,896 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX71,649,341 - 71,894,896 (-)Ensemblpanpan1.1panPan2
HDAC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X56,357,205 - 56,574,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX56,357,177 - 56,574,401 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX47,183,095 - 47,400,619 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X57,411,265 - 57,628,877 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX57,411,268 - 57,628,840 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X55,325,722 - 55,544,604 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X56,723,145 - 56,940,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X56,571,889 - 56,789,465 (-)NCBIUU_Cfam_GSD_1.0
Hdac8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X45,327,793 - 45,554,498 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367621,425,335 - 1,652,063 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367621,425,337 - 1,652,058 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX58,210,192 - 58,450,573 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X58,210,182 - 58,450,681 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HDAC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X62,154,374 - 62,393,149 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX62,154,365 - 62,393,196 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660654,003,868 - 4,261,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249032,620,501 - 2,852,822 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249032,620,571 - 2,852,247 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hdac8
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:117
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000004224
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
BE121059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X67,391,749 - 67,391,964 (+)MAPPERmRatBN7.2
Rnor_6.0X72,737,197 - 72,737,411NCBIRnor6.0
Rnor_6.0X72,170,345 - 72,170,559NCBIRnor6.0
Rnor_5.0X73,012,230 - 73,012,444UniSTSRnor5.0
Rnor_5.0X73,573,073 - 73,573,287UniSTSRnor5.0
RGSC_v3.4X90,342,461 - 90,342,675UniSTSRGSC3.4
CeleraX67,745,352 - 67,745,566UniSTS
Cytogenetic MapXq31UniSTS
RH131931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X67,585,843 - 67,586,025 (+)MAPPERmRatBN7.2
Rnor_6.0X72,362,972 - 72,363,153NCBIRnor6.0
Rnor_5.0X73,204,857 - 73,205,038UniSTSRnor5.0
RGSC_v3.4X90,537,432 - 90,537,613UniSTSRGSC3.4
CeleraX67,939,224 - 67,939,405UniSTS
Cytogenetic MapXq31UniSTS
AA850209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X67,398,771 - 67,398,972 (+)MAPPERmRatBN7.2
Rnor_6.0X72,744,223 - 72,744,423NCBIRnor6.0
Rnor_6.0X72,177,371 - 72,177,571NCBIRnor6.0
Rnor_5.0X73,019,256 - 73,019,456UniSTSRnor5.0
Rnor_5.0X73,580,099 - 73,580,299UniSTSRnor5.0
RGSC_v3.4X90,349,487 - 90,349,687UniSTSRGSC3.4
CeleraX67,752,376 - 67,752,576UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004224   ⟹   ENSRNOP00000004224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX67,385,289 - 67,592,923 (-)Ensembl
Rnor_6.0 EnsemblX72,163,777 - 72,370,044 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096384   ⟹   ENSRNOP00000083825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX67,407,021 - 67,592,676 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104585   ⟹   ENSRNOP00000094093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX67,386,211 - 67,592,676 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106251   ⟹   ENSRNOP00000080045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX67,494,297 - 67,592,923 (-)Ensembl
RefSeq Acc Id: NM_001126373   ⟹   NP_001119845
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X71,425,240 - 71,632,865 (-)NCBI
mRatBN7.2X67,385,288 - 67,592,923 (-)NCBI
Rnor_6.0X72,163,777 - 72,370,051 (-)NCBI
Rnor_5.0X73,566,613 - 73,589,000 (-)NCBI
Rnor_5.0X73,694,610 - 73,698,948 (-)NCBI
RGSC_v3.4X90,336,001 - 90,544,511 (-)RGD
CeleraX67,738,891 - 67,946,303 (-)RGD
Sequence:
RefSeq Acc Id: XM_017602109   ⟹   XP_017457598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X71,425,240 - 71,632,561 (-)NCBI
mRatBN7.2X67,385,288 - 67,593,014 (-)NCBI
Rnor_6.0X72,163,777 - 72,370,057 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099900   ⟹   XP_038955828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X71,541,891 - 71,632,561 (-)NCBI
mRatBN7.2X67,498,831 - 67,593,003 (-)NCBI
RefSeq Acc Id: XM_063280146   ⟹   XP_063136216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X71,455,001 - 71,632,561 (-)NCBI
RefSeq Acc Id: XM_063280147   ⟹   XP_063136217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X71,425,240 - 71,632,561 (-)NCBI
RefSeq Acc Id: XM_063280148   ⟹   XP_063136218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X71,574,034 - 71,632,561 (-)NCBI
RefSeq Acc Id: NP_001119845   ⟸   NM_001126373
- UniProtKB: B1WC68 (UniProtKB/Swiss-Prot),   A0A8I6GB67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457598   ⟸   XM_017602109
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZP78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004224   ⟸   ENSRNOT00000004224
RefSeq Acc Id: XP_038955828   ⟸   XM_039099900
- Peptide Label: isoform X4
- UniProtKB: A6IQE7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083825   ⟸   ENSRNOT00000096384
Ensembl Acc Id: ENSRNOP00000094093   ⟸   ENSRNOT00000104585
Ensembl Acc Id: ENSRNOP00000080045   ⟸   ENSRNOT00000106251
RefSeq Acc Id: XP_063136217   ⟸   XM_063280147
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063136216   ⟸   XM_063280146
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063136218   ⟸   XM_063280148
- Peptide Label: isoform X5
Protein Domains
Histone deacetylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC68-F1-model_v2 AlphaFold B1WC68 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562895 AgrOrtholog
BioCyc Gene G2FUF-2072 BioCyc
Ensembl Genes ENSRNOG00000003122 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030327 UniProtKB/Swiss-Prot
  ENSRNOG00060025503 UniProtKB/Swiss-Prot
  ENSRNOG00065016757 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004224.7 UniProtKB/Swiss-Prot
  ENSRNOT00000096384.1 UniProtKB/TrEMBL
  ENSRNOT00000104585.1 UniProtKB/TrEMBL
  ENSRNOT00000106251.1 UniProtKB/TrEMBL
  ENSRNOT00055052640 UniProtKB/Swiss-Prot
  ENSRNOT00060044247 UniProtKB/Swiss-Prot
  ENSRNOT00065027969 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.800.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9099275 IMAGE-MGC_LOAD
InterPro HDAC_PDAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363481 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187908 IMAGE-MGC_LOAD
NCBI Gene 363481 ENTREZGENE
PANTHER HISTONE DEACETYLASE 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hist_deacetyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hdac8 PhenoGen
PIRSF His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003122 RatGTEx
  ENSRNOG00055030327 RatGTEx
  ENSRNOG00060025503 RatGTEx
  ENSRNOG00065016757 RatGTEx
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZP78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALD5_RAT UniProtKB/TrEMBL
  A0A8I6GB67 ENTREZGENE, UniProtKB/TrEMBL
  A6IQE7 ENTREZGENE, UniProtKB/TrEMBL
  B1WC68 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hdac8  histone deacetylase 8  LOC103690124  uncharacterized LOC103690124  Data merged from RGD:9188277 737654 PROVISIONAL
2014-08-25 LOC103690124  uncharacterized LOC103690124      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Hdac8  histone deacetylase 8   Hdac8_predicted  histone deacetylase 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Hdac8_predicted  histone deacetylase 8 (predicted)  RGD1562895_predicted  similar to Histone deacetylase 8 (HD8) (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1562895_predicted  similar to Histone deacetylase 8 (HD8) (predicted)  LOC363481  similar to Histone deacetylase 8 (HD8)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363481  similar to Histone deacetylase 8 (HD8)      Symbol and Name status set to provisional 70820 PROVISIONAL