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Gene: HDAC8 (histone deacetylase 8) Homo sapiens
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Symbol: HDAC8
Name: histone deacetylase 8
Description: Exhibits Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including negative regulation of protein ubiquitination; regulation of chromosome organization; and regulation of protein stability. Localizes to nucleoplasm and plasma membrane. Implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Biomarker of Hirschsprung's disease and chronic obstructive pulmonary disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDA07; CDLS5; HD8; HDACL1; histone deacetylase-like 1; KDAC8; MRXS6; RPD3; Wilson-Turner syndrome (mental retardation, X-linked, syndromic-6, with gynecomastia and obesity); Wilson-Turner X-linked mental retardation syndrome; WTS
Orthologs:
Mus musculus (house mouse) : Hdac8 (histone deacetylase 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac8 (histone deacetylase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac8 (histone deacetylase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC8 (histone deacetylase 8)
Canis lupus familiaris (dog) : HDAC8 (histone deacetylase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac8 (histone deacetylase 8)
Sus scrofa (pig) : HDAC8 (histone deacetylase 8)
Chlorocebus sabaeus (African green monkey) : HDAC8 (histone deacetylase 8)
Heterocephalus glaber (naked mole-rat) : Hdac8 (histone deacetylase 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX72,329,516 - 72,573,101 (-)EnsemblGRCh38hg38GRCh38
GRCh38X72,329,516 - 72,573,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X71,549,366 - 71,792,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X71,466,091 - 71,709,378 (-)NCBINCBI36hg18NCBI36
Build 34X71,332,387 - 71,575,674NCBI
CeleraX71,892,584 - 72,136,175 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX65,303,729 - 65,547,461 (-)NCBIHuRef
CHM1_1X71,442,370 - 71,685,931 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HDAC8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344478
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-04-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.