| 2641 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding; CD8 receptor binding; enzyme binding; INVOLVED IN cellular response to glycine; cellular response to growth factor stimulus; cellular response to hydrogen peroxide; PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; e icosanoid signaling pathway; ASSOCIATED WITH Burns; Sepsis; temporal lobe epilepsy; FOUND IN dendrite; glutamatergic synapse; mitochondrion; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 20 | 44322635 | 44514498 | Rat | 493 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731929 | FYN | FYN proto-oncogene, Src family tyrosine kinase | This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn 700;'>fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008] | 6 | 111660332 | 111873452 | Human | 557 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731930 | Fyn | Fyn proto-oncogene, Src family tyrosine kinase | Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of dendritic spine maintenance; positive regulation of tyrosine phosphorylation o f STAT protein; and reelin-mediated signaling pathway. Acts upstream of or within several processes, including activated T cell proliferation; negative regulation of protein metabolic process; and nervous system development. Located in several cellular components, including actin filament; membrane raft; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; alcohol dependence; and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 39245735 | 39441377 | Mouse | 660 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9064220 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits alpha-tubulin binding (ortholog); CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN actin filament (ortholog); cell body (ortholog); cell periphery (ortholog) | NW_004955411 | 36403156 | 36597660 | Chinchilla | 247 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11825903 | FYN | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog) | 6 | 109469750 | 109684086 | Bonobo | 252 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12067709 | FYN | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog) | 12 | 68105060 | 68316630 | Dog | 264 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12566780 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog) | NW_004936679 | 388500 | 588518 | Squirrel | 247 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14050710 | FYN | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 268 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18356632 | FYN | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog) | | | | Green Monkey | 249 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18917612 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits alpha-tubulin binding (ortholog); CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN actin filament (ortholog); cell body (ortholog); cell periphery (ortholog) | | | | Naked Mole-Rat | 251 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155233921 | fyn | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625996205 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits alpha-tubulin binding (ortholog); CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN actin filament (ortholog); cell body (ortholog); cell periphery (ortholog) | | | | Black Rat | 247 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155233920 | fyn.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248278 | fyn.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6893411 | Fynem1Mcwi | FYN oncogene related to SRC, FGR, YES; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is a 7-bp deletion in exon 4 (del 383-389) | | | | Rat | | symbol , name , old_gene_symbol | gene, allele |
| 6893380 | Fynem6Mcwi | FYN oncogene related to SRC, FGR, YES; zinc finger nuclease induced mutant 6, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is an 8-bp deletion in exon 4 (del 385-392) | | | | Rat | | symbol , name , old_gene_symbol | gene, allele |
| 1624094 | Frk | fyn-related kinase | Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; cell surface receptor protein tyrosine kinase signaling pathway; and negative regulation of transcription by RNA polymerase II. Predic ted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 34359396 | 34487530 | Mouse | 121 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316290 | Fyb1 | FYN binding protein 1 | The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript vari ants encoding different isoforms. [provided by RefSeq, May 2013] | 15 | 6552280 | 6695089 | Mouse | 131 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1563421 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding; INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortholog); INTER ACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 57360084 | 57508609 | Rat | 112 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603714 | FYB1 | FYN binding protein 1 | The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] | 5 | 39105252 | 39274528 | Human | 145 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 8820600 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | NW_004955426 | 23621355 | 23777086 | Chinchilla | 23 | name | gene, protein-coding, MODEL [RefSeq] |
| 11898598 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | 5 | 71100184 | 71268471 | Bonobo | 23 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12109797 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN anchoring junction (inferred); cytoplasm (inferred); plasma m embrane (inferred) | 4 | 69729481 | 69876962 | Dog | 32 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12576807 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | NW_004936518 | 3063257 | 3169469 | Squirrel | 23 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13931172 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN anchoring junction (inferred); cytoplasm (inferred); plasma m embrane (inferred) | | | | Pig | 32 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18471770 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN anchoring junction (inferred); cytoplasm (inferred); plasma m embrane (inferred) | | | | Green Monkey | 32 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18934805 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Naked Mole-Rat | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626030860 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | | | | Black Rat | 23 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1564074 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog); membrane raft (ortholog); INTERACTS WITH bisphenol A; glyphosate; lead diacetate | 5 | 124906005 | 125029867 | Rat | 67 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1604211 | FYB2 | FYN binding protein 2 | Involved in T cell receptor signaling pathway and cell adhesion mediated by integrin. Located in immunological synapse and membrane raft. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 56718789 | 56826914 | Human | 63 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1618117 | Fyb2 | FYN binding protein 2 | Predicted to be involved in cell adhesion mediated by integrin; cell surface receptor signaling pathway; and protein localization to plasma membrane. Predicted to be located in immunological synapse and membrane raft. Predicted to be active in plasma membrane. Orthologous to human FYB2 (FYN 'font-weight:700;'>FYN binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 104692431 | 104874061 | Mouse | 68 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8917005 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog); membrane raft (ortholog) | NW_004955464 | 2897292 | 2996606 | Chinchilla | 5 | name | gene, protein-coding, MODEL [RefSeq] |
| 11726120 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); protein localization to plasma membrane (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | 1 | 56002100 | 56077222 | Bonobo | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12240564 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog) | 5 | 52680685 | 52804155 | Dog | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12522202 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); protein localization to plasma membrane (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | NW_004936522 | 4802274 | 4867954 | Squirrel | 12 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13940404 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); T cell receptor signaling pathway (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | | | | Pig | 12 | name | gene, protein-coding, MODEL [RefSeq] |
| 18765220 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); protein localization to plasma membrane (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | | | | Green Monkey | 12 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18913103 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); FOUND IN immunological synapse (ortholog) | | | | Naked Mole-Rat | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 625879081 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog); membrane raft (ortholog) | | | | Black Rat | 5 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18926819 | LOC101714333 | FYN-binding protein pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18927946 | LOC101718901 | FYN-binding protein pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 9063431 | LOC102026154 | FYN-binding protein pseudogene | | NW_004955534 | 2796216 | 2798595 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 18921513 | LOC101697026 | tyrosine-protein kinase Fyn-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18905687 | LOC101707972 | tyrosine-protein kinase Fyn-like | ENCODES a protein that exhibits ATP binding (inferred); G protein-coupled receptor binding (inferred); kinase activity (inferred); FOUND IN cytoplasm (inferred); dendrite (inferred); membrane (inferred) | | | | Naked Mole-Rat | 15 | name | gene, protein-coding, MODEL [RefSeq] |
| 1308966 | Efs | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN cell adhesion (inferred); ASSOCIATED WITH Crohn's disease (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 32362401 | 32374490 | Rat | 85 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319047 | EFS | embryonal Fyn-associated substrate | The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin binding leads to the subsequent phosphorylation of a CAS protein. Additional binding of SRC family kinases leads to CAS hyperphosphorylation and the creation of binding sites for CRK and other proteins that cause actin cytoskeleton reorganization. This gene plays a role in integrin-mediated cell attachment, spreading, and migration and also plays a role in both normal and malignant cellular transformation. This broadly expressed gene has been shown to play a role in neurite outgrowth and its expression in the thymus and lymphocytes is important for T cell maturation and the development of immunological self-tolerance. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020] | 14 | 23356406 | 23365172 | Human | 89 | name | gene, protein-coding, REVIEWED [RefSeq] |
| 1319048 | Efs | embryonal Fyn-associated substrate | Enables SH3 domain binding activity. Predicted to be involved in cell migration and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Is expressed in several structures, including ali mentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Used to study Crohn's disease. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 55154087 | 55164222 | Mouse | 94 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8727811 | Efs | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (ortholog); SH3 domain binding (ortholog); ASSOCIATED WITH Crohn's disease (ortholog) | NW_004955409 | 36973522 | 36981079 | Chinchilla | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 11767894 | EFS | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (inferred); SH3 domain binding (inferred); INVOLVED IN cell adhesion (inferred); cell migration (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); ASSOCIATED WITH Crohn's disease (ortholog); FOUND IN cytoplasm (inferred); focal adhesion (inferred); plasma membrane (inferred) | 14 | 4174676 | 4185215 | Bonobo | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 12229638 | EFS | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (inferred); SH3 domain binding (inferred); transmembrane transporter activity (inferred); INVOLVED IN cell adhesion (inferred); iron ion transport (inferred); monoatomic ion transport (inferred); ASSOCIATED WITH Crohn's disease (ortholo g); FOUND IN membrane (inferred); organelle membrane (inferred); plasma membrane (inferred) | 8 | 3600597 | 3612563 | Dog | 26 | name | gene, protein-coding, MODEL [RefSeq] |
| 12570351 | Efs | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (inferred); SH3 domain binding (inferred); INVOLVED IN cell adhesion (inferred); cell migration (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); ASSOCIATED WITH Crohn's disease (ortholog); FOUND IN cytoplasm (inferred); focal adhesion (inferred); plasma membrane (inferred) | NW_004936722 | 1009966 | 1019093 | Squirrel | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13908263 | EFS | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (inferred); SH3 domain binding (inferred); INVOLVED IN cell adhesion (inferred); ASSOCIATED WITH Crohn's disease (ortholog) | | | | Pig | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 18783773 | EFS | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (inferred); SH3 domain binding (inferred); INVOLVED IN cell adhesion (inferred); cell migration (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); ASSOCIATED WITH Crohn's disease (ortholog); FOUND IN cytoplasm (inferred); focal adhesion (inferred); plasma membrane (inferred) | | | | Green Monkey | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 18935637 | Efs | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN cell adhesion (inferred); cell migration (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); ASSOCIATED WITH Crohn's disease (ortholog); FOUND IN cytoplasm (inferred); focal adhesion (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 625859695 | Efs | embryonal Fyn-associated substrate | ENCODES a protein that exhibits protein domain specific binding (ortholog); SH3 domain binding (ortholog); ASSOCIATED WITH Crohn's disease (ortholog) | | | | Black Rat | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 621423 | Frk | fyn-related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity; INVOLVED IN cell differentiation; negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholo g); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 20 | 39820441 | 39926065 | Rat | 112 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734122 | FRK | fyn related Src family tyrosine kinase | The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] | 6 | 115931149 | 116100725 | Human | 123 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 8898798 | Frk | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (ortholog) ; nucleoplasm (ortholog) | NW_004955526 | 736446 | 892331 | Chinchilla | 13 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11786144 | FRK | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 6 | 113748464 | 113903350 | Bonobo | 28 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12184158 | FRK | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 12 | 71659397 | 71756213 | Dog | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12471680 | Frk | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936824 | 575618 | 677775 | Squirrel | 27 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13901562 | FRK | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH graphene oxide | | | | Pig | 33 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18470786 | FRK | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 28 | name | gene, protein-coding, MODEL [RefSeq] |
| 18920689 | Frk | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (ortholog) ; nucleoplasm (ortholog) | | | | Naked Mole-Rat | 26 | name | gene, protein-coding, MODEL [RefSeq] |
| 626140872 | Frk | fyn related Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cell differentiation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH glucose intolerance (ortholog); Goldenhar syndrome (ortholog); FOUND IN cytoplasm (ortholog) ; nucleoplasm (ortholog) | | | | Black Rat | 13 | name | gene, protein-coding, MODEL [RefSeq] |
| 8714138 | LOC102016684 | tyrosine-protein kinase Fyn pseudogene | | NW_004955465 | 730076 | 731579 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 1307224 | Rictor | RPTOR independent companion of MTOR, complex 2 | ENCODES a protein that exhibits ATP binding (ortholog); enzyme-substrate adaptor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN positive regulation of endothelial cell proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; r egulation of phosphorylation; PARTICIPATES IN mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH breast ductal carcinoma (ortholog); colon cancer (ortholog); colorectal adenocarcinoma (ortholog); FOUND IN endoplasmic reticulum (ortholog); lysosome (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol | 2 | 57539279 | 57631291 | Rat | 198 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1623765 | Gpatch8 | G patch domain containing 8 | Enables mRNA binding activity. Acts upstream of or within hemopoiesis and mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in brain; cerebellum; and forebrain. Orthologous to human GPATCH8 (G-patch domain containing 8). [provided by Alliance of Genome Resources, Jul 20 25] | 11 | 102366737 | 102447217 | Mouse | 67 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1323506 | Rbfox2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of definitive erythrocyte differentiation. Acts upstream of or within dendrite morphogenesis; neuromuscular process controlling balance; and radial glia guided migration of Purkinje cel l. Located in nucleus. Is expressed in several structures, including blastocyst; brain; dorsal root ganglion; early embryo; and limb. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RBFOX2 (RNA binding fox-1 homolog 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 76963190 | 77193058 | Mouse | 246 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1345057 | SKAP2 | src kinase associated phosphoprotein 2 | The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This prot ein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] | 7 | 26654770 | 26864590 | Human | 122 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 619568 | CAV1 | caveolin 1 | The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and prom oting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010] | 7 | 116525009 | 116561185 | Human | 957 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 734022 | NCAM1 | neural cell adhesion molecule 1 | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous s ystem by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020] | 11 | 112961420 | 113278436 | Human | 291 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1604582 | PRAM1 | PML-RARA regulated adaptor molecule 1 | The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retin oic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008] | 19 | 8490056 | 8502640 | Human | 67 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1349191 | ZAP70 | zeta chain of T cell receptor associated protein kinase 70 | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated si gnal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 2 | 97713576 | 97756364 | Human | 315 | description | gene, protein-coding, REVIEWED [RefSeq] |
