| 2288 | Cck | cholecystokinin | ENCODES a protein that exhibits hormone activity; neuropeptide hormone activity; peptide hormone receptor binding (ortholog); INVOLVED IN apoptotic DNA fragmentation; eating behavior; memory; ASSOCIATED WITH cataract; Experimental Diabetes Mellitus; Hyperalgesia; FOUND IN axon hillock; axon initial segment; dendrite; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 130031012 | 130037702 | Rat | 240 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10298 | Cck | cholecystokinin | This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015] | 9 | 121318890 | 121324728 | Mouse | 257 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737505 | CCK | cholecystokinin | This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015] | 3 | 42257826 | 42266185 | Human | 240 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8892859 | Cck | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); peptide hormone receptor binding (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); cholecystokinin signaling pathway (ortholog); ASSOCIATED WITH acute pancrea titis (ortholog); alcohol dependence (ortholog); Alcohol Withdrawal Delirium (ortholog); FOUND IN axon (ortholog); axon hillock (ortholog); axon initial segment (ortholog) | NW_004955420 | 28438806 | 28443458 | Chinchilla | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11869762 | CCK | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); eating behavior (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); alcohol dependence (ortholog); Alcohol Withdr awal Delirium (ortholog); FOUND IN axon hillock (ortholog); axon initial segment (ortholog); dendrite (ortholog) | 3 | 42168012 | 42176358 | Bonobo | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12425793 | CCK | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); eating behavior (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); alcohol dependence (ortholog); Alcohol Withdr awal Delirium (ortholog); FOUND IN axon hillock (ortholog); axon initial segment (ortholog); dendrite (ortholog) | 23 | 11414254 | 11419990 | Dog | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12582443 | Cck | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); eating behavior (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); alcohol dependence (ortholog); Alcohol Withdr awal Delirium (ortholog); FOUND IN axon hillock (ortholog); axon initial segment (ortholog); dendrite (ortholog) | NW_004936695 | 2776705 | 2782280 | Squirrel | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13993395 | CCK | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); eating behavior (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); alcohol dependence (ortholog); Alcohol Withdr awal Delirium (ortholog); FOUND IN axon (ortholog); axon hillock (ortholog); axon initial segment (ortholog) | | | | Pig | 80 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18398116 | CCK | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); eating behavior (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); alcohol dependence (ortholog); Alcohol Withdr awal Delirium (ortholog); FOUND IN axon hillock (ortholog); axon initial segment (ortholog); dendrite (ortholog) | | | | Green Monkey | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911299 | Cck | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); peptide hormone receptor binding (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); cholecystokinin signaling pathway (ortholog); ASSOCIATED WITH acute pancrea titis (ortholog); alcohol dependence (ortholog); Alcohol Withdrawal Delirium (ortholog); FOUND IN axon hillock (ortholog); axon initial segment (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257747 | cck | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626075960 | Cck | cholecystokinin | ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); peptide hormone receptor binding (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); cholecystokinin signaling pathway (ortholog); ASSOCIATED WITH acute pancrea titis (ortholog); alcohol dependence (ortholog); Alcohol Withdrawal Delirium (ortholog); FOUND IN axon (ortholog); axon hillock (ortholog); axon initial segment (ortholog) | | | | Black Rat | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252512 | cck.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257746 | cck.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1319357 | RIPK2 | receptor interacting serine/threonine kinase 2 | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It i s a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008] | 8 | 89757816 | 89791064 | Human | 284 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1319358 | Ripk2 | receptor (TNFRSF)-interacting serine-threonine kinase 2 | This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent ac tivator of nuclear factor kappa B and inducer of apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016] | 4 | 16122740 | 16163674 | Mouse | 324 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731770 | CCKAR | cholecystokinin A receptor | This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008] | 4 | 26481396 | 26490484 | Human | 108 | symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735565 | CCKBR | cholecystokinin B receptor | This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK 'font-weight:700;'>CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015] | 11 | 6259838 | 6272127 | Human | 173 | symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1344975 | PTK7 | protein tyrosine kinase 7 (inactive) | This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] | 6 | 43076314 | 43161715 | Human | 136 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2289 | Cckar | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity; peptide hormone binding (ortholog); INVOLVED IN animal organ regeneration; cellular response to hormone stimulus; eating behavior; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH abnormal body temperature homeostasis; abnormal taste sensitivity; polyphagia; ASSOCIATED WITH obesity; pancreatic cancer; type 2 diabetes mellitus; FOUND IN endosome; terminal bouton; membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride | 14 | 61505270 | 61513618 | Rat | 114 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10299 | Cckar | cholecystokinin A receptor | Predicted to enable cholecystokinin receptor activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Predicted to be located in several cellular components, including endosome; nucleoplasm; and terminal bouton. Predicted to be active in plasma membrane. Is exp ressed in several structures, including brain; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 53855827 | 53865046 | Mouse | 153 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 2290 | Cckbr | cholecystokinin B receptor | ENCODES a protein that exhibits gastrin receptor activity; cholecystokinin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN behavioral defense response; ERK1 and ERK2 cascade; estrous cycle; PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynami cs pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH colitis; Experimental Diabetes Mellitus; Hyperalgesia; FOUND IN membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-catechin; 6-propyl-2-thiouracil; alpha-Zearalanol | 1 | 169183578 | 169193583 | Rat | 184 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10300 | Cckbr | cholecystokinin B receptor | This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation a nd memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015] | 7 | 105075201 | 105085546 | Mouse | 234 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12279488 | CCKBR | cholecystokinin B receptor | ENCODES a protein that exhibits gastrin receptor activity (ortholog); INVOLVED IN behavioral defense response (ortholog); digestive tract development (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine p harmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN plasma membrane (ortholog) | 21 | 29602066 | 29606343 | Dog | 71 | symbol , old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 736302 | DBI | diazepam binding inhibitor, acyl-CoA binding protein | This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 2 | 119366977 | 119372543 | Human | 242 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1614323 | Ptk7 | PTK7 protein tyrosine kinase 7 | Acts upstream of or within several processes, including cochlea morphogenesis; heart development; and morphogenesis of an epithelium. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; nervous system; paraxial mesenchyme; reproductive system; and sensory organ. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 46875377 | 46940975 | Mouse | 178 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16569939 | AC018358.1 | novel transcript, antisense to CCK | | | | | Human | | name | gene, lncrna |
| 12224114 | CCKAR | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithiasis (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); terminal bouton (ortholog) | 3 | 84010700 | 84019066 | Dog | 57 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 3749 | Spink1 | serine peptidase inhibitor, Kazal type 1 | ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity; peptidase inhibitor activity (ortholog); INVOLVED IN cellular response to peptide hormone stimulus; negative regulation of serine-type endopeptidase activity; positive regulation of cytosolic calcium ion concentration; ASS OCIATED WITH Acute Experimental Pancreatitis; Chronic Experimental Pancreatitis; Inflammation; FOUND IN extracellular space; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 1-nitropropane | 18 | 36121626 | 36133596 | Rat | 218 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8731061 | Cckar | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithias is (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); membrane (ortholog); plasma membrane (ortholog) | NW_004955443 | 18738029 | 18748684 | Chinchilla | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11962726 | CCKAR | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithiasis (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); terminal bouton (ortholog) | 4 | 20881340 | 20890986 | Bonobo | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12578545 | Cckar | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithiasis (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); terminal bouton (ortholog) | NW_004936477 | 3306898 | 3314659 | Squirrel | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14156590 | CCKAR | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithiasis (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); terminal bouton (ortholog) | | | | Pig | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18590044 | CCKAR | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithiasis (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); terminal bouton (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928267 | Cckar | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithias is (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); terminal bouton (ortholog) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235773 | cckar | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626075292 | Cckar | cholecystokinin A receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); axonogenesis (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); cholelithias is (ortholog); Gallbladder Neoplasms (ortholog); FOUND IN endosome (ortholog); membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 8983154 | Cckbr | cholecystokinin B receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); gastrin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN behavioral defense response (ortholog); cholecystokinin signaling pathway (ortholog); digestive tract development (ortholog); PARTICIPAT ES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog) | NW_004955414 | 22001351 | 22011275 | Chinchilla | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11735423 | CCKBR | cholecystokinin B receptor | ENCODES a protein that exhibits gastrin receptor activity (ortholog); INVOLVED IN behavioral defense response (ortholog); digestive tract development (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine p harmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN plasma membrane (ortholog) | 11 | 6393435 | 6405821 | Bonobo | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12518105 | Cckbr | cholecystokinin B receptor | ENCODES a protein that exhibits gastrin receptor activity (ortholog); INVOLVED IN behavioral defense response (ortholog); digestive tract development (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine p harmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN plasma membrane (ortholog) | NW_004936842 | 329551 | 341491 | Squirrel | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13873807 | CCKBR | cholecystokinin B receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); gastrin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN behavioral defense response (ortholog); cholecystokinin signaling pathway (ortholog); digestive tract development (ortholog); PARTICIPAT ES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH zearalenone | | | | Pig | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18556733 | CCKBR | cholecystokinin B receptor | ENCODES a protein that exhibits gastrin receptor activity (ortholog); INVOLVED IN behavioral defense response (ortholog); digestive tract development (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine p harmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN plasma membrane (ortholog) | | | | Green Monkey | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913986 | Cckbr | cholecystokinin B receptor | ENCODES a protein that exhibits gastrin receptor activity (ortholog); INVOLVED IN behavioral defense response (ortholog); digestive tract development (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine p harmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287657706 | cckbr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625993695 | Cckbr | cholecystokinin B receptor | ENCODES a protein that exhibits cholecystokinin receptor activity (ortholog); gastrin receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN behavioral defense response (ortholog); cholecystokinin signaling pathway (ortholog); digestive tract development (ortholog); PARTICIPAT ES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); colitis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235772 | cckar.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858902 | cckar.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859600 | cckar.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863584 | cckar.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865370 | cckar.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182582 | cckar.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 286086580 | cckbr.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288057168 | cckbr.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14372251 | CCKLR-17D1 | | | | | | Fly | | symbol | gene, null |
| 14370703 | CCKLR-17D3 | | | | | | Fly | | symbol | gene, null |
| 1349737 | CCL28 | C-C motif chemokine ligand 28 | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotac tic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] | 5 | 43356975 | 43412391 | Human | 116 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1552437 | Ccl28 | C-C motif chemokine ligand 28 | Enables chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and killing of cells of another organism. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be active in extracellular s pace. Predicted to colocalize with secretory granule. Orthologous to human CCL28 (C-C motif chemokine ligand 28). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 120085355 | 120115895 | Mouse | 137 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1343149 | HLA-C | major histocompatibility complex, class I, C | HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020] | 6 | 31268749 | 31272092 | Human | 172 | UniProt , GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1349444 | HLA-A | major histocompatibility complex, class I, A | HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020] | 6 | 29942532 | 29945870 | Human | 300 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1352836 | HLA-B | major histocompatibility complex, class I, B | HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] | 6 | 31353875 | 31357179 | Human | 573 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1351810 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II mo lecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008] | 6 | 32637406 | 32655272 | Human | 464 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1353906 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II mole cules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] | 6 | 32659467 | 32666657 | Human | 709 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 734118 | MMP14 | matrix metallopeptidase 14 | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secrete d as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008] | 14 | 22836585 | 22847758 | Human | 557 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 736735 | RHD | Rh blood group D antigen | The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD p rotein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 25272486 | 25330445 | Human | 92 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1342931 | PRKD2 | protein kinase D2 | The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bin d to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 19 | 46674316 | 46717114 | Human | 176 | description | gene, protein-coding, REVIEWED [RefSeq] |
