MIR93 (microRNA 93) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MIR93 (microRNA 93) Homo sapiens
Analyze
Symbol: MIR93
Name: microRNA 93
RGD ID: 1344413
HGNC Page HGNC
Description: Predicted to be involved in several processes, including cellular response to forskolin; long-term synaptic potentiation; and negative regulation of B cell apoptotic process. Biomarker of hepatocellular carcinoma.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-93; miR-93; MIRN9; MIRN93
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7100,093,768 - 100,093,847 (-)EnsemblGRCh38hg38GRCh38
GRCh387100,093,768 - 100,093,847 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37799,691,391 - 99,691,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,529,326 - 99,529,405 (-)NCBINCBI36hg18NCBI36
Celera794,426,050 - 94,426,129 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef794,327,042 - 94,327,121 (-)NCBIHuRef
CHM1_1799,621,548 - 99,621,627 (-)NCBICHM1_1
CRA_TCAGchr7v2799,051,511 - 99,051,590 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:11914277   PMID:12554860   PMID:15325244   PMID:15978578   PMID:16381832   PMID:17604727   PMID:17616659   PMID:18320040   PMID:18328430   PMID:18728182   PMID:18974142   PMID:19486339  
PMID:19671678   PMID:20167074   PMID:20190813   PMID:20519629   PMID:20889907   PMID:20956944   PMID:21037258   PMID:21402054   PMID:21831295   PMID:21959981   PMID:22180714   PMID:22465665  
PMID:22467200   PMID:22556343   PMID:22581829   PMID:22685420   PMID:22773266   PMID:22999472   PMID:23111389   PMID:23285084   PMID:23354160   PMID:23493574   PMID:23509296   PMID:23525285  
PMID:23611780   PMID:23617747   PMID:23679328   PMID:24036151   PMID:24037530   PMID:24433094   PMID:24523873   PMID:24606013   PMID:24606633   PMID:24643999   PMID:24721397   PMID:24865188  
PMID:25007957   PMID:25064468   PMID:25183046   PMID:25238878   PMID:25243570   PMID:25309979   PMID:25371073   PMID:25578493   PMID:25633810   PMID:25649143   PMID:25695884   PMID:25698383  
PMID:25753045   PMID:25818544   PMID:25823655   PMID:25892549   PMID:25908172   PMID:26087719   PMID:26124181   PMID:26175939   PMID:26423400   PMID:26427659   PMID:26581907   PMID:26582398  
PMID:26646931   PMID:26756543   PMID:26986724   PMID:27021515   PMID:27089500   PMID:27279231   PMID:27665403   PMID:27744427   PMID:27829043   PMID:27840899   PMID:27866993   PMID:27878244  
PMID:28401709   PMID:28431233   PMID:28499590   PMID:28500896   PMID:28518139   PMID:28677748   PMID:28748353   PMID:28765915   PMID:28791407   PMID:28797104   PMID:28798470   PMID:28817550  
PMID:28842285   PMID:28920955   PMID:28984384   PMID:29045821   PMID:29109831   PMID:29110645   PMID:29115452   PMID:29161413   PMID:29258605   PMID:29299981   PMID:29309884   PMID:29363887  
PMID:29375208   PMID:29551286   PMID:29673440   PMID:29704631   PMID:29762838   PMID:29859516   PMID:29859935   PMID:29955039   PMID:30098344   PMID:30154547   PMID:30262143   PMID:30365088  
PMID:30390344   PMID:30415006   PMID:30455080   PMID:30537722   PMID:30543885   PMID:30579843   PMID:30582208   PMID:30654687   PMID:30689165   PMID:30946881   PMID:31059098   PMID:31092328  
PMID:31128026   PMID:31182601   PMID:31210305   PMID:31298317   PMID:31298364   PMID:31301086   PMID:31383784   PMID:31420931   PMID:31432162   PMID:31486510   PMID:31602161   PMID:31615875  
PMID:31648231   PMID:31707599   PMID:31773703   PMID:31931772   PMID:31953562   PMID:31993998   PMID:32046397   PMID:32068322   PMID:32293494   PMID:32307002   PMID:32307765   PMID:32473920  
PMID:32481356   PMID:32719439   PMID:32784653   PMID:32967763  


Genomics

Comparative Map Data
MIR93
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7100,093,768 - 100,093,847 (-)EnsemblGRCh38hg38GRCh38
GRCh387100,093,768 - 100,093,847 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37799,691,391 - 99,691,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,529,326 - 99,529,405 (-)NCBINCBI36hg18NCBI36
Celera794,426,050 - 94,426,129 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef794,327,042 - 94,327,121 (-)NCBIHuRef
CHM1_1799,621,548 - 99,621,627 (-)NCBICHM1_1
CRA_TCAGchr7v2799,051,511 - 99,051,590 (-)NCBI
Mir93
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,163,785 - 138,163,872 (-)NCBIGRCm39mm39
GRCm39 Ensembl5138,163,785 - 138,163,872 (-)Ensembl
GRCm385138,165,523 - 138,165,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,165,523 - 138,165,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,606,751 - 138,606,838 (-)NCBIGRCm37mm9NCBIm37
Celera5135,144,855 - 135,144,942 (-)NCBICelera
Cytogenetic Map5G2NCBI
Mir93
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21217,043,135 - 17,043,221 (-)NCBI
Rnor_6.0 Ensembl1219,307,543 - 19,307,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01219,307,543 - 19,307,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01221,365,173 - 21,365,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1218,973,305 - 18,973,391 (-)NCBICelera
Cytogenetic Map12q11NCBI
MIR93
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,498,780 - 9,498,840 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MYPOPhsa-miR-93-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TP53INP1hsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18974142
CDKN1Ahsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI18328430
CDKN1Ahsa-miR-93-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19153141
CDKN1Ahsa-miR-93-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20190813
E2F1hsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19486339
E2F1hsa-miR-93-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
MAPK9hsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20065103
VEGFAhsa-miR-93-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayFunctional MTI18320040
ITGB8hsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20956944
KAT2Bhsa-miR-93-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI18728182
TUSC2hsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19671678
PTENhsa-miR-93-5pMirtarbaseexternal_infoGFP reporter assay//qRT-PCR//Western blotFunctional MTI22465665
PURAhsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22835829
LATS2hsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23111389
EPHA4hsa-miR-93-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
SLC5A3hsa-miR-93-5pTarbaseexternal_infoSequencingPOSITIVE
TAF6Lhsa-miR-93-5pMirecordsexternal_infoNANA18728182
TUSC2hsa-miR-93-5pMirecordsexternal_info{unchanged}NA19671678
E2F1hsa-miR-93-5pMirecordsexternal_infoNANA19486339
CDKN1Ahsa-miR-93-5pMirecordsexternal_info{changed}NA19422085
CCNB1hsa-miR-93-5pOncomiRDBexternal_infoNANA22581829
F3hsa-miR-93-5pOncomiRDBexternal_infoNANA22556343
PTENhsa-miR-93-5pOncomiRDBexternal_infoNANA22465665
HDAC8hsa-miR-93-5pOncomiRDBexternal_infoNANA22180714
ZBTB4hsa-miR-93-5pOncomiRDBexternal_infoNANA21765466
ITGB8hsa-miR-93-5pOncomiRDBexternal_infoNANA20956944
TUSC2hsa-miR-93-5pOncomiRDBexternal_infoNANA19671678
E2F1hsa-miR-93-5pOncomiRDBexternal_infoNANA19486339
CDKN1Ahsa-miR-93-5pOncomiRDBexternal_infoNANA19422085
CDKN1Ahsa-miR-93-5pOncomiRDBexternal_infoNANA19153141

Predicted Targets
Summary Value
Count of predictions:40135
Count of gene targets:13384
Count of transcripts:27642
Interacting mature miRNAs:hsa-miR-93-3p, hsa-miR-93-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 28 5 4 228 5 34 9 26 8 68 72 2 1 1 2
Low 809 454 452 169 667 146 1140 461 662 251 575 513 32 160 626 2
Below cutoff 291 234 153 59 131 33 388 301 481 35 87 72 26 109 273

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,093,768 - 100,093,847 (-)Ensembl
RefSeq Acc Id: NR_029510
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,093,768 - 100,093,847 (-)NCBI
GRCh37799,691,391 - 99,691,470 (-)RGD
Celera794,426,050 - 94,426,129 (-)RGD
HuRef794,327,042 - 94,327,121 (-)ENTREZGENE
CHM1_1799,621,548 - 99,621,627 (-)NCBI
CRA_TCAGchr7v2799,051,511 - 99,051,590 (-)ENTREZGENE
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1		 pathogenic
NM_005916.4(MCM7):c.1283C>T (p.Thr428Ile) single nucleotide variant Malignant melanoma [RCV000068039] Chr7:100096086 [GRCh38]
Chr7:99693709 [GRCh37]
Chr7:99531645 [NCBI36]
Chr7:7q22.1		 not provided
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-100348063)x3 copy number gain See cases [RCV000135630] Chr7:99195836..100348063 [GRCh38]
Chr7:98793459..99945686 [GRCh37]
Chr7:98631395..99783622 [NCBI36]
Chr7:7q22.1		 likely benign
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1		 pathogenic|uncertain significance
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99932610-102473188)x3 copy number gain See cases [RCV000138109] Chr7:99932610..102473188 [GRCh38]
Chr7:99530233..102113635 [GRCh37]
Chr7:99368169..101900640 [NCBI36]
Chr7:7q22.1		 uncertain significance
GRCh38/hg38 7q22.1(chr7:99880388-100288453)x3 copy number gain See cases [RCV000142715] Chr7:99880388..100288453 [GRCh38]
Chr7:99478011..99886076 [GRCh37]
Chr7:99315947..99724012 [NCBI36]
Chr7:7q22.1		 likely benign|uncertain significance
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:99593346-102470275)x1 copy number loss See cases [RCV001195072] Chr7:99593346..102470275 [GRCh37]
Chr7:7q22.1		 likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31645 AgrOrtholog
COSMIC MIR93 COSMIC
Ensembl Genes ENSG00000207757 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385024 ENTREZGENE
GTEx ENSG00000207757 GTEx
HGNC ID HGNC:31645 ENTREZGENE
Human Proteome Map MIR93 Human Proteome Map
miRBase MI0000095 ENTREZGENE
NCBI Gene 407050 ENTREZGENE
OMIM 612984 OMIM
PharmGKB PA164723005 PharmGKB
RNAcentral URS00000DDD35 RNACentral
  URS00000FB1B1 RNACentral
  URS0000149452 RNACentral