| 2802 | Hmgb1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding; bent DNA binding; crossed form four-way junction DNA binding; INVOLVED IN actin cytoskeleton organization; cell morphogenesis; cellular response to interleukin-1; PARTICIPATES IN pro-inflammatory cytokine mediated pathway; cisplatin drug pathway; mism atch repair pathway; ASSOCIATED WITH Acute Experimental Pancreatitis; Acute Lung Injury; Acute-On-Chronic Liver Failure; FOUND IN cytosol; extracellular space; membrane raft; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol | 12 | 11009236 | 11015941 | Rat | 813 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10711 | Hmgb1 | high mobility group box 1 | This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentia tion and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015] | 5 | 148983512 | 148989867 | Mouse | 901 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1605729 | HMGB1 | high mobility group box 1 | This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentia tion and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015] | 13 | 30456704 | 30617597 | Human | 840 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8885884 | Hmgb1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); C-X-C chemokine binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of innate immune response (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN cisplatin drug pa thway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog); chromatin (ortholog) | NW_004955431 | 15373207 | 15377339 | Chinchilla | 295 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 11969507 | HMGB1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); crossed form four-way junction DNA binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell morphogenesis (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN cispla tin drug pathway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN chromatin (ortholog); cytosol (ortholog); extracellular space (ortholog) | 13 | 11737942 | 11894923 | Bonobo | 323 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12060047 | HMGB1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); bubble DNA binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); apoptotic cell clearance (ortholog); cell morphogenesis (ortholog); PARTICIPATES IN cisplatin drug pathway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN chromatin (ortholog); cytosol (ortholog); extracellular space (ortholog) | 25 | 9431223 | 9558167 | Dog | 316 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12460385 | Hmgb1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); C-X-C chemokine binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of innate immune response (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN cisplatin drug pa thway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog); chromatin (ortholog) | NW_004936472 | 25236728 | 25246585 | Squirrel | 317 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 13970387 | HMGB1 | high mobility group box 1 | ENCODES a protein that exhibits non-sequence-specific DNA binding, bending; 5S rRNA binding (ortholog); bent DNA binding (ortholog); INVOLVED IN double-strand break repair via nonhomologous end joining; MyD88-dependent toll-like receptor signaling pathway; nucleosome assembly; PARTICIPATES IN cispla tin drug pathway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN chromatin; alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog) | | | | Pig | 324 | symbol , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18394901 | HMGB1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); C-X-C chemokine binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of innate immune response (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN cisplatin drug pa thway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog); chromatin (ortholog) | | | | Green Monkey | 320 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18932407 | Hmgb1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); bubble DNA binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of innate immune response (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN cisplatin drug pathway ; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog); chromatin (ortholog) | | | | Naked Mole-Rat | 321 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 155231060 | hmgb1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625961276 | Hmgb1 | high mobility group box 1 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); C-X-C chemokine binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of innate immune response (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN cisplatin drug pa thway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog); chromatin (ortholog) | | | | Black Rat | 295 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 155231059 | hmgb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856578 | hmgb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861677 | hmgb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863198 | hmgb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864244 | hmgb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626179254 | hmgb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2289890 | Hmgb1-ps1 | high mobility group box 1, pseudogene 1 | INTERACTS WITH bleomycin A2; trovafloxacin | 11 | 41032485 | 41034809 | Mouse | 2 | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1589719 | Hmgb1-ps2 | high mobility group box 1, pseudogene 2 | INTERACTS WITH N-methyl-4-phenylpyridinium | 17 | 30246256 | 30248135 | Rat | 1 | symbol , PhenoGen | gene, pseudo, PROVISIONAL [RefSeq] |
| 2292470 | Hmgb1-ps2 | high mobility group box 1, pseudogene 2 | | X | 144958839 | 144959773 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1588759 | Hmgb1-ps3 | high mobility group box 1, pseudogene 3 | INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 7 | 124830224 | 124832753 | Rat | 3 | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1616856 | Hmgb1-ps3 | high mobility group box 1, pseudogene 3 | INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl | 11 | 63736916 | 63737773 | Mouse | 1 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 2301656 | Hmgb1-ps4 | high mobility group box 1, pseudogene 4 | | 19 | 6642129 | 6643369 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1565435 | Hmgb1-ps5 | high-mobility group box 1, pseudogene 5 | INTERACTS WITH ammonium chloride | 4 | 62772731 | 62773791 | Rat | 1 | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2294385 | Hmgb1-ps5 | high mobility group box 1, pseudogene 5 | | 3 | 95437723 | 95438350 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 5147082 | Hmgb1-ps6 | high mobility group box 1, pseudogene 6 | INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl | 16 | 31810071 | 31810684 | Mouse | 1 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1613921 | Hmgb1-ps7 | high-mobility group high mobility group box 1, pseudogene 7 | PARTICIPATES IN base excision repair pathway; INTERACTS WITH 1,2-dimethylhydrazine; benzo[a]pyrene; benzo[b]fluoranthene | 7 | 41670149 | 41671427 | Mouse | 9 | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1584050 | Hmgb1-ps8 | high-mobility group box 1, pseudogene 8 | | 16 | 39039090 | 39041318 | Rat | 1 | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 2295949 | Hmgb1-ps8 | high mobility group box 1, pseudogene 8 | INTERACTS WITH dimethylarsinic acid; methylarsonic acid; sodium arsenate | | | | Mouse | 4 | symbol , PhenoGen , old_gene_symbol | gene, pseudo |
| 15037892 | Hmgb1-ps9 | high mobility group box 1, pseudogene 9 | | 13 | 101174159 | 101176629 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 15039169 | Hmgb1-rs5 | high mobility group box 1, related sequence 5 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15038351 | Hmgb1-rs6 | high mobility group box 1, related sequence 6 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15038335 | Hmgb1-rs8 | high mobility group box 1, related sequence 8 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15037544 | Hmgb1-rs9 | high mobility group box 1, related sequence 9 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1614658 | Hmgb1-ps10 | high mobility group box1, pseudogene 10 | PARTICIPATES IN base excision repair pathway | | | | Mouse | 1 | symbol , PhenoGen , old_gene_symbol | gene, pseudo |
| 2295194 | Hmgb1-ps11 | high mobility group box 1, pseudogene 11 | | 13 | 65584262 | 65585057 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1559806 | Hmgb1-ps15 | high-mobility group box 1, pseudogene 15 | | 10 | 23578176 | 23579468 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40980049 | Hmgb1-ps16 | high-mobility group box 1, pseudogene 16 | | 2 | 57133245 | 57133900 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1565627 | Hmgb1-ps17 | high-mobility group box 1, pseudogene 17 | | 13 | 26649392 | 26652883 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41237666 | Hmgb1-ps18 | high-mobility group box 1, pseudogene 18 | | 4 | 67458841 | 68059076 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1564699 | Hmgb1-ps19 | high-mobility group box 1, pseudogene 19 | INTERACTS WITH methoxychlor | 4 | 97072527 | 97167014 | Rat | 1 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 6485887 | Hmgb1-ps20 | high-mobility group box 1, pseudogene 20 | | 1 | 166725441 | 166726089 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7623636 | Hmgb1-ps22 | high-mobility group box 1, pseudogene 22 | | 18 | 44966220 | 44967203 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41113289 | Hmgb1-ps28 | high-mobility group box 1, pseudogene 28 | | 16 | 55477627 | 55478701 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1592556 | Hmgb1-ps29 | high-mobility group box 1, pseudogene 29 | | X | 87932976 | 87933844 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40936624 | Hmgb1-ps30 | high-mobility group box 1, pseudogene 30 | | 18 | 75238721 | 75240677 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1562266 | Hmgb1-ps31 | high-mobility group box 1, pseudogene 31 | INTERACTS WITH indole-3-methanol | 18 | 40155354 | 40156261 | Rat | 2 | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41352397 | Hmgb1-ps32 | high-mobility group box 1, pseudogene 32 | | 1 | 107109539 | 107114715 | Rat | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, MODEL [RefSeq] |
| 1587112 | Hmgb1-ps33 | high-mobility group box 1, pseudogene 33 | PARTICIPATES IN base excision repair pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride | 19 | 71943091 | 71944367 | Rat | 17 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 40938697 | Hmgb1-ps34 | high mobility group box 1, pseudogene 34 | ENCODES a pseudogene that exhibits cytokine activity (inferred); DNA binding (inferred); heparin binding (inferred); INVOLVED IN cell development (inferred); cellular response to cytokine stimulus (inferred); chemotaxis (inferred); FOUND IN chromosome (inferred); nucleus (inferred) | X | 75429080 | 75430340 | Rat | 32 | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1616861 | Hmgb1-rs10 | high mobility group box 1, related sequence 10 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1616860 | Hmgb1-rs11 | high mobility group box 1, related sequence 11 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1616859 | Hmgb1-rs12 | high mobility group box 1, related sequence 12 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1616858 | Hmgb1-rs13 | high mobility group box 1, related sequence 13 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1616857 | Hmgb1-rs14 | high mobility group box 1, related sequence 14 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1616855 | Hmgb1-rs16 | high mobility group box 1, related sequence 16 | | 9 | 104046617 | 104047073 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1619515 | Hmgb1-rs17 | high mobility group box 1, related sequence 17 | INTERACTS WITH 1,2-dimethylhydrazine; 3,4-methylenedioxymethamphetamine; folic acid | 8 | 33974339 | 33975785 | Mouse | 3 | symbol , PhenoGen | gene, pseudo, PROVISIONAL [RefSeq] |
| 1616854 | Hmgb1-rs18 | high mobility group box 1, related sequence 18 | | 4 | 67436790 | 67437231 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 15038525 | Hmgb1-rs19 | high mobility group box 1, related sequence 19 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15038171 | Hmgb1-rs20 | high mobility group box 1, related sequence 20 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15037191 | Hmgb1-rs21 | high mobility group box 1, related sequence 21 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15039125 | Hmgb1-rs22 | high mobility group box 1, related sequence 22 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15038512 | Hmgb1-rs23 | high mobility group box 1, related sequence 23 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 620444 | Hbp1 | HMG-box transcription factor 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; INVOLVED IN negative regulation of transcription by RNA polymerase II; positive regulation of potassium ion transport; nega tive regulation of lipid transport (ortholog); ASSOCIATED WITH COVID-19 (ortholog); osteoarthritis (ortholog); FOUND IN nuclear speck (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 3H-1,2-dithiole-3-thione | 6 | 54257118 | 54283373 | Rat | 165 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16571014 | AL353648.1 | novel transcript, antisense to HMGB1 | | | | | Human | | name | gene, lncrna |
| 16562328 | AL132640.2 | high mobility group box 1 (HMGB1) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 16565971 | AL356423.1 | high mobility group box 1 (HMGB1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 6480893 | HMGB3P25 | high mobility group box 3 pseudogene 25 | | 11 | 87480642 | 87481337 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1612427 | Hmgb1l | high mobility group box 1-like | | 6 | 131583348 | 131585985 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 11444414 | Hmgb1l1 | high mobility group box 1 like 1 | ENCODES a protein that exhibits cytokine activity (inferred); DNA binding (inferred); heparin binding (inferred); INVOLVED IN cell development (inferred); cellular response to cytokine stimulus (inferred); chemotaxis (inferred); FOUND IN chromosome (inferred); nucleus (inferred); INTERACTS WITH bisp henol A | 1 | 88942974 | 88944444 | Rat | 33 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 11468204 | Hmgb1l2 | high mobility group box 1 like 2 | ENCODES a protein that exhibits bubble DNA binding (ortholog); DNA binding, bending (ortholog); four-way junction DNA binding (ortholog); INVOLVED IN DNA geometric change (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); endoplasmic reticulum-Golgi intermediate compartment (inferred) | X | 112467960 | 112469220 | Rat | 48 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1594733 | Hmgb1l3 | high mobility group box 1 like 3 | ENCODES a protein that exhibits cytokine activity (inferred); DNA binding (inferred); heparin binding (inferred); INVOLVED IN cell development (inferred); cellular response to cytokine stimulus (inferred); chemotaxis (inferred); FOUND IN chromosome (inferred); nucleus (inferred) | 3 | 163238867 | 163253134 | Rat | 33 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1565762 | Hmgb1l4 | high mobility group box 1 like 4 | | 13 | 2966027 | 2971557 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1563668 | Hmgb1l5 | high mobility group box 1 like 5 | ENCODES a protein that exhibits cytokine activity (inferred); DNA binding (inferred); heparin binding (inferred); INVOLVED IN cell development (inferred); cellular response to cytokine stimulus (inferred); chemotaxis (inferred); PARTICIPATES IN base excision repair pathway; FOUND IN chromosome (infe rred); nucleus (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 10 | 40269191 | 40270053 | Rat | 36 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1345595 | HMGB1P1 | high mobility group box 1 pseudogene 1 | This gene may represent an evolving retropseudogene of the high-mobility group box 1 gene, which has multiple pseudogenes. This gene has an intact open reading frame, where the length of encoded protein is conserved, compared to the high-mobility group box 1 protein. However, due to the lack of conc lusive evidence for specific transcription at this location, this locus is currently represented as a pseudogene. [provided by RefSeq, Jan 2010] | 20 | 57487941 | 57489130 | Human | 41 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1349227 | HMGB1P3 | high mobility group box 1 pseudogene 3 | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine | 2 | 230514924 | 230516086 | Human | 3 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1346593 | HMGB1P4 | high mobility group box 1 pseudogene 4 | INTERACTS WITH valproic acid | 2 | 170600138 | 170602384 | Human | 1 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1345412 | HMGB1P5 | high mobility group box 1 pseudogene 5 | INTERACTS WITH aristolochic acid A; beta-lapachone; bisphenol A | 3 | 22381721 | 22382915 | Human | 8 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1353312 | HMGB1P6 | high mobility group box 1 pseudogene 6 | INTERACTS WITH aristolochic acid A; DDE; sodium arsenite | 15 | 71163472 | 71165512 | Human | 3 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 4888929 | HMGB1P7 | high mobility group box 1 pseudogene 7 | | 10 | 31913149 | 31913754 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1605444 | HMGB1P8 | high mobility group box 1 pseudogene 8 | | 15 | 89135081 | 89136685 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1605140 | HMGB1P9 | high mobility group box 1 pseudogene 9 | | 2 | 218200276 | 218201845 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1344648 | HMGB1P10 | high mobility group box 1 pseudogene 10 | INTERACTS WITH cadmium dichloride; isobutanol; methylparaben | 22 | 26560428 | 26561616 | Human | 5 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 4110492 | HMGB1P11 | high mobility group box 1 pseudogene 11 | | 1 | 171270963 | 171271588 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 3207498 | HMGB1P12 | high mobility group box 1 pseudogene 12 | | X | 111434427 | 111435015 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 4144938 | HMGB1P13 | high mobility group box 1 pseudogene 13 | | 6 | 132868230 | 132868859 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1352474 | HMGB1P14 | high mobility group box 1 pseudogene 14 | | 14 | 58284709 | 58285833 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 5490928 | HMGB1P15 | high mobility group box 1 pseudogene 15 | | X | 50930915 | 50931693 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4145220 | HMGB1P16 | high mobility group box 1 pseudogene 16 | | X | 36211004 | 36211932 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5490927 | HMGB1P17 | high mobility group box 1 pseudogene 17 | | 6 | 135636110 | 135636713 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4145166 | HMGB1P18 | high mobility group box 1 pseudogene 18 | | 1 | 80283247 | 80284169 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5490924 | HMGB1P19 | high mobility group box 1 pseudogene 19 | INTERACTS WITH thiram | 8 | 123123110 | 123123684 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4145240 | HMGB1P20 | high mobility group box 1 pseudogene 20 | INTERACTS WITH thiram | 6 | 53234991 | 53236326 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6769423 | HMGB1P21 | high mobility group box 1 pseudogene 21 | | 5 | 78644078 | 78644950 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6483724 | HMGB1P22 | high mobility group box 1 pseudogene 22 | | 5 | 125265263 | 125265802 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480879 | HMGB1P23 | high mobility group box 1 pseudogene 23 | | 8 | 29218905 | 29219472 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5132780 | HMGB1P24 | high mobility group box 1 pseudogene 24 | | 17 | 37143461 | 37144379 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4145241 | HMGB1P25 | high mobility group box 1 pseudogene 25 | | 2 | 9018063 | 9019004 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4145180 | HMGB1P26 | high mobility group box 1 pseudogene 26 | | 1 | 229705011 | 229706022 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4890233 | HMGB1P27 | high mobility group box 1 pseudogene 27 | | 2 | 191174203 | 191175122 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4145157 | HMGB1P28 | high mobility group box 1 pseudogene 28 | | 4 | 41841623 | 41844052 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480889 | HMGB1P29 | high mobility group box 1 pseudogene 29 | | 5 | 124220344 | 124221100 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480891 | HMGB1P30 | high mobility group box 1 pseudogene 30 | | 3 | 148824782 | 148825387 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480882 | HMGB1P31 | high mobility group box 1 pseudogene 31 | | 2 | 54051334 | 54051760 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 5490920 | HMGB1P32 | high mobility group box 1 pseudogene 32 | | X | 98422135 | 98422742 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480894 | HMGB1P33 | high mobility group box 1 pseudogene 33 | | 15 | 56323099 | 56323737 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4890115 | HMGB1P34 | high mobility group box 1 pseudogene 34 | | 14 | 67615484 | 67616094 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5490925 | HMGB1P35 | high mobility group box 1 pseudogene 35 | | 5 | 77146568 | 77147157 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889676 | HMGB1P36 | high mobility group box 1 pseudogene 36 | | 3 | 70753854 | 70754573 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889048 | HMGB1P37 | high mobility group box 1 pseudogene 37 | INTERACTS WITH temozolomide | 9 | 121519652 | 121520391 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480881 | HMGB1P38 | high mobility group box 1 pseudogene 38 | | 3 | 79957366 | 79958246 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4888930 | HMGB1P39 | high mobility group box 1 pseudogene 39 | | 6 | 75319032 | 75319980 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889052 | HMGB1P40 | high mobility group box 1 pseudogene 40 | | 11 | 20574132 | 20575359 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480880 | HMGB1P41 | high mobility group box 1 pseudogene 41 | INTERACTS WITH sodium arsenite | 8 | 80812080 | 80812462 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480892 | HMGB1P42 | high mobility group box 1 pseudogene 42 | | 11 | 120935730 | 120936667 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4888928 | HMGB1P43 | high mobility group box 1 pseudogene 43 | | 15 | 84940507 | 84941132 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889251 | HMGB1P44 | high mobility group box 1 pseudogene 44 | | 4 | 77963940 | 77964530 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889265 | HMGB1P45 | high mobility group box 1 pseudogene 45 | | 1 | 50398862 | 50399370 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889253 | HMGB1P46 | high mobility group box 1 pseudogene 46 | | 8 | 107173199 | 107173809 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6480883 | HMGB1P47 | high mobility group box 1 pseudogene 47 | | 5 | 51409417 | 51410219 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889369 | HMGB1P48 | high mobility group box 1 pseudogene 48 | | 1 | 45530822 | 45532621 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889250 | HMGB1P49 | high mobility group box 1 pseudogene 49 | | 12 | 27702338 | 27702906 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 12790871 | HMGB1P50 | high mobility group box 1 pseudogene 50 | | 10 | 49551308 | 49552652 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 12790846 | HMGB1P51 | high mobility group box 1 pseudogene 51 | | 15 | 58672281 | 58673098 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1313529 | CTCFL | CCCTC-binding factor like | CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primari ly in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012] | 20 | 57495965 | 57525652 | Human | 69 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 11825675 | LOC106634197 | putative high mobility group protein B1-like 1 | ENCODES a protein that exhibits damaged DNA binding (inferred); DNA binding (inferred); lipid binding (inferred); INVOLVED IN cell development (inferred); DNA metabolic process (inferred); immune response (inferred); FOUND IN chromosome (inferred); condensed chromosome (inferred); nucleus (inferred) | 20 | 53828198 | 53829282 | Bonobo | 30 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310613 | Itgav | integrin subunit alpha V | ENCODES a protein that exhibits signaling receptor binding; C-X3-C chemokine binding (ortholog); collagen binding (ortholog); INVOLVED IN angiogenesis; cell migration; positive regulation of cell population proliferation; PARTICIPATES IN integrin mediated signaling pathway; platelet-derived growth f actor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH Alveolar Bone Loss; Carotid Artery Injuries; Choroidal Neovascularization; FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cell surface (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 3 | 89245382 | 89333512 | Rat | 373 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8806657 | Itgav | integrin subunit alpha V | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); collagen binding (ortholog); coreceptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN integrin mediated sign aling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cell surface (ortholog) | NW_004955403 | 11588536 | 11669809 | Chinchilla | 125 | description | gene, protein-coding, MODEL [RefSeq] |
| 11754811 | ITGAV | integrin subunit alpha V | ENCODES a protein that exhibits collagen binding (ortholog); signaling receptor binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic cell clearance (ortholog); blood vessel development (ortholog); PARTICIPATES IN integrin mediated sig naling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (inferred); alphav-beta3 integrin-IGF-1-IGF1R complex (inferred); cell surface (inferred) | 2B | 73880962 | 73972486 | Bonobo | 139 | description | gene, protein-coding, MODEL [RefSeq] |
| 12288715 | ITGAV | integrin subunit alpha V | ENCODES a protein that exhibits collagen binding (ortholog); signaling receptor binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic cell clearance (ortholog); blood vessel development (ortholog); PARTICIPATES IN integrin mediated sig naling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (inferred); alphav-beta3 integrin-IGF-1-IGF1R complex (inferred); cell surface (inferred) | 36 | 28815215 | 28890569 | Dog | 133 | description | gene, protein-coding, MODEL [RefSeq] |
| 12600844 | Itgav | integrin subunit alpha V | ENCODES a protein that exhibits collagen binding (ortholog); signaling receptor binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic cell clearance (ortholog); blood vessel development (ortholog); PARTICIPATES IN integrin mediated sig naling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (inferred); alphav-beta3 integrin-IGF-1-IGF1R complex (inferred); cell surface (inferred) | NW_004936506 | 10750116 | 10839018 | Squirrel | 134 | description | gene, protein-coding, MODEL [RefSeq] |
| 18796818 | ITGAV | integrin subunit alpha V | ENCODES a protein that exhibits collagen binding (ortholog); signaling receptor binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic cell clearance (ortholog); blood vessel development (ortholog); PARTICIPATES IN integrin mediated sig naling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (inferred); alphav-beta3 integrin-IGF-1-IGF1R complex (inferred); cell surface (inferred) | | | | Green Monkey | 137 | description | gene, protein-coding, MODEL [RefSeq] |
| 18903000 | Itgav | integrin subunit alpha V | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); collagen binding (ortholog); coreceptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN integrin mediated sign aling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 123 | description | gene, protein-coding, MODEL [RefSeq] |
| 626027469 | Itgav | integrin subunit alpha V | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); collagen binding (ortholog); coreceptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN integrin mediated sign aling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cell surface (ortholog) | | | | Black Rat | 125 | description | gene, protein-coding, MODEL [RefSeq] |
| 8890490 | Itgb3 | integrin subunit beta 3 | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); cell adhesion molecule binding (ortholog); cell adhesion receptor activity (ortholog); INVOLVED IN apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); blood coagulation, fibrin clot format ion (ortholog); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute myeloid leukemia (ortholog); Arterial Occlusive Diseases (ortholog); FOUND IN alpha9-beta1 integrin-ADAM8 complex (ortholog); alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog) | NW_004955478 | 9788192 | 9830254 | Chinchilla | 248 | description | gene, protein-coding, MODEL [RefSeq] |
| 12349367 | ITGB3 | integrin subunit beta 3 | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); cell adhesion molecule binding (ortholog); cell adhesion receptor activity (ortholog); INVOLVED IN apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); blood coagulation, fibrin clot format ion (ortholog); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute myeloid leukemia (ortholog); Arterial Occlusive Diseases (ortholog); FOUND IN alpha9-beta1 integrin-ADAM8 complex (ortholog); alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog) | 9 | 9179667 | 9231061 | Dog | 261 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18901528 | Itgb3 | integrin subunit beta 3 | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); cell adhesion molecule binding (ortholog); cell adhesion receptor activity (ortholog); INVOLVED IN apolipoprotein A-I-mediated signaling pathway (ortholog); blood coagulation, fibrin clot formation (ortholog); cell-cell adhesion me diated by integrin (ortholog); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute myeloid leukemia (ortholog); Arterial Occlusive Diseases (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); apical plasma membrane (ortholog) | | | | Naked Mole-Rat | 264 | description | gene, protein-coding, MODEL [RefSeq] |